Published peptide research references
Elamipretide
Governed registry record
26 approved source records with original-source links. Source verification confirms the reference and its connection to this record; it does not certify every scientific conclusion or establish safety or efficacy.
Open the peptide evidence profile →Approved source records
Beyond the injection: delivery systems reshaping retinal disease management.
DOI: 10.1080/14656566.2025.2496424PMID: 40319468
Source identity and connection checked by Codex (AI).
Elamipretide: First Approval.
Matt Shirley · Drugs · 2026
Is an emerging pharmacotherapeutic era for rare mitochondrial diseases here?
Jirair K Bedoyan; Jerry Vockley · Cell metabolism · 2026
RePOWER: An International, Prospective, Non-Interventional Registry of Patients With Primary Mitochondrial Myopathy.
Amel Karaa; Amy Goldstein; Bruce H Cohen; Richard H Haas; Jerry Vockley; Gráinne S Gorman; Michelangelo Mancuso; RePOWER, MMPOWER‐3, and MOTOR investigators · Clinical genetics · 2026
Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
Christopher L Mendias; Tariq M Awan · Sports medicine (Auckland, N.Z.) · 2026
Synergistic mitochondrial homeostasis regulation and cholinergic circuits reconstruction via a one-step synthesized multifunctional hydrogel facilitates spinal cord injury repair.
Yiqian Luo; Pan Jiang; Daoqiang Huang; Hong Li; Jiale He; Ruoqi Shen; Yunheng Jiang; Limin Rong; Bin Liu · Bioactive materials · 2026
Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential.
Cheryl Tung; Fahimeh Varzideh; Emanuele Farroni; Pasquale Mone; Urna Kansakar; Stanislovas S Jankauskas; Gaetano Santulli · International journal of molecular sciences · 2025
Examination of mitochondria- and inflammasome-mediated mechanisms of clozapine-induced myocarditis using patient-derived iPSC cardiomyocytes.
Nazanin Vaziri; Timothy E Shutt; Wasi Karim; Thomas J Raedler; Christos Pantelis; Naveen Thomas; Mahesh Jayaram; Steven C Greenway; Chad A Bousman · Molecular psychiatry · 2025
Mitochondrial Dysfunction: The Silent Catalyst of Kidney Disease Progression.
Nikola Pavlović; Marinela Križanac; Marko Kumrić; Katarina Vukojević; Joško Božić · Cells · 2025
SS-31 Targets NOS2 to Enhance Osteogenic Differentiation in Aged BMSCs by Restoring Mitochondrial Function.
Sen Duan; Qindong Zhang; Jinqiang Zhu; Jiaming Wang · Organogenesis · 2025
SS-31@Fer-1 Alleviates ferroptosis in hypoxia/reoxygenation cardiomyocytes via mitochondrial targeting.
Hao Zheng; Jinbo Ou; Hui Han; Qizheng Lu; Yunli Shen · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
Targeting ANT1 to regulate PINK1/Parkin-mediated mitophagy is an effective treatment of trauma-induced tendon heterotopic ossification.
Guanzhi Li; Tong Li; Ye Deng; Xiao Deng; Chao Chen; Bin Yu; Kairui Zhang · Journal of orthopaedic translation · 2025
Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization.
Yasmyn E Winstanley; Ryan D Rose; Alexander P Sobinoff; Linda L Wu; Deepak Adhikari; Qing-Hua Zhang; Jadon K Wells; Lee H Wong; Hazel H Szeto; Sandra G Piltz; Paul Q Thomas; Mark A Febbraio · Nature communications · 2025
ALCAT1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease.
Yiqun Hao; Yanqin Fan; Jun Feng; Zijing Zhu; Zilv Luo; Hongtu Hu; Weiwei Li; Hongxia Yang; Guohua Ding · Cell communication and signaling : CCS · 2024
Effect of Aficamten on Health Status Outcomes in Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA-HCM.
Charles F Sherrod; Sara Saberi; Michael E Nassif; Brian L Claggett; Caroline J Coats; Pablo Garcia-Pavia; James L Januzzi; Gregory D Lewis; Changsheng Ma; Martin S Maron; Zi Michael Miao; Iacopo Olivotto · Journal of the American College of Cardiology · 2024
Genome-Wide CRISPR Screen Identifies Phospholipid Scramblase 3 as the Biological Target of Mitoprotective Drug SS-31.
Josie A Silvaroli; Bijay Bisunke; Ji Young Kim; Amanda Stayton; Laura A Jayne; Shirely A Martinez; Christopher Nguyen; Prisha S Patel; Thitinee Vanichapol; Vivek Verma; Juheb Akhter; Subhashini Bolisetty · Journal of the American Society of Nephrology : JASN · 2024
Genotype-specific effects of elamipretide in patients with primary mitochondrial myopathy: a post hoc analysis of the MMPOWER-3 trial.
Amel Karaa; Enrico Bertini; Valerio Carelli; Bruce Cohen; Gregory M Ennes; Marni J Falk; Amy Goldstein; Gráinne Gorman; Richard Haas; Michio Hirano; Thomas Klopstock; Mary Kay Koenig · Orphanet journal of rare diseases · 2024
Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial.
Amel Karaa; Enrico Bertini; Valerio Carelli; Bruce H Cohen; Gregory M Enns; Marni J Falk; Amy Goldstein; Gráinne Siobhan Gorman; Richard Haas; Michio Hirano; Thomas Klopstock; Mary Kay Koenig · Neurology · 2023
A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction.
Zhi Zheng; Cai Lei; Hongbing Liu; Mingchao Jiang; Zongtao Zhou; Yuqi Zhao; Cui-Yun Yu; Hua Wei · Advanced healthcare materials · 2022
Elamipretide for Barth syndrome cardiomyopathy: gradual rebuilding of a failed power grid.
Hani N Sabbah · Heart failure reviews · 2022
Quality of life in Barth syndrome.
Alexander Y Kim; Hilary Vernon; Ryan Manuel; Mohammed Almuqbil; Brittany Hornby · Therapeutic advances in rare disease · 2022
Targeting mitochondrial dysfunction with elamipretide.
Chukwuemeka Obi; Alexander T Smith; Gregory J Hughes; Adedayo A Adeboye · Heart failure reviews · 2022
Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD).
Sonali Nashine · Cells · 2021
Mitochondrial protein interaction landscape of SS-31.
Juan D Chavez; Xiaoting Tang; Matthew D Campbell; Gustavo Reyes; Philip A Kramer; Rudy Stuppard; Andrew Keller; Huiliang Zhang; Peter S Rabinovitch; David J Marcinek; James E Bruce · Proceedings of the National Academy of Sciences of the United States of America · 2020
Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
Weixing Zhao; Zhipeng Xu; Jiangbei Cao; Qiang Fu; Yishuang Wu; Xiaoying Zhang; Yue Long; Xuan Zhang; Yitian Yang; Yunfeng Li; Weidong Mi · Journal of neuroinflammation · 2019
Novel cell-penetrating peptide targeting mitochondria.
Carmine Pasquale Cerrato; Marco Pirisinu; Efstathios Nikolaos Vlachos; Ülo Langel · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015