2026Phase 1–2 human evidence
Evidence strength C · 63/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 68/100
- Directness
- 45/100
- Population relevance
- 78/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
Our objective is to present the pharmacological mechanisms, safety profiles, and regulatory status of prominent approved and unapproved peptides marketed direct to patients, including AOD-9604 (anti-obesity drug 9604), BPC-157 (body protection compound 157), CJC-1295, FS-344 (fol …
- Authors
- Mendias CL, Awan TM.
- Source
- peer_reviewed_research
- DOI
- 10.1007/s40279-026-02437-0
- PubMed
- 41966639
Open original source2025Phase 1–2 human evidence
Evidence strength C · 63/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 68/100
- Directness
- 45/100
- Population relevance
- 78/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids.
Interestingly, the expression level of the gene TMSB4X that encodes thymosin beta 4 (Tbeta4) significantly decreased both in fAD organoids' neurons and AD patients' excitatory neurons. ...
2025Phase 1–2 human evidence
Evidence strength C · 63/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 68/100
- Directness
- 45/100
- Population relevance
- 78/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Recombinant human thymosin beta 4 improves ischemic cardiac dysfunction in mice and patients with acute ST-segment elevation myocardial infarction after reperfusion.
AIMS: Despite advancements in primary percutaneous coronary intervention (PCI), cardiac dysfunction remains a challenge in patients with ST-segment elevation myocardial infarction (STEMI). Although thymosin beta 4 has shown cardioprotective effects in preclin …
2012Animal research
Evidence strength D · 50/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 46/100
- Directness
- 45/100
- Population relevance
- 25/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Thymosin beta 4 ameliorates hyperglycemia and improves insulin resistance of KK Cg-Ay/J mouse.
OBJECT: To evaluate the efficacy of thymosin beta 4 (Tbeta(4)) on hyperglycemia and insulin sensitivity in a mouse model of type 2 diabetes mellitus (T2DM). ...
2023Animal research
Evidence strength D · 50/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 46/100
- Directness
- 45/100
- Population relevance
- 25/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome.
Endothelial Sirt1 deficiency, by inhibiting autophagy and activating nuclear factor-kappa B signaling, augments expression and secretion of thymosin beta-4 (Tbeta4) that promotes insulin signaling in skeletal myotubes. Thus, unlike in skeletal myocytes, Sirt1 …
2017Animal research
Evidence strength D · 50/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 46/100
- Directness
- 45/100
- Population relevance
- 25/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Recombinant adeno-associated virus carrying thymosin beta(4) suppresses experimental colitis in mice.
AIM: To investigate the protective effect of a recombinant adeno-associated virus carrying thymosin beta(4) (AAV-Tbeta(4)) on murine colitis via intracolonic administration. METHODS: AAV-Tbeta(4) was prepared and intracolonically used to mediate the secretory …
2016Animal research
Evidence strength D · 50/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 46/100
- Directness
- 45/100
- Population relevance
- 25/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Loss of endogenous thymosin beta(4) accelerates glomerular disease.
However, the role of endogenous thymosin beta(4) in the kidney is unknown. We demonstrate that thymosin beta(4) is expressed prominently in podocytes of developing and adult mouse glomeruli. ...Lack of thymosin beta(4 …
2023Animal research
Evidence strength D · 50/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 46/100
- Directness
- 45/100
- Population relevance
- 25/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Thymosin beta 4 prevents systemic lipopolysaccharide-induced plaque load in middle-age APP/PS1 mice.
Lipopolysaccharide (LPS) produced by the gut during systemic infections and inflammation is thought to contribute to Alzheimer's disease (AD) progression. Since thymosin beta 4 (Tbeta4) effectively reduces LPS-induced inflammation in sepsis, we tested its pot …
1985Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Thymosin beta 4-like peptides.
This peer-reviewed source examines Thymosin beta 4-like peptides.
- Authors
2020Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Thymosin beta 4 attenuates PrP(106-126)-induced human brain endothelial cells dysfunction.
Prion diseases are neurodegenerative pathologies characterized by the accumulation of altered forms of the prion protein (PrP), named PrP(Sc). Thymosin beta 4 (Tbeta(4)) is an actin-sequestering peptide known to bind monomeric actin and inhibit its polymeriza …
2023Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Thymosin beta 4: A potential novel adjunct treatment for bacterial keratitis.
To this end, treatments are needed that both regulate the inflammatory response and promote corneal wound healing to resolve visual disturbances and improve quality of life. Thymosin beta 4 is a small, naturally occurring 43-amino-acid protein that promotes w …
2025Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Mechanistic study of the Tβ4/SLC7A11 signaling pathway regulating breast cancer evolution.
This peer-reviewed source examines Mechanistic study of the Tβ4/SLC7A11 signaling pathway regulating breast cancer evolution.
1985Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Thymosin beta 4.
This peer-reviewed source examines Thymosin beta 4.
- Authors
- Low TL, Goldstein AL.
2026Laboratory research
Evidence strength C · 63/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 88/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 72/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Peptide Supplements and Their Therapeutic Applications in Sports Medicine.
PURPOSE: To summarize existing peer-reviewed data on 6 emerging peptides (BPC-157, thymosin beta-4 or TB-500, CJC-1295, MK-677, ipamorelin, and GHK-Cu [copper peptide]) for musculoskeletal recovery and enhancement in animal and human models. ... …
2012Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications.
INTRODUCTION: Thymosin beta(4), a low molecular weight, naturally-occurring peptide plays a vital role in the repair and regeneration of injured cells and tissues. ...Thymosin beta(4) also decreases the number of myofibroblasts in wounds, …
2007Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
The beta-thymosin enigma.
Actin dynamics in nonmuscle cells is controlled by the availability of actin nucleating sites and actin monomers. Thymosin beta-4 (Tbeta-4) has been implicated in modulating the availability of actin monomers in a large variety of cells. ...
2007Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
beta-Thymosins.
The identification of a biological function of thymosin beta(4) was tedious. In 1990, Dan Safer and his colleagues recognized that thymosin beta(4) sequesters G-actin. ...Several biological effects are attributed to thymosin bet …
2024Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
The subcommissural organ regulates brain development via secreted peptides.
Unbiased peptidomic analysis revealed enrichment of three SCO-derived peptides, namely, thymosin beta 4, thymosin beta 10 and NP24, and their reintroduction into SCO-ablated brain ventricles substantially rescued developmental defects. ...
2025Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Enhancing fat graft survival: thymosin beta-4 facilitates mitochondrial transfer from ADSCs via tunneling nanotubes by upregulating the Rac/F-actin pathway.
This study aims to enhance the survival of fat grafts by investigating the role of thymosin beta-4 (Tbeta4) in facilitating mitochondrial transfer from adipose-derived stem cells (ADSCs) to adipocytes and newly formed blood vessels within the grafts via tunne …
1997Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells.
Thymosin beta 4 (T beta 4) is a 4.9 kDa polypeptide that interacts with G-actin and is thought to be an important mediator in cell proliferation, migration, and differentiation. ...
2017Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Thymosin Beta-4 Is Elevated in Women With Heart Failure With Preserved Ejection Fraction.
BACKGROUND: Thymosin beta-4 (TB4) is an X-linked gene product with cardioprotective properties. Little is known about plasma concentration of TB4 in heart failure (HF), and its relationship with other cardiovascular biomarkers. ...
2007Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Localization of thymosin beta-4 in tumors.
Overexpression of thymosin beta-4 has been linked to malignant progression but the localization of this polypeptide within tumors is incompletely known. ...The degree of staining of breast cancer cells for thymosin beta-4 correlated neith …
2014Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Thymosin beta 4 gene silencing decreases stemness and invasiveness in glioblastoma.
Thymosin beta 4 gene silencing promotes differentiation of neural stem cells whereas thymosin beta 4 overexpression initiates cortical folding of developing brain hemispheres. A role of thymosin beta 4 in malignant gl …
2023Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Thymosin Beta 4 Protects Hippocampal Neuronal Cells against PrP (106-126) via Neurotrophic Factor Signaling.
Prion protein peptide (PrP) has demonstrated neurotoxicity in brain cells, resulting in the progression of prion diseases with spongiform degenerative, amyloidogenic, and aggregative properties. Thymosin beta 4 (Tbeta(4)) plays a role in the nervous system an …
2023Laboratory research
Evidence strength D · 49/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
- Source authority
- 78/100
- Study design and bias control
- 42/100
- Directness
- 45/100
- Population relevance
- 30/100
- Reporting quality
- 68/100
- Replication
- 45/100
Automated structured-metadata baseline; full-text risk-of-bias review may revise this rating.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Thymosin beta-4 - A potential tool in healing middle ear lesions in adult mammals.
Consequentially, a need for substances which actively promote tympanic cell migration and proliferation is deemed essential. In our study, we utilized Thymosin beta-4 (TB4), a 43aa peptide possessing many regenerative properties in various organ systems. ...