MOTS-c

Approved source records

1. Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.

   Mendias CL, Awan TM. · 2026

   DOI: 10.1007/s40279-026-02437-0PMID: 41966639

2. Circulating Mitochondrial Open Reading Frame of the 12S Ribosomal RNA Type-c Is Higher in Acute Coronary Syndrome and Is a Prognostic Biomarker for Major Cardiac Events in Patients With Acute Myocardial Infarction: A Case-Control Study.

   Cao P, Wang B, Zhang N, Yang J, Tong Q, Gong Z. · 2025

   DOI: 10.1161/JAHA.125.041905PMID: 41368821

3. Exercise-Induced Muscle-Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging.

   Tero-Vescan A, Degens H, Matsakas A, Ștefănescu R, Ősz BE, Slevin M. · 2025

   DOI: 10.3390/ph18081222PMID: 40872612

4. MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes.

   Li X, Zhan F, Qiu G, Lu P, Shen Z, Qi Y, Wu M, Chu M, Feng J, Wen Z, Yao X, Wang A, Jin W, Zhang X, Liao J, Zhang J, Song M, Wang W, Wang X. · 2025

   DOI: 10.1016/j.redox.2025.103681PMID: 40403491

5. MOTS-c: Magical Molecule for Diabetic Cardiomyopathy?

   Yerra VG, Connelly KA. · 2025

   DOI: 10.1007/s10557-025-07689-yPMID: 40172798

6. Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Dynamics as a Complementary Marker of Treatment Response in Newly Diagnosed Multiple Myeloma: A Prospective Analysis.

   Erol V, Avci E, Kabukcu Hacioglu S, Guler N, Akgun Cagliyan G, Ünver Koluman B, Kendir IC, Elver O, Kara K, Kaya E, Alayvaz Aslan N. · 2025

   DOI: 10.7759/cureus.98204PMID: 41479490

7. MOTS-c modulates skeletal muscle function by directly binding and activating CK2.

   Kumagai H, Kim SJ, Miller B, Zempo H, Tanisawa K, Natsume T, Lee SH, Wan J, Leelaprachakul N, Kumagai ME, Ramirez R 2nd, Mehta HH, Cao K, Oh TJ, Wohlschlegel JA, Sha J, Nishida Y, Fuku N, Dobashi S, Miyamoto-Mikami E, Takaragawa M, Fuku M, Yoshihara T, Naito H, Kawakami R, Torii S, Midorikawa T, Oka K, Hara M, Iwasaka C, Yamada Y, Higaki Y, Tanaka K, Yen K, Cohen P. · 2024

   DOI: 10.1016/j.isci.2024.111212PMID: 39559755

8. Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.

   Yin Y, Li Y, Ma B, Ren C, Zhao S, Li J, Gong Y, Yang H, Li J. · 2024

   DOI: 10.1002/advs.202405620PMID: 39321430

9. Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.

   Kumagai H, Kim SJ, Miller B, Natsume T, Wan J, Kumagai ME, Ramirez R 2nd, Lee SH, Sato A, Mehta HH, Yen K, Cohen P. · 2024

   DOI: 10.1152/ajpendo.00285.2023PMID: 38170165

10. Novel function of MOTS-c in mitochondrial remodelling contributes to its antiviral role during HBV infection.

    Lin C, Luo L, Xun Z, Zhu C, Huang Y, Ye Y, Zhang J, Chen T, Wu S, Zhan F, Yang B, Liu C, Ran N, Ou Q. · 2024

    DOI: 10.1136/gutjnl-2023-330389PMID: 37788894

11. MOTS-c Functionally Prevents Metabolic Disorders.

    Gao Y, Wei X, Wei P, Lu H, Zhong L, Tan J, Liu H, Liu Z. · 2023

    DOI: 10.3390/metabo13010125PMID: 36677050

12. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.

    Zheng Y, Wei Z, Wang T. · 2023

    DOI: 10.3389/fendo.2023.1120533PMID: 36761202

13. Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases.

    Mohtashami Z, Singh MK, Neto FT, Salimiaghdam N, Hasanpour H, Kenney MC. · 2023

    DOI: 10.3390/antiox12020518PMID: 36830076

14. Role of MOTS-c in the regulation of bone metabolism.

    Yi X, Hu G, Yang Y, Li J, Jin J, Chang B. · 2023

    DOI: 10.3389/fphys.2023.1149120PMID: 37200834

15. Comparison of Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Levels in Patients With Multiple Sclerosis and Healthy Controls.

    Tekin S, Bir LS, Avci E, Şenol H, Tekin I, Çınkır U. · 2022

    DOI: 10.7759/cureus.26981PMID: 35989823

16. Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c).

    Yoon TK, Lee CH, Kwon O, Kim MS. · 2022

    DOI: 10.4093/dmj.2022.0092PMID: 35656563

17. Mitochondria-derived peptides in aging and healthspan.

    Miller B, Kim SJ, Kumagai H, Yen K, Cohen P. · 2022

    DOI: 10.1172/JCI158449PMID: 35499074

18. The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.

    Yin Y, Pan Y, He J, Zhong H, Wu Y, Ji C, Liu L, Cui X. · 2022

    DOI: 10.1016/j.phrs.2021.105987PMID: 34798268

19. Mitochondrial-derived peptides and exercise.

    Woodhead JST, Merry TL. · 2021

    DOI: 10.1016/j.bbagen.2021.130011PMID: 34520826

20. Mitochondrial-derived peptides in energy metabolism.

    Merry TL, Chan A, Woodhead JST, Reynolds JC, Kumagai H, Kim SJ, Lee C. · 2020

    DOI: 10.1152/ajpendo.00249.2020PMID: 32776825

21. MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.

    Benayoun BA, Lee C. · 2019

    DOI: 10.1002/bies.201900046PMID: 31378979

22. Mitochondrial peptides-appropriate options for therapeutic exploitation.

    Popov LD. · 2019

    DOI: 10.1007/s00441-019-03049-zPMID: 31131430

23. Mitochondrial-Derived Peptides Exacerbate Senescence.

    Mendelsohn AR, Larrick JW. · 2018

    DOI: 10.1089/rej.2018.2114PMID: 30058454

24. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.

    Kim KH, Son JM, Benayoun BA, Lee C. · 2018

    DOI: 10.1016/j.cmet.2018.06.008PMID: 29983246

25. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.

    Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. · 2015

    DOI: 10.1016/j.cmet.2015.02.009PMID: 25738459