Humanin

Overview

Humanin is a mitochondrial-derived peptide investigated in cellular stress and metabolic biology. Associations involving circulating humanin and experiments with related fragments do not establish a treatment in humans.

Evidence quality

WPF’s atlas includes observational human work on circulating humanin in chronic kidney disease, gestational diabetes, and other settings, as well as mechanistic and fragment-peptide studies. These designs measure different things and cannot be combined into a demonstrated therapeutic effect.

Safety concerns

No published source-linked citations or jurisdiction-specific regulatory records are attached to this Directory entry. An association or laboratory result does not establish causality, an effective intervention, or clinical safety.

Citations as of this version

• Diagnostic potential of serum humanin in breast cancer among the Egyptian population.
• Characterization of the Effects of a Humanin Fragment Peptide (HNF<sub>14</sub>) in Age-Related Macular Degeneration.
• Mitochondrial-derived Peptides and Cytoprotection in ARDS: Emerging Therapeutic Promise of Humanin.
• Low Dose Ketamine Preconditions Astrocyte Mitochondria to Achieve Antidepressant Efficacy via Adenosine, Humanin, and Melatonin Upregulation and Efflux.
• Mitochondrial-derived peptides in energy metabolism.
• Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats.
• Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats
• Mitochondrial-Derived Peptides Exacerbate Senescence.
• Mitochondrial stress and mitokines in aging.
• Repeated Humanin Treatment Attenuates Oxidative Stress, Inflammation, and Apoptosis in Diabetic Cardiac Tissue.
• Diagnostic Value of Serum Humanin-Like 3 Levels in Multiple Sclerosis Patients with Predominant Optic Nerve and Spinal Cord Involvement: A Preliminary Study.
• Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease.
• Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction.
• Renoprotective Effect of S14G-Humanin on Renal Ischemia/Reperfusion Injury by Activation of STAT3 and ERK 1/2 Signal Transduction Pathways in Rats
• Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway.
• Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats
• Humanin analogue promotes metabolic reprogramming to protect the ischemic heart
• Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull. (2026)
• Altered placental expression of small humanin-like peptides in gestational diabetes mellitus. (2026)
• Network Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class). (2026)
• Mitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions. (2026)
• Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells. (2026)
• Assessment of mitochondrial peptide humanin in women with polycystic ovary syndrome: serum and skeletal muscle profile. (2026)
• Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats. (2026)
• Humanin as a Molecular Indicator of Semen Quality and Cryotolerance in Crossbred Cattle. (2026)
• Humanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy. (2026)
• Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity. (2026)
• Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells. (2026)
• Humanin ameliorates diabetes-induced testicular damage in a streptozotocin-induced mouse model. (2026)
• Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice. (2026)
• Humanin Mitigates Aβ-Induced Retinal Pigment Epithelium Injury via AMPK-Beclin1-Dependent Mitophagy. (2026)
• S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis. (2026)
• Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients. (2026)
• [Effects of cardiac rehabilitation and predictive value of Humanin/CRP ratio in patients with acute exacerbation of chronic heart failure]. (2026)
• S14G-humanin attenuates renal ischaemia-reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats. (2026)
• A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders. (2025)
• Ameliorative effects of Gly[14]-humanin on cyclophosphamide-induced premature ovarian insufficiency and underlying mechanisms. (2025)
• HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation. (2025)
• Detection of Mitochondrial-Derived Peptide Humanin in Semen and Reproductive Tract of Caprine Along With Its Relation to Seasonality. (2025)
• Potential Role of High-Intensity Interval Training-Induced Increase in Humanin Levels for the Management of Type 2 Diabetes. (2025)
• Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study. (2025)
• Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease. (2025)
• Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification. (2025)
• Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine. (2025)
• The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects. (2025)
• Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis. (2025)
• Humanin variants aggregate to produce different fibril morphologies. (2025)
• S14G-Humanin ameliorates ovarian dysfunction in a cyclophosphamide-induced premature ovarian insufficiency mouse model. (2025)
• Quantitative proteomics analysis reveals the protective role of S14G-humanin in septic acute kidney injury using 4D-label-free and PRM Approaches. (2024)
• Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice. (2024)
• Impaired Expression of Humanin during Adrenocortical Carcinoma. (2024)
• Effects of Humanin G (HNG) on angiogenesis and neurodegeneration markers in Age-related Macular Degeneration (AMD). (2024)
• Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer. (2024)
• Humanin activates integrin αV-TGFβ axis and leads to glioblastoma progression. (2024)
• Humanin's impact on pain markers and neuronal viability in diabetic neuropathy model. (2024)
• Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology. (2024)
• Humanin P3S, haplogroup N1b and the risk of Alzheimer's disease. (2024)
• Humanin Treatment Protects Against Venetoclax-Induced Bone Growth Retardation in <i>Ex Vivo</i> Cultured Rat Bones. (2024)
• Humanin-G Ameliorates Hemorrhage-Induced Acute Lung Injury in Mice Through AMPKα1-Dependent and -Independent Mechanisms. (2024)
• SERUM HUMANIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE-ORGAN DYSFUNCTION SYNDROME. (2024)
• [Gly14]-humanin exerts a protective effect against D-galactose-induced primary ovarian insufficiency in mice. (2024)
• [Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6. (2024)
• Unbalanced circulating Humanin levels and cardiovascular risk in chronic hemodialysis patients: a pilot, prospective study. (2024)
• Humanin ameliorates TBI-related cognitive impairment by attenuating mitochondrial dysfunction and inflammation. (2024)
• The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study. (2023)
• Effectiveness of analog of Humanin in ameliorating streptozotocin-induced diabetic nephropathy in Sprague Dawley rats. (2023)
• A novel beneficial role of humanin on intestinal apoptosis and dysmotility in a rat model of ischemia reperfusion injury. (2023)
• Stability Determination of Intact Humanin-G with Characterizations of Oxidation and Dimerization Patterns. (2023)
• S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice. (2023)
• S14G-Humanin ameliorates ovalbumin-induced airway inflammation in asthma mediated by inhibition of toll-like receptor 4 (TLR4) expression and the nuclear factor κ-B (NF-κB)/early growth response protein-1 (Egr-1) pathway. (2023)
• S14G-humanin alleviates acute lung injury by inhibiting the activation of NF-κB. (2023)
• Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects. (2023)
• Age-related Changes in Humanin Expression in the Ovarian Tissue of Rat. (2023)
• PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS. (2023)
• A novel link between chronic inflammation and humanin regulation in children. (2023)
• Intranasal delivery of mitochondrial protein humanin rescues cell death and promotes mitochondrial function in Parkinson's disease. (2023)
• Exogenous humanin and MOTS-c function as protective agents against gentamicin-induced hair cell damage. (2023)
• Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6. (2023)
• Humanin gene expression in subjects with Parkinson's disease. (2023)
• Humanin and Its Pathophysiological Roles in Aging: A Systematic Review. (2023)
• Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: A focus on oxidative stress, inflammation, and apoptosis. (2023)
• A New Antioxidant Marker in Cord Blood of Fetuses with Late Fetal Growth Restriction: Humanin. (2023)
• Exploring the potential of humanin as a biomarker for early breast cancer detection: a study of serum levels and diagnostic performance. (2023)
• Revolutionalizing the age old conventional treatment of psoriasis: An animal based comparative study between methylprednisolone and different doses of a novel anti-oxidant humanin analogue (HNG). (2022)
• Cardio-protective role of Humanin in myocardial ischemia-reperfusion. (2022)
• Cryoprotection of humanin-like peptides in seminal plasma for ejaculated spermatozoa of crossbred bulls. (2022)
• Humanin Ameliorates Late-onset Hypogonadism in Aged Male Rats. (2022)
• An evidence of Humanin-like peptide and Humanin mediated cryosurvival of spermatozoa in buffalo bulls. (2022)
• Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans. (2022)
• Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target. (2022)
• Structural basis of FPR2 in recognition of Aβ₄₂ and neuroprotection by humanin. (2022)
• The role of humanin in the regulation of reproduction. (2022)
• The role of humanin in natural stress tolerance: An underexplored therapeutic avenue. (2022)
• [Gly14]-Humanin inhibits an angiotensin II-induced vascular smooth muscle cell phenotypic switch via ameliorating intracellular oxidative stress. (2022)
• Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition. (2022)
• Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD). (2022)
• Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension. (2022)
• Humanin derivative, HNG, enhances neurotransmitter release. (2022)
• Cryoprotectant with a mitochondrial derived peptide, humanin, improves post-thaw quality of buffalo spermatozoa. (2022)
• The protective effects of S14G-humanin on gestational diabetes mellitus symptoms. (2022)
• The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis. (2022)
• Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice. (2022)
• Humanin and Alzheimer's disease: The beginning of a new field. (2022)
• Oxidative Damage? Not a Problem! The Characterization of Humanin-like Mitochondrial Peptide in Anoxia Tolerant Freshwater Turtles. (2021)
• Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model-Based Study. (2021)
• [Gly14]-Humanin Ameliorates High Glucose-Induced Apoptosis by Inhibiting the Expression of MicroRNA-155 in Endothelial Microparticles. (2021)
• The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†. (2021)
• Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway. (2021)
• Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival. (2021)
• The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction. (2021)
• The emerging role of mitochondrial derived peptide humanin in the testis. (2021)
• The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway. (2021)
• Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging. (2021)
• Humanin: A Potential Treatment for PCOS? (2021)
• S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1. (2021)
• Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases. (2021)
• Humanin protects cortical neurons from calyculin A-induced neurotoxicities by increasing PP2A activity and SOD. (2021)
• Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases. (2021)
• High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. (2020)
• The Mitochondria-Derived Peptide Humanin Improves Recovery from Intracerebral Hemorrhage: Implication of Mitochondria Transfer and Microglia Phenotype Change. (2020)
• Cytoprotective role of humanin in lens epithelial cell oxidative stress‑induced injury. (2020)
• Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders. (2020)
• The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. (2020)
• Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer. (2020)
• Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway. (2020)
• Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers. (2020)
• Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules. (2020)
• Novel humanin analogs confer neuroprotection and myoprotection to neuronal and myoblast cell cultures exposed to ischemia-like and doxorubicin-induced cell death insults. (2020)
• HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition. (2020)
• Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration. (2020)
• [Gly14]-humanin restores cathepsin D function via FPRL1 and promotes autophagic degradation of Ox-LDL in HUVECs. (2020)
• The humanin peptide mediates ELP nanoassembly and protects human retinal pigment epithelial cells from oxidative stress. (2020)
• Assay Development and Measurement of the Aging Biomarker Humanin. (2020)
• Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3. (2020)
• Humanin Ameliorates Free Fatty Acid-Induced Endothelial Inflammation by Suppressing the NLRP3 Inflammasome. (2020)
• Murine maternal dietary restriction affects neural Humanin expression and cellular profile. (2020)
• Interaction of amyloid beta with humanin and acetylcholinesterase is modulated by ATP. (2020)
• Humanin prevents undesired apoptosis of chondrocytes without interfering with the anti-inflammatory effect of dexamethasone in collagen-induced arthritis. (2020)
• Humanin: A mitochondria-derived peptide with emerging properties. (2020)
• Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease. (2019)
• Mitochondrial Peptide Humanin Protects Silver Nanoparticles-Induced Neurotoxicity in Human Neuroblastoma Cancer Cells (SH-SY5Y). (2019)
• Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment. (2019)
• Humanin levels in human seminal plasma and spermatozoa are related to sperm quality. (2019)
• Humanin Nanoparticles for Reducing Pathological Factors Characteristic of Age-Related Macular Degeneration. (2019)
• Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment. (2019)
• Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization. (2019)
• A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome. (2019)
• Using Small Peptide Segments of Amyloid-β and Humanin to Examine their Physical Interactions. (2019)
• Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases. (2019)
• The humanin analogue (HNG) prevents temozolomide-induced male germ cell apoptosis and other adverse effects in severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma. (2019)
• Potent humanin analogue (HNG) protects human sperm from freeze-thaw-induced damage. (2019)
• Cytoprotective role of S14G-humanin (HNG) in ultraviolet-B induced epidermal stem cells injury. (2019)
• Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study. (2019)
• The Mitochondrial Peptide Humanin Targets but Does Not Denature Amyloid Oligomers in Type II Diabetes. (2019)
• Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity. (2018)
• Interaction of Insulin-Like Growth Factor-Binding Protein 3 With Hyaluronan and Its Regulation by Humanin and CD44. (2018)
• Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. (2018)
• Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin. (2018)
• Plasma humanin as a prognostic biomarker for canine myxomatous mitral valve disease: a comparison with plasma NT-roBNP. (2018)
• Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity. (2018)
• Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2. (2018)
• Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors. (2018)
• Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction. (2018)
• A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity. (2018)
• Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins. (2018)
• Comparison of serum concentrations of humanin in women with and without gestational diabetes mellitus. (2018)
• The Neurovascular Protective Effect of S14G-Humanin in a Murine MCAO Model and Brain Endothelial Cells. (2018)
• [The level of circulating humanin in patients with ischemic heart disease.] (2018)
• Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice. (2018)
• Humanin Exerts Neuroprotection During Cardiac Ischemia-Reperfusion Injury. (2018)
• S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse. (2018)
• Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells. (2018)
• Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway. (2018)
• Humanin is an endogenous activator of chaperone-mediated autophagy. (2018)
• Serum humanin concentrations in women with pre-eclampsia compared to women with uncomplicated pregnancies. (2018)
• Neuroprotective effect of G¹⁴-humanin on global cerebral ischemia/reperfusion by activation of SOCS3 - STAT3 - MCL-1 signal transduction pathway in rats. (2017)
• Humanin Specifically Interacts with Amyloid-β Oligomers and Counteracts Their in vivo Toxicity. (2017)
• Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction. (2017)
• Humanin affects object recognition and gliosis in short-term cuprizone-treated mice. (2017)
• Humanin ameliorates diazepam-induced memory deficit in mice. (2017)
• Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. (2017)
• Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells. (2017)
• High-dose Humanin analogue applied during ischemia exerts cardioprotection against ischemia/reperfusion injury by reducing mitochondrial dysfunction. (2017)
• Pseudogenization of the <i>Humanin</i> gene is common in the mitochondrial DNA of many vertebrates. (2017)
• Effects of humanin on experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats. (2017)
• Gly[14]-humanin inhibits ox-LDL uptake and stimulates cholesterol efflux in macrophage-derived foam cells. (2017)
• Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness. (2017)
• Humanin analogue, S14G-humanin, has neuroprotective effects against oxygen glucose deprivation/reoxygenation by reactivating Jak2/Stat3 signaling through the PI3K/AKT pathway. (2017)
• The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. (2016)
• Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism. (2016)
• Humanin: Functional Interfaces with IGF-I. (2016)
• Humanin prevents brain mitochondrial dysfunction in a cardiac ischaemia-reperfusion injury model. (2016)
• Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress. (2016)
• [Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats. (2016)
• Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione. (2016)
• Humanin exerts cardioprotection against cardiac ischemia/reperfusion injury through attenuation of mitochondrial dysfunction. (2016)
• Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors. (2016)
• Potential Roles of Humanin on Apoptosis in the Heart. (2016)
• The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus. (2016)
• Solution NMR structure and inhibitory effect against amyloid-β fibrillation of Humanin containing a d-isomerized serine residue. (2016)
• Increased oligodendrogenesis by humanin promotes axonal remyelination and neurological recovery in hypoxic/ischemic brains. (2015)
• Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β. (2015)
• Humanin Derivatives Inhibit Necrotic Cell Death in Neurons. (2015)
• The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice. (2015)
• Humanin protects against chemotherapy-induced stage-specific male germ cell apoptosis in rats. (2015)
• Protective effects of Humanin and calmodulin-like skin protein in Alzheimer's disease and broad range of abnormalities. (2015)
• The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs. (2015)
• Central effects of humanin on hepatic triglyceride secretion. (2015)
• Humanin Does Not Protect Against STZ-Induced Spatial Memory Impairment. (2015)
• Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production. (2015)
• The effect of sex on humanin levels in healthy adults and patients with uncomplicated type 1 diabetes mellitus. (2015)
• Protective effects of humanin on okadaic Acid-induced neurotoxicities in cultured cortical neurons. (2014)
• Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity not by NMDA receptor. (2014)
• Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment. (2014)
• Humanin attenuated the change of voltage-dependent potassium currents in hippocampal neurons induced by anoxia. (2014)
• Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis. (2014)
• New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects. (2014)
• Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats. (2014)
• Humanin: a possible linkage between Alzheimer's disease and type 2 diabetes. (2014)
• Inactive C8A‑humanin analog is as stable as a potent S14G‑humanin analog. (2014)
• IGF-I regulates the age-dependent signaling peptide humanin. (2014)
• Apollon/Bruce is upregulated by Humanin. (2014)
• Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells. (2014)
• The emerging role of the mitochondrial-derived peptide humanin in stress resistance. (2013)
• S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein. (2013)
• [Gly14]-Humanin offers neuroprotection through glycogen synthase kinase-3β inhibition in a mouse model of intracerebral hemorrhage. (2013)
• Humanin: a harbinger of mitochondrial-derived peptides? (2013)
• SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase. (2013)
• Humanin binds MPP8: mapping interaction sites of the peptide and protein. (2013)
• A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts. (2013)
• Neuroprotective Peptide humanin inhibits inflammatory response in astrocytes induced by lipopolysaccharide. (2013)
• Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents. (2013)
• Circulating humanin levels are associated with preserved coronary endothelial function. (2013)
• The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis. (2013)
• [Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice. (2013)
• Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin. (2013)
• Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell. (2013)
• Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor. (2013)
• Humanin: a novel functional molecule for the green synthesis of graphene. (2013)
• S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice. (2012)
• Interaction structure of the complex between neuroprotective factor humanin and Alzheimer's β-amyloid peptide revealed by affinity mass spectrometry and molecular modeling. (2012)
• D-Ser-containing humanin shows promotion of fibril formation. (2012)
• [[Gly14]-humanin protects against Aβ₃₁₋₃₅-induced impairment of spatial learning and memory in rats]. (2012)
• Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans. (2012)
• Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice. (2012)
• Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase. (2012)
• Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. (2011)
• The biological activity of Humanin analogs correlates with structure stabilities in solution. (2011)
• A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice. (2011)
• Structure of three Humanin peptides with different activities upon interaction with liposome. (2011)
• Advances in characterization of neuroprotective peptide, humanin. (2011)
• Humanin signal for Alzheimer's disease. (2011)
• VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin. (2011)
• [Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities]. (2011)
• Structure changes of natively disordered Humanin in the presence of lipid. (2010)
• Immunolocalization of humanin in human sperm and testis. (2010)
• Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties (2010)
• Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury. (2010)
• Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress. (2010)
• [Effect of [Gly14]-Humanin on Abeta(25-35)-induced PC12 cell apoptosis]. (2010)
• Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice. (2010)
• [Gly(14)]-humanin rescues long-term potentiation from amyloid beta protein-induced impairment in the rat hippocampal CA1 region in vivo. (2010)
• Protective effects of [Gly14]-Humanin on beta-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction. (2010)
• The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice. (2010)
• Humanin protects neurons against apoptosis induced by Abeta31-35 through suppression of intrinsic pathway. (2010)
• Humanin and the receptors for humanin. (2010)
• Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130. (2009)
• In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives. (2009)
• Humanin; a defender against Alzheimer's disease? (2009)
• Humanin: a novel central regulator of peripheral insulin action. (2009)
• Humanin structural versatility and interaction with model cerebral cortex membranes. (2009)
• Opposing Roles of Insulin-Like Growth Factor Binding Protein 3 and Humanin in the Regulation of Testicular Germ Cell Apoptosis (2009)
• Evidence for potential functionality of nuclearly-encoded humanin isoforms. (2009)
• Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin. (2009)
• Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway (2008)
• Structural and dynamical studies of Humanin in water and TFE/water mixture: a molecular dynamics simulation. (2008)
• The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues (2008)
• Activity-dependent neurotrophic factor, ADNF, determines the structure characteristics of Colivelin, a fusion protein of ADNF9 and Humanin analog. (2008)
• The complex structure transition of Humanin peptides by sodium dodecylsulfate and trifluoroethanol. (2008)
• Structural preferences of neuroprotective S14G-humanin peptide analyzed by molecular modeling and circular dichroism. (2007)
• Mapping the specific cytoprotective interaction of humanin with the pro-apoptotic protein bid. (2007)
• Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease. (2006)
• Zinc(II) binds to the neuroprotective peptide humanin. (2006)
• Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia (2006)
• Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis. (2006)
• Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis. (2006)
• [Recent progress in neuroprotection of humanin against Alzheimer's disease-relevant neurotoxicity]. (2006)
• The secondary structure analysis of a potent Ser14Gly analog of antiAlzheimer peptide, Humanin, by circular dichroism. (2006)
• [Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system]. (2006)
• Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits an unknown post-cysteine cleavage specificity. (2006)
• Humanin Is a Novel Neuroprotective Agent Against Stroke (2006)
• Humanin Attenuates Apoptosis Induced by DRPLA Proteins With Expanded Polyglutamine Stretches (2005)
• Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL (2005)
• Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality. (2005)
• Effect of humanin on decreased ATP levels of human lymphocytes harboring A3243G mutant mitochondrial DNA (2005)
• A humanin derivative, S14G‐HN, prevents amyloid‐β‐induced memory impairment in mice (2005)
• Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent (2005)
• Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak (2005)
• Development of a Femtomolar-Acting Humanin Derivative Named Colivelin by Attaching Activity-Dependent Neurotrophic Factor to Its N Terminus: Characterization of Colivelin-Mediated Neuroprotection against Alzheimer's Disease-Relevant InsultsIn VitroandIn Vivo (2005)
• Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase (2005)
• Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity. (2005)
• Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection. (2005)
• Construction of a eukaryotic expression plasmid of Humanin. (2005)
• N-Formylated humanin activates both formyl peptide receptor-like 1 and 2 (2004)
• Effect of humanin analogues on experimentally induced impairment of spatial memory in rats. (2004)
• Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin. (2004)
• Humanin: After the Discovery (2004)
• Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor. (2004)
• High-yield, solid-phase synthesis of humanin, an Alzheimer's disease associated, novel 24-mer peptide which contains a difficult sequence. (2004)
• Unravelling the role of Humanin. (2004)
• Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide. (2004)
• Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Aβ1–40 (2003)
• Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults (2003)
• Humanin peptide suppresses apoptosis by interfering with Bax activation (2003)
• Humanin rescues human cerebrovascular smooth muscle cells from Aβ‐induced toxicity (2003)
• Humanin improves impaired metabolic activity and prolongs survival of serum-deprived human lymphocytes (2003)
• Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease‐related neurotoxicity: functional potentiation by isomerization and dimerization (2003)
• A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease‐relevant insults (2003)
• Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis (2003)
• Humanin rescues cortical neurons from prion-peptide-induced apoptosis (2003)
• Humanin inhibits cell death of serum-deprived PC12h cells (2002)
• A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity. (2002)
• Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults (2002)
• Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults (2001)
• [Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo. (2001)
• Mechanisms of Neuroprotection by a Novel Rescue Factor Humanin from Swedish Mutant Amyloid Precursor Protein (2001)

Regulatory status as of this version

• United States — FDA: not_approved
• European Union — EMA: not_approved