Overall rank 276 · Score 80 · 2026 May-Jun
Comparative real-world outcomes of tirzepatide vs semaglutide in patients with obesity and type2 diabetes: A retrospective propensity-matched cohort study.
Diabetes & vascular disease research
ObservationalAI-recommended Tier CReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 277 · Score 80 · 2025 Aug
Associations of semaglutide with Alzheimer's disease-related dementias in patients with type 2 diabetes: A real-world target trial emulation study.
Journal of Alzheimer's disease : JAD
ObservationalAI-recommended Tier CReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 278 · Score 80 · 2025
Semaglutide Therapy and Accelerated Sarcopenia in Older Adults with Type 2 Diabetes: A 24-Month Retrospective Cohort Study.
Drug design, development and therapy
ObservationalAI-recommended Tier CReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 279 · Score 80 · 2025 Sep
Early worsening of diabetic retinopathy in individuals with type 2 diabetes treated with tirzepatide: a real-world cohort study.
Diabetologia
ObservationalAI-recommended Tier COphthalmic
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 280 · Score 80 · 2025 Aug 12
GLP-1RA-Associated Diabetic Lumbosacral Radiculoplexus and Common Fibular Neuropathies: A Case-Control Evaluation.
Neurology
ObservationalAI-recommended Tier COphthalmic
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 281 · Score 80 · 2025 Jul 24
Harnessing Facebook to Investigate Real-World Mentions of Adverse Events of Glucagon-Like Peptide-1 Receptor Agonist (GLP-1 RA) Medications: Observational Study of Facebook Posts From 2022 to 2024.
JMIR infodemiology
ObservationalAI-recommended Tier CPediatric & adolescent
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 282 · Score 80 · 2025 Oct 5
Real-world safety comparison of liraglutide and semaglutide in weight management: Insights from European pharmacovigilance data.
European journal of pharmacology
ObservationalAI-recommended Tier CReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 283 · Score 80 · 2025 Oct
Semaglutide 2.4 mg Clinical Outcomes in Patients with Obesity or Overweight: A Real-World Retrospective Comparative Cohort Study.
Advances in therapy
ObservationalAI-recommended Tier CReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 284 · Score 80 · 2025 Dec 1
Association of semaglutide use with outcomes in chronic plantar heel pain: a prospective observational cohort and a pilot interventional study.
International journal of surgery (London, England)
ObservationalAI-recommended Tier CReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 285 · Score 80 · 2025 Aug 1
Trends in glucagon-like peptide 1 receptor agonist prescribing patterns.
The American journal of managed care
ObservationalAI-recommended Tier CReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 286 · Score 80 · 2025 Dec
Treat to target in weight management with semaglutide: Real-world evidence from an eHealth clinic.
Diabetes, obesity & metabolism
ObservationalAI-recommended Tier CReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 287 · Score 80 · 2025 Sep 30
Blinded by the drug? A vigilyze signal linking semaglutide to NAION.
International ophthalmology
ObservationalAI-recommended Tier COphthalmic
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 288 · Score 80 · 2025
Predictive factors for HbA1c and weight loss associated with semaglutide treatment in type 2 diabetes mellitus: real-world clinical evidence.
Frontiers in endocrinology
ObservationalAI-recommended Tier CType 2 diabetes
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 289 · Score 80 · 2025 Nov 4
Semaglutide and diabetic retinopathy: an OHDSI network study.
BMJ open diabetes research & care
ObservationalAI-recommended Tier COphthalmic
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 290 · Score 79 · 2024 Sep 25
Semaglutide treatment for children with obesity: an observational study.
Archives of disease in childhood
ObservationalAI-recommended Tier CWeight loss & obesityMASH & liverDiscontinuation & regainReal-world evidencePediatric & adolescent
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 291 · Score 79 · 2024 Sep 1
Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity.
JAMA internal medicine
ObservationalAI-recommended Tier CWeight loss & obesityCardiovascularDiscontinuation & regainReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 292 · Score 79 · 2024 Oct
The Use of Semaglutide in Patients With Renal Failure-A Retrospective Cohort Study.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
ObservationalAI-recommended Tier CType 2 diabetesKidneyDiscontinuation & regainReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 293 · Score 79 · 2024 Apr
Semaglutide and Tirzepatide for the Management of Weight Recurrence After Sleeve Gastrectomy: A Retrospective Cohort Study.
Obesity surgery
ObservationalAI-recommended Tier CDiscontinuation & regainReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 294 · Score 79 · 2024 Jul
Risk of diabetic retinopathy and diabetic macular oedema with sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists in type 2 diabetes: a real-world data study from a global federated database.
Diabetologia
ObservationalAI-recommended Tier COphthalmicReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 295 · Score 79 · 2024
The maintenance of long-term weight loss after semaglutide withdrawal in obese women with PCOS treated with metformin: a 2-year observational study.
Frontiers in endocrinology
ObservationalAI-recommended Tier CDiscontinuation & regainReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 296 · Score 79 · 2024
Changes in body weight and composition, metabolic parameters, and quality of life in patients with type 2 diabetes treated with subcutaneous semaglutide in real-world clinical practice.
Frontiers in endocrinology
ObservationalAI-recommended Tier CType 2 diabetesReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 297 · Score 79 · 2024 Feb
Weight loss response in patients with obesity treated with injectable semaglutide in a real-world setting.
Endocrine
ObservationalAI-recommended Tier CReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 298 · Score 79 · 2024 Jan
Association of semaglutide with risk of suicidal ideation in a real-world cohort.
Nature medicine
ObservationalAI-recommended Tier CReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 299 · Score 79 · 2024 Aug
Association of semaglutide with reduced incidence and relapse of cannabis use disorder in real-world populations: a retrospective cohort study.
Molecular psychiatry
ObservationalAI-recommended Tier CReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Overall rank 300 · Score 79 · 2024 May 28
Associations of semaglutide with incidence and recurrence of alcohol use disorder in real-world population.
Nature communications
ObservationalAI-recommended Tier CReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains observational evidence with a Tier C recommendation. No experimental retesting was performed or required.
Source registry generated 2026-09-17; AI appraisal completed 2026-09-22 under WPF-SGLT-AI-APPRAISAL-1.0. Humans resolve only the three displayed exceptions and record one accountable bundle publication decision. Records can appear in multiple domains; domain totals therefore overlap.