{"schemaVersion":"wpf-profile-export-v1","exportedAt":"2026-09-18T15:31:43.747Z","profile":{"slug":"tb-500","name":"TB-500","aliases":["TB500","Thymosin beta-4 fragment","Tβ4-related peptide"],"category":"Synthetic thymosin-related research peptide"},"synthesis":{"mechanism":"TB-500 is a non-standardized market name commonly associated with a synthetic fragment or derivative of thymosin beta-4. Thymosin beta-4 binds actin and has been studied in cell migration, angiogenesis, inflammation, and repair; those findings cannot automatically be attributed to every product sold as TB-500.","evidence":"The broader thymosin beta-4 literature is substantial, but direct, composition-confirmed TB-500 human evidence is sparse. This corpus labels parent-peptide and pathway studies as contextual rather than direct evidence for the marketed compound.","safety":"Because TB-500 identity, purity, formulation, and exposure may vary, human safety cannot be inferred from endogenous thymosin beta-4 biology. Long-term systemic safety, immunogenicity, angiogenic consequences, interactions, and product-quality risks remain unresolved.","observationalBoundary":"The archive deliberately distinguishes TB-500 from full-length thymosin beta-4 and records analytical, preclinical, human, regulatory, and anti-doping sources in separate evidence lanes.","openQuestions":"What molecular entity is present in products labeled TB-500? 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We demonstrate that thymosin beta(4) is expressed prominently in podocytes of developing and adult mouse glomeruli. ...Lack of thymosin beta(4 …","authors":"Vasilopoulou E, Kolatsi-Joannou M, Lindenmeyer MT, White KE, Robson MG, Cohen CD, Sebire NJ, Riley PR, Winyard PJ, Long DA.","publishingOrg":null,"publicationYear":2016,"doi":"10.1016/j.kint.2016.06.032","pubmedId":"27575556","jurisdiction":null,"dateAccessed":"2026-09-08T19:33:45.384Z","editorialNotes":"AI-assisted corpus expansion authorized by owner on 2026-09-08. 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