2024Phase 3 human evidence
Genotype-specific effects of elamipretide in patients with primary mitochondrial myopathy: a post hoc analysis of the MMPOWER-3 trial.
PubMed-indexed journal article; randomized controlled trial; clinical trial, phase iii; research support, n.i.h., extramural; research support, non-u.s. gov't examining genotype-specific effects of elamipretide in patients with primary mitochondrial myopathy: a post hoc analysis of the mmpower-3 trial. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Amel Karaa; Enrico Bertini; Valerio Carelli; Bruce Cohen; Gregory M Ennes; Marni J Falk; Amy Goldstein; Gráinne Gorman; Richard Haas; Michio Hirano; Thomas Klopstock; Mary Kay Koenig
- Source
- Orphanet journal of rare diseases
- DOI
- 10.1002/crt2.41
- PubMed
- 39574155
Open original source2023Phase 3 human evidence
Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial.
PubMed-indexed randomized controlled trial; clinical trial, phase iii; journal article; research support, non-u.s. gov't examining efficacy and safety of elamipretide in individuals with primary mitochondrial myopathy: the mmpower-3 randomized clinical trial. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Amel Karaa; Enrico Bertini; Valerio Carelli; Bruce H Cohen; Gregory M Enns; Marni J Falk; Amy Goldstein; Gráinne Siobhan Gorman; Richard Haas; Michio Hirano; Thomas Klopstock; Mary Kay Koenig
- Source
- Neurology
- DOI
- 10.1101/2020.11.20.20235580
- PubMed
- 37268435
Open original source2024Phase 3 human evidence
Effect of Aficamten on Health Status Outcomes in Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA-HCM.
PubMed-indexed journal article; randomized controlled trial; clinical trial, phase iii; multicenter study examining effect of aficamten on health status outcomes in obstructive hypertrophic cardiomyopathy: results from sequoia-hcm. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Charles F Sherrod; Sara Saberi; Michael E Nassif; Brian L Claggett; Caroline J Coats; Pablo Garcia-Pavia; James L Januzzi; Gregory D Lewis; Changsheng Ma; Martin S Maron; Zi Michael Miao; Iacopo Olivotto
- Source
- Journal of the American College of Cardiology
- DOI
- 10.1016/j.jacc.2021.10.045
- PubMed
- 39217569
Open original source2026Observational human evidence
Elamipretide: First Approval.
PubMed-indexed journal article; review examining elamipretide: first approval. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Matt Shirley
- Source
- Drugs
- DOI
- 10.1002/jcsm.12559
- PubMed
- 41335372
Open original source2025Observational human evidence
SS-31@Fer-1 Alleviates ferroptosis in hypoxia/reoxygenation cardiomyocytes via mitochondrial targeting.
PubMed-indexed journal article examining ss-31@fer-1 alleviates ferroptosis in hypoxia/reoxygenation cardiomyocytes via mitochondrial targeting. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Hao Zheng; Jinbo Ou; Hui Han; Qizheng Lu; Yunli Shen
- Source
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- DOI
- 10.1016/j.biopha.2025.117832
- PubMed
- 39848110
Open original source2025Observational human evidence
Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization.
PubMed-indexed journal article examining telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Yasmyn E Winstanley; Ryan D Rose; Alexander P Sobinoff; Linda L Wu; Deepak Adhikari; Qing-Hua Zhang; Jadon K Wells; Lee H Wong; Hazel H Szeto; Sandra G Piltz; Paul Q Thomas; Mark A Febbraio
- Source
- Nature communications
- DOI
- 10.1038/s41588-018-0055-6
- PubMed
- 40087268
Open original source2025Observational human evidence
Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential.
PubMed-indexed journal article; review examining elamipretide: a review of its structure, mechanism of action, and therapeutic potential. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Cheryl Tung; Fahimeh Varzideh; Emanuele Farroni; Pasquale Mone; Urna Kansakar; Stanislovas S Jankauskas; Gaetano Santulli
- Source
- International journal of molecular sciences
- DOI
- 10.1161/CIRCINTERVENTIONS.117.005487
- PubMed
- 39940712
Open original source2022Observational human evidence
Targeting mitochondrial dysfunction with elamipretide.
PubMed-indexed journal article; review; research support, non-u.s. gov't examining targeting mitochondrial dysfunction with elamipretide. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Chukwuemeka Obi; Alexander T Smith; Gregory J Hughes; Adedayo A Adeboye
- Source
- Heart failure reviews
- DOI
- 10.1056/NEJMoa2025797
- PubMed
- 35037146
Open original source2025Observational human evidence
Examination of mitochondria- and inflammasome-mediated mechanisms of clozapine-induced myocarditis using patient-derived iPSC cardiomyocytes.
PubMed-indexed journal article examining examination of mitochondria- and inflammasome-mediated mechanisms of clozapine-induced myocarditis using patient-derived ipsc cardiomyocytes. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Nazanin Vaziri; Timothy E Shutt; Wasi Karim; Thomas J Raedler; Christos Pantelis; Naveen Thomas; Mahesh Jayaram; Steven C Greenway; Chad A Bousman
- Source
- Molecular psychiatry
- DOI
- 10.1038/s41380-025-02935-z
- PubMed
- 39962181
Open original source2021Observational human evidence
Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD).
PubMed-indexed journal article; review examining potential therapeutic candidates for age-related macular degeneration (amd). Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Sonali Nashine
- Source
- Cells
- DOI
- 10.1167/iovs.11-7524
- PubMed
- 34572131
Open original source2026Observational human evidence
RePOWER: An International, Prospective, Non-Interventional Registry of Patients With Primary Mitochondrial Myopathy.
PubMed-indexed journal article; multicenter study; observational study; research support, non-u.s. gov't examining repower: an international, prospective, non-interventional registry of patients with primary mitochondrial myopathy. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Amel Karaa; Amy Goldstein; Bruce H Cohen; Richard H Haas; Jerry Vockley; Gráinne S Gorman; Michelangelo Mancuso; RePOWER, MMPOWER‐3, and MOTOR investigators
- Source
- Clinical genetics
- DOI
- 10.1111/cge.70026
- PubMed
- 40785393
Open original source2020Observational human evidence
Mitochondrial protein interaction landscape of SS-31.
PubMed-indexed journal article; research support, n.i.h., extramural; research support, non-u.s. gov't examining mitochondrial protein interaction landscape of ss-31. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Juan D Chavez; Xiaoting Tang; Matthew D Campbell; Gustavo Reyes; Philip A Kramer; Rudy Stuppard; Andrew Keller; Huiliang Zhang; Peter S Rabinovitch; David J Marcinek; James E Bruce
- Source
- Proceedings of the National Academy of Sciences of the United States of America
- DOI
- 10.1101/2020.01.02.893362
- PubMed
- 32554501
Open original source2025Observational human evidence
Targeting ANT1 to regulate PINK1/Parkin-mediated mitophagy is an effective treatment of trauma-induced tendon heterotopic ossification.
PubMed-indexed journal article examining targeting ant1 to regulate pink1/parkin-mediated mitophagy is an effective treatment of trauma-induced tendon heterotopic ossification. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Guanzhi Li; Tong Li; Ye Deng; Xiao Deng; Chao Chen; Bin Yu; Kairui Zhang
- Source
- Journal of orthopaedic translation
- DOI
- 10.1093/eurheartj/ehv597
- PubMed
- 41542093
Open original source2024Observational human evidence
Genome-Wide CRISPR Screen Identifies Phospholipid Scramblase 3 as the Biological Target of Mitoprotective Drug SS-31.
PubMed-indexed letter; research support, non-u.s. gov't; research support, n.i.h., extramural examining genome-wide crispr screen identifies phospholipid scramblase 3 as the biological target of mitoprotective drug ss-31. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Josie A Silvaroli; Bijay Bisunke; Ji Young Kim; Amanda Stayton; Laura A Jayne; Shirely A Martinez; Christopher Nguyen; Prisha S Patel; Thitinee Vanichapol; Vivek Verma; Juheb Akhter; Subhashini Bolisetty
- Source
- Journal of the American Society of Nephrology : JASN
- DOI
- 10.1021/bi701962c
- PubMed
- 38530359
Open original source2025Observational human evidence
Mitochondrial Dysfunction: The Silent Catalyst of Kidney Disease Progression.
PubMed-indexed journal article; review; research support, non-u.s. gov't examining mitochondrial dysfunction: the silent catalyst of kidney disease progression. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Nikola Pavlović; Marinela Križanac; Marko Kumrić; Katarina Vukojević; Joško Božić
- Source
- Cells
- DOI
- 10.4103/ijot.ijot_37_23
- PubMed
- 40497970
Open original source2022Observational human evidence
Elamipretide for Barth syndrome cardiomyopathy: gradual rebuilding of a failed power grid.
PubMed-indexed journal article; review; research support, non-u.s. gov't examining elamipretide for barth syndrome cardiomyopathy: gradual rebuilding of a failed power grid. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Hani N Sabbah
- Source
- Heart failure reviews
- DOI
- 10.1681/ASN.2016070761
- PubMed
- 34623544
Open original source2026Observational human evidence
Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
PubMed-indexed journal article; review examining safety and efficacy of approved and unapproved peptide therapies for musculoskeletal injuries and athletic performance. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Christopher L Mendias; Tariq M Awan
- Source
- Sports medicine (Auckland, N.Z.)
- DOI
- 10.1038/sj.embor.7400236
- PubMed
- 41966639
Open original source2024Observational human evidence
ALCAT1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease.
PubMed-indexed video-audio media; journal article; research support, non-u.s. gov't examining alcat1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Yiqun Hao; Yanqin Fan; Jun Feng; Zijing Zhu; Zilv Luo; Hongtu Hu; Weiwei Li; Hongxia Yang; Guohua Ding
- Source
- Cell communication and signaling : CCS
- DOI
- 10.1186/s12964-023-01399-4
- PubMed
- 38200543
Open original source2022Observational human evidence
A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction.
PubMed-indexed journal article; research support, non-u.s. gov't examining a ros-responsive liposomal composite hydrogel integrating improved mitochondrial function and pro-angiogenesis for efficient treatment of myocardial infarction. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Zhi Zheng; Cai Lei; Hongbing Liu; Mingchao Jiang; Zongtao Zhou; Yuqi Zhao; Cui-Yun Yu; Hua Wei
- Source
- Advanced healthcare materials
- DOI
- 10.1002/adhm.202200990
- PubMed
- 35848825
Open original source2026Observational human evidence
Is an emerging pharmacotherapeutic era for rare mitochondrial diseases here?
PubMed-indexed journal article examining is an emerging pharmacotherapeutic era for rare mitochondrial diseases here?. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Jirair K Bedoyan; Jerry Vockley
- Source
- Cell metabolism
- DOI
- 10.1016/j.cmet.2026.04.014
- PubMed
- 42229401
Open original source2022Observational human evidence
Quality of life in Barth syndrome.
PubMed-indexed journal article examining quality of life in barth syndrome. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Alexander Y Kim; Hilary Vernon; Ryan Manuel; Mohammed Almuqbil; Brittany Hornby
- Source
- Therapeutic advances in rare disease
- DOI
- 10.1177/26330040221093743
- PubMed
- 37180415
Open original source2026Observational human evidence
Synergistic mitochondrial homeostasis regulation and cholinergic circuits reconstruction via a one-step synthesized multifunctional hydrogel facilitates spinal cord injury repair.
PubMed-indexed journal article examining synergistic mitochondrial homeostasis regulation and cholinergic circuits reconstruction via a one-step synthesized multifunctional hydrogel facilitates spinal cord injury repair. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Yiqian Luo; Pan Jiang; Daoqiang Huang; Hong Li; Jiale He; Ruoqi Shen; Yunheng Jiang; Limin Rong; Bin Liu
- Source
- Bioactive materials
- DOI
- 10.1016/j.bioactmat.2025.12.009
- PubMed
- 41551770
Open original source2025Observational human evidence
SS-31 Targets NOS2 to Enhance Osteogenic Differentiation in Aged BMSCs by Restoring Mitochondrial Function.
PubMed-indexed journal article examining ss-31 targets nos2 to enhance osteogenic differentiation in aged bmscs by restoring mitochondrial function. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Sen Duan; Qindong Zhang; Jinqiang Zhu; Jiaming Wang
- Source
- Organogenesis
- DOI
- 10.1073/pnas.2207993120
- PubMed
- 40570323
Open original source2019Animal research
Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
PubMed-indexed journal article examining elamipretide (ss-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Weixing Zhao; Zhipeng Xu; Jiangbei Cao; Qiang Fu; Yishuang Wu; Xiaoying Zhang; Yue Long; Xuan Zhang; Yitian Yang; Yunfeng Li; Weidong Mi
- Source
- Journal of neuroinflammation
- DOI
- 10.1186/1742-2094-9-106
- PubMed
- 31747905
Open original source2015Laboratory research
Novel cell-penetrating peptide targeting mitochondria.
PubMed-indexed journal article examining novel cell-penetrating peptide targeting mitochondria. Machine-staged source candidate; findings and limitations require accountable review before publication.
- Authors
- Carmine Pasquale Cerrato; Marco Pirisinu; Efstathios Nikolaos Vlachos; Ülo Langel
- Source
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fj.14-269225
- PubMed
- 26195590
Open original source