Humanin

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Humanin — Peptide Scientific Intelligence

What we know

Evidence, claims, and boundaries

The project separates represented evidence from qualification, contradiction, uncertainty, and what the evidence does not establish.

Reconciled domain conclusions

6 conclusions connected to 0 featured studies

Humanin no longer relies on the legacy “no public claim” state. Each research domain publishes a bounded conclusion, confidence level, evidence synthesis, limitations, geographic applicability, regulatory interpretation, and research gaps.

Inspect the reconciled evidence atlas

Inspect the published evidence record309 governed records · titles, provenance, and original-source linksOpen records ↓

2022Observational human evidence

Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension.

Content-verified record concerning Humanin: "Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension." Abstract excerpt: Autophagy, a highly conserved homeostatic mechanism, is essential for cell survival. The decline of autophagy function has been implicated in various diseases as well as aging. Although mitochondria play a key role in the autophagy process, whether mitochondrial-derived peptides are involved in this process has not been explored. We developed a high through put screening method to identify potenti

Source: peer_reviewed_research
DOI: 10.1016/j.bbagen.2021.130017
PubMed: 34624450

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2025Observational human evidence

HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation.

Content-verified record concerning Humanin: "HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation." Abstract excerpt: Elimination of apoptotic neutrophils by macrophages, a process called efferocytosis, is a critical step in the resolution of inflammation. Efferocytosis induces the reprogramming of macrophages towards a pro-resolving phenotype and triggers the secretion of pro-resolving factors. While mouse efferocytic macrophages are well-described, less is known about human efferocytic macrophages. Here, using

Scientific context

Chemistry and represented biological context

Existing reviewed chemistry is preserved as scientific context. Chemistry and mechanism information do not establish clinical efficacy or safety.

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Chemical identity

Molecular and structural record

Structured record

Molecular formula: C119H204N34O32S2
Molecular weight: 2687.2
SMILES: CCC(C)C(C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(C)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(CC2=CC=CC=C2)NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)C3CCCN3C(=O)C(C)NC(=O)C(CCSC)N
InChI: InChI=1S/C119H204N34O32S2/c1-19-65(14)92(112(180)144-81(54-90(160)161)104(172)145-82(52-63(10)11)115(183)153-46-29-37-87(153)110(178)149-91(64(12)13)111(179)139-72(32-23-24-41-120)97(165)136-74(35-27-44-130-119(126)127)98(166)135-73(34-26-43-129-118(124)125)96(164)133-67(16)116(184)185)150-99(167)75(38-39-89(158)159)137-106(174)84(57-155)147-113(181)93(68(17)156)151-105(173)79(51-62(8)9)142-101(169)77(49-60(4)5)140-100(168)76(48-59(2)3)141-102(170)78(50-61(6)7)143-108(176)85(58-186)148-107(175)83(56-154)146-103(171)80(53-69-30-21-20-22-31-69)134-88(157)55-131-95(163)71(33-25-42-128-117(122)123)138-109(177)86-36-28-45-152(86)114(182)66(15)132-94(162)70(121)40-47-187-18/h20-22,30-31,59-68,70-87,91-93,154-156,186H,19,23-29,32-58,120-121H2,1-18H3,(H,131,163)(H,132,162)(H,133,164)(H,134,157)(H,135,166)(H,136,165)(H,137,174)(H,138,177)(H,139,179)(H,140,168)(H,141,170)(H,142,169)(H,143,176)(H,144,180)(H,145,172)(H,146,171)(H,147,181)(H,148,175)(H,149,178)(H,150,167)(H,151,173)(H,158,159)(H,160,161)(H,184,185)(H4,122,123,128)(H4,124,125,129)(H4,126,127,130)/t65-,66-,67-,68+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,91-,92-,93-/m0/s1
InChIKey: DPEUWKZJZIPZKE-OFANTOPUSA-N

Chemical identity describes the recorded molecular information. It does not establish biological activity, clinical efficacy, safety, or therapeutic suitability.

Research

How the scientific record is developing

Chronology, unresolved research questions, opportunities, and researcher activity remain descriptive rather than evaluative.

Research chronology

2001 · study · Temporal status not established
[Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo.
peer_reviewed_research
2001 · study · Temporal status not established
Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults
peer_reviewed_research
2001 · study · Temporal status not established
Mechanisms of Neuroprotection by a Novel Rescue Factor Humanin from Swedish Mutant Amyloid Precursor Protein
peer_reviewed_research
2002 · study · Temporal status not established
Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults
peer_reviewed_research
2002 · study · Temporal status not established
A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity.
peer_reviewed_research
2002 · study · Temporal status not established
Humanin inhibits cell death of serum-deprived PC12h cells
peer_reviewed_research
2003 · study · Temporal status not established
Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Aβ1–40
peer_reviewed_research
2003 · study · Temporal status not established
Humanin rescues human cerebrovascular smooth muscle cells from Aβ‐induced toxicity
peer_reviewed_research
2003 · study · Temporal status not established
Humanin improves impaired metabolic activity and prolongs survival of serum-deprived human lymphocytes
peer_reviewed_research
2003 · study · Temporal status not established
Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis
peer_reviewed_research
2003 · study · Temporal status not established
Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease‐related neurotoxicity: functional potentiation by isomerization and dimerization
peer_reviewed_research
2003 · study · Temporal status not established
Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults
peer_reviewed_research
2003 · study · Temporal status not established
Humanin rescues cortical neurons from prion-peptide-induced apoptosis
peer_reviewed_research
2003 · study · Temporal status not established
Humanin peptide suppresses apoptosis by interfering with Bax activation
peer_reviewed_research
2003 · study · Temporal status not established
A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease‐relevant insults
peer_reviewed_research
2004 · study · Temporal status not established
Effect of humanin analogues on experimentally induced impairment of spatial memory in rats.
peer_reviewed_research
2004 · study · Temporal status not established
Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide.
peer_reviewed_research
2004 · study · Temporal status not established
Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin.
peer_reviewed_research
2004 · study · Temporal status not established
Humanin: After the Discovery
peer_reviewed_research
2004 · study · Temporal status not established
Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor.
peer_reviewed_research
2004 · study · Temporal status not established
N-Formylated humanin activates both formyl peptide receptor-like 1 and 2
peer_reviewed_research
2004 · study · Temporal status not established
Unravelling the role of Humanin.
peer_reviewed_research
2004 · study · Temporal status not established
High-yield, solid-phase synthesis of humanin, an Alzheimer's disease associated, novel 24-mer peptide which contains a difficult sequence.
peer_reviewed_research
2005 · study · Temporal status not established
Development of a Femtomolar-Acting Humanin Derivative Named Colivelin by Attaching Activity-Dependent Neurotrophic Factor to Its N Terminus: Characterization of Colivelin-Mediated Neuroprotection against Alzheimer's Disease-Relevant InsultsIn VitroandIn Vivo
peer_reviewed_research
2005 · study · Temporal status not established
Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.
peer_reviewed_research
2005 · study · Temporal status not established
Humanin Attenuates Apoptosis Induced by DRPLA Proteins With Expanded Polyglutamine Stretches
peer_reviewed_research
2005 · study · Temporal status not established
A humanin derivative, S14G‐HN, prevents amyloid‐β‐induced memory impairment in mice
peer_reviewed_research
2005 · study · Temporal status not established
Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity.
peer_reviewed_research
2005 · study · Temporal status not established
Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak
peer_reviewed_research
2005 · study · Temporal status not established
Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase
peer_reviewed_research
2005 · study · Temporal status not established
Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent
peer_reviewed_research
2005 · study · Temporal status not established
Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL
peer_reviewed_research
2005 · study · Temporal status not established
Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality.
peer_reviewed_research
2005 · study · Temporal status not established
Effect of humanin on decreased ATP levels of human lymphocytes harboring A3243G mutant mitochondrial DNA
peer_reviewed_research
2005 · study · Temporal status not established
Construction of a eukaryotic expression plasmid of Humanin.
peer_reviewed_research
2006 · study · Temporal status not established
Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease.
peer_reviewed_research
2006 · study · Temporal status not established
Zinc(II) binds to the neuroprotective peptide humanin.
peer_reviewed_research
2006 · study · Temporal status not established
The secondary structure analysis of a potent Ser14Gly analog of antiAlzheimer peptide, Humanin, by circular dichroism.
peer_reviewed_research
2006 · study · Temporal status not established
Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia
peer_reviewed_research
2006 · study · Temporal status not established
Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis.
peer_reviewed_research
2006 · study · Temporal status not established
Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis.
peer_reviewed_research
2006 · study · Temporal status not established
[Recent progress in neuroprotection of humanin against Alzheimer's disease-relevant neurotoxicity].
peer_reviewed_research
2006 · study · Temporal status not established
[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system].
peer_reviewed_research
2006 · study · Temporal status not established
Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits an unknown post-cysteine cleavage specificity.
peer_reviewed_research
2006 · study · Temporal status not established
Humanin Is a Novel Neuroprotective Agent Against Stroke
peer_reviewed_research
2007 · study · Temporal status not established
Structural preferences of neuroprotective S14G-humanin peptide analyzed by molecular modeling and circular dichroism.
peer_reviewed_research
2007 · study · Temporal status not established
Mapping the specific cytoprotective interaction of humanin with the pro-apoptotic protein bid.
peer_reviewed_research
2008 · study · Temporal status not established
Structural and dynamical studies of Humanin in water and TFE/water mixture: a molecular dynamics simulation.
peer_reviewed_research
2008 · study · Temporal status not established
The complex structure transition of Humanin peptides by sodium dodecylsulfate and trifluoroethanol.
peer_reviewed_research
2008 · study · Temporal status not established
The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues
peer_reviewed_research
2008 · study · Temporal status not established
Activity-dependent neurotrophic factor, ADNF, determines the structure characteristics of Colivelin, a fusion protein of ADNF9 and Humanin analog.
peer_reviewed_research
2008 · study · Temporal status not established
Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway
peer_reviewed_research
2009 · study · Temporal status not established
In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives.
peer_reviewed_research
2009 · study · Temporal status not established
Humanin structural versatility and interaction with model cerebral cortex membranes.
peer_reviewed_research
2009 · study · Temporal status not established
Humanin: a novel central regulator of peripheral insulin action.
peer_reviewed_research
2009 · study · Temporal status not established
Humanin; a defender against Alzheimer's disease?
peer_reviewed_research
2009 · study · Temporal status not established
Evidence for potential functionality of nuclearly-encoded humanin isoforms.
peer_reviewed_research
2009 · study · Temporal status not established
Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.
peer_reviewed_research
2009 · study · Temporal status not established
Opposing Roles of Insulin-Like Growth Factor Binding Protein 3 and Humanin in the Regulation of Testicular Germ Cell Apoptosis
peer_reviewed_research
2009 · study · Temporal status not established
Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin.
peer_reviewed_research
2010 · study · Temporal status not established
Humanin and the receptors for humanin.
peer_reviewed_research
2010 · study · Temporal status not established
[Gly(14)]-humanin rescues long-term potentiation from amyloid beta protein-induced impairment in the rat hippocampal CA1 region in vivo.
peer_reviewed_research
2010 · study · Temporal status not established
Protective effects of [Gly14]-Humanin on beta-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction.
peer_reviewed_research
2010 · study · Temporal status not established
Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury.
peer_reviewed_research
2010 · study · Temporal status not established
Structure changes of natively disordered Humanin in the presence of lipid.
peer_reviewed_research
2010 · study · Temporal status not established
Humanin protects neurons against apoptosis induced by Abeta31-35 through suppression of intrinsic pathway.
peer_reviewed_research
2010 · study · Temporal status not established
Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties
peer_reviewed_research
2010 · study · Temporal status not established
Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress.
peer_reviewed_research
2010 · study · Temporal status not established
Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice.
peer_reviewed_research
2010 · study · Temporal status not established
[Effect of [Gly14]-Humanin on Abeta(25-35)-induced PC12 cell apoptosis].
peer_reviewed_research
2010 · study · Temporal status not established
The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice.
peer_reviewed_research
2010 · study · Temporal status not established
Immunolocalization of humanin in human sperm and testis.
peer_reviewed_research
2011 · study · Temporal status not established
Humanin signal for Alzheimer's disease.
peer_reviewed_research
2011 · study · Temporal status not established
[Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities].
peer_reviewed_research
2011 · study · Temporal status not established
VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin.
peer_reviewed_research
2011 · study · Temporal status not established
Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice.
peer_reviewed_research
2011 · study · Temporal status not established
A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice.
peer_reviewed_research
2011 · study · Temporal status not established
Structure of three Humanin peptides with different activities upon interaction with liposome.
peer_reviewed_research
2011 · study · Temporal status not established
The biological activity of Humanin analogs correlates with structure stabilities in solution.
peer_reviewed_research
2011 · study · Temporal status not established
Advances in characterization of neuroprotective peptide, humanin.
systematic_review_or_meta_analysis
2012 · study · Temporal status not established
S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice.
peer_reviewed_research
2012 · study · Temporal status not established
Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase.
peer_reviewed_research
2012 · study · Temporal status not established
Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice.
peer_reviewed_research
2012 · study · Temporal status not established
Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans.
peer_reviewed_research
2012 · study · Temporal status not established
[[Gly14]-humanin protects against Aβ₃₁₋₃₅-induced impairment of spatial learning and memory in rats].
peer_reviewed_research
2012 · study · Temporal status not established
D-Ser-containing humanin shows promotion of fibril formation.
peer_reviewed_research
2012 · study · Temporal status not established
Interaction structure of the complex between neuroprotective factor humanin and Alzheimer's β-amyloid peptide revealed by affinity mass spectrometry and molecular modeling.
peer_reviewed_research
2013 · study · Temporal status not established
S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein.
peer_reviewed_research
2013 · study · Temporal status not established
[Gly14]-Humanin offers neuroprotection through glycogen synthase kinase-3β inhibition in a mouse model of intracerebral hemorrhage.
peer_reviewed_research
2013 · study · Temporal status not established
Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents.
peer_reviewed_research
2013 · study · Temporal status not established
The emerging role of the mitochondrial-derived peptide humanin in stress resistance.
peer_reviewed_research
2013 · study · Temporal status not established
Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin.
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2013 · study · Temporal status not established
Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor.
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2013 · study · Temporal status not established
A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts.
peer_reviewed_research
2013 · study · Temporal status not established
Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell.
peer_reviewed_research
2013 · study · Temporal status not established
[Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice.
peer_reviewed_research
2013 · study · Temporal status not established
Circulating humanin levels are associated with preserved coronary endothelial function.
peer_reviewed_research
2013 · study · Temporal status not established
Neuroprotective Peptide humanin inhibits inflammatory response in astrocytes induced by lipopolysaccharide.
peer_reviewed_research
2013 · study · Temporal status not established
The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis.
peer_reviewed_research
2013 · study · Temporal status not established
Humanin binds MPP8: mapping interaction sites of the peptide and protein.
peer_reviewed_research
2013 · study · Temporal status not established
Humanin: a harbinger of mitochondrial-derived peptides?
peer_reviewed_research
2013 · study · Temporal status not established
Humanin: a novel functional molecule for the green synthesis of graphene.
peer_reviewed_research
2013 · study · Temporal status not established
SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase.
peer_reviewed_research
2014 · study · Temporal status not established
Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity not by NMDA receptor.
peer_reviewed_research
2014 · study · Temporal status not established
Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells.
peer_reviewed_research
2014 · study · Temporal status not established
Apollon/Bruce is upregulated by Humanin.
peer_reviewed_research
2014 · study · Temporal status not established
IGF-I regulates the age-dependent signaling peptide humanin.
peer_reviewed_research
2014 · study · Temporal status not established
Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats.
peer_reviewed_research
2014 · study · Temporal status not established
Inactive C8A‑humanin analog is as stable as a potent S14G‑humanin analog.
peer_reviewed_research
2014 · study · Temporal status not established
Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis.
peer_reviewed_research
2014 · study · Temporal status not established
Protective effects of humanin on okadaic Acid-induced neurotoxicities in cultured cortical neurons.
peer_reviewed_research
2014 · study · Temporal status not established
Humanin: a possible linkage between Alzheimer's disease and type 2 diabetes.
peer_reviewed_research
2014 · study · Temporal status not established
Humanin attenuated the change of voltage-dependent potassium currents in hippocampal neurons induced by anoxia.
peer_reviewed_research
2014 · study · Temporal status not established
Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment.
peer_reviewed_research
2014 · study · Temporal status not established
New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects.
peer_reviewed_research
2015 · study · Temporal status not established
Humanin Does Not Protect Against STZ-Induced Spatial Memory Impairment.
peer_reviewed_research
2015 · study · Temporal status not established
Humanin Derivatives Inhibit Necrotic Cell Death in Neurons.
peer_reviewed_research
2015 · study · Temporal status not established
Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β.
peer_reviewed_research
2015 · study · Temporal status not established
Humanin protects against chemotherapy-induced stage-specific male germ cell apoptosis in rats.
peer_reviewed_research
2015 · study · Temporal status not established
Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production.
peer_reviewed_research
2015 · study · Temporal status not established
The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs.
peer_reviewed_research
2015 · study · Temporal status not established
Central effects of humanin on hepatic triglyceride secretion.
peer_reviewed_research
2015 · study · Temporal status not established
The effect of sex on humanin levels in healthy adults and patients with uncomplicated type 1 diabetes mellitus.
peer_reviewed_research
2015 · study · Temporal status not established
Protective effects of Humanin and calmodulin-like skin protein in Alzheimer's disease and broad range of abnormalities.
systematic_review_or_meta_analysis
2015 · study · Temporal status not established
Increased oligodendrogenesis by humanin promotes axonal remyelination and neurological recovery in hypoxic/ischemic brains.
peer_reviewed_research
2015 · study · Temporal status not established
The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.
peer_reviewed_research
2016 · study · Temporal status not established
Humanin: Functional Interfaces with IGF-I.
peer_reviewed_research
2016 · study · Temporal status not established
Humanin prevents brain mitochondrial dysfunction in a cardiac ischaemia-reperfusion injury model.
peer_reviewed_research
2016 · study · Temporal status not established
Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress.
peer_reviewed_research
2016 · study · Temporal status not established
[Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats.
peer_reviewed_research
2016 · study · Temporal status not established
The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.
peer_reviewed_research
2016 · study · Temporal status not established
The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus.
peer_reviewed_research
2016 · study · Temporal status not established
Solution NMR structure and inhibitory effect against amyloid-β fibrillation of Humanin containing a d-isomerized serine residue.
peer_reviewed_research
2016 · study · Temporal status not established
Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione.
peer_reviewed_research
2016 · study · Temporal status not established
Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors.
peer_reviewed_research
2016 · study · Temporal status not established
Potential Roles of Humanin on Apoptosis in the Heart.
peer_reviewed_research
2016 · study · Temporal status not established
Humanin exerts cardioprotection against cardiac ischemia/reperfusion injury through attenuation of mitochondrial dysfunction.
peer_reviewed_research
2016 · study · Temporal status not established
Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism.
peer_reviewed_research
2017 · study · Temporal status not established
Humanin analogue, S14G-humanin, has neuroprotective effects against oxygen glucose deprivation/reoxygenation by reactivating Jak2/Stat3 signaling through the PI3K/AKT pathway.
peer_reviewed_research
2017 · study · Temporal status not established
High-dose Humanin analogue applied during ischemia exerts cardioprotection against ischemia/reperfusion injury by reducing mitochondrial dysfunction.
peer_reviewed_research
2017 · study · Temporal status not established
Neuroprotective effect of G14-humanin on global cerebral ischemia/reperfusion by activation of SOCS3 - STAT3 - MCL-1 signal transduction pathway in rats.
peer_reviewed_research
2017 · study · Temporal status not established
Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells.
peer_reviewed_research
2017 · study · Temporal status not established
Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness.
peer_reviewed_research
2017 · study · Temporal status not established
Humanin ameliorates diazepam-induced memory deficit in mice.
peer_reviewed_research
2017 · study · Temporal status not established
Humanin affects object recognition and gliosis in short-term cuprizone-treated mice.
peer_reviewed_research
2017 · study · Temporal status not established
Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction.
peer_reviewed_research
2017 · study · Temporal status not established
Humanin Specifically Interacts with Amyloid-β Oligomers and Counteracts Their in vivo Toxicity.
peer_reviewed_research
2017 · study · Temporal status not established
Effects of humanin on experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats.
peer_reviewed_research
2017 · study · Temporal status not established
Pseudogenization of the Humanin gene is common in the mitochondrial DNA of many vertebrates.
peer_reviewed_research
2017 · study · Temporal status not established
Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage.
peer_reviewed_research
2017 · study · Temporal status not established
Gly[14]-humanin inhibits ox-LDL uptake and stimulates cholesterol efflux in macrophage-derived foam cells.
peer_reviewed_research
2018 · study · Temporal status not established
Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans.
peer_reviewed_research
2018 · study · Temporal status not established
Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells.
peer_reviewed_research
2018 · study · Temporal status not established
Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2.
peer_reviewed_research
2018 · study · Temporal status not established
Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity.
peer_reviewed_research
2018 · study · Temporal status not established
Serum humanin concentrations in women with pre-eclampsia compared to women with uncomplicated pregnancies.
peer_reviewed_research
2018 · study · Temporal status not established
Humanin Exerts Neuroprotection During Cardiac Ischemia-Reperfusion Injury.
peer_reviewed_research
2018 · study · Temporal status not established
A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity.
peer_reviewed_research
2018 · study · Temporal status not established
Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors.
peer_reviewed_research
2018 · study · Temporal status not established
Comparison of serum concentrations of humanin in women with and without gestational diabetes mellitus.
peer_reviewed_research
2018 · study · Temporal status not established
The Neurovascular Protective Effect of S14G-Humanin in a Murine MCAO Model and Brain Endothelial Cells.
peer_reviewed_research
2018 · study · Temporal status not established
Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice.
peer_reviewed_research
2018 · study · Temporal status not established
Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin.
peer_reviewed_research
2018 · study · Temporal status not established
Humanin is an endogenous activator of chaperone-mediated autophagy.
peer_reviewed_research
2018 · study · Temporal status not established
Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway.
peer_reviewed_research
2018 · study · Temporal status not established
S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse.
peer_reviewed_research
2018 · study · Temporal status not established
Plasma humanin as a prognostic biomarker for canine myxomatous mitral valve disease: a comparison with plasma NT-roBNP.
peer_reviewed_research
2018 · study · Temporal status not established
[The level of circulating humanin in patients with ischemic heart disease.]
peer_reviewed_research
2018 · study · Temporal status not established
Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins.
peer_reviewed_research
2018 · study · Temporal status not established
Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction.
peer_reviewed_research
2018 · study · Temporal status not established
Interaction of Insulin-Like Growth Factor-Binding Protein 3 With Hyaluronan and Its Regulation by Humanin and CD44.
peer_reviewed_research
2018 · study · Temporal status not established
Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity.
peer_reviewed_research
2019 · study · Temporal status not established
Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment.
peer_reviewed_research
2019 · study · Temporal status not established
Humanin levels in human seminal plasma and spermatozoa are related to sperm quality.
peer_reviewed_research
2019 · study · Temporal status not established
Humanin Nanoparticles for Reducing Pathological Factors Characteristic of Age-Related Macular Degeneration.
peer_reviewed_research
2019 · study · Temporal status not established
Cytoprotective role of S14G-humanin (HNG) in ultraviolet-B induced epidermal stem cells injury.
peer_reviewed_research
2019 · study · Temporal status not established
Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases.
peer_reviewed_research
2019 · study · Temporal status not established
Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment.
peer_reviewed_research
2019 · study · Temporal status not established
Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease.
peer_reviewed_research
2019 · study · Temporal status not established
Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization.
peer_reviewed_research
2019 · study · Temporal status not established
The humanin analogue (HNG) prevents temozolomide-induced male germ cell apoptosis and other adverse effects in severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma.
peer_reviewed_research
2019 · study · Temporal status not established
Potent humanin analogue (HNG) protects human sperm from freeze-thaw-induced damage.
peer_reviewed_research
2019 · study · Temporal status not established
Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study.
peer_reviewed_research
2019 · study · Temporal status not established
Mitochondrial Peptide Humanin Protects Silver Nanoparticles-Induced Neurotoxicity in Human Neuroblastoma Cancer Cells (SH-SY5Y).
peer_reviewed_research
2019 · study · Temporal status not established
The Mitochondrial Peptide Humanin Targets but Does Not Denature Amyloid Oligomers in Type II Diabetes.
peer_reviewed_research
2019 · study · Temporal status not established
Using Small Peptide Segments of Amyloid-β and Humanin to Examine their Physical Interactions.
peer_reviewed_research
2019 · study · Temporal status not established
A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.
peer_reviewed_research
2020 · study · Temporal status not established
The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan.
peer_reviewed_research
2020 · study · Temporal status not established
Humanin prevents undesired apoptosis of chondrocytes without interfering with the anti-inflammatory effect of dexamethasone in collagen-induced arthritis.
peer_reviewed_research
2020 · study · Temporal status not established
Humanin Ameliorates Free Fatty Acid-Induced Endothelial Inflammation by Suppressing the NLRP3 Inflammasome.
peer_reviewed_research
2020 · study · Temporal status not established
HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition.
peer_reviewed_research
2020 · study · Temporal status not established
Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders.
peer_reviewed_research
2020 · study · Temporal status not established
The Mitochondria-Derived Peptide Humanin Improves Recovery from Intracerebral Hemorrhage: Implication of Mitochondria Transfer and Microglia Phenotype Change.
peer_reviewed_research
2020 · study · Temporal status not established
High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men.
peer_reviewed_research
2020 · study · Temporal status not established
Murine maternal dietary restriction affects neural Humanin expression and cellular profile.
peer_reviewed_research
2020 · study · Temporal status not established
Assay Development and Measurement of the Aging Biomarker Humanin.
peer_reviewed_research
2020 · study · Temporal status not established
Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration.
peer_reviewed_research
2020 · study · Temporal status not established
Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway.
peer_reviewed_research
2020 · study · Temporal status not established
Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer.
peer_reviewed_research
2020 · study · Temporal status not established
Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers.
peer_reviewed_research
2020 · study · Temporal status not established
Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules.
peer_reviewed_research
2020 · study · Temporal status not established
The humanin peptide mediates ELP nanoassembly and protects human retinal pigment epithelial cells from oxidative stress.
peer_reviewed_research
2020 · study · Temporal status not established
[Gly14]-humanin restores cathepsin D function via FPRL1 and promotes autophagic degradation of Ox-LDL in HUVECs.
peer_reviewed_research
2020 · study · Temporal status not established
Novel humanin analogs confer neuroprotection and myoprotection to neuronal and myoblast cell cultures exposed to ischemia-like and doxorubicin-induced cell death insults.
peer_reviewed_research
2020 · study · Temporal status not established
Cytoprotective role of humanin in lens epithelial cell oxidative stress‑induced injury.
peer_reviewed_research
2020 · study · Temporal status not established
Interaction of amyloid beta with humanin and acetylcholinesterase is modulated by ATP.
peer_reviewed_research
2020 · study · Temporal status not established
Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3.
peer_reviewed_research
2020 · study · Temporal status not established
Humanin: A mitochondria-derived peptide with emerging properties.
peer_reviewed_research
2021 · study · Temporal status not established
Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway.
peer_reviewed_research
2021 · study · Temporal status not established
Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model-Based Study.
peer_reviewed_research
2021 · study · Temporal status not established
[Gly14]-Humanin Ameliorates High Glucose-Induced Apoptosis by Inhibiting the Expression of MicroRNA-155 in Endothelial Microparticles.
peer_reviewed_research
2021 · study · Temporal status not established
The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction.
peer_reviewed_research
2021 · study · Temporal status not established
The emerging role of mitochondrial derived peptide humanin in the testis.
peer_reviewed_research
2021 · study · Temporal status not established
Oxidative Damage? Not a Problem! The Characterization of Humanin-like Mitochondrial Peptide in Anoxia Tolerant Freshwater Turtles.
peer_reviewed_research
2021 · study · Temporal status not established
The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†.
peer_reviewed_research
2021 · study · Temporal status not established
Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases.
peer_reviewed_research
2021 · study · Temporal status not established
Humanin protects cortical neurons from calyculin A-induced neurotoxicities by increasing PP2A activity and SOD.
peer_reviewed_research
2021 · study · Temporal status not established
Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases.
peer_reviewed_research
2021 · study · Temporal status not established
Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival.
peer_reviewed_research
2021 · study · Temporal status not established
S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1.
peer_reviewed_research
2021 · study · Temporal status not established
The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway.
peer_reviewed_research
2021 · study · Temporal status not established
Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging.
peer_reviewed_research
2021 · study · Temporal status not established
Humanin: A Potential Treatment for PCOS?
peer_reviewed_research
2022 · study · Temporal status not established
Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension.
peer_reviewed_research
2022 · study · Temporal status not established
Humanin Ameliorates Late-onset Hypogonadism in Aged Male Rats.
peer_reviewed_research
2022 · study · Temporal status not established
[Gly14]-Humanin inhibits an angiotensin II-induced vascular smooth muscle cell phenotypic switch via ameliorating intracellular oxidative stress.
peer_reviewed_research
2022 · study · Temporal status not established
Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition.
peer_reviewed_research
2022 · study · Temporal status not established
Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD).
peer_reviewed_research
2022 · study · Temporal status not established
The protective effects of S14G-humanin on gestational diabetes mellitus symptoms.
peer_reviewed_research
2022 · study · Temporal status not established
The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis.
peer_reviewed_research
2022 · study · Temporal status not established
Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.
peer_reviewed_research
2022 · study · Temporal status not established
Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target.
peer_reviewed_research
2022 · study · Temporal status not established
Humanin derivative, HNG, enhances neurotransmitter release.
peer_reviewed_research
2022 · study · Temporal status not established
The role of humanin in natural stress tolerance: An underexplored therapeutic avenue.
peer_reviewed_research
2022 · study · Temporal status not established
The role of humanin in the regulation of reproduction.
peer_reviewed_research
2022 · study · Temporal status not established
An evidence of Humanin-like peptide and Humanin mediated cryosurvival of spermatozoa in buffalo bulls.
peer_reviewed_research
2022 · study · Temporal status not established
Cryoprotection of humanin-like peptides in seminal plasma for ejaculated spermatozoa of crossbred bulls.
peer_reviewed_research
2022 · study · Temporal status not established
Cardio-protective role of Humanin in myocardial ischemia-reperfusion.
peer_reviewed_research
2022 · study · Temporal status not established
Humanin and Alzheimer's disease: The beginning of a new field.
peer_reviewed_research
2022 · study · Temporal status not established
Revolutionalizing the age old conventional treatment of psoriasis: An animal based comparative study between methylprednisolone and different doses of a novel anti-oxidant humanin analogue (HNG).
peer_reviewed_research
2022 · study · Temporal status not established
Structural basis of FPR2 in recognition of Aβ42 and neuroprotection by humanin.
peer_reviewed_research
2022 · study · Temporal status not established
Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.
peer_reviewed_research
2022 · study · Temporal status not established
Cryoprotectant with a mitochondrial derived peptide, humanin, improves post-thaw quality of buffalo spermatozoa.
peer_reviewed_research
2023 · study · Temporal status not established
S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice.
peer_reviewed_research
2023 · study · Temporal status not established
S14G-Humanin ameliorates ovalbumin-induced airway inflammation in asthma mediated by inhibition of toll-like receptor 4 (TLR4) expression and the nuclear factor κ-B (NF-κB)/early growth response protein-1 (Egr-1) pathway.
peer_reviewed_research
2023 · study · Temporal status not established
S14G-humanin alleviates acute lung injury by inhibiting the activation of NF-κB.
peer_reviewed_research
2023 · study · Temporal status not established
Exogenous humanin and MOTS-c function as protective agents against gentamicin-induced hair cell damage.
peer_reviewed_research
2023 · study · Temporal status not established
Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: A focus on oxidative stress, inflammation, and apoptosis.
peer_reviewed_research
2023 · study · Temporal status not established
Stability Determination of Intact Humanin-G with Characterizations of Oxidation and Dimerization Patterns.
peer_reviewed_research
2023 · study · Temporal status not established
Intranasal delivery of mitochondrial protein humanin rescues cell death and promotes mitochondrial function in Parkinson's disease.
peer_reviewed_research
2023 · study · Temporal status not established
A novel link between chronic inflammation and humanin regulation in children.
peer_reviewed_research
2023 · study · Temporal status not established
Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6.
peer_reviewed_research
2023 · study · Temporal status not established
Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects.
peer_reviewed_research
2023 · study · Temporal status not established
PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS.
peer_reviewed_research
2023 · study · Temporal status not established
Age-related Changes in Humanin Expression in the Ovarian Tissue of Rat.
peer_reviewed_research
2023 · study · Temporal status not established
A novel beneficial role of humanin on intestinal apoptosis and dysmotility in a rat model of ischemia reperfusion injury.
peer_reviewed_research
2023 · study · Temporal status not established
Effectiveness of analog of Humanin in ameliorating streptozotocin-induced diabetic nephropathy in Sprague Dawley rats.
peer_reviewed_research
2023 · study · Temporal status not established
Exploring the potential of humanin as a biomarker for early breast cancer detection: a study of serum levels and diagnostic performance.
peer_reviewed_research
2023 · study · Temporal status not established
Humanin gene expression in subjects with Parkinson's disease.
peer_reviewed_research
2023 · study · Temporal status not established
Humanin and Its Pathophysiological Roles in Aging: A Systematic Review.
systematic_review_or_meta_analysis
2023 · study · Temporal status not established
The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study.
peer_reviewed_research
2023 · study · Temporal status not established
A New Antioxidant Marker in Cord Blood of Fetuses with Late Fetal Growth Restriction: Humanin.
peer_reviewed_research
2024 · study · Temporal status not established
Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer.
peer_reviewed_research
2024 · study · Temporal status not established
Unbalanced circulating Humanin levels and cardiovascular risk in chronic hemodialysis patients: a pilot, prospective study.
peer_reviewed_research
2024 · study · Temporal status not established
SERUM HUMANIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE-ORGAN DYSFUNCTION SYNDROME.
peer_reviewed_research
2024 · study · Temporal status not established
Humanin activates integrin αV-TGFβ axis and leads to glioblastoma progression.
peer_reviewed_research
2024 · study · Temporal status not established
Humanin's impact on pain markers and neuronal viability in diabetic neuropathy model.
peer_reviewed_research
2024 · study · Temporal status not established
Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology.
peer_reviewed_research
2024 · study · Temporal status not established
Humanin P3S, haplogroup N1b and the risk of Alzheimer's disease.
peer_reviewed_research
2024 · study · Temporal status not established
Humanin Treatment Protects Against Venetoclax-Induced Bone Growth Retardation in Ex Vivo Cultured Rat Bones.
peer_reviewed_research
2024 · study · Temporal status not established
Humanin-G Ameliorates Hemorrhage-Induced Acute Lung Injury in Mice Through AMPKα1-Dependent and -Independent Mechanisms.
peer_reviewed_research
2024 · study · Temporal status not established
[Gly14]-humanin exerts a protective effect against D-galactose-induced primary ovarian insufficiency in mice.
peer_reviewed_research
2024 · study · Temporal status not established
[Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6.
peer_reviewed_research
2024 · study · Temporal status not established
Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice.
peer_reviewed_research
2024 · study · Temporal status not established
Quantitative proteomics analysis reveals the protective role of S14G-humanin in septic acute kidney injury using 4D-label-free and PRM Approaches.
peer_reviewed_research
2024 · study · Temporal status not established
Effects of Humanin G (HNG) on angiogenesis and neurodegeneration markers in Age-related Macular Degeneration (AMD).
peer_reviewed_research
2024 · study · Temporal status not established
Humanin ameliorates TBI-related cognitive impairment by attenuating mitochondrial dysfunction and inflammation.
peer_reviewed_research
2024 · study · Temporal status not established
Impaired Expression of Humanin during Adrenocortical Carcinoma.
peer_reviewed_research
2025 · study · Temporal status not established
HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation.
peer_reviewed_research
2025 · study · Temporal status not established
Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification.
peer_reviewed_research
2025 · study · Temporal status not established
S14G-Humanin ameliorates ovarian dysfunction in a cyclophosphamide-induced premature ovarian insufficiency mouse model.
peer_reviewed_research
2025 · study · Temporal status not established
Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study.
peer_reviewed_research
2025 · study · Temporal status not established
Humanin variants aggregate to produce different fibril morphologies.
peer_reviewed_research
2025 · study · Temporal status not established
Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine.
peer_reviewed_research
2025 · study · Temporal status not established
Ameliorative effects of Gly[14]-humanin on cyclophosphamide-induced premature ovarian insufficiency and underlying mechanisms.
peer_reviewed_research
2025 · study · Temporal status not established
A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders.
peer_reviewed_research
2025 · study · Temporal status not established
Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease.
peer_reviewed_research
2025 · study · Temporal status not established
Detection of Mitochondrial-Derived Peptide Humanin in Semen and Reproductive Tract of Caprine Along With Its Relation to Seasonality.
peer_reviewed_research
2025 · study · Temporal status not established
Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis.
peer_reviewed_research
2025 · study · Temporal status not established
Potential Role of High-Intensity Interval Training-Induced Increase in Humanin Levels for the Management of Type 2 Diabetes.
peer_reviewed_research
2025 · study · Temporal status not established
The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects.
peer_reviewed_research
2026 · study · Temporal status not established
Humanin as a Molecular Indicator of Semen Quality and Cryotolerance in Crossbred Cattle.
peer_reviewed_research
2026 · study · Temporal status not established
Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients.
peer_reviewed_research
2026 · study · Temporal status not established
S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis.
peer_reviewed_research
2026 · study · Temporal status not established
S14G-humanin attenuates renal ischaemia-reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats.
peer_reviewed_research
2026 · study · Temporal status not established
Assessment of mitochondrial peptide humanin in women with polycystic ovary syndrome: serum and skeletal muscle profile.
peer_reviewed_research
2026 · study · Temporal status not established
Humanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy.
peer_reviewed_research
2026 · study · Temporal status not established
Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity.
peer_reviewed_research
2026 · study · Temporal status not established
Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells.
peer_reviewed_research
2026 · study · Temporal status not established
Humanin ameliorates diabetes-induced testicular damage in a streptozotocin-induced mouse model.
peer_reviewed_research
2026 · study · Temporal status not established
Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice.
peer_reviewed_research
2026 · study · Temporal status not established
Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull.
peer_reviewed_research
2026 · study · Temporal status not established
Mitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions.
peer_reviewed_research
2026 · study · Temporal status not established
Altered placental expression of small humanin-like peptides in gestational diabetes mellitus.
peer_reviewed_research
2026 · study · Temporal status not established
Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.
peer_reviewed_research
2026 · study · Temporal status not established
Network Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class).
peer_reviewed_research
2026 · study · Temporal status not established
Humanin Mitigates Aβ-Induced Retinal Pigment Epithelium Injury via AMPK-Beclin1-Dependent Mitophagy.
peer_reviewed_research
2026 · study · Temporal status not established
[Effects of cardiac rehabilitation and predictive value of Humanin/CRP ratio in patients with acute exacerbation of chronic heart failure].
peer_reviewed_research
2026 · study · Temporal status not established
Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats.
peer_reviewed_research
2026 · regulatory · Temporal status not established
Regulatory review: not_approved
European Union — EMA
2026 · regulatory · Temporal status not established
Regulatory review: not_approved
United States — FDA

The represented chronology reflects records currently included in the governed dataset and does not claim to represent the entire scientific literature.

What still needs investigation

Claim traceability

No institutional claim record is currently represented for this peptide.

Evidence is missing or not represented as studied; this is not a conclusion that the intervention does not work.

Humanin research, ranked and separated by purpose

Humanin: what this atlas does and does not establish

Known limitations of this pass

Practice-defining evidence

Strong supporting evidence

Contextual evidence

Signal-generating evidence

Suggested citation

No community pattern is displayed yet

The state of the record

Evidence, claims, and boundaries

6 conclusions connected to 0 featured studies

Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension.

HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation.

Chemistry and represented biological context

Molecular and structural record

Continue through the research system

Research discovery

How the scientific record is developing

Research chronology

[Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo.

Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults

Mechanisms of Neuroprotection by a Novel Rescue Factor Humanin from Swedish Mutant Amyloid Precursor Protein

Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults

A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity.

Humanin inhibits cell death of serum-deprived PC12h cells

Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Aβ1–40

Humanin rescues human cerebrovascular smooth muscle cells from Aβ‐induced toxicity

Humanin improves impaired metabolic activity and prolongs survival of serum-deprived human lymphocytes

Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis

Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease‐related neurotoxicity: functional potentiation by isomerization and dimerization

Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults

Humanin rescues cortical neurons from prion-peptide-induced apoptosis

Humanin peptide suppresses apoptosis by interfering with Bax activation

A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease‐relevant insults

Effect of humanin analogues on experimentally induced impairment of spatial memory in rats.

Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide.

Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin.

Humanin: After the Discovery

Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor.

N-Formylated humanin activates both formyl peptide receptor-like 1 and 2

Unravelling the role of Humanin.

High-yield, solid-phase synthesis of humanin, an Alzheimer's disease associated, novel 24-mer peptide which contains a difficult sequence.

Development of a Femtomolar-Acting Humanin Derivative Named Colivelin by Attaching Activity-Dependent Neurotrophic Factor to Its N Terminus: Characterization of Colivelin-Mediated Neuroprotection against Alzheimer's Disease-Relevant InsultsIn VitroandIn Vivo

Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.

Humanin Attenuates Apoptosis Induced by DRPLA Proteins With Expanded Polyglutamine Stretches

A humanin derivative, S14G‐HN, prevents amyloid‐β‐induced memory impairment in mice

Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity.

Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak

Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase

Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent

Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL

Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality.

Effect of humanin on decreased ATP levels of human lymphocytes harboring A3243G mutant mitochondrial DNA

Construction of a eukaryotic expression plasmid of Humanin.

Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease.

Zinc(II) binds to the neuroprotective peptide humanin.

The secondary structure analysis of a potent Ser14Gly analog of antiAlzheimer peptide, Humanin, by circular dichroism.

Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia

Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis.

Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis.

[Recent progress in neuroprotection of humanin against Alzheimer's disease-relevant neurotoxicity].

[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system].

Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits an unknown post-cysteine cleavage specificity.

Humanin Is a Novel Neuroprotective Agent Against Stroke

Structural preferences of neuroprotective S14G-humanin peptide analyzed by molecular modeling and circular dichroism.

Mapping the specific cytoprotective interaction of humanin with the pro-apoptotic protein bid.

Structural and dynamical studies of Humanin in water and TFE/water mixture: a molecular dynamics simulation.

The complex structure transition of Humanin peptides by sodium dodecylsulfate and trifluoroethanol.

The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues

Activity-dependent neurotrophic factor, ADNF, determines the structure characteristics of Colivelin, a fusion protein of ADNF9 and Humanin analog.

Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway

In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives.

Humanin structural versatility and interaction with model cerebral cortex membranes.

Humanin: a novel central regulator of peripheral insulin action.

Humanin; a defender against Alzheimer's disease?

Evidence for potential functionality of nuclearly-encoded humanin isoforms.

Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.

Opposing Roles of Insulin-Like Growth Factor Binding Protein 3 and Humanin in the Regulation of Testicular Germ Cell Apoptosis