Published peptide research references
Ziconotide
Governed registry record
153 approved source records with original-source links. Source verification confirms the reference and its connection to this record; it does not certify every scientific conclusion or establish safety or efficacy.
Open the peptide evidence profile →Approved source records
A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide)
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A Simple Approach to Assign Disulfide Connectivity for Ziconotide via Partial Reduction Without Alkylation.
DOI: 10.1002/rcm.10026PMID: 40084697
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Determination of related substances in disulfide-rich peptide ziconotide by establishing tandem mass spectrometry methods.
DOI: 10.1016/j.jpha.2024.101037PMID: 39386004
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Efficacy and safety of the Ca<sub>v</sub>2.2 blocker Ziconotide in pain: a meta-analysis and systematic review.
DOI: 10.1097/pr9.0000000000001363PMID: 41255849
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Functional crosstalk between neuropeptide FF system and N-type voltage-gated calcium channels in ziconotide-mediated antinociception in mice.
DOI: 10.1007/s00213-026-07053-4PMID: 41910723
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ID:15841 A Case of Prolonged Psychosis With Intrathecal Ziconotide
DOI: 10.1016/j.neurom.2022.02.146
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Recurrent Ziconotide-Associated Delirium and Psychosis: A Case Report.
DOI: 10.1097/jcp.0000000000002021PMID: 40511848
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Scalable Ligand-Receptor Binding Affinity Landscape: A Case Study with Ziconotide and Ca<sub>V</sub>2.2
DOI: 10.20944/preprints202409.0877.v1
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Ziconotide ( ω‐conotoxin MVIIA )—Efficient solid‐phase synthesis of a linear precursor peptide and its strategic native folding
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Ziconotide and pain in multiple sclerosis: a case report
DOI: 10.22541/au.176521176.64921719/v1
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Ziconotide as an Opioid Rescue: Economic, Clinical, and Subgroup Considerations [Letter].
DOI: 10.2147/jpr.s571927PMID: 41229894
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Intrathecal Ziconotide Long-Term Management in Chronic Postamputation Pain.
2026
Real-Life Data on Ziconotide-Based Intrathecal Therapy in Patients With Cancer Pain: Interim Analysis of the Observational Practice in Clinics Registry.
2026
Can Ziconotide Be Used to Replace Opioids? Exploratory Clinical Experience in 5 Patients Treated in the Pain Unit.
2025
Dilution of Ziconotide for Intrathecal Trial: The Effect of Dilution on the Incidence of Side Effects and Pain Relief: A Single-center Retrospective Case-control Study.
2025
A Benefit/Risk Assessment of Intrathecal Ziconotide in Chronic Pain: A Narrative Review.
2024
A comprehensive review on ziconotide.
2024
Intrathecal Ziconotide Infusion Therapy for Oncologic Refractory Neuropathic Pain: Case Report With High-Dose Intraventricular Ziconotide After 15 Years of Treatment.
2024
Intrathecal ziconotide for the treatment of chronic pain: a collection of clinical experiences and literature review.
2024
Physicochemical Stability Study of the Morphine-Bupivacaine-Ziconotide Association.
2024
SPIDOL study protocol for the assessment of intrathecal ziconotide antalgic efficacy for severe refractory neuropathic pain due to spinal cord lesions.
2024
Ziconotide and psychosis: from a case report to a scoping review.
2024
A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide).
2023
Long-Term Follow-Up (>11 Years) on Successful Pregnancies With Ziconotide Monotherapy for Arachnoiditis-Related Chronic Pain.
2023
Microneedle-mediated delivery of Ziconotide-loaded liposomes fused with exosomes for analgesia.
2023
Physicochemical Stability Study of the Morphine-Ropivacaine-Ziconotide Association in Implantable Pumps for Intrathecal Administration.
2023
Ziconotide for the Management of Cancer Pain: A Budget Impact Analysis.
2023
Intrathecal Administration of Ziconotide as a Potential Treatment for Chronic Migraines.
2022
Effect of First-Line Ziconotide Intrathecal Drug Therapy for Neuropathic Pain on Disability, Emotional Well-Being, and Pain Catastrophizing.
2021
Intrathecal pain management with ziconotide: Time for consensus?
2021
Short-Term Outcomes of a High-Volume, Low-Concentration Bolus Starting Dose Technique With Ziconotide: A Case Series.
2021
Stability Study of Admixtures Combining Ziconotide With Morphine or Sufentanil in Polypropylene Syringes.
2021
Structure of human Ca<sub>v</sub>2.2 channel blocked by the painkiller ziconotide.
2021
[What became of Prialt®? : Observational study on the use of ziconotide in the treatment of chronic pain].
2021
Antidepressant-like and memory-enhancing effects of the N-type calcium channel blocker ziconotide in rats.
2020
Effectiveness and Safety of Intrathecal Ziconotide: Final Results of the Patient Registry of Intrathecal Ziconotide Management (PRIZM).
2020
Intracerebroventricular administration of N-type calcium channel blocker ziconotide displays anticonvulsant, anxiolytic, and sedative effects in rats: A preclinical and pilot study.
2020
Study of Physicochemical Stability of Ziconotide in Medication Cassette Reservoir.
2020
Ziconotide for Management of Cancer Pain Refractory to Pharmacotherapy: An Update.
2020
Ziconotide-Induced Oro-lingual Dyskinesia: 3 Cases.
2020
Intrathecal Therapy for Chronic Pain: A Review of Morphine and Ziconotide as Firstline Options.
2019
Low-Dose Intrathecal Ziconotide for Spasticity From Primary Lateral Sclerosis: A Case Report.
2019
Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways.
2019
Ziconotide for spinal cord injury-related pain.
2019
Do the potential benefits outweigh the risks? An update on the use of ziconotide in clinical practice.
2018
Effectiveness and Safety of Intrathecal Ziconotide: Interim Analysis of the Patient Registry of Intrathecal Ziconotide Management (PRIZM).
2018
Ziconotide-induced psychosis: A case report and literature review.
2018
Chemical Stability of Morphine, Ropivacaine, and Ziconotide in Combination for Intrathecal Analgesia.
2017
Perioperative Management of a Patient With an Intrathecal Drug Delivery Device Infusing Ziconotide: A Case Report.
2017
The Pharmacology of Spinal Opioids and Ziconotide for the Treatment of Non-Cancer Pain.
2017
Use of Low Dose Ziconotide as First-Line Intrathecal Monotherapy.
2017
Ziconotide Monotherapy: A Systematic Review of Randomised Controlled Trials.
2017
Delivery of ziconotide to cerebrospinal fluid via intranasal pathway for the treatment of chronic pain.
2016
Does pain relief influence recovery of consciousness? A case report of a patient treated with ziconotide.
2016
Intracerebroventricular Pain Treatment with Analgesic Mixtures including Ziconotide for Intractable Pain.
2016
Intrathecal Ziconotide: Dosing and Administration Strategies in Patients With Refractory Chronic Pain.
2016
Ziconotide intrathecal delivery as treatment for secondary therapeutic failure of motor cortex stimulation after 6 years.
2016
Acute rhabdomyolysis in a patient with long-term exposure to intrathecal ziconotide: a case report.
2015
Aseptic arachnoiditis in a patient treated with intrathecal morphine infusion: symptom resolution on switch to ziconotide.
2015
Dual Effect of Ziconotide in Primary Erythromelalgia.
2015
Influence of pH and temperature on ziconotide stability in intrathecal analgesic admixtures in implantable pumps and syringes.
2015
Intrathecal Pharmacology Update: Novel Dosing Strategy for Intrathecal Monotherapy Ziconotide on Efficacy and Sustainability.
2015
Intrathecal Ziconotide and Morphine for Pain Relief: A Case Series of Eight Patients with Refractory Cancer Pain, Including Five Cases of Neuropathic Pain.
2015
Rationale for Prospective Assays of Intrathecal Mixtures Including Morphine, Ropivacaine and Ziconotide: Prevention of Adverse Events and Feasibility in Clinical Practice.
2015
Tailored delivery of analgesic ziconotide across a blood brain barrier model using viral nanocontainers.
2015
The Relationship Between the Mechanisms of Action and Safety Profiles of Intrathecal Morphine and Ziconotide: A Review of the Literature.
2015
Ziconotide Combination Intrathecal Therapy for Noncancer Pain Is Limited Secondary to Delayed Adverse Effects: A Case Series With a 24-Month Follow-Up.
2015
Ziconotide Trialing by Intrathecal Bolus Injections: An Open-Label Non-Randomized Clinical Trial in Postoperative/Posttraumatic Neuropathic Pain Patients Refractory to Conventional Treatment.
2015
Ziconotide-induced psychosis: a case report.
2015
Dyskinesia caused by ziconotide-baclofen combination in an adolescent affected by cerebral palsy.
2014
In vitro stability of low-concentration ziconotide alone or in admixtures in intrathecal pumps.
2014
Acute cardiovascular toxicity of low-dose intrathecal ziconotide.
2013
Administering ziconotide and monitoring patients treated with ziconotide: expert opinions.
2013
Bolus intrathecal injection of ziconotide (Prialt®) to evaluate the option of continuous administration via an implanted intrathecal drug delivery (ITDD) system: a pilot study.
2013
Intrathecal ziconotide: a review of its use in patients with chronic pain refractory to other systemic or intrathecal analgesics.
2013
Spinal morphine but not ziconotide or gabapentin analgesia is affected by alternative splicing of voltage-gated calcium channel CaV2.2 pre-mRNA.
2013
Ziconotide: a clinical update and pharmacologic review.
2013
Intrathecal combination of ziconotide and morphine for refractory cancer pain: a rapidly acting and effective choice.
2012
Pharmacokinetic analysis of ziconotide (SNX-111), an intrathecal N-type calcium channel blocking analgesic, delivered by bolus and infusion in the dog.
2012
Ziconotide adverse events in patients with cancer pain: a multicenter observational study of a slow titration, multidrug protocol.
2012
Can ziconotide as a N-type voltage-sensitive calcium channel blocker open a new mode for treatment of autism? A hypothesis.
2011
Increased risk of suicide under intrathecal ziconotide treatment? - a warning.
2011
Italian registry on long-term intrathecal ziconotide treatment.
2011
Psychiatric predisposition to autonomic and abnormal perception side-effects of ziconotide: a case series study.
2011
Trigeminal neuralgia relief with intrathecal ziconotide.
2011
Ziconotide: A rapid detoxification protocol for the conversion from intrathecal morphine--the Raffaeli Detoxification Model.
2011
[Experience in treatment of patients with neuropathic facial pain using ziconotide].
2011
[Neuropsychiatric side effects of intrathecal ziconotide].
2011
CNSB004 (Leconotide) causes antihyperalgesia without side effects when given intravenously: a comparison with ziconotide in a rat model of diabetic neuropathic pain.
2010
Case report: successful treatment of a patient with trigeminal neuropathy using ziconotide.
2010
Considerations and methodology for trialing ziconotide.
2010
Ziconotide combination intrathecal therapy: rationale and evidence.
2010
Ziconotide for treatment of severe chronic pain.
2010
[Recommendations for the management of chronic pain by intrathecal ziconotide].
2010
Cost-effectiveness of ziconotide in intrathecal pain management for severe chronic pain patients in the UK.
2009
Intrathecal therapy: what has changed with the introduction of ziconotide.
2009
Intrathecal ziconotide and baclofen provide pain relief in seven patients with neuropathic pain and spasticity: case reports.
2009
Intrathecal ziconotide and opioid combination therapy for noncancer pain: an observational study.
2009
Intrathecal ziconotide for complex regional pain syndrome: seven case reports.
2009
Intrathecal ziconotide for neuropathic pain: a review.
2009
Long-term intrathecal ziconotide for chronic pain: an open-label study.
2009
Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain.
2009
Continuous Intrathecal Infusion of Ziconotide for Treatment of Chronic Malignant and Nonmalignant Pain Over 12 Months: A Prospective, Open-label Study.
2008
Dilution and compounding of ziconotide for intrathecal administration.
2008
Intrathecal therapy with ziconotide: clinical experience and considerations on its use.
2008
Intrathecal ziconotide for severe chronic pain: safety and tolerability results of an open-label, long-term trial.
2008
Open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of morphine in patients receiving ziconotide for severe chronic pain.
2008
Phase II, open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of ziconotide in patients receiving intrathecal morphine for severe chronic pain.
2008
Statistical evaluation of the chemical stability of ziconotide solutions during simulated intrathecal administration.
2008
Using ziconotide for intrathecal infusions.
2008
Ziconotide: an update and review.
2008
Chemical stability of ziconotide-clonidine hydrochloride admixtures with and without morphine sulfate during simulated intrathecal administration.
2007
Nonclinical safety of ziconotide: an intrathecal analgesic of a new pharmaceutical class.
2007
Successful reduction of neuropathic pain associated with spinal cord injury via of a combination of intrathecal hydromorphone and ziconotide: a case report.
2007
Ziconotide: a review of its pharmacology and use in the treatment of pain.
2007
[Ziconotide: an innovative alternative for intense chronic neuropathic pain].
2007
A randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic pain.
2006
An effective treatment of severe complex regional pain syndrome type 1 in a child using high doses of intrathecal ziconotide.
2006
Intrathecal ziconotide for refractory chronic pain.
2006
Intrathecal ziconotide in the treatment of chronic nonmalignant pain: a randomized, double-blind, placebo-controlled clinical trial.
2006
Treatment challenges and complications with ziconotide monotherapy in established pump patients.
2006
Ziconotide infusion for severe chronic pain: case series of patients with neuropathic pain.
2006
Ziconotide--a novel neuron-specific calcium channel blocker for the intrathecal treatment of severe chronic pain--a short review.
2006
Ziconotide.
2006
Ziconotide: a new nonopioid intrathecal analgesic for the treatment of chronic pain.
2006
Ziconotide: a new option for refractory pain.
2006
[New medications; ziconotide].
2006
Elan: ziconotide review focused on off-label uses.
2005
New drugs: tigecycline, ziconotide, and clofarabine.
2005
Ziconotide (Prialt) for chronic pain.
2005
Ziconotide, an intrathecally administered N-type calcium channel antagonist for the treatment of chronic pain.
2005
Ziconotide: can we use it in palliative care?
2005
Intrathecal ziconotide for chronic pain.
2004
Intrathecal ziconotide for refractory pain.
2004
Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial.
2004
Ziconotide: neuronal calcium channel blocker for treating severe chronic pain.
2004
Pharmacokinetics and pharmacodynamics of intrathecal ziconotide in chronic pain patients.
2003
Intractable delirium associated with ziconotide successfully treated with electroconvulsive therapy.
2002
Long-term intrathecal ziconotide therapy: a case study and discussion.
2001
Ziconotide (Elan Pharmaceuticals).
2001
Adverse effects associated with the intrathecal administration of ziconotide.
2000
An evaluation of intrathecal ziconotide for the treatment of chronic pain.
2000
Bioavailability of Ziconotide in brain: influx from blood, stability, and diffusion.
2000
Effects of intrathecal administration of ziconotide, a selective neuronal N-type calcium channel blocker, on mechanical allodynia and heat hyperalgesia in a rat model of postoperative pain.
2000
Improvement in mitochondrial dysfunction as a new surrogate efficiency measure for preclinical trials: dose-response and time-window profiles for administration of the calcium channel blocker Ziconotide in experimental brain injury.
2000
Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats.
2000
Neurobehavioral protection by the neuronal calcium channel blocker ziconotide in a model of traumatic diffuse brain injury in rats.
2000
Ziconotide for the treatment of severe spasticity after spinal cord injury.
2000
Ziconotide, a new N-type calcium channel blocker, administered intrathecally for acute postoperative pain.
2000
Effects of an N-type calcium channel antagonist (SNX 111; Ziconotide) on calcium-45 accumulation following fluid-percussion injury.
1999
The neuroprotective effects of intrathecal administration of the selective N-type calcium channel blocker ziconotide in a rat model of spinal ischemia.
1999
USAN Council. List No.421. New names. Ziconotide.
1999
Ziconotide. CI 1009, SNX 111.
1999