{"schemaVersion":"wpf-profile-export-v1","exportedAt":"2026-09-24T04:43:28.260Z","profile":{"slug":"humanin","name":"Humanin","aliases":[],"category":"Mitochondrial-derived peptide"},"synthesis":{"mechanism":"Humanin is a mitochondrial-derived peptide investigated in cellular stress and metabolic biology. Associations involving circulating humanin and experiments with related fragments do not establish a treatment in humans.","evidence":"WPF’s atlas includes observational human work on circulating humanin in chronic kidney disease, gestational diabetes, and other settings, as well as mechanistic and fragment-peptide studies. These designs measure different things and cannot be combined into a demonstrated therapeutic effect.","safety":"No published source-linked citations or jurisdiction-specific regulatory records are attached to this Directory entry. An association or laboratory result does not establish causality, an effective intervention, or clinical safety.","observationalBoundary":"WPF's separate observational archive may include contributor reports mentioning humanin. As with every entry in that archive, these de-identified reports can suggest questions but cannot establish causation, efficacy, comparative safety, or event frequency, and any such report should be read as concerning the specific peptide rather than related experimental fragments.","openQuestions":"How reliably is humanin measured across studies? Are observed human associations reproducible after accounting for confounding? Which experimental findings, if any, translate into controlled human interventions?"},"completion":{"version":"wpf-profile-v1.1","verifiedSourceCount":309,"evidenceDepth":"depth_target_met","complete":false,"checks":[{"key":"overview","passed":true,"actual":219,"required":100,"severity":"blocking"},{"key":"evidence_summary","passed":true,"actual":292,"required":100,"severity":"blocking"},{"key":"safety_summary","passed":true,"actual":231,"required":100,"severity":"blocking"},{"key":"archive_boundary","passed":true,"actual":371,"required":75,"severity":"blocking"},{"key":"open_questions","passed":true,"actual":211,"required":75,"severity":"blocking"},{"key":"verified_sources","passed":true,"actual":309,"required":1,"severity":"blocking"},{"key":"evidence_depth_target","passed":true,"actual":309,"required":25,"severity":"warning"},{"key":"reviewed_sources","passed":false,"actual":0,"required":1,"severity":"blocking"},{"key":"chemistry","passed":true,"actual":true,"required":true,"severity":"blocking"},{"key":"regulatory_context","passed":true,"actual":2,"required":2,"severity":"blocking"},{"key":"claims","passed":false,"actual":0,"required":1,"severity":"blocking"},{"key":"claim_traceability","passed":true,"actual":0,"required":0,"severity":"blocking"},{"key":"regulatory_freshness","passed":true,"actual":0,"required":0,"severity":"warning"}],"failures":["reviewed_sources","claims"]},"chemistry":{"id":"98c97cdb-b19a-4101-9859-1c7cff9d4528","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","molecularFormula":"C119H204N34O32S2","molecularWeight":2687.2,"aminoAcidSequence":null,"smiles":"CCC(C)C(C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(C)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(CC2=CC=CC=C2)NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)C3CCCN3C(=O)C(C)NC(=O)C(CCSC)N","inchi":"InChI=1S/C119H204N34O32S2/c1-19-65(14)92(112(180)144-81(54-90(160)161)104(172)145-82(52-63(10)11)115(183)153-46-29-37-87(153)110(178)149-91(64(12)13)111(179)139-72(32-23-24-41-120)97(165)136-74(35-27-44-130-119(126)127)98(166)135-73(34-26-43-129-118(124)125)96(164)133-67(16)116(184)185)150-99(167)75(38-39-89(158)159)137-106(174)84(57-155)147-113(181)93(68(17)156)151-105(173)79(51-62(8)9)142-101(169)77(49-60(4)5)140-100(168)76(48-59(2)3)141-102(170)78(50-61(6)7)143-108(176)85(58-186)148-107(175)83(56-154)146-103(171)80(53-69-30-21-20-22-31-69)134-88(157)55-131-95(163)71(33-25-42-128-117(122)123)138-109(177)86-36-28-45-152(86)114(182)66(15)132-94(162)70(121)40-47-187-18/h20-22,30-31,59-68,70-87,91-93,154-156,186H,19,23-29,32-58,120-121H2,1-18H3,(H,131,163)(H,132,162)(H,133,164)(H,134,157)(H,135,166)(H,136,165)(H,137,174)(H,138,177)(H,139,179)(H,140,168)(H,141,170)(H,142,169)(H,143,176)(H,144,180)(H,145,172)(H,146,171)(H,147,181)(H,148,175)(H,149,178)(H,150,167)(H,151,173)(H,158,159)(H,160,161)(H,184,185)(H4,122,123,128)(H4,124,125,129)(H4,126,127,130)/t65-,66-,67-,68+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,91-,92-,93-/m0/s1","inchikey":"DPEUWKZJZIPZKE-OFANTOPUSA-N","structureImageUrl":"https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/16131438/PNG","createdAt":"2026-09-23T02:36:53.871Z","updatedAt":"2026-09-23T02:36:53.871Z"},"evidence":[{"id":"83fa76a0-1a8b-4062-b7a7-aa3e13b811a8","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Altered placental expression of small humanin-like peptides in gestational diabetes mellitus.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/42453115/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Altered placental expression of small humanin-like peptides in gestational diabetes mellitus.\" Abstract excerpt: Gestational diabetes mellitus (GDM) is characterized by maternal insulin resistance and hyperglycemia and has been associated with placental mitochondrial alterations. Small humanin-like peptides (SHLP1-6), encoded within the mitochondrial 16S rRNA region, have been described as mitochondria-derived peptides (MDPs) with reported cytoprotective and metabolic effects in experimental settings. Howeve","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.48101/ujms.v131.14142","pubmedId":"42453115","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.48101/ujms.v131.14142","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:39.789Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e46741fb-09e5-4725-823b-22d7980c2799","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Assessment of mitochondrial peptide humanin in women with polycystic ovary syndrome: serum and skeletal muscle profile.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/41186863/","evidenceTier":"animal","summary":"Human measurement study in a defined population; associations cannot establish an intervention.","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.1007/s40618-025-02747-6","pubmedId":"41186863","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Upgraded from an entered/unverified draft to a content-verified citation. Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":"This publication addresses Humanin in the specific setting identified in its title.","supportNature":"Screened source-level context; specific outcomes and evidence tier await appraisal.","qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s40618-025-02747-6","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T02:12:35.584Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"52148e27-997b-4dda-8832-f874f6799592","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/41849628/","evidenceTier":"observational","summary":"Content-verified record concerning Humanin: \"Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients.\" Abstract excerpt: Cardiovascular morbidity and mortality (CVMM) remain highly prevalent among end-stage kidney disease (ESKD) patients undergoing chronic hemodialysis (HD). Nevertheless, risk prediction in this setting is limited by the complexity of factors involved and the individual patients' characteristics. In this study, we evaluated whether circulating levels of Humanin, a micropeptide reflecting mitochondri","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.1159/000551517","pubmedId":"41849628","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: human_observational. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1159/000551517","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:33.378Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"8c2a37a5-e820-481a-ae2c-2abffcaa7b2a","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Mitigates Aβ-Induced Retinal Pigment Epithelium Injury via AMPK-Beclin1-Dependent Mitophagy.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/42333946/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Mitigates Aβ-Induced Retinal Pigment Epithelium Injury via AMPK-Beclin1-Dependent Mitophagy.\" Abstract excerpt: Amyloid beta (A&#x3b2;), a key component of drusen in age-related macular degeneration (AMD), induces oxidative stress, mitochondrial dysfunction, and degeneration in the retinal pigment epithelium (RPE), contributing to progressive vision loss in the elderly. We investigated the protective role of Humanin (HN), a mitochondria-derived peptide with known neuroprotective effects in A&#x3b2;-related ","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.1111/acel.70601","pubmedId":"42333946","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/acel.70601","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:27.799Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"4042b42e-9ea6-41b0-87a3-9ba1a8740a27","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/42346352/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice.\" Abstract excerpt: Objective : Diabetes mellitus is closely associated with mitochondrial dysfunction, which disrupts cellular energy metabolism and perturbs hormonal homeostasis. Humanin (HN), a 24-amino acid peptide encoded within the mitochondrial genome, has attracted considerable attention due to its cytoprotective and metabolic regulatory properties. Despite its recognized biological potential, the role of HN ","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.3390/metabo16060373","pubmedId":"42346352","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=161, totalMentions=4). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3390/metabo16060373","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:56.787Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"18c6b31d-0d35-48e1-8b9b-5b8d80e48aca","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin ameliorates diabetes-induced testicular damage in a streptozotocin-induced mouse model.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/42438323/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin ameliorates diabetes-induced testicular damage in a streptozotocin-induced mouse model.\" Abstract excerpt: Diabetes mellitus is a major metabolic disorder closely associated with oxidative stress and male reproductive dysfunction. Humanin, a mitochondria-derived peptide, has been reported to exert cytoprotective, anti-apoptotic and antioxidant effects in various disease models; however, its role in diabetes-induced testicular damage remains unclear. This study aimed to investigate the effects of humani","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.1113/ep093912","pubmedId":"42438323","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=124, totalMentions=8). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1113/ep093912","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:56.667Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f1062dca-7707-475b-b057-b285a6e71bbf","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin as a Molecular Indicator of Semen Quality and Cryotolerance in Crossbred Cattle.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/42223320/","evidenceTier":"observational","summary":"Content-verified record concerning Humanin: \"Humanin as a Molecular Indicator of Semen Quality and Cryotolerance in Crossbred Cattle.\" Abstract excerpt: The present study aimed to assess the presence of humanin in the sperm of crossbred cattle bulls using immunocytochemistry and to evaluate its potential as a semen quality marker. For this, a total of 49 ejaculates were collected from three Vrindavani crossbred bulls and were evaluated for volume, individual progressive motility (IPM), abnormality, and sperm concentration. The ejaculates were grou","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.1111/rda.70240","pubmedId":"42223320","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=50, totalMentions=7). Imported evidence lane: human_observational. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/rda.70240","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:56.269Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"de08661a-7846-4c28-9950-bb451b9d0002","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/41864362/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity.\" Abstract excerpt: Humanin is a mitochondrial-derived peptide with cytoprotective properties, but how it has evolved in response to different oxidative stress levels in mammals is not fully understood. This study examines how Humanin sequences have adapted to species-specific metabolic and environmental pressures. We compared the peptide in several mammalian species categorized by their distinct oxidative stress pro","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.1016/j.freeradbiomed.2026.03.033","pubmedId":"41864362","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=5). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.freeradbiomed.2026.03.033","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:56.487Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"c396eeee-c6d4-4daa-9a14-1060bf7808c6","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/41550496/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy.\" Abstract excerpt: Duchenne muscular dystrophy (DMD) is a progressive muscle disease for which glucocorticoid (GC) treatment is standard therapy. Patients typically suffer from short stature and osteoporosis, caused by the underlying disease and adverse effects of GCs. We investigated whether the mitochondrial peptide humanin (HNG) could prevent GC-induced growth retardation and osteoporosis in mouse models of DMD. ","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.1016/j.bbrep.2025.102421","pubmedId":"41550496","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=301, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbrep.2025.102421","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:56.416Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"cf8fceac-2b3f-47ea-abd5-7f1e2d850bdd","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/42480246/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats.\" Abstract excerpt: Selective serotonin reuptake inhibitors (SSRIs) such as paroxetine frequently induce male sexual dysfunction by disrupting neuroendocrine balance and central dopaminergic pathways. This study investigated whether humanin, a mitochondria-derived peptide, could mitigate paroxetine-induced reproductive and behavioral impairments in male Sprague-Dawley rats. In Phase 1, fifty rats were randomized into","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.1016/j.repbio.2026.101254","pubmedId":"42480246","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=213, totalMentions=7). Imported evidence lane: human_interventional. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.repbio.2026.101254","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:56.070Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"918ac975-55dc-4b93-971a-f1ac61a78dba","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/42153337/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells.\" Abstract excerpt: Recent investigations show that mitochondrial impairment significantly contributes to endothelial damage in septic acute respiratory distress syndrome (ARDS). Humanin (HN) and its derivative Humanin-G (HNG) are mitochondrial polypeptides which have been identified as inhibitors of cellular apoptosis and neuroprotective agents against oxidative stress. This study aims to elucidate the effects of HN","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.1093/ajrcmb/aanag079","pubmedId":"42153337","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=159, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1093/ajrcmb/aanag079","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:56.595Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"6312c375-0b3e-47c5-a89d-50e1db5955e3","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/41634054/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull.\" Abstract excerpt: The sperm quality, freezability, and fertility of crossbred bulls exhibit significant unpredictability, which consequently impacts the breeding program. The present study documents the supplementation of humanin, a mitochondria-derived peptide, on crossbred bull's sperm quality, freezability, antioxidant status and in-vitro fertility. For this objective a total of 24 ejaculates, 8 from each of the","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.1038/s41598-025-30931-4","pubmedId":"41634054","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1038/s41598-025-30931-4","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:37.458Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e72836d2-5950-44f0-bff4-0d8658317719","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Mitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/42397223/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Mitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions.\" Abstract excerpt: In brief: Redox imbalance compromises granulosa cell survival and follicle fate. This study identifies the mitochondrial-derived peptide Humanin (HN) as a cytoprotective factor that protects granulosa cells under oxidative condItions. Abstract: Granulosa cell function is essential for proper ovarian physiology. Redox imbalance compromises granulosa cell survival, thereby impacting follicle fate wi","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.1093/reprod/xaag082","pubmedId":"42397223","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1093/reprod/xaag082","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:37.535Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"b40a6120-6b2f-4b19-b620-ddbe23fa4cd6","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/41732124/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.\" Abstract excerpt: Glucocorticoids, such as dexamethasone (DEXA), are effective therapeutics but cause severe muscle wasting. Mitochondrial-derived peptides (MDPs) are promising countermeasures, but their effectiveness is largely unexplored. We tested the hypothesis that the MDP S14G-humanin (HNG) and the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) mitigate DEXA-induced atrophy in human skeletal myot","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.14814/phy2.70791","pubmedId":"41732124","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.14814/phy2.70791","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:40.320Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"4f98066a-c041-4608-bb56-c68ef677422d","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Network Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class).","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/42509775/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Network Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class).\" Abstract excerpt: This study presents an in-depth analysis of an interactome comprising approximately 1033 nodes, focusing on its topology, reliability, and functional implications, with particular attention to the small mitochondrial proteins of the Humanin family and their nuclear-encoded MTRNR2Lx paralogs. The analysis, conducted through stringent high-reliability filters and experimentally supported interaction","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.3390/biom16070981","pubmedId":"42509775","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3390/biom16070981","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:43.813Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"57eb8aa3-a4b5-488a-b258-88ca01479571","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/42492881/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis.\" Abstract excerpt: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, with limited therapeutic options. S14G-humanin (HNG), a potent analog of humanin, exerts protective effects in various diseases, but its role in DN remains unexplored. DN was induced in C57BL/6 mice via high-fat diet and streptozotocin (STZ), with or without HNG treatment. Renal injury, necroptosis, and Z-DNA/ZBP1 pathways ","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.1016/j.ejphar.2026.179175","pubmedId":"42492881","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=114, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.ejphar.2026.179175","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:01.126Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"b248d2c0-f493-4790-b03a-6d8bf9c6617e","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"S14G-humanin attenuates renal ischaemia-reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/42672739/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"S14G-humanin attenuates renal ischaemia-reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats.\" Abstract excerpt: Renal ischaemia-reperfusion (I/R) injury leads to acute tubular necrosis and renal failure, triggering pathological mechanisms including inflammation, reactive oxygen species generation, apoptosis and mitochondrial dysfunction. The mitochondrial peptide humanin (HN), known to possess anti-apoptotic and anti-inflammatory properties, has been shown to counteract oxidative stress and restore mitochon","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.1113/ep094006","pubmedId":"42672739","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=254, totalMentions=3). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1113/ep094006","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:01.202Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"5f32943f-2b3d-4ca4-a220-17899294054c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Effects of cardiac rehabilitation and predictive value of Humanin/CRP ratio in patients with acute exacerbation of chronic heart failure].","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/42736132/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"[Effects of cardiac rehabilitation and predictive value of Humanin/CRP ratio in patients with acute exacerbation of chronic heart failure].\" Abstract excerpt: Objective: To evaluate the effects of a standardized rehabilitation protocol on physical performance, exercise tolerance, and prognosis in hospitalized patients with acute exacerbation of chronic heart failure (CHF), and to explore the clinical value of the serum Humanin (a mitochondria-derived peptide) to C-reactive protein (CRP) ratio in prognostic risk stratification. Methods: This non-randomiz","authors":null,"publishingOrg":null,"publicationYear":2026,"doi":"10.3760/cma.j.cn112148-20260515-00320","pubmedId":"42736132","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: human_interventional. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3760/cma.j.cn112148-20260515-00320","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:42.474Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"72137722-beca-46d4-b4e9-09347060820e","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/39950467/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders.\" Abstract excerpt: Autophagy is a self-eating cellular process in which the cell breaks down worn-out organelles, damaged/defective proteins, and toxins. Impaired autophagy is a significant factor in the development of various metabolic disorders, along with oxidative stress, inflammation, mitochondrial and endoplasmic reticulum dysfunction. These disorders pose a significant health and economic burden on the global","authors":null,"publishingOrg":null,"publicationYear":2025,"doi":"10.2174/0109298665363711250112050930","pubmedId":"39950467","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2174/0109298665363711250112050930","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:38.783Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"67dbd4b7-74c5-4f52-8400-8f22d1091f91","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Ameliorative effects of Gly[14]-humanin on cyclophosphamide-induced premature ovarian insufficiency and underlying mechanisms.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/40639309/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Ameliorative effects of Gly[14]-humanin on cyclophosphamide-induced premature ovarian insufficiency and underlying mechanisms.\" Abstract excerpt: Can Gly[14]-humanin (HNG) improve cyclophosphamide-induced premature ovarian insufficiency (POI)? A POI model was induced in female rats by intraperitoneal injection of cyclophosphamide, followed by treatment with an intraperitoneal injection of HNG. Ovarian weight, ovarian index, regularity of the oestrous cycle, numbers of various types of follicle, hormone concentrations, and expression of the ","authors":null,"publishingOrg":null,"publicationYear":2025,"doi":"10.1016/j.rbmo.2025.104901","pubmedId":"40639309","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.rbmo.2025.104901","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:38.251Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"b8547bac-5734-450c-be70-7f1e03514499","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Detection of Mitochondrial-Derived Peptide Humanin in Semen and Reproductive Tract of Caprine Along With Its Relation to Seasonality.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/40838645/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Detection of Mitochondrial-Derived Peptide Humanin in Semen and Reproductive Tract of Caprine Along With Its Relation to Seasonality.\" Abstract excerpt: Humanin is the first short peptide in a speculated group of peptides produced by mitochondria that possess potent cytoprotective properties against various forms of stress. Despite being a prevalent peptide in testes and spermatozoa, there has been no report on the identification or quantification of humanin in buck sperm cells or the reproductive tract. This study aimed to establish the presence ","authors":null,"publishingOrg":null,"publicationYear":2025,"doi":"10.1111/rda.70113","pubmedId":"40838645","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/rda.70113","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:40.398Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e25b0569-c766-437d-b611-f83ce83f6c48","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/40768089/","evidenceTier":"observational","summary":"Content-verified record concerning Humanin: \"Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification.\" Abstract excerpt: This study aimed to evaluate the diagnostic significance of circulating mitochondrial-derived peptides, Humanin and MOTS-c, the long non-coding RNA GAS5, and exosomal microRNAs miR-21 and miR-103 in stratifying prostate diseases, including benign prostatic hyperplasia (BPH), precancerous lesions (PL), and prostate cancer (PCa). These biomarkers were selected based on their established roles in cel","authors":null,"publishingOrg":null,"publicationYear":2025,"doi":"10.1007/s10238-025-01810-z","pubmedId":"40768089","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: human_observational. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s10238-025-01810-z","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:35.958Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"5f65c734-68e4-4471-8bfe-2fd36103fb67","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/40877234/","evidenceTier":"observational","summary":"Content-verified record concerning Humanin: \"HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation.\" Abstract excerpt: Elimination of apoptotic neutrophils by macrophages, a process called efferocytosis, is a critical step in the resolution of inflammation. Efferocytosis induces the reprogramming of macrophages towards a pro-resolving phenotype and triggers the secretion of pro-resolving factors. While mouse efferocytic macrophages are well-described, less is known about human efferocytic macrophages. Here, using ","authors":null,"publishingOrg":null,"publicationYear":2025,"doi":"10.1038/s41419-025-07909-1","pubmedId":"40877234","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: human_observational. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1038/s41419-025-07909-1","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:27.647Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"55f97d06-fff5-4b9f-bad5-518a40db4ec9","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/39510375/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine.\" Abstract excerpt: Neuropathic pain is associated with diverse etiologies, including sciatica, diabetes, and the use of chemotherapeutic agents. Despite the varied origins, mitochondrial dysfunction, oxidative stress, and inflammatory cytokines are recognized as key contributing factors in both the initiation and maintenance of neuropathic pain. The effects of the mitochondrial-derived peptide humanin on neuropathic","authors":null,"publishingOrg":null,"publicationYear":2025,"doi":"10.1016/j.neuropharm.2024.110207","pubmedId":"39510375","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=378, totalMentions=11). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.neuropharm.2024.110207","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:56.931Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f2eb9a84-6619-46e3-9816-b3f10ee753e5","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin variants aggregate to produce different fibril morphologies.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/40543583/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin variants aggregate to produce different fibril morphologies.\" Abstract excerpt: Humanin is an endogenous human peptide with cytoprotective effects, including inhibition of apoptosis via interaction with BCL-2 proteins such as BAX. The therapeutic benefits of HN have been well-documented, and administering humanin and related endogenous human peptides for treatment of disease, aging, and enhancement of athletic performance is becoming more widespread. However, very little is k","authors":null,"publishingOrg":null,"publicationYear":2025,"doi":"10.1016/j.jbc.2025.110403","pubmedId":"40543583","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=3). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.jbc.2025.110403","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:56.859Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"83d1abd0-d358-4759-a43b-9bd0959c5efb","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/41303353/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease.\" Abstract excerpt: Humanin (HN) and MOTS-c are mitochondrial-derived peptides (MDPs) known for their neuroprotective and metabolic functions. Their circulating and tissue levels decline with age and in neurodegenerative diseases such as Alzheimer's disease (AD). This study aimed to evaluate whether blood and plasma gene expression and plasma protein levels of HN and MOTS-c are associated with AD markers, their role ","authors":null,"publishingOrg":null,"publicationYear":2025,"doi":"10.3390/ijms262210866","pubmedId":"41303353","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3390/ijms262210866","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:40.091Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"d1781c4f-80a8-4b75-aaf9-a0a15e8c276f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/39435863/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis.\" Abstract excerpt: Oligoasthenozoospermia is a common cause of male infertility, for which effective treatments are urgently needed. Humanin (HN) is a peptide associated with this condition. To investigate the ameliorative effect of [Gly14]-Humanin (HNG) on oligoasthenozoospermia and the mechanisms. Mice were treated with cyclophosphamide (CP) to construct a mice model of oligoasthenozoospermia. The resulting model ","authors":null,"publishingOrg":null,"publicationYear":2025,"doi":"10.1111/andr.13786","pubmedId":"39435863","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/andr.13786","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:42.922Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e6df5dc5-9363-4d64-909e-a25ca7609501","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/39846683/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study.\" Abstract excerpt: Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder associated with an increased risk of cardiovascular disease (CVD), largely driven by peripheral endothelial dysfunction (ED). Humanin, a mitochondrial-derived peptide, has been suggested to play a protective role in endothelial function. However, the relationship between Humanin levels and ED in RA, as well as the interaction b","authors":null,"publishingOrg":null,"publicationYear":2025,"doi":"10.3390/ncrna11010005","pubmedId":"39846683","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=197, totalMentions=11). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3390/ncrna11010005","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:01.909Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"1bc376b6-1503-408f-a5a6-5fba5d2b7883","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Potential Role of High-Intensity Interval Training-Induced Increase in Humanin Levels for the Management of Type 2 Diabetes.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/39936487/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Potential Role of High-Intensity Interval Training-Induced Increase in Humanin Levels for the Management of Type 2 Diabetes.\" Abstract excerpt: This study investigated the effect of 8 weeks of high-intensity interval training (HIIT) on oxidative stress, inflammation, and apoptosis in rats with type 2 diabetes (T2D), focusing on the role of the Humanin (HN). In this study, 28 male Wistar rats were assigned to one of four groups: healthy control (CO), diabetes control (T2D), exercise (EX), and diabetes + exercise (T2D + EX). After diabetes ","authors":null,"publishingOrg":null,"publicationYear":2025,"doi":"10.1111/jcmm.70396","pubmedId":"39936487","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/jcmm.70396","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:43.582Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"d26afd36-2371-496e-b769-097f840c9e5b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"S14G-Humanin ameliorates ovarian dysfunction in a cyclophosphamide-induced premature ovarian insufficiency mouse model.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/40811024/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"S14G-Humanin ameliorates ovarian dysfunction in a cyclophosphamide-induced premature ovarian insufficiency mouse model.\" Abstract excerpt: Premature ovarian insufficiency (POI) is a major cause of female infertility, for which effective therapies remain limited. S14G-Humanin (HNG), a potent analogue of Humanin, exhibits strong antioxidant and anti-apoptotic properties and has demonstrated cytoprotective effects in various tissues, including the ovary. In this study, a cyclophosphamide (CP)-induced POI mouse model was established to e","authors":null,"publishingOrg":null,"publicationYear":2025,"doi":"10.1093/molehr/gaaf042","pubmedId":"40811024","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=129, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1093/molehr/gaaf042","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:01.314Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"00aec8a7-2e1c-475d-b71b-ed97cf09dd3d","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/40090538/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects.\" Abstract excerpt: Humanin (HN) is an endogenous micropeptide also known as a mitochondria-derived peptide. It has a neuroprotective effect against Alzheimer's disease (AD) and other neurodegenerative diseases by improving hippocampal acetylcholine and attenuating the development of oxidative stress and associated neurotoxicity. HN protects the neuron from the toxic effects of amyloid beta (A&#x3b2;). HN is regarded","authors":null,"publishingOrg":null,"publicationYear":2025,"doi":"10.1016/j.ejphar.2025.177510","pubmedId":"40090538","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.ejphar.2025.177510","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:37.150Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3d018936-a20f-4810-9f16-075e495473d9","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/39079574/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice.\" Abstract excerpt: Male patients who undergo prepubertal chemotherapy face the dual problems of fertility preservation in adulthood, including low testosterone, hypersexual function, and infertility. Humanin, as a small polypeptide coded within the mitochondrial DNA, with the mitochondrial short open reading frame named MOTS-c, both was believed to regulate mitochondrial homeostasis, be anti-inflammatory, improve me","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.1016/j.reprotox.2024.108674","pubmedId":"39079574","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=181, totalMentions=4). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.reprotox.2024.108674","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:02.887Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"adc639dd-bf2e-43a1-95f8-8010c9ef05bc","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Effects of Humanin G (HNG) on angiogenesis and neurodegeneration markers in Age-related Macular Degeneration (AMD).","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/38029849/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Effects of Humanin G (HNG) on angiogenesis and neurodegeneration markers in Age-related Macular Degeneration (AMD).\" Abstract excerpt: Advanced stages of Age-related Macular Degeneration (AMD) are characterized by retinal neurodegeneration and aberrant angiogenesis, and mitochondrial dysfunction contributes to the pathogenesis of AMD. In this study, we tested the hypothesis that Humanin G (HNG), a cytoprotective mitochondrial-derived peptide, positively regulates cell proliferation, cell death, and the protein levels of angiogene","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.1016/j.mito.2023.11.001","pubmedId":"38029849","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=247, totalMentions=3). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.mito.2023.11.001","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:03.602Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e88d18db-8359-418c-9c6e-ab7ebe0ff0b9","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin P3S, haplogroup N1b and the risk of Alzheimer's disease.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/38757793/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin P3S, haplogroup N1b and the risk of Alzheimer's disease.\" Abstract excerpt: A commentary of the paper 'Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology' that appeared recently in Aging Cell. The possible association of a mitochondrial haplogroup with a disease is frequently discussed. The Humanin peptide encoded by the mtDNA has been shown to play an important regulatory role in cell metabolism. There are variant","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.1111/acel.14207","pubmedId":"38757793","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=27, totalMentions=11). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/acel.14207","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:57.512Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"0fa2ece0-c3bf-41cb-a881-9b86a75327d9","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Treatment Protects Against Venetoclax-Induced Bone Growth Retardation in <i>Ex Vivo</i> Cultured Rat Bones.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/38328478/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Treatment Protects Against Venetoclax-Induced Bone Growth Retardation in <i>Ex Vivo</i> Cultured Rat Bones.\" Abstract excerpt: Recent preclinical studies reported that the BCL-2 inhibitor venetoclax can impair bone growth. A strategy to prevent such a side effect of this promising anticancer drug is highly desired. Earlier in vitro and in vivo studies suggested that the mitochondrial peptide humanin has the potential to prevent drug-induced growth impairment. We hypothesized that co-treatment with the humanin analog HNG m","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.1210/jendso/bvae009","pubmedId":"38328478","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=268, totalMentions=3). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1210/jendso/bvae009","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:57.645Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"ad3385f8-f187-4ca3-aff4-6536fbed3ef9","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin activates integrin αV-TGFβ axis and leads to glioblastoma progression.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/38942749/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin activates integrin αV-TGFβ axis and leads to glioblastoma progression.\" Abstract excerpt: The role of mitochondria peptides in the spreading of glioblastoma remains poorly understood. In this study, we investigated the mechanism underlying intracranial glioblastoma progression. Our findings demonstrate that the mitochondria-derived peptide, humanin, plays a significant role in enhancing glioblastoma progression through the intratumoral activation of the integrin alpha V (ITGAV)-TGF bet","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.1038/s41419-024-06790-8","pubmedId":"38942749","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=253, totalMentions=7). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1038/s41419-024-06790-8","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:57.010Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"55523929-0803-41f5-bb9e-f3abde4450ad","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin ameliorates TBI-related cognitive impairment by attenuating mitochondrial dysfunction and inflammation.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37926362/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin ameliorates TBI-related cognitive impairment by attenuating mitochondrial dysfunction and inflammation.\" Abstract excerpt: Traumatic brain injury (TBI) often results in a reduction of the capacity of cells to sustain energy demands, thus, compromising neuronal function and plasticity. Here we show that the mitochondrial activator humanin (HN) counteracts a TBI-related reduction in mitochondrial bioenergetics, including oxygen consumption rate. HN normalized the disruptive action of TBI on memory function, and restored","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.1016/j.bbadis.2023.166937","pubmedId":"37926362","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbadis.2023.166937","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:27.874Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"ef55804d-0c7d-4a2a-bb6c-f06d80a98641","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/38520065/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology.\" Abstract excerpt: The APOE4 allele is recognized as a significant genetic risk factor to Alzheimer's disease (AD) and influences longevity. Nonetheless, some APOE4 carriers exhibit resistance to AD even in advanced age. Humanin, a mitochondrial-derived peptide comprising 24 amino acids, has variants linked to cognitive resilience and longevity. Our research uncovered a unique humanin variant, P3S, specifically enri","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.1111/acel.14153","pubmedId":"38520065","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=202, totalMentions=9). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/acel.14153","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:57.311Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"22802fe9-edba-4cbe-a511-8a67ab646c00","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin's impact on pain markers and neuronal viability in diabetic neuropathy model.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/38599217/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin's impact on pain markers and neuronal viability in diabetic neuropathy model.\" Abstract excerpt: This study investigates the impact of chronic humanin (HN) treatment on pain-related markers (NMDA, substance P, TRPV1, and IL-1&#x3b2;) in diabetic mice's dorsal root ganglia (DRG). Additionally, we assess the effects of HN on cellular viability in DRG neurons. In vivo experiments involved 15&#xa0;days of HN administration (4 mg/kg) to diabetic mice ( n &#xa0;=&#xa0;10). Protein levels of NMDA, I","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.1080/13813455.2024.2336922","pubmedId":"38599217","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=46, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1080/13813455.2024.2336922","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:57.120Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"d892a385-5a38-40a9-b07d-05f2a7f6eb87","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin-G Ameliorates Hemorrhage-Induced Acute Lung Injury in Mice Through AMPKα1-Dependent and -Independent Mechanisms.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/39595179/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin-G Ameliorates Hemorrhage-Induced Acute Lung Injury in Mice Through AMPKα1-Dependent and -Independent Mechanisms.\" Abstract excerpt: Background/Objectives : The severity of acute lung injury is significantly impacted by age and sex in patients with hemorrhagic shock. AMP-activated protein kinase (AMPK) is a crucial regulator of energy metabolism but its activity declines with aging. Humanin is a mitochondrial peptide that exerts cytoprotective effects in response to oxidative stressors and is associated with longevity. Using a ","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.3390/biomedicines12112615","pubmedId":"39595179","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=253, totalMentions=8). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3390/biomedicines12112615","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:58.444Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"1231b678-ebf4-48a5-8e1b-c6accb14b37f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/38314601/","evidenceTier":"observational","summary":"Content-verified record concerning Humanin: \"Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer.\" Abstract excerpt: Lung and breast cancer are the most frequent causes of death from cancer globally. The objectives of this research were to evaluate the serum mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) and humanin levels in lung or breast cancer patients, and investigate the impacts of radiation therapy on the circulating levels of these peptides. 35 lung cancer patients, 34 breast cancer patients","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.2174/0118744710254730231114181358","pubmedId":"38314601","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: human_observational. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2174/0118744710254730231114181358","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:39.549Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e040892e-85e9-4b92-8d11-cb994f0133c7","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Impaired Expression of Humanin during Adrenocortical Carcinoma.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/38256114/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Impaired Expression of Humanin during Adrenocortical Carcinoma.\" Abstract excerpt: The discovery of mitochondria-derived peptides (MDPs) has provided a new perspective on mitochondrial function. MDPs encoded by mitochondrial DNA (mtDNA) can act as hormone-like peptides, influencing cell survival and proliferation. Among these peptides, humanin has been identified as a crucial factor for maintaining cell survival and preventing cell death under various conditions. Adrenocortical ","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.3390/ijms25021038","pubmedId":"38256114","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3390/ijms25021038","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:35.671Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3f9df02d-c1e3-4026-b2eb-3b11aeb28c00","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Quantitative proteomics analysis reveals the protective role of S14G-humanin in septic acute kidney injury using 4D-label-free and PRM Approaches.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/39332154/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Quantitative proteomics analysis reveals the protective role of S14G-humanin in septic acute kidney injury using 4D-label-free and PRM Approaches.\" Abstract excerpt: Mitochondrial dysfunction contributes to septic acute kidney injury (S-AKI), making mitochondrial protection a potential therapeutic strategy. This study investigates the effects of S14G-humanin (HNG) in S-AKI, utilizing 4D-label-free and parallel reaction monitoring (PRM) techniques for proteomic analysis. An S-AKI model was created in male C57BL/6 mice using lipopolysaccharide (LPS) injection, f","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.1016/j.bbrc.2024.150630","pubmedId":"39332154","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbrc.2024.150630","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:43.287Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"8f96adfd-3c36-43a5-bb8d-5258c3ebf641","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"SERUM HUMANIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE-ORGAN DYSFUNCTION SYNDROME.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37917869/","evidenceTier":"observational","summary":"Content-verified record concerning Humanin: \"SERUM HUMANIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE-ORGAN DYSFUNCTION SYNDROME.\" Abstract excerpt: Background: Multiple-organ dysfunction syndrome disproportionately contributes to pediatric sepsis morbidity. Humanin (HN) is a small peptide encoded by mitochondrial DNA and thought to exert cytoprotective effects in endothelial cells and platelets. We sought to test the association between serum HN (sHN) concentrations and multiple-organ dysfunction syndrome in a prospectively enrolled cohort of","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.1097/shk.0000000000002266","pubmedId":"37917869","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: human_observational. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1097/shk.0000000000002266","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:32.563Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"d787ce75-bd82-4fcf-bcca-6abf99650ce8","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Unbalanced circulating Humanin levels and cardiovascular risk in chronic hemodialysis patients: a pilot, prospective study.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/39102184/","evidenceTier":"observational","summary":"Content-verified record concerning Humanin: \"Unbalanced circulating Humanin levels and cardiovascular risk in chronic hemodialysis patients: a pilot, prospective study.\" Abstract excerpt: Mortality and cardiovascular (CV) risk prediction in individuals with end-stage kidney disease (ESKD) on chronic hemodialysis (HD) remains challenging due to the multitude of implicated factors. In a multicenter ESKD-HD cohort, we tested the prognostic yield of the assessment of&#xa0;circulating Humanin, a small mitochondrial-derived peptide involved in CV protection, on CV events and mortality. W","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.1007/s40620-024-02032-4","pubmedId":"39102184","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: human_observational. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s40620-024-02032-4","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:35.599Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"cac48c64-5bf1-45f9-b7e8-be9f1c5cb9d4","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/39730568/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"[Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6.\" Abstract excerpt: High glucose (HG) induced endothelial senescence is related to endothelial dysfunction and cardiovascular complications in diabetic patients. Humanin, a member of mitochondrial derived peptides (MDPs), is thought to contribute to aging-related cardiovascular protection. The goal of the study is to explore the pathogenesis of HG-induced endothelial senescence and potential anti-senescent effects of","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.1038/s41598-024-81878-x","pubmedId":"39730568","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=142, totalMentions=5). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1038/s41598-024-81878-x","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:02.172Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"9f8c0a03-dab0-4961-8153-f0b3f1be3d31","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Gly14]-humanin exerts a protective effect against D-galactose-induced primary ovarian insufficiency in mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/38163419/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"[Gly14]-humanin exerts a protective effect against D-galactose-induced primary ovarian insufficiency in mice.\" Abstract excerpt: Is there a protective effect of the humanin derivative [Gly14]-humanin (HNG) on a D-gal-induced mouse model of primary ovarian insufficiency (POI), and what is the underlying mechanism? D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model. Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks. Ovarian morphology, func","authors":null,"publishingOrg":null,"publicationYear":2024,"doi":"10.1016/j.rbmo.2023.103330","pubmedId":"38163419","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=36, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.rbmo.2023.103330","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:02.101Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"1393e5f5-3865-4274-96a0-738c9b573276","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"A New Antioxidant Marker in Cord Blood of Fetuses with Late Fetal Growth Restriction: Humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37366369/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"A New Antioxidant Marker in Cord Blood of Fetuses with Late Fetal Growth Restriction: Humanin.\" Abstract excerpt: Purpose: This study investigated the Humanin levels in the umbilical cord blood of fetuses with late fetal growth restriction (FGR) and -evaluated their association with perinatal outcomes. Materials and Methods: A total of 95 single pregnancies between 32-41 wk (45 with late FGR and 50 controls) were included. Doppler parameters, birth weight and the need for neonatal intensive care unit admissio","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.1080/15513815.2023.2229432","pubmedId":"37366369","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1080/15513815.2023.2229432","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:44.102Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"aa7d2bd0-3a54-4167-848d-1678be3275c5","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"A novel beneficial role of humanin on intestinal apoptosis and dysmotility in a rat model of ischemia reperfusion injury.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37020079/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"A novel beneficial role of humanin on intestinal apoptosis and dysmotility in a rat model of ischemia reperfusion injury.\" Abstract excerpt: A prevalent clinical problem including sepsis, shock, necrotizing enterocolitis, and mesenteric thrombosis is intestinal ischemia/reperfusion (I/R) injury. Humanin (HN), a recently identified mitochondrial polypeptide, exhibits antioxidative and antiapoptotic properties. This work aimed to study the role of HN in a model of experimental intestinal I/R injury and its effect on associated dysmotilit","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.1007/s00424-023-02804-0","pubmedId":"37020079","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s00424-023-02804-0","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:36.699Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"b2033505-5506-426f-b8cb-c546502c0be3","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"A novel link between chronic inflammation and humanin regulation in children.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/38322155/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"A novel link between chronic inflammation and humanin regulation in children.\" Abstract excerpt: Children with inflammatory bowel disease (IBD) often suffer from poor bone growth and impaired bone health. Humanin is a cytoprotective factor expressed in bone and other tissues and we hypothesized that humanin levels are suppressed in conditions of chronic inflammation. To address this, humanin levels were analyzed in serum samples from IBD patients and in ex vivo cultured human growth plate tis","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.3389/fendo.2023.1142310","pubmedId":"38322155","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3389/fendo.2023.1142310","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:40.914Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"598a5c2b-dfd6-4f2b-917a-d56d861f288e","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Age-related Changes in Humanin Expression in the Ovarian Tissue of Rat.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37115400/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Age-related Changes in Humanin Expression in the Ovarian Tissue of Rat.\" Abstract excerpt: This study examined humanin expression in rat ovarian tissue, its cellular localization, and its correlation with rat age under physiological conditions. A total of 40 Sprague-Dawley rats of various ages (2, 12, 30, and 60 days old and 1 year old) were grouped by age. Immunofluorescence and immunohistochemical techniques were used to observe humanin expression and cellular location in the ovarian ","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.1007/s11596-023-2732-7","pubmedId":"37115400","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s11596-023-2732-7","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:35.742Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"ac9a478e-769f-444f-83e4-27032ba5d4e2","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Effectiveness of analog of Humanin in ameliorating streptozotocin-induced diabetic nephropathy in Sprague Dawley rats.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37119975/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Effectiveness of analog of Humanin in ameliorating streptozotocin-induced diabetic nephropathy in Sprague Dawley rats.\" Abstract excerpt: Diabetes mellitus&#xa0;(DM) is associated with numerous complications, including nephropathy, which principally occur due to hyperglycemia-induced oxidative stress and inflammation. Humanin&#xa0;(HN), a novel peptide generated from mitochondria, has anti-oxidant and anti-inflammatory potential as observed in different disease models. However, role of HN in diabetic nephropathy (DN) has not yet bee","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.1016/j.peptides.2023.171014","pubmedId":"37119975","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.peptides.2023.171014","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:36.775Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f3de6079-7f9f-4529-9e00-3505635a2537","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/36799414/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects.\" Abstract excerpt: Coronavirus Disease 2019 (COVID-19) is a life-threatening and persistent pandemic with high rates of mortality and morbidity. Although a dysfunction in the mitochondria occurs in COVID-19 pathogenesis, the contribution of mitochondrial-derived peptides to its pathophysiology has not yet been completely elucidated. The goals of this research were to assess the circulating humanin and mitochondrial ","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.2174/1389203724666230217101202","pubmedId":"36799414","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2174/1389203724666230217101202","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:34.860Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"7e2406b4-7cf3-43fb-bce3-7564a7d332cb","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37644144/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6.\" Abstract excerpt: Mitochondrial-derived peptides are encoded by mitochondrial DNA but have biological activity outside mitochondria. Eight of these are encoded by sequences within the mitochondrial 12S and 16S ribosomal genes: humanin, MOTS-c, and the six SHLP peptides, SHLP1-SHLP6. These peptides have various effects in cell culture and animal models, affecting neuroprotection, insulin sensitivity, and apoptosis, ","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.1038/s41598-023-41053-0","pubmedId":"37644144","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1038/s41598-023-41053-0","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:43.138Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"9f06a790-7ac3-48f0-ac21-981f7bf5cc71","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Exogenous humanin and MOTS-c function as protective agents against gentamicin-induced hair cell damage.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37633181/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Exogenous humanin and MOTS-c function as protective agents against gentamicin-induced hair cell damage.\" Abstract excerpt: Loss of hair cells can lead to irreversible sensorineural hearing loss. Therefore, hair cell preservation is critical for hearing. Mitochondrial derived peptides (MDPs) are bioactive peptides and prominent members of this family are humanin (HN) and the mitochondrial-open-reading frame of the twelve S c (MOTS-c). The protective roles of HN and MOTS-c in age-related diseases and in various tissues ","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.1016/j.bbrc.2023.08.033","pubmedId":"37633181","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=233, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbrc.2023.08.033","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:02.961Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"ab15902a-e153-4aed-ab2d-3bd955c6a0b0","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Exploring the potential of humanin as a biomarker for early breast cancer detection: a study of serum levels and diagnostic performance.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37552125/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Exploring the potential of humanin as a biomarker for early breast cancer detection: a study of serum levels and diagnostic performance.\" Abstract excerpt: Breast cancer is a leading cause of cancer death in women worldwide, and early detection is crucial for effective treatment. Mitochondrial dysfunction has been linked to cancer development and progression. Humanin, a mitochondrial-derived peptide, has been shown to have cytoprotective effects and may be involved in breast cancer development. In this study, we aimed to investigate the potential of ","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.1080/1354750x.2023.2246700","pubmedId":"37552125","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1080/1354750x.2023.2246700","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:36.850Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3a8cf8cc-f830-4c09-b24d-096950778dc8","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin and Its Pathophysiological Roles in Aging: A Systematic Review.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37106758/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin and Its Pathophysiological Roles in Aging: A Systematic Review.\" Abstract excerpt: Senescence is a cellular aging process in all multicellular organisms. It is characterized by a decline in cellular functions and proliferation, resulting in increased cellular damage and death. These conditions play an essential role in aging and significantly contribute to the development of age-related complications. Humanin is a mitochondrial-derived peptide (MDP), encoded by mitochondrial DNA","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.3390/biology12040558","pubmedId":"37106758","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: systematic review or meta-analysis. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=322, totalMentions=5). Imported evidence lane: synthesis. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"systematic_review_or_meta_analysis","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3390/biology12040558","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:00.668Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"c79859b2-2604-4185-8362-b6f9ba5c6da9","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin gene expression in subjects with Parkinson's disease.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/36626066/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin gene expression in subjects with Parkinson's disease.\" Abstract excerpt: Bradykinesia, tremor, rigidity and postural instability are the hallmark of Parkinson's disease (PD). Non-motor symptoms including cognitive, behavioral, and neuropsychiatric changes, sensory and sleep disturbances that may precede the motor symptoms by years. The peculiar pathological features of PD are decreased dopaminergic neurons and dopamine levels in the substantia nigra pars compacta and p","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.1007/s11033-022-08132-3","pubmedId":"36626066","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s11033-022-08132-3","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:31.216Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"617bfd35-01e6-40e3-be12-5ed66e29e05b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Intranasal delivery of mitochondrial protein humanin rescues cell death and promotes mitochondrial function in Parkinson's disease.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37351170/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Intranasal delivery of mitochondrial protein humanin rescues cell death and promotes mitochondrial function in Parkinson's disease.\" Abstract excerpt: Rationale: Mitochondrial dysfunction is a key factor in the pathogenesis of Parkinson's disease (PD). Accordingly, many aspects of mitochondrial function have been studied as a putative therapeutic target. Here we present a novel strategy to promote mitochondrial function and protect against Parkinson's disease by the peptide encoded within mitochondrial genome, mitochondria-derived peptide (MDP) ","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.7150/thno.84165","pubmedId":"37351170","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.7150/thno.84165","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:40.766Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"92d58a30-00af-422e-bc79-c5340f0ff053","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37079467/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS.\" Abstract excerpt: Introduction: Despite therapeutic advances in hemorrhagic shock, mortality from multiple organ failure remains high. We previously showed that the &#x3b1;1 subunit of AMP-activated protein kinase (AMPK), a crucial regulator of mitochondrial function, exerts a protective role in hemorrhagic shock. Humanin is a mitochondrial peptide with cytoprotective properties against cellular stress. Here, we in","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.1097/shk.0000000000002134","pubmedId":"37079467","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1097/shk.0000000000002134","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:35.084Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"41d1341a-2d9c-46a8-a595-29705bc54c44","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: A focus on oxidative stress, inflammation, and apoptosis.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37467966/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: A focus on oxidative stress, inflammation, and apoptosis.\" Abstract excerpt: Diabetes is known to cause cognitive impairments through various mechanisms, including oxidative stress, inflammation, and apoptosis. Humanin (HN) has been shown to have protective effects on cognitive impairments induced by factors such as A&#x3b2;, muscarinic receptor antagonists, and aging in rodents. However, the mechanisms underlying the protective effects of HN in the prefrontal cortex and h","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.1016/j.bbr.2023.114584","pubmedId":"37467966","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbr.2023.114584","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:37.606Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"2b1b1932-0a08-4ba9-8d4b-9f4c2fd9f77e","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"S14G-Humanin ameliorates ovalbumin-induced airway inflammation in asthma mediated by inhibition of toll-like receptor 4 (TLR4) expression and the nuclear factor κ-B (NF-κB)/early growth response protein-1 (Egr-1) pathway.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37451839/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"S14G-Humanin ameliorates ovalbumin-induced airway inflammation in asthma mediated by inhibition of toll-like receptor 4 (TLR4) expression and the nuclear factor κ-B (NF-κB)/early growth response protein-1 (Egr-1) pathway.\" Abstract excerpt: Asthma is a chronic inflammatory disease with a high morbidity rate in children and significantly impacts their healthy growth. It is reported that Th2 cell-mediated airway inflammation and activated oxidative stress are involved in the pathogenesis of asthma. S14G-humanin (HNG) is a derivative of Humanin with higher activity. The present study proposes to explore the potential treating property o","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.18632/aging.204874","pubmedId":"37451839","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=266, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.18632/aging.204874","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:01.504Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"8f96b891-b214-4329-aa5c-56aa9f3341f0","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"S14G-humanin alleviates acute lung injury by inhibiting the activation of NF-κB.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/38054825/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"S14G-humanin alleviates acute lung injury by inhibiting the activation of NF-κB.\" Abstract excerpt: Acute lung injury (ALI) is characterized by severely damaged alveoli and blood vessels, seriously affecting the health of patients and causing a high mortality rate. The pathogenesis of ALI is complex, with inflammatory reactions and oxidative stress (OS) mainly involved. S14G humanin (HNG) is derived from humanin (HN), which is claimed with promising anti-inflammatory functions. Herein, the prote","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.18632/aging.205267","pubmedId":"38054825","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=278, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.18632/aging.205267","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:01.577Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"9471400f-492d-4e77-8325-530f6001f59b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/38045183/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice.\" Abstract excerpt: S14G-humanin (HNG), an analog of the mitochondria-derived peptide humanin, has demonstrated protective effects against various cardiovascular diseases. However, the specific pharmacological effects of HNG in heart failure (HF) have not been previously reported. Therefore, in this study, we aimed to investigate the potential protective effect of HNG in HF using a mouse model. HF was induced in mice","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.1016/j.heliyon.2023.e21892","pubmedId":"38045183","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=5, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.heliyon.2023.e21892","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:01.384Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"84f5937e-3d7d-4808-97ad-f6778c4cf4b9","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Stability Determination of Intact Humanin-G with Characterizations of Oxidation and Dimerization Patterns.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/36979450/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Stability Determination of Intact Humanin-G with Characterizations of Oxidation and Dimerization Patterns.\" Abstract excerpt: Humanin is the first identified mitochondrial-derived peptide. Humanin-G (HNG) is a variant of Humanin that has significantly higher cytoprotective properties. Here, we describe the stability features of HNG in different conditions and characterize HNG degradation, oxidation, and dimerization patterns over short-term and long-term periods. HNG solutions were prepared in high-performance liquid chr","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.3390/biom13030515","pubmedId":"36979450","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3390/biom13030515","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:38.858Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"1f06ee17-2a27-4730-a3d0-bbae895569e7","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/37814907/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study.\" Abstract excerpt: Does a humanin analogue (HNG) have a therapeutic effect on intrauterine adhesions (IUAs) caused by uterine cavity surgery in a rat model? HNG supplementation attenuated the development of endometrial fibrosis and IUAs, improved fertility, and contributed to the regulation of endometrial fibrosis by inhibiting endometrial ferroptosis in rats with IUAs. IUAs, which are characterized by endometrial f","authors":null,"publishingOrg":null,"publicationYear":2023,"doi":"10.1093/humrep/dead196","pubmedId":"37814907","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=7, totalMentions=7). Imported evidence lane: human_interventional. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1093/humrep/dead196","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:01.053Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"7955ed52-45f1-450e-a01e-88484fc34816","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"An evidence of Humanin-like peptide and Humanin mediated cryosurvival of spermatozoa in buffalo bulls.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/36183493/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"An evidence of Humanin-like peptide and Humanin mediated cryosurvival of spermatozoa in buffalo bulls.\" Abstract excerpt: Buffalo spermatozoa are vulnerable to cryo-injuries due to inherent deficiency of endogenous antioxidants, high polyunsaturated fatty acids (PUFA) content in plasma membrane and low cholesterol/phospholipid (C/P) ratio. Humanin is a potent cytoprotective agent that protects the cells against oxidative stress and apoptosis. The present study was designed to establish the presence of Humanin in buff","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1016/j.theriogenology.2022.09.013","pubmedId":"36183493","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.theriogenology.2022.09.013","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:34.118Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e0e88662-45b3-434c-b3da-07d405c8bd53","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Cardio-protective role of Humanin in myocardial ischemia-reperfusion.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/34896254/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Cardio-protective role of Humanin in myocardial ischemia-reperfusion.\" Abstract excerpt: Mitochondria-derived peptides (MDPs) are bioactive peptides encoded by and secreted from the mitochondria. To date, a few MDPs including humanin, MOTS-c and SHLP1-6, and their diverse biological functions have been identified. The first and most studied MDP is humanin, a 24-amino-acid poly peptide. It was first identified in 2001 in the surviving neurons of patient with Alzheimer's disease, and si","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1016/j.bbagen.2021.130066","pubmedId":"34896254","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbagen.2021.130066","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:36.399Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"9036d398-fbad-4143-ac56-b01c5cddab26","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/34525397/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.\" Abstract excerpt: Humanin is an endogenous mitochondria-derived peptide that plays critical roles in oxidative stress, inflammation and CAD. In this study, we measured the levels of circulating humanin, markers of oxidative stress and inflammation in patients with unstable angina and MI and studied the relationship between these parameters and major adverse cardiac events (MACE). A total of 327 subjects were recrui","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1016/j.bbagen.2021.130010","pubmedId":"34525397","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbagen.2021.130010","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:33.823Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"6ef6934c-ad6d-450c-8e1f-82c73a7905eb","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/36119052/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.\" Abstract excerpt: Endothelial dysfunction plays a central role in the pathogenesis of sepsis-mediated multiple organ failure. Several clinical and experimental studies have suggested that the glycocalyx is an early target of endothelial injury during an infection. Colivelin, a synthetic derivative of the mitochondrial peptide humanin, has displayed cytoprotective effects in oxidative conditions. In the current stud","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.3389/fimmu.2022.984298","pubmedId":"36119052","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3389/fimmu.2022.984298","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:39.628Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f9a2ea66-9b8e-41c1-b4e5-ae4c216b4dbe","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Cryoprotectant with a mitochondrial derived peptide, humanin, improves post-thaw quality of buffalo spermatozoa.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/35315868/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Cryoprotectant with a mitochondrial derived peptide, humanin, improves post-thaw quality of buffalo spermatozoa.\" Abstract excerpt: Semen cryopreservation results in deleterious effects on spermatozoa, including lipid peroxidation and a reduction in the total antioxidant components of seminal plasma. The ultimate outcome of these changes is a reduction in post-thaw semen quality. A mitochondrial derived peptide, humanin, a potent cytoprotective and antioxidant agent was used in the present study. To evaluate the efficacy of a ","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.54680/fr22110110212","pubmedId":"35315868","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.54680/fr22110110212","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:41.803Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e11b391f-0387-4ff0-aede-3bffa7e0499d","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Cryoprotection of humanin-like peptides in seminal plasma for ejaculated spermatozoa of crossbred bulls.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/36626132/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Cryoprotection of humanin-like peptides in seminal plasma for ejaculated spermatozoa of crossbred bulls.\" Abstract excerpt: Cryopreservation process negatively affects spermatozoa functions. Humanin, a small polypeptide encoded in the mitochondrial genome, is well known for its role in cell survival. To quantify the endogenous levels of humanin in seminal plasma of crossbred Frieswal bulls and to study its role in cryoprotection. The presence of humanin in bull spermatozoa was also investigated. A total of 40 semen sam","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.54680/fr22510110712","pubmedId":"36626132","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.54680/fr22510110712","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:34.411Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"10a29975-eb45-41ff-a892-077deac7ee49","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD).","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/35576057/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD).\" Abstract excerpt: Inflammation plays a crucial role in the etiology and pathogenesis of AMD (Age-related Macular Degeneration). Humanin G (HNG) is a Mitochondrial Derived Peptide (MDP) that is cytoprotective in AMD and can protect against mitochondrial and cellular stress induced by damaged AMD mitochondria. The goal of this study was to test our hypothesis that inflammation-associated marker protein levels are inc","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.18632/aging.204074","pubmedId":"35576057","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=110, totalMentions=8). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.18632/aging.204074","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:03.078Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"c132e153-b4bd-4b13-b54e-a0011fb50575","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Ameliorates Late-onset Hypogonadism in Aged Male Rats.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/35086467/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Ameliorates Late-onset Hypogonadism in Aged Male Rats.\" Abstract excerpt: The potential to reproduce declines with age. Late-onset hypogonadism is characterized by reduced serum testosterone. Humanin is a mitochondrial-derived signaling peptide encoded by short open reading frames within the mitochondrial genome. It may protect against some age-related diseases such as atherosclerosis by its cytoprotective effects. The study aimed to investigate the potential anti-aging","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.2174/1874467215666220127115602","pubmedId":"35086467","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=118, totalMentions=5). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2174/1874467215666220127115602","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:58.517Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"5ee8aeae-85e5-4187-b919-5065307f35fc","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin and Alzheimer's disease: The beginning of a new field.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/34626746/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Humanin and Alzheimer's disease: The beginning of a new field.\" Abstract excerpt: Humanin (HN) is an endogenous peptide factor and known as a member of mitochondrial-derived peptides. We first found the gene encoding this novel 24-residue peptide in a brain of an Alzheimer's disease (AD) patient as an antagonizing factor against neuronal cell death induced by AD-associated insults. This review presents an overview of HN actions in AD-related conditions among its wide range of a","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1016/j.bbagen.2021.130024","pubmedId":"34626746","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbagen.2021.130024","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:30.479Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"de8e86ed-843d-4f1f-b430-bab0aca5267b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin derivative, HNG, enhances neurotransmitter release.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/35843407/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin derivative, HNG, enhances neurotransmitter release.\" Abstract excerpt: Humanin (HN) is an endogenous 24-residue peptide that was first identified as a protective factor against neuronal death in Alzheimer's disease (AD). We previously demonstrated that the highly potent HN derivative HNG (HN with substitution of Gly for Ser14) ameliorated cognitive impairment in AD mouse models. Despite the accumulating evidence on the antagonizing effects of HN against cognitive def","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1016/j.bbagen.2022.130204","pubmedId":"35843407","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbagen.2022.130204","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:27.947Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3d4d7c92-1ddb-467e-a9d2-a87dc9e4fbf5","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/34624450/","evidenceTier":"observational","summary":"Content-verified record concerning Humanin: \"Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension.\" Abstract excerpt: Autophagy, a highly conserved homeostatic mechanism, is essential for cell survival. The decline of autophagy function has been implicated in various diseases as well as aging. Although mitochondria play a key role in the autophagy process, whether mitochondrial-derived peptides are involved in this process has not been explored. We developed a high through put screening method to identify potenti","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1016/j.bbagen.2021.130017","pubmedId":"34624450","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: human_observational. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbagen.2021.130017","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:27.723Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"b6a2b57a-c261-4aac-9d35-0528e5edf9f0","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Revolutionalizing the age old conventional treatment of psoriasis: An animal based comparative study between methylprednisolone and different doses of a novel anti-oxidant humanin analogue (HNG).","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/35978518/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Revolutionalizing the age old conventional treatment of psoriasis: An animal based comparative study between methylprednisolone and different doses of a novel anti-oxidant humanin analogue (HNG).\" Abstract excerpt: Psoriasis is a chronic skin disease with 2-4% of prevalence worldwide conferring a major burden on health systems. It is assumed that the prevalence might increase due to climatic change and deterioration of protective ozone barrier. With the chances of increasing prevalence, newer and specific treatment options need to be explored. Skin is a constant target of oxidative stress owing to continuous","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1016/j.intimp.2022.108990","pubmedId":"35978518","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: human_interventional. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.intimp.2022.108990","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:44.990Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e1e83366-06ae-40bd-86fb-37aee9621fc5","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/35104624/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition.\" Abstract excerpt: Alzheimer's disease (AD), Parkinson's disease (PD), and age-related macular degeneration (AMD) are common among neurodegenerative diseases, but investigations into novel therapeutic approaches are currently limited. Humanin (HN) is a mitochondrial-derived peptide found in brain tissues of patients with familial AD and has been increasingly investigated in AD and other neurodegenerative diseases. I","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1016/j.bbagen.2022.130097","pubmedId":"35104624","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=216, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbagen.2022.130097","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:02.768Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"bdb0647f-8186-493e-aaa9-6380927dd526","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Structural basis of FPR2 in recognition of Aβ<sub>42</sub> and neuroprotection by humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/35365641/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Structural basis of FPR2 in recognition of Aβ<sub>42</sub> and neuroprotection by humanin.\" Abstract excerpt: Formyl peptide receptor 2 (FPR2) has been shown to mediate the cytotoxic effects of the &#x3b2; amyloid peptide A&#x3b2; 42 and serves as a receptor for humanin, a peptide that protects neuronal cells from damage by A&#x3b2; 42 , implying its involvement in the pathogenesis of Alzheimer's disease (AD). However, the interaction pattern between FPR2 and A&#x3b2; 42 or humanin remains unknown. Here w","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1038/s41467-022-29361-x","pubmedId":"35365641","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1038/s41467-022-29361-x","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:43.886Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3904a96c-04de-4038-81d0-29890a377165","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/35951114/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target.\" Abstract excerpt: The etiology of mild traumatic brain injury (mTBI) remains elusive due to the tissue and cellular heterogeneity of the affected brain regions that underlie cognitive impairments and subsequent neurological disorders. This complexity is further exacerbated by disrupted circuits within and between cell populations across brain regions and the periphery, which occur at different timescales and in spa","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1007/s00018-022-04495-9","pubmedId":"35951114","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s00018-022-04495-9","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:44.322Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"92650fb2-8b1c-4a3a-ba27-8bec8d4523d2","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/34965184/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis.\" Abstract excerpt: Gout is a common and complex form of arthritis that has brought great inconveniences to the normal lives of patients. It is reported that oxidative stress and nod-like receptor family protein 3 (NLRP3) inflammasome-mediated inflammatory reactions are involved in the pathogenesis of gout arthritis. S14G-humanin (S14G-HNG) is a modified peptide of HNG with higher inhibitory activity on the accumulat","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1080/21655979.2021.2001911","pubmedId":"34965184","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1080/21655979.2021.2001911","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:37.954Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"288a0a5a-c4f9-474b-9064-8457933b3efd","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The protective effects of S14G-humanin on gestational diabetes mellitus symptoms.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/35536048/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The protective effects of S14G-humanin on gestational diabetes mellitus symptoms.\" Abstract excerpt: Gestational diabetes mellitus is a frequently diagnosed glucose metabolic disorder during pregnancy. Diabetes mellitus has been found to pose important health risks to the developing fetus, mother, and offspring. Here, we investigated the protective effects of S14G-humanin, a potent humanin analogue, against maternal and neonatal adverse outcomes in mice with diabetes mellitus. The results show th","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1080/09513590.2022.2073348","pubmedId":"35536048","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1080/09513590.2022.2073348","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:37.882Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"2352d9cc-959c-4c22-9f13-0ef189f12046","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The role of humanin in natural stress tolerance: An underexplored therapeutic avenue.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/34626747/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The role of humanin in natural stress tolerance: An underexplored therapeutic avenue.\" Abstract excerpt: The discovery of humanin (HN/MTRNR2) 20&#xa0;years ago blazed a trail to identifying mitochondrial derived peptides with biological function. Humanin is associated with pro-survival, cytoprotective, anti-inflammatory, and anti-oxidative properties and may play a role in reducing neurodegenerative and metabolic disease progression. Although the role of humanin in vitro and in vivo laboratory models","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1016/j.bbagen.2021.130022","pubmedId":"34626747","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbagen.2021.130022","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:33.451Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"4a28869b-c910-478f-b914-1cc6a37cde58","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The role of humanin in the regulation of reproduction.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/34626748/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The role of humanin in the regulation of reproduction.\" Abstract excerpt: Humanin, a mitochondria-derived peptide, has been found to exert variously protective function in many tissues, especially in the nervous tissues. However, relatively limited studies have focused on the role of humanin in the regulation of reproduction. Current observations indicate that humanin plays an important role in regulating the response of the cell to oxidative stress and apoptosis in ova","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1016/j.bbagen.2021.130023","pubmedId":"34626748","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbagen.2021.130023","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:33.595Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e7694805-2f0a-493b-be77-cdc659d40655","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Gly14]-Humanin inhibits an angiotensin II-induced vascular smooth muscle cell phenotypic switch via ameliorating intracellular oxidative stress.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/36289015/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"[Gly14]-Humanin inhibits an angiotensin II-induced vascular smooth muscle cell phenotypic switch via ameliorating intracellular oxidative stress.\" Abstract excerpt: Angiotensin II (AngII) is involved in the pathogenesis of hypertensive artery remodeling by inducing a phenotypic switch in vascular smooth muscle cells [Gly14]-Humanin (HNG), a humanin analogue, exerts potent cytoprotective effects both in vitro and in vivo . This study aimed to investigate the effects of HNG on an AngII-induced phenotypic switch in VSMCs and the potential mechanisms underlying t","authors":null,"publishingOrg":null,"publicationYear":2022,"doi":"10.1177/09603271221136208","pubmedId":"36289015","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=161, totalMentions=4). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1177/09603271221136208","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:02.246Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f6319b3f-9649-41f9-b831-5ab9105d792f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/33131010/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging.\" Abstract excerpt: Fibroblast Growth Factor 21 (FGF21), Growth Differentiation Factor 15 (GDF15), and Humanin (HN) are mitochondrial stress-related mitokines, whose role in health and disease is still debated. In this study, we confirmed that their plasma levels are positively correlated with age in healthy subjects. However, when looking at patients with type 2 diabetes (T2D) or Alzheimer's disease (AD), two age-re","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.1007/s11357-020-00287-w","pubmedId":"33131010","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s11357-020-00287-w","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:42.624Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"1b206ddd-5a3b-4a74-acfa-9b89469f5c47","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model-Based Study.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/33693742/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model-Based Study.\" Abstract excerpt: Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is characterized by hyperandrogenism and insulin resistance (IR); however, the pathogenesis of local ovarian IR in PCOS remains largely unclear. Humanin, a mitochondria-derived peptide, has been reported to be associated with IR. Our previous study confirmed that humanin is expressed in multiple cell","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.1210/endocr/bqab056","pubmedId":"33693742","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=244, totalMentions=9). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1210/endocr/bqab056","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:58.692Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"87f14978-fc5b-4555-9501-7a4424f33d1f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin protects cortical neurons from calyculin A-induced neurotoxicities by increasing PP2A activity and SOD.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32408779/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin protects cortical neurons from calyculin A-induced neurotoxicities by increasing PP2A activity and SOD.\" Abstract excerpt: Humanin (HN) is an extensive neuroprotective peptide. This study aims to investigate the neuroprotective effects of HN on Calyculin A (CA)-induced neurotoxicities in cortical neurons and the underlying mechanism. CA was added into the cultured cortical neurons to induce neurotoxicity. Cortical neurons were preincubated with HN which plays a protective role. 3-(4,5-Dimethylthiazol-2-yl)-2,5-dipheny","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.1080/00207454.2020.1769617","pubmedId":"32408779","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1080/00207454.2020.1769617","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:28.099Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"87fd72df-e98c-405e-912a-03c35bbf4bc8","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/33337472/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway.\" Abstract excerpt: Polycystic ovary syndrome (PCOS) is the most common endocrinological pathology among women of reproductive age, whereas the pathogenesis is still not fully understood. Systemic and ovarian oxidative stress (OS) imbalance is a pivotal feature of PCOS. Humanin, a mitochondria-derived peptide, has been reported to function as an antioxidant in cardiomyocytes, pancreatic beta cells and other cells, bu","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.1093/molehr/gaaa081","pubmedId":"33337472","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=251, totalMentions=8). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1093/molehr/gaaa081","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:58.590Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"b521fe63-3029-4c12-b2aa-06dfc1b49db4","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin: A Potential Treatment for PCOS?","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/33899108/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin: A Potential Treatment for PCOS?\" (identity confirmed; no abstract text available to excerpt.)","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.1210/endocr/bqab085","pubmedId":"33899108","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1210/endocr/bqab085","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:31.291Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"c136a3b6-9a7d-4d53-ac75-98a28e0b8680","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/33130077/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases.\" Abstract excerpt: Humanin (HN) is a small mitochondrial-derived cytoprotective polypeptide encoded by mtDNA. HN exhibits protective effects in several cell types, including leukocytes, germ cells, neurons, tissues against cellular stress conditions and apoptosis through regulating various signaling mechanisms, such as JAK/STAT pathway and interaction of BCL-2 family of protein. HN is an essential cytoprotective pep","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.1016/j.lfs.2020.118679","pubmedId":"33130077","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.lfs.2020.118679","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:28.023Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"7c608406-ca1b-4aba-8b77-ddadb6092d0b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/33764899/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival.\" Abstract excerpt: Humanin (HN) is a short peptide involved in many biological processes such as apoptosis, cell survival, inflammatory response, and reaction to stressors like oxidative stress, between others. In the ovary, a correct balance between pro- and anti-apoptotic factors is crucial for folliculogenesis. In the follicular atresia, survival or death of granulosa cells is a critical process. The goal of this","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.1530/rep-20-0197","pubmedId":"33764899","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1530/rep-20-0197","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:34.044Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"c0b02aff-d55d-4fe7-9ffb-76cc2974cf32","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Oxidative Damage? Not a Problem! The Characterization of Humanin-like Mitochondrial Peptide in Anoxia Tolerant Freshwater Turtles.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/33387248/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Oxidative Damage? Not a Problem! The Characterization of Humanin-like Mitochondrial Peptide in Anoxia Tolerant Freshwater Turtles.\" Abstract excerpt: Mitochondria was long thought to be an \"end function\" organelle that regulated the metabolic flux and apoptosis in the cell. However, with the discovery of&#xa0;the mitochondrial peptide (MDP) humanin (HN/MTRNR2), the cytoprotective and pro-survival applications of MDPs have taken the forefront of therapeutic and diagnostic research. However, the regulation of humanin-like MDPs in natural model sy","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.1007/s10930-020-09944-7","pubmedId":"33387248","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s10930-020-09944-7","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:42.023Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"0eb54ab4-a95e-4918-8b19-4e69d83fa834","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/34177809/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases.\" Abstract excerpt: Physiological reactive oxygen species (ROS) are important regulators of intercellular signal transduction. Oxidative and antioxidation systems maintain a dynamic balance under physiological conditions. Increases in ROS levels destroy the dynamic balance, leading to oxidative stress damage. Oxidative stress is involved in the pathogenesis of aging-related cardiovascular diseases (ACVD), such as ath","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.3389/fendo.2021.683151","pubmedId":"34177809","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3389/fendo.2021.683151","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:36.031Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"70ce08c8-206e-45b4-92cc-51b06d4ffe7c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/34459932/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1.\" Abstract excerpt: UV-B stimulation can induce retinopathy, whose pathogenesis is currently unclear. UV-B mediated inflammation in retinal endothelial cells is reported to be involved in the pathogenesis of retinopathy. S14G-humanin (HNG) is a neuroprotective peptide that has recently been reported to exert significant anti-inflammatory effects and protective properties against cell death. The present study aims to ","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.1007/s00011-021-01489-4","pubmedId":"34459932","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s00011-021-01489-4","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:32.487Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"24f08199-16b5-4b98-8dbe-f7304de94543","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/33330922/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†.\" Abstract excerpt: Humanin (HN) is a mitochondrial-derived peptide that protects many cells/tissues from damage. We previously demonstrated that HN reduces stress-induced male germ cell apoptosis in rodents. HN action in neuronal cells is mediated through its binding to a trimeric cell membrane receptor composed of glycoprotein 130 (gp130), IL-27 receptor subunit (IL-27R, also known as WSX-1/TCCR), and ciliary neuro","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.1093/biolre/ioaa225","pubmedId":"33330922","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1093/biolre/ioaa225","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:44.615Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"b80465ee-8428-4d14-a764-bc3b2818c611","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The emerging role of mitochondrial derived peptide humanin in the testis.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/34534645/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The emerging role of mitochondrial derived peptide humanin in the testis.\" Abstract excerpt: The discovery of mitochondrial derive peptides (MDPs) has spotlighted mitochondria as central hubs in control and regulation of cell viability and metabolism in the testis in response to intracellular and extracellular stresses. MDPs (Humanin, MOTS-c and SHLP-2) are present in testes. Humanin, the first MDP, is predominantly expressed in Leydig cells, and moderately in germ cells and seminal plasm","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.1016/j.bbagen.2021.130009","pubmedId":"34534645","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbagen.2021.130009","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:41.287Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"782f02fd-5ea2-4300-9570-044220b73754","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/34605740/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway.\" Abstract excerpt: Pulpitis is reported in large populations of patients and significantly impacts their normal life quality. It is reported that the lipopolysaccharide (LPS) in Gram-negative bacteria induces severe inflammation in dental pulp tissues. S14G-humanin is a derivative of humanin and has been recently confirmed to possess promising anti-inflammatory properties. The current study aims to explore the possi","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.1080/21655979.2021.1979914","pubmedId":"34605740","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1080/21655979.2021.1979914","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:38.175Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"c7734238-ca60-4cf1-86cf-5dd00cc9618d","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/34506248/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction.\" Abstract excerpt: Excessive oxidative stress, inflammation, and myocardial hypertrophy have been associated with diabetic cardiomyopathy (DCM). S14G-humanin (HNG) is a potent humanin analogue that has demonstrated cytoprotective effects in a variety of cells and tissues. However, the pharmacological function of HNG in diabetic cardiomyopathy has not yet been reported. In the present study, we investigated the prote","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.1080/21655979.2021.1964894","pubmedId":"34506248","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1080/21655979.2021.1964894","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:38.028Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"609be918-c65c-47c9-9d49-5345f913ad47","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Gly14]-Humanin Ameliorates High Glucose-Induced Apoptosis by Inhibiting the Expression of MicroRNA-155 in Endothelial Microparticles.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/34079312/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"[Gly14]-Humanin Ameliorates High Glucose-Induced Apoptosis by Inhibiting the Expression of MicroRNA-155 in Endothelial Microparticles.\" Abstract excerpt: Humanin, a newly emerging endogenously expressed cytoprotective peptide, has been shown to have anti-apoptotic properties effects by protecting neuronal cells injury. Endothelial microparticles (EMPs) are considered as vital mediators in intercellular communication. EMPs may regulate various physiological and pathological processes by transferring mRNAs and microRNAs (miRNAs) to recipient cells. E","authors":null,"publishingOrg":null,"publicationYear":2021,"doi":"10.2147/dmso.s306026","pubmedId":"34079312","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2147/dmso.s306026","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:02.369Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"129e414a-6886-480c-9a06-b76073ca8cfe","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Assay Development and Measurement of the Aging Biomarker Humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32410037/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Assay Development and Measurement of the Aging Biomarker Humanin.\" Abstract excerpt: Biomarkers that reflect aging could be used to target age-related diseases with precision and monitor treatment efficacy. One such biomarker is humanin, a 24-amino acid mitochondrial-derived peptide encoded within the mitochondrial 16S rRNA gene. Humanin is measured in biological fluids, associates with many aging phenotypes, and attenuates aging in several animal models. In this chapter, we highl","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1007/978-1-0716-0592-9_18","pubmedId":"32410037","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/978-1-0716-0592-9_18","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:42.099Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"01d25137-8843-491d-ab1e-06d7d6ae2c9c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Cytoprotective role of humanin in lens epithelial cell oxidative stress‑induced injury.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32627019/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Cytoprotective role of humanin in lens epithelial cell oxidative stress‑induced injury.\" Abstract excerpt: Oxidative stress-induced injury and apoptosis of human lens epithelial cells (HLECs) are early events in the development of age&#x2011;related cataracts (ARCs). Humanin (HN) is a mitochondrial&#x2011;related peptide that serves a cytoprotective role in various cell types and animal models. Following HN knockdown or overexpression, the level of reactive oxygen species (ROS), mitochondrial membrane ","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.3892/mmr.2020.11202","pubmedId":"32627019","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3892/mmr.2020.11202","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:35.814Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"da6ad33e-0182-4b84-aa34-cd963e963b48","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32604799/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition.\" Abstract excerpt: The hair follicle goes through repetitive cycles including anagen, catagen, and telogen. The interaction of dermal papilla cells (DPCs) and keratinocytes regulates the hair cycle and hair growth. Humanin was discovered in the surviving brain cells of patients with Alzheimer's disease. HNG, a humanin analogue, activates cell growth, proliferation, and cell cycle progression, and it protects cells f","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.3390/ijms21124553","pubmedId":"32604799","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=196, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3390/ijms21124553","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:02.030Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f6c8cb21-2778-40f7-8606-55ce9c116593","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32271093/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men.\" Abstract excerpt: Humanin is a small regulatory peptide encoded within the 16S ribosomal RNA gene ( MT-RNR2 ) of the mitochondrial genome that has cellular cyto- and metabolo-protective properties similar to that of aerobic exercise training. Here we investigated whether acute high-intensity interval exercise or short-term high-intensity interval training (HIIT) impacted skeletal muscle and plasma humanin levels. V","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1152/japplphysiol.00032.2020","pubmedId":"32271093","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1152/japplphysiol.00032.2020","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:40.474Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"a2e49126-1194-434c-a90b-5c8db8013c0b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Ameliorates Free Fatty Acid-Induced Endothelial Inflammation by Suppressing the NLRP3 Inflammasome.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32923762/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Ameliorates Free Fatty Acid-Induced Endothelial Inflammation by Suppressing the NLRP3 Inflammasome.\" Abstract excerpt: Cardiovascular disease (CVD) has been considered as a major risk factor of death in recent decades. In CVDs, the NLRP3 inflammasome is important for inflammatory response and vascular damage. Therefore, safe and effective treatments to decrease NLRP3 inflammasome activation are required. Increased levels of free fatty acid (FFA) have been associated with the progression of CVD. Humanin, a kind of ","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1021/acsomega.0c01778","pubmedId":"32923762","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=381, totalMentions=8). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1021/acsomega.0c01778","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:58.883Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"ca91563c-3f72-415f-8fe5-7d9b414210e7","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32383868/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3.\" Abstract excerpt: It is known that the humanin (HN) peptide binding to amyloid-&#x3b2; (A&#x3b2;) protects against its cytotoxic effects, while acetylcholinesterase (AChE) binding to A&#x3b2; increases its aggregation and cytotoxicity. HN is also known to bind the insulin-like growth factor binding protein-3 (IGFBP-3). Here, we examined the regulation of A&#x3b2; conformations by HN, AChE, and IGFBP-3 both in vitro","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1021/acs.biochem.0c00274","pubmedId":"32383868","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1021/acs.biochem.0c00274","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:30.555Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"bc548fcf-1bcc-496c-9fd2-e5f84d6bf478","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32444831/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer.\" Abstract excerpt: Humanin (HN) is a mitochondrial-derived peptide with cytoprotective effect in many tissues. Administration of HN analogs has been proposed as therapeutic approach for degenerative diseases. Although HN has been shown to protect normal tissues from chemotherapy, its role in tumor pathogenesis is poorly understood. Here, we evaluated the effect of HN on the progression of experimental triple negativ","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1038/s41598-020-65381-7","pubmedId":"32444831","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1038/s41598-020-65381-7","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:28.252Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"a67b646a-6ea7-4eb8-89a8-e03179d488a0","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32174022/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules.\" Abstract excerpt: HNG, a highly potent mutant of the anti-Alzheimer peptide-humanin, has been shown to protect against ischaemia-reperfusion (I/R) injury. However, the underlying mechanism related to platelet activation remains unknown. We proposed that HNG has an effect on platelet function and thrombus formation. In this study, platelet aggregation, granule secretion, clot retraction, integrin activation and adhe","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1111/jcmm.15151","pubmedId":"32174022","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/jcmm.15151","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:28.399Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e542c48d-0da9-4c1e-b5d2-d16697e6516e","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32245619/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway.\" Abstract excerpt: The pathogenesis of non-alcoholic fatty liver disease (NAFLD) remains unclear. Humanin (HN), a cytoprotective polypeptide, reportedly exhibits neuroprotective effects via suppression of inflammation and improvement of insulin resistance in neurons. This study aim was to investigate effects of HN on lipid accumulation in the hepatocytes and insulin signaling, and explore the underlying mechanisms. ","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1016/j.bbrc.2020.03.128","pubmedId":"32245619","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbrc.2020.03.128","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:28.175Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"7f22a331-caff-48d7-8dae-38c756c8a0d9","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin prevents undesired apoptosis of chondrocytes without interfering with the anti-inflammatory effect of dexamethasone in collagen-induced arthritis.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31172921/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin prevents undesired apoptosis of chondrocytes without interfering with the anti-inflammatory effect of dexamethasone in collagen-induced arthritis.\" Abstract excerpt: Prolonged use of glucocorticoids (GCs) for treatment of inflammatory and autoimmune conditions may have several negative side effects, such as impaired bone growth which has been linked to increased apoptosis in growth plate chondrocytes. It has recently been shown that humanin, a small mitochondrial derived peptide, rescues growth plate chondrocytes from GC-induced apoptosis. Our aim was to study","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":null,"pubmedId":"31172921","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=271, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"pmid:31172921","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:58.764Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"127e2ba6-f8bc-4483-9e07-44ca670e7845","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/33106313/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers.\" Abstract excerpt: Members of the B-cell lymphoma (BCL-2) protein family regulate mitochondrial outer membrane permeabilization (MOMP), a phenomenon in which mitochondria become porous and release death-propagating complexes during the early stages of apoptosis. Pro-apoptotic BCL-2 proteins oligomerize at the mitochondrial outer membrane during MOMP, inducing pore formation. Of current interest are endogenous factor","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1074/jbc.ra120.013023","pubmedId":"33106313","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1074/jbc.ra120.013023","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:28.326Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"864b99f6-a738-4ecb-991c-b32f5917e44c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin: A mitochondria-derived peptide with emerging properties.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32800320/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin: A mitochondria-derived peptide with emerging properties.\" (identity confirmed; no abstract text available to excerpt.)","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1016/j.ancard.2020.07.015","pubmedId":"32800320","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.ancard.2020.07.015","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:31.364Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f56eff7f-4699-4402-ab46-cf0f20759750","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Interaction of amyloid beta with humanin and acetylcholinesterase is modulated by ATP.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/33145964/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Interaction of amyloid beta with humanin and acetylcholinesterase is modulated by ATP.\" Abstract excerpt: Humanin (HN) is known to bind amyloid beta (A&#x3b2;)-inducing cytoprotective effects, while binding of acetylcholinesterase (AChE) to A&#x3b2; increases its aggregation and cytotoxicity. Previously, we showed that binding of HN to A&#x3b2; blocks aggregation induced by AChE and that HN decreases but does not abolish A&#x3b2;-AChE interactions in A549 cell media. Here, we set out to shed light on ","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1002/2211-5463.13023","pubmedId":"33145964","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1002/2211-5463.13023","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:38.632Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"03e06e55-7620-454f-a322-3ce9b71fa1bd","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32768357/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration.\" Abstract excerpt: The mitochondrial-derived peptides (MDPs) are a new class of small open reading frame encoded polypeptides with pleiotropic properties. The prominent members are Humanin (HN) and small HN-like peptide (SHLP) 2, which encode 16S rRNA, while mitochondrial open reading frame of the twelve S c (MOTS-c) encodes 12S rRNA of the mitochondrial genome. While the multifunctional properties of HN and its ana","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1016/j.redox.2020.101663","pubmedId":"32768357","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.redox.2020.101663","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:43.958Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"ac8bc565-5118-43c0-b022-3b41ee95ba49","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Murine maternal dietary restriction affects neural Humanin expression and cellular profile.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31840315/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Murine maternal dietary restriction affects neural Humanin expression and cellular profile.\" Abstract excerpt: To understand the cellular basis for the neurodevelopmental effects of intrauterine growth restriction (IUGR), we examined the global and regional expression of various cell types within murine (Mus musculus) fetal brain. Our model employed maternal calorie restriction to 50% daily food intake from gestation day 10-19, producing IUGR offspring. Offspring had smaller head sizes with larger head:bod","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1002/jnr.24568","pubmedId":"31840315","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1002/jnr.24568","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:41.357Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"00a3b89f-e1bc-4709-b7fa-06592e13af5b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Novel humanin analogs confer neuroprotection and myoprotection to neuronal and myoblast cell cultures exposed to ischemia-like and doxorubicin-induced cell death insults.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32889021/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Novel humanin analogs confer neuroprotection and myoprotection to neuronal and myoblast cell cultures exposed to ischemia-like and doxorubicin-induced cell death insults.\" Abstract excerpt: Humanin (HN) is a 24-amino acid mitochondrial-derived peptide, best known for its ability to protect neurons from damage caused by ischemic stroke and neurodegenerative insults and cardiomyocytes from myocardial infarction or doxorubicin (Dox)-induced cardiotoxicity. This study examines the neuroprotective and myoprotective effects of HN novel synthetic analogs HUJInin and c(D-Ser14-HN), prepared ","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1016/j.peptides.2020.170399","pubmedId":"32889021","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.peptides.2020.170399","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:32.637Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"63963c20-7c6e-4e38-853d-6b1afef7288e","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32680738/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders.\" Abstract excerpt: The mitochondria produce specific peptides-mitochondrial-derived peptides-that mediate the transcriptional stress response by their translocation into the nucleus and interaction with deoxyribonucleic acid. Mitochondrial-derived peptides are regulators of metabolism. This class of peptides comprises humanin, mitochondrial open reading frame of the 12S ribosomal ribonucleic acid type c (MOTS-c) and","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1016/j.acvd.2020.03.020","pubmedId":"32680738","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=301, totalMentions=5). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.acvd.2020.03.020","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:02.441Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"cb00fe82-19d3-40cd-b4f1-8fc1448210ca","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The Mitochondria-Derived Peptide Humanin Improves Recovery from Intracerebral Hemorrhage: Implication of Mitochondria Transfer and Microglia Phenotype Change.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31980585/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The Mitochondria-Derived Peptide Humanin Improves Recovery from Intracerebral Hemorrhage: Implication of Mitochondria Transfer and Microglia Phenotype Change.\" Abstract excerpt: Astrocytes are an integral component of the neurovascular unit where they act as homeostatic regulators, especially after brain injuries, such as stroke. One process by which astrocytes modulate homeostasis is the release of functional mitochondria (Mt) that are taken up by other cells to improve their function. However, the mechanisms underlying the beneficial effect of Mt transfer are unclear an","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1523/jneurosci.2212-19.2020","pubmedId":"31980585","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1523/jneurosci.2212-19.2020","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:38.543Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"88614eba-763b-4424-bfba-ab6586ebf159","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The humanin peptide mediates ELP nanoassembly and protects human retinal pigment epithelial cells from oxidative stress.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31655204/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The humanin peptide mediates ELP nanoassembly and protects human retinal pigment epithelial cells from oxidative stress.\" Abstract excerpt: Humanin (HN) is a hydrophobic 24-amino acid peptide derived from mitochondrial DNA that modulates cellular responses to oxidative stress and protects human retinal pigment epithelium (RPE) cells from apoptosis. To solubilize HN, this report describes two genetically-encoded fusions between HN and elastin-like polypeptides (ELP). ELPs provide steric stabilization and/or thermo-responsive phase sepa","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1016/j.nano.2019.102111","pubmedId":"31655204","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.nano.2019.102111","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:32.183Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"005437a3-ee4d-437f-90fc-807d8992bfb6","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32575074/","evidenceTier":"observational","summary":"Content-verified record concerning Humanin: \"The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan.\" Abstract excerpt: Humanin is a member of a new family of peptides that are encoded by short open reading frames within the mitochondrial genome. It is conserved in animals and is both neuroprotective and cytoprotective. Here we report that in C. elegans the overexpression of humanin is sufficient to increase lifespan, dependent on daf-16/Foxo . Humanin transgenic mice have many phenotypes that overlap with the worm","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.18632/aging.103534","pubmedId":"32575074","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: human_observational. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.18632/aging.103534","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:38.708Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"822e80e7-299b-418a-8a28-231ffc84bfcc","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Gly14]-humanin restores cathepsin D function via FPRL1 and promotes autophagic degradation of Ox-LDL in HUVECs.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32917500/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"[Gly14]-humanin restores cathepsin D function via FPRL1 and promotes autophagic degradation of Ox-LDL in HUVECs.\" Abstract excerpt: Abnormal aggregation of oxidized low-density lipoprotein (Ox-LDL) in vascular endothelial cells (VECs) is one of the major pathological changes in atherosclerotic lesions. Our research aimed to assess the mechanism of humanin (HN) in promoting autophagic degradation of Ox-LDL in HUVECs. Flow cytometry and lipid quantitation results showed that Ox-LDL caused lipid and cholesterol accumulation in HU","authors":null,"publishingOrg":null,"publicationYear":2020,"doi":"10.1016/j.numecd.2020.07.022","pubmedId":"32917500","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.numecd.2020.07.022","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:33.011Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"9b5844d4-9487-4b9a-903e-09bae0f7d7e6","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31088495/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.\" Abstract excerpt: Q fever fatigue syndrome (QFS) is a well-documented state of prolonged fatigue following around 20% of acute Q fever infections. It has been hypothesized that low grade inflammation plays a role in its aetiology. In this study, we aimed to identify transcriptome profiles that could aid to better understand the pathophysiology of QFS. RNA of monocytes was collected from QFS patients (n = 10), chron","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.1186/s12967-019-1906-3","pubmedId":"31088495","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1186/s12967-019-1906-3","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:41.509Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f934c31a-5cb6-4e56-93ae-33fc00a9f540","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Cytoprotective role of S14G-humanin (HNG) in ultraviolet-B induced epidermal stem cells injury.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30508736/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Cytoprotective role of S14G-humanin (HNG) in ultraviolet-B induced epidermal stem cells injury.\" Abstract excerpt: Skin provides the protective barrier for our body and undergoes the continuous regeneration in order to overcome damage from exposure to harmful environments and wounds. Epidermal stem cells (ESCs) play critical roles in skin regeneration. Humanin analogue, S14G-humanin (HNG), a prominent member of a newly discovered family of mitochondrial-derived peptides, has been shown to be a cytoprotective d","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.1016/j.biopha.2018.11.059","pubmedId":"30508736","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.biopha.2018.11.059","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:37.235Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"a466497a-e30c-41d0-b054-e7add4bd4b0b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30503199/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study.\" Abstract excerpt: Is humanin present in the human ovary and follicular fluid? What relationship exists between humanin concentration in the follicular fluid and ovarian reserve and clinical outcomes after IVF and intracytoplasmic sperm injection (ICSI)? Follicular fluid samples were collected from 179 patients undergoing their first IVF or ICSI cycle during oocyte retrieval. Ovarian tissues were collected from two ","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.1016/j.rbmo.2018.11.002","pubmedId":"30503199","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.rbmo.2018.11.002","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:34.264Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"9cff3194-44b6-4921-beb5-cf0e81bd52eb","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Nanoparticles for Reducing Pathological Factors Characteristic of Age-Related Macular Degeneration.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30381074/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Nanoparticles for Reducing Pathological Factors Characteristic of Age-Related Macular Degeneration.\" Abstract excerpt: Humanin is a novel neuronal peptide that has displayed potential in the treatment of Alzheimer's Disease through the suppression of inflammatory IL-6 cytokine receptors. Such receptors are found throughout the body, including the eye, suggesting its other potential applications. Age-related Macular Degeneration (AMD) is the leading cause of blindness in the developing world. There is no cure for t","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.2174/1567201815666181031163111","pubmedId":"30381074","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2174/1567201815666181031163111","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:59.214Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"1709531f-1e78-4488-bce5-b4271e317590","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31690630/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization.\" Abstract excerpt: The mitochondrial, or intrinsic, apoptosis pathway is regulated mainly by members of the B-cell lymphoma 2 (BCL-2) protein family. BCL-2-associated X apoptosis regulator (BAX) plays a pivotal role in the initiation of mitochondria-mediated apoptosis as one of the factors causing mitochondrial outer-membrane permeabilization (MOMP). Of current interest are endogenous BAX ligands that inhibit its MO","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.1074/jbc.ra119.011297","pubmedId":"31690630","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1074/jbc.ra119.011297","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:28.476Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"c8544add-58f4-4e89-bf6c-a0aab2cddecc","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30657335/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment.\" Abstract excerpt: Glucocorticoids (GCs) are frequently used to treat chronic disorders in children, including inflammation and cancer. Prolonged treatment with GCs is well known to impair bone growth, an effect linked to increased apoptosis and suppressed proliferation in growth plate chondrocytes. We hypothesized that the endogenous antiapoptotic protein humanin (HN) may prevent these effects. Interestingly, GC-in","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.1096/fj.201801741r","pubmedId":"30657335","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=340, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1096/fj.201801741r","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:59.025Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3a104982-0ad9-47fb-a70b-e7d5f4a78242","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin levels in human seminal plasma and spermatozoa are related to sperm quality.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30920769/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin levels in human seminal plasma and spermatozoa are related to sperm quality.\" Abstract excerpt: Humanin has reportedly been expressed in testis and spermatozoa, but no study has yet reported its presence in human seminal plasma (SP). The aim of this study was to investigate the presence of humanin in human SP and to determine the correlation between humanin levels in SP/spermatozoa and sperm quality. Semen samples for SP/sperm humanin level measurement were collected from 164 patients who at","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.1111/andr.12614","pubmedId":"30920769","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=15). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/andr.12614","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:59.098Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"ea0c4d23-5b71-4310-920f-e11b87331aec","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31172328/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment.\" Abstract excerpt: The mitochondrial-derived peptides (MDPs) are a novel group of natural occurring peptides that have important signaling functions and biological activity. Both humanin and small-humanin-like peptide 2 (SHLP2) have been reported to act as insulin sensitizers and modulate metabolism. By using a metabolomic approach, this study explores how the plasma metabolite profile is regulated in response to hu","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.1007/s11306-019-1549-7","pubmedId":"31172328","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s11306-019-1549-7","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:42.771Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"27dee058-df2f-41f3-b10f-aa8f02c7c33f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Mitochondrial Peptide Humanin Protects Silver Nanoparticles-Induced Neurotoxicity in Human Neuroblastoma Cancer Cells (SH-SY5Y).","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31505887/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Mitochondrial Peptide Humanin Protects Silver Nanoparticles-Induced Neurotoxicity in Human Neuroblastoma Cancer Cells (SH-SY5Y).\" Abstract excerpt: The extensive usage of silver nanoparticles (AgNPs) as medical products such as antimicrobial and anticancer agents has raised concerns about their harmful effects on human beings. AgNPs can potentially induce oxidative stress and apoptosis in cells. However, humanin (HN) is a small secreted peptide that has cytoprotective and neuroprotective cellular effects. The aim of this study was to assess t","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.3390/ijms20184439","pubmedId":"31505887","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3390/ijms20184439","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:35.158Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"76983659-129b-48d1-9994-0d28b5783ad6","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30582721/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases.\" Abstract excerpt: Mitochondrial-derived peptides (MDPs) are encoded within the mitochondrial genome. They signal within the cell or are released to act as autocrine/paracrine/endocrine cytoprotective factors playing a key role in the cellular stress response. The first reported and better characterized MDP is humanin (HN), which exerts robust protective effects against a myriad of cytotoxic stimuli in many cell typ","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.1080/14728222.2019.1559300","pubmedId":"30582721","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1080/14728222.2019.1559300","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:37.678Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"56aebe2d-3c52-46a4-adb3-c8bf977034c3","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Potent humanin analogue (HNG) protects human sperm from freeze-thaw-induced damage.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30959025/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Potent humanin analogue (HNG) protects human sperm from freeze-thaw-induced damage.\" Abstract excerpt: This study was aimed to investigate the protective effect of potent humanin analogue (HNG) supplementation to freezing media on freezing-thawing induced human sperm damage. We collected semen samples with normal sperm parameters from 15 healthy men. After the swim-up processing, the motile spermatozoa from each of the men were allocated to four equal groups: In the control group, the spermatozoa w","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.1016/j.cryobiol.2019.04.001","pubmedId":"30959025","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.cryobiol.2019.04.001","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:32.787Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"efb380fb-c109-419e-90cb-95341cfa3425","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31432706/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease.\" Abstract excerpt: Advanced chronic kidney disease (CKD) is characterized by a premature aging phenotype of multifactorial origin. Mitochondrial dysfunction is prevalent in CKD and has been proposed as a major contributor to poor muscle function. Although the mitochondria-derived peptides (MDPs) humanin and mitochondrial open reading frame of 12S rRNA-c (MOTS-c) are involved in cell survival, suppression of apoptosi","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.1152/ajprenal.00202.2019","pubmedId":"31432706","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1152/ajprenal.00202.2019","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:43.362Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"5631b9c0-adbb-4162-9ccf-6a239e9220aa","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The Mitochondrial Peptide Humanin Targets but Does Not Denature Amyloid Oligomers in Type II Diabetes.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31456396/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The Mitochondrial Peptide Humanin Targets but Does Not Denature Amyloid Oligomers in Type II Diabetes.\" Abstract excerpt: Mitochondrially derived peptides (MDPs) such as humanin (HN) have shown a remarkable ability to modulate neurological amyloids and apoptosis-associated proteins in cells and animal models. Recently, we found that humanin-like peptides also inhibit amyloid formation outside of neural environments in islet amyloid polypeptide (IAPP) fibrils and plaques, which are hallmarks of Type II diabetes. Howev","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.1021/jacs.9b04995","pubmedId":"31456396","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1021/jacs.9b04995","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:36.479Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"487ec281-e881-48a6-b0cc-425b09b2baba","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The humanin analogue (HNG) prevents temozolomide-induced male germ cell apoptosis and other adverse effects in severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31085184/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The humanin analogue (HNG) prevents temozolomide-induced male germ cell apoptosis and other adverse effects in severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma.\" Abstract excerpt: Subfertility is a major concern of long-term cancer survivors at the reproductive age. We have previously demonstrated that a potent humanin analogue, HNG, protected chemotherapy-induced apoptosis in germ cells but not cancer cells in a metastatic melanoma allograft model. In this study, we utilized severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma to study the effect of ","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.1016/j.yexmp.2019.104261","pubmedId":"31085184","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.yexmp.2019.104261","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:32.262Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"8db3e14a-6208-408e-9dc2-66f684292869","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Using Small Peptide Segments of Amyloid-β and Humanin to Examine their Physical Interactions.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30950343/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Using Small Peptide Segments of Amyloid-β and Humanin to Examine their Physical Interactions.\" Abstract excerpt: Amyloid fibrils in Alzheimer's disease are composed of amyloid-&#x3b2; (A&#x3b2;) peptides of variant lengths. Humanin (HN), a 24 amino acid residue neuroprotective peptide, is known to interact with the predominant A&#x3b2; isoform in the brain, A&#x3b2; (1-40). Here, we constructed smaller segments of A&#x3b2; and HN and identified residues in HN important for both HN-HN and HN-A&#x3b2; interact","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.2174/0929866526666190405122117","pubmedId":"30950343","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2174/0929866526666190405122117","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:41.064Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"9b40ff4b-d71a-4ec8-afe3-9c58b20262b3","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29161500/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity.\" Abstract excerpt: Humanin (HN), a 24-amino acid bioactive peptide, has been shown to increase cell survival of neurons after exposure to A&#x3b2; and NMDA-induced toxicity and thus could be beneficial in the treatment of Alzheimer's disease (AD). The neuroprotection by HN is reported to be primarily through its agonist binding properties to the gp130 receptor. However, the peptidic nature of HN presents challenges ","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1021/acschemneuro.7b00350","pubmedId":"29161500","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1021/acschemneuro.7b00350","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:38.323Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"290f4dce-e7c0-4c21-8f50-a3cdcb2c7dcd","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29352443/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors.\" Abstract excerpt: Pituitary tumors are the most common primary intracranial neoplasms. Humanin (HN) and Rattin (HNr), a rat homolog of HN, are short peptides with a cytoprotective action. In the present study, we aimed to evaluate whether endogenous HNr plays an antiapoptotic role in pituitary tumor cells. Thus, we used RNA interference based on short-hairpin RNA (shRNA) targeted to HNr (shHNr). A plasmid including","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1007/s10495-018-1444-0","pubmedId":"29352443","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s10495-018-1444-0","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:39.307Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"b4349ec5-b2ff-49cf-a717-43fecf91d93e","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29502044/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin.\" Abstract excerpt: The endonuclease G gene (Endog), which codes for a mitochondrial nuclease, was identified as a determinant of cardiac hypertrophy. How ENDOG controls cardiomyocyte growth is still unknown. Thus, we aimed at finding the link between ENDOG activity and cardiomyocyte growth. Endog deficiency induced reactive oxygen species (ROS) accumulation and abnormal growth in neonatal rodent cardiomyocytes, alte","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1016/j.redox.2018.02.021","pubmedId":"29502044","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.redox.2018.02.021","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:44.844Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"251600b2-7cc6-4673-8e17-de6922ae5ef9","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30004252/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice.\" Abstract excerpt: Cardiac fibrosis is a biological process that increases with age and contributes to myocardial dysfunction. Humanin (HN) is an endogenous mitochondria-derived peptide that has cytoprotective effects and reduces oxidative stress. The present study aimed to test the hypothesis that chronic supplementation of exogenous HN in middle-aged mice could prevent and reverse cardiac fibrosis and apoptosis in","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1152/ajpheart.00685.2017","pubmedId":"30004252","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1152/ajpheart.00685.2017","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:41.214Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"cef0d53b-169b-4176-bcc6-9f4d744c213f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Comparison of serum concentrations of humanin in women with and without gestational diabetes mellitus.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29909696/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Comparison of serum concentrations of humanin in women with and without gestational diabetes mellitus.\" Abstract excerpt: Humanin (MT-RNR2) is an endogenous polypeptide that is involved in many diseases, including T2DM. Gestational diabetes mellitus (GDM) is defined as hyperglycemia during pregnancy. The aim of this study was to evaluate serum humanin levels in women with or without GDM and to elucidate possible correlations with anthropometric parameters, metabolic parameters and the incidence of GDM. Eighty-four wo","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1080/09513590.2018.1482869","pubmedId":"29909696","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1080/09513590.2018.1482869","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:39.864Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"beecb99c-4aab-4ea4-8613-bd9c4d29d6e8","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29590129/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction.\" Abstract excerpt: Intrauterine growth restriction (IUGR) results from a lack of nutrients transferred to the developing fetus, particularly oxygen and glucose. Increased expression of the cytoprotective mitochondrial peptide, humanin (HN), and the glucose transporter 8, GLUT8, has been reported under conditions of hypoxic stress. However, the presence and cellular localization of HN and GLUT8 in IUGR-related placen","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1371/journal.pone.0193583","pubmedId":"29590129","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1371/journal.pone.0193583","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:30.703Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"b97850bb-c92b-4b39-b082-74f998e6fce0","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30274308/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway.\" Abstract excerpt: Humanin (HN) is a novel 24-amino acid peptide that protects neurons against N-methyl-d-aspartate (NMDA)-induced toxicity. However, the contribution of the different mitogen-activated protein kinases (MAPKs) signals to HN neuroprotection against NMDA neurotoxicity remains unclear. The present study was therefore aimed to investigate neuroprotective mechanisms of HN. We analyzed intracellular Ca 2+ ","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.3390/ijms19102982","pubmedId":"30274308","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3390/ijms19102982","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:28.628Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"9d7cc892-1ef0-423f-8e0b-149268736e04","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Exerts Neuroprotection During Cardiac Ischemia-Reperfusion Injury.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29376862/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Exerts Neuroprotection During Cardiac Ischemia-Reperfusion Injury.\" Abstract excerpt: Cardiac ischemia-reperfusion (I/R) injury has been shown to impair brain function. Humanin analogue (HNG) given prior to cardiac ischemia has been shown to attenuate both heart and brain mitochondrial dysfunction caused by cardiac I/R injury. In a clinical setting, patients received medical treatment for acute myocardial infarction either during or after the onset of myocardial ischemia; thus, in ","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.3233/jad-170708","pubmedId":"29376862","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=83, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3233/jad-170708","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:59.552Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"cece6179-78b2-4fac-8ac9-01d65a57b4f0","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30242290/","evidenceTier":"observational","summary":"Content-verified record concerning Humanin: \"Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans.\" Abstract excerpt: Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neurodegenerative disease. Here we demonstrate that humanin administration has neuropr","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1038/s41598-018-32616-7","pubmedId":"30242290","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=209, totalMentions=5). Imported evidence lane: human_observational. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1038/s41598-018-32616-7","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:56.342Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"22b6e38d-fbc5-4b65-96fa-33a92475c7f7","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29775411/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity.\" Abstract excerpt: The chemotherapeutic effect of doxorubicin (Dox) is limited by cumulative dose-dependent cardiotoxicity in cancer survivors. Dexrazoxane (DRZ) is approved to prevent Dox-induced cardiotoxicity. Humanin and its synthetic analog HNG have a cytoprotective effect on the heart. To investigate the cardioprotective efficacy of HNG alone or in combination with DRZ against Dox-induced cardiotoxicity, 80 ad","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1152/ajpheart.00155.2018","pubmedId":"29775411","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=194, totalMentions=3). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1152/ajpheart.00155.2018","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:59.480Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"c3131d2c-5d3e-41b4-9637-b0adacfa617d","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29265109/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins.\" Abstract excerpt: Humanin (HN) is a 24-residue peptide identified from the brain of a patient with Alzheimer's disease (AD). HN has been found to protect against neuronal insult caused by A&#x3b2; peptides or transfection of familial AD mutant genes. In order to elucidate the molecular mechanisms of HN neuroprotection, we explored the effects of HN on the association of Bax or Bid with lipid bilayers and their olig","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1038/aps.2017.169","pubmedId":"29265109","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1038/aps.2017.169","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:30.627Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"8fb8a69c-18d8-4887-a1d6-a4c5bc743ddd","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/28802666/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity.\" Abstract excerpt: Humanin (HN) is an endogenous peptide that exerts cytoprotection against oxidative stress and apoptosis. We recently reported that Humanin analogue (HNG) pretreatment can reduce reactive oxygen species production in the heart subjected to ischemia/reperfusion (I/R) injury via attenuating mitochondrial dysfunction. However, it is unclear if HNG has direct effects on mitochondrial function against o","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1016/j.mito.2017.08.001","pubmedId":"28802666","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=2). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.mito.2017.08.001","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:00.799Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"7fade022-b4fe-4486-8612-30b8a960149c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin is an endogenous activator of chaperone-mediated autophagy.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29187525/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin is an endogenous activator of chaperone-mediated autophagy.\" Abstract excerpt: Chaperone-mediated autophagy (CMA) serves as quality control during stress conditions through selective degradation of cytosolic proteins in lysosomes. Humanin (HN) is a mitochondria-associated peptide that offers cytoprotective, cardioprotective, and neuroprotective effects in vivo and in vitro. In this study, we demonstrate that HN directly activates CMA by increasing substrate binding and trans","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1083/jcb.201606095","pubmedId":"29187525","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1083/jcb.201606095","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:28.551Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"992648d1-1a92-4ede-bc8e-dcadbcae8182","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30029058/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2.\" Abstract excerpt: Endothelial dysfunction and vascular complications induced by hyperglycemia play an important role in the pathological development of atherosclerosis in diabetes. Humanin, a 24-amino acid mitochondria-derived polypeptide, has displayed its cytoprotective effects in diverse cell types and tissues. In the current study, we aimed to characterize the effects of humanin on high glucose-induced endothel","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1016/j.molimm.2018.07.008","pubmedId":"30029058","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=163, totalMentions=10). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.molimm.2018.07.008","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:59.408Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"8f136818-bc13-428f-ac49-038337b299b2","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29432738/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells.\" Abstract excerpt: Mitochondrial dysfunction is associated with &#x3b2;-cell failure and insulin resistance in diabetes. Humanin is an endogenous cytoprotective peptide. In the current study, we aimed to define the effects of Humanin on mitochondrial biogenesis in pancreatic &#x3b2;-cells. Our findings demonstrated that Humanin treatment significantly increased the expression of PGC-1&#x3b1; and its downstream targe","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1016/j.bbrc.2018.02.071","pubmedId":"29432738","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=102, totalMentions=8). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbrc.2018.02.071","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:59.285Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e6e5376f-12a4-46d2-931b-d8893aa4768f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Interaction of Insulin-Like Growth Factor-Binding Protein 3 With Hyaluronan and Its Regulation by Humanin and CD44.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30184438/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Interaction of Insulin-Like Growth Factor-Binding Protein 3 With Hyaluronan and Its Regulation by Humanin and CD44.\" Abstract excerpt: Insulin-like growth factor-binding protein-3 (IGFBP-3) belongs to a family of IGF-binding proteins. Humanin is a peptide known to bind residues 215-232 of mature IGFBP-3 in the C-terminal region of the protein. This region of IGFBP-3 was shown earlier to bind certain glycosaminoglycans including hyaluronan (HA). Here, we characterized the binding affinities of the IGFBP-3 protein and peptide ( 215","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1021/acs.biochem.8b00635","pubmedId":"30184438","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1021/acs.biochem.8b00635","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:44.468Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"aa9b71f5-19bf-4273-b8ab-520666536b59","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Plasma humanin as a prognostic biomarker for canine myxomatous mitral valve disease: a comparison with plasma NT-roBNP.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30605282/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Plasma humanin as a prognostic biomarker for canine myxomatous mitral valve disease: a comparison with plasma NT-roBNP.\" Abstract excerpt: Myxomatous mitral valve disease (MMVD) is a cardiac condition commonly found in older dogs. The disease process can lead to heart failure (HF). In HF, an increase of reactive oxygen species (ROS) and abnormal mitochondrial activity, as well as apoptosis, have been reported. Humanin (HN) is a polypeptide that has a cardioprotective effect against apoptosis and oxidative stress. The purposes of this","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.24425/124305","pubmedId":"30605282","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.24425/124305","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:32.863Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"a91a3534-10eb-4a03-bdd0-0a8c91e5e246","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29058763/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse.\" Abstract excerpt: Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by A&#x3b2; plaque deposition in the brain, which is related to the disorder of autophagosome maturation, transport, and formation of autolysosome. Notably, abnormal insulin signaling is connected with cognitive dysfunction in AD. In this study, using APP/PS1 transgenic mice as AD model, we investigated the mechanism","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1002/jcb.26452","pubmedId":"29058763","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1002/jcb.26452","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:32.411Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"83cdfbda-791d-4a87-ac69-4f1fb1f8197b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Serum humanin concentrations in women with pre-eclampsia compared to women with uncomplicated pregnancies.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/28110609/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Serum humanin concentrations in women with pre-eclampsia compared to women with uncomplicated pregnancies.\" Abstract excerpt: To compare serum humanin concentrations in pregnant women with and without pre-eclampsia (PE). A case-control study where pregnant women (PE group, n = 37; control group, n = 34) studied through history parameters (gynecological, obstetrical, personal, and family), physical and sonographic examination parameters [body mass index (BMI), blood pressure obstetrical ultrasound], and biochemical/hormon","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1080/14767058.2017.1285885","pubmedId":"28110609","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=17, totalMentions=7). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1080/14767058.2017.1285885","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:01.838Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"220d890a-ed7f-4129-960f-eabed0dc2e26","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The Neurovascular Protective Effect of S14G-Humanin in a Murine MCAO Model and Brain Endothelial Cells.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29999240/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The Neurovascular Protective Effect of S14G-Humanin in a Murine MCAO Model and Brain Endothelial Cells.\" Abstract excerpt: Endothelial dysfunction is fundamental to ischemic stroke and brain injury. The humanin analogue S14G-humanin (HNG) has been shown to be a cytoprotective derivative. In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro. In a murine middle cerebral artery occlusion (MCAO) stroke model, HNG ameliorates cerebral infarction and suppresses the production of TNF-&#x3b1;","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.1002/iub.1869","pubmedId":"29999240","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1002/iub.1869","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:40.623Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"6997179a-6b2d-413b-b533-e893e441bfa6","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[The level of circulating humanin in patients with ischemic heart disease.]","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/30726649/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"[The level of circulating humanin in patients with ischemic heart disease.]\" Abstract excerpt: At present, great interest is caused with evaluation of new markers in blood circulation for the estimation a tissue oxidative metabolism disturbance due to the presence of secondary mitochondrial dysfunction in patients with coronary heart disease. &#x421;oronary heart disease is generally accompanied with a decline in mitochondrial respiration and represents the root cause of metabolic abnormali","authors":null,"publishingOrg":null,"publicationYear":2018,"doi":"10.18821/0869-2084-2018-63-8-466-470","pubmedId":"30726649","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.18821/0869-2084-2018-63-8-466-470","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:36.551Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"706d90b9-bcf0-4607-acb9-0aeec5505a41","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/28462847/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness.\" Abstract excerpt: Cancer cells may exhibit outsourcing of their high energy need in order to avoid the intrinsic mitochondrial apoptosis. Reduced mitochondrial respiration and accumulation of mitochondrial genome mutations are among metabolic transformations in this regard. Mitochondrial humanin (MT-RNR2) is a small peptide with anti-apoptotic activities attributed to binding some pro-apoptotic proteins. The curren","authors":null,"publishingOrg":null,"publicationYear":2017,"doi":"10.1016/j.jnci.2017.04.001","pubmedId":"28462847","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.jnci.2017.04.001","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:44.542Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"fe8c0e0d-154c-44da-8bbe-f6e3fe6837a8","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Effects of humanin on experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/28361841/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Effects of humanin on experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats.\" Abstract excerpt: The excessive apoptosis of intestinal epithelial cells (IECs) partly accounts for the development of colonic inflammation and eventually results in ulcerative colitis (UC). Humanin, an endogenous anti-apoptotic peptide, has previously been shown to protect against Alzheimer's disease and a variety of cellular insults. The present study aimed to investigate the effects of glysin variant of humanin ","authors":null,"publishingOrg":null,"publicationYear":2017,"doi":"10.4103/sjg.sjg_318_16","pubmedId":"28361841","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.4103/sjg.sjg_318_16","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:33.307Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f4eec8c2-4494-4bfb-baf3-0dd8526ba99e","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Gly[14]-humanin inhibits ox-LDL uptake and stimulates cholesterol efflux in macrophage-derived foam cells.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/27815075/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Gly[14]-humanin inhibits ox-LDL uptake and stimulates cholesterol efflux in macrophage-derived foam cells.\" Abstract excerpt: Foam cell formation, which is caused by imbalanced cholesterol influx and efflux by macrophages, plays a vital role in the occurrence and development of atherosclerosis. Humanin (HN), a mitochondria-derived peptide, can prevent the production of reactive oxygen species and death of human aortic endothelial cells exposed to oxidized low-density lipoprotein (ox-LDL) and has a protective effect on pa","authors":null,"publishingOrg":null,"publicationYear":2017,"doi":"10.1016/j.bbrc.2016.10.138","pubmedId":"27815075","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=170, totalMentions=2). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbrc.2016.10.138","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:02.696Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f47ef095-7b4f-46f0-9422-563f402c3bf4","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"High-dose Humanin analogue applied during ischemia exerts cardioprotection against ischemia/reperfusion injury by reducing mitochondrial dysfunction.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/28726291/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"High-dose Humanin analogue applied during ischemia exerts cardioprotection against ischemia/reperfusion injury by reducing mitochondrial dysfunction.\" Abstract excerpt: Although the gold standard treatment for acute myocardial infarction is reperfusion therapy, reperfusion itself can cause myocardial damage via induction of cardiac mitochondrial dysfunction. This can lead to increased myocardial infarct size, arrhythmias, and left ventricular (LV) dysfunction. Recently, a newly discovered peptide, Humanin, has been shown to exert several beneficial effects includ","authors":null,"publishingOrg":null,"publicationYear":2017,"doi":"10.1111/1755-5922.12289","pubmedId":"28726291","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=334, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/1755-5922.12289","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:03.148Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"d9a707bb-2f6f-4e7f-989b-b5699e2378bf","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/28726777/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage.\" Abstract excerpt: Age-related macular degeneration (AMD) ranks third among the leading causes of visual impairment with a blindness prevalence rate of 8.7%. Despite several treatment regimens, such as anti-angiogenic drugs, laser therapy, and vitamin supplementation, being available for wet AMD, to date there are no FDA-approved therapies for dry AMD. Substantial evidence implicates mitochondrial damage and retinal","authors":null,"publishingOrg":null,"publicationYear":2017,"doi":"10.1038/cddis.2017.348","pubmedId":"28726777","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: human_interventional. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1038/cddis.2017.348","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:27.569Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"09f22191-36fc-47c9-8559-02d8d47d3e13","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Specifically Interacts with Amyloid-β Oligomers and Counteracts Their in vivo Toxicity.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/28282805/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Specifically Interacts with Amyloid-β Oligomers and Counteracts Their in vivo Toxicity.\" Abstract excerpt: The 24-residue peptide humanin (HN) has been proposed as a peptide-based inhibitor able to interact directly with amyloid-&#x3b2; (A&#x3b2;) oligomers and interfere with the formation and/or biological properties of toxic A&#x3b2; species. When administered exogenously, HN, or its synthetic S14G-derivative (HNG), exerted multiple cytoprotective effects, counteracting the A&#x3b2;-induced toxicity.","authors":null,"publishingOrg":null,"publicationYear":2017,"doi":"10.3233/jad-160951","pubmedId":"28282805","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3233/jad-160951","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:28.926Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"669cbc43-edef-4b6f-9611-281dfd599c5a","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin affects object recognition and gliosis in short-term cuprizone-treated mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29070438/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin affects object recognition and gliosis in short-term cuprizone-treated mice.\" Abstract excerpt: Humanin (HN) is a 24-residue peptide that manipulates cell survival under various stresses. A highly potent HN derivative, HNG, reduced amyloid burden and neuroinflammation and suppressed cognitive impairment in Alzheimer's disease model mice. Cuprizone (CPZ), a copper chelator, provokes demyelination in the central nervous system of mice. A shorter (one week) exposure to CPZ induces schizophrenia","authors":null,"publishingOrg":null,"publicationYear":2017,"doi":"10.1016/j.npep.2017.10.002","pubmedId":"29070438","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.npep.2017.10.002","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:28.780Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"653136f8-1403-4b7b-ac28-5006a02558f0","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin ameliorates diazepam-induced memory deficit in mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/27814910/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin ameliorates diazepam-induced memory deficit in mice.\" Abstract excerpt: Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in rodents. To understand the effects of HN on brain function, we tested the effect ","authors":null,"publishingOrg":null,"publicationYear":2017,"doi":"10.1016/j.npep.2016.10.008","pubmedId":"27814910","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.npep.2016.10.008","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:28.703Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"5a8187b0-e880-4ce5-88f0-f2e3ebbfee0e","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin analogue, S14G-humanin, has neuroprotective effects against oxygen glucose deprivation/reoxygenation by reactivating Jak2/Stat3 signaling through the PI3K/AKT pathway.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29043002/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin analogue, S14G-humanin, has neuroprotective effects against oxygen glucose deprivation/reoxygenation by reactivating Jak2/Stat3 signaling through the PI3K/AKT pathway.\" Abstract excerpt: Stroke, characterized by a disruption of blood supply to the brain, is a major cause of morbidity and mortality worldwide. Although humanin, a 24-amino acid polypeptide, has been identified to have multiple neuroprotective functions, the level of humanin in plasma has been demonstrated to decrease with age, which likely limits the effects against stroke injury. A potent humanin analogue, S14G-huma","authors":null,"publishingOrg":null,"publicationYear":2017,"doi":"10.3892/etm.2017.4934","pubmedId":"29043002","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=132, totalMentions=5). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3892/etm.2017.4934","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:59.625Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"4262510c-9704-44f3-941b-221e80bedb1b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/28458518/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction.\" Abstract excerpt: N -methyl-D-aspartate (NDMA) receptor-mediated excitotoxicity has been implicated in a variety of pathological situations such as Alzheimer's disease (AD) and Parkinson's disease. However, no effective treatments for the same have been developed so far. Humanin (HN) is a 24-amino acid peptide originally cloned from the brain of patients with AD and it prevents stress-induced cell death in many cel","authors":null,"publishingOrg":null,"publicationYear":2017,"doi":"10.2147/dddt.s133042","pubmedId":"28458518","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2147/dddt.s133042","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:28.854Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"65edfd09-0a5b-4cfe-a75d-737615a861fa","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Neuroprotective effect of G<sup>14</sup>-humanin on global cerebral ischemia/reperfusion by activation of SOCS3 - STAT3 - MCL-1 signal transduction pathway in rats.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/28720038/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Neuroprotective effect of G<sup>14</sup>-humanin on global cerebral ischemia/reperfusion by activation of SOCS3 - STAT3 - MCL-1 signal transduction pathway in rats.\" Abstract excerpt: Humanin (HN) has been identified to suppress neuron death. Gly 14 -HN (HNG), as a variant of HN, can decrease infarct volume after ischemia/reperfusion (I/R) injury. This study aimed to investigate the neuroprotective mechanism of HNG on global cerebral I/R (GI) in rats. Rats were randomly divided into 13 groups: Sham group, GI groups and HNG groups. Both GI group and HNG groups included six time ","authors":null,"publishingOrg":null,"publicationYear":2017,"doi":"10.1080/01616412.2017.1352187","pubmedId":"28720038","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1080/01616412.2017.1352187","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:40.169Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"9217ec97-9a04-4f22-b08a-8495e3aa4405","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/28814984/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells.\" Abstract excerpt: Age-related macular degeneration (AMD) is the leading cause of severe and irreversible vision loss and is characterized by progressive degeneration of the retina resulting in loss of central vision. The retinal pigment epithelium (RPE) is a critical site of pathology of AMD. Mitochondria and the endoplasmic reticulum which lie in close anatomic proximity to each other are targets of oxidative stre","authors":null,"publishingOrg":null,"publicationYear":2017,"doi":"10.1155/2017/1675230","pubmedId":"28814984","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1155/2017/1675230","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:42.548Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"0eb88c41-3f5a-4213-b3cb-61cf981e6f5f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Pseudogenization of the <i>Humanin</i> gene is common in the mitochondrial DNA of many vertebrates.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/28825450/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Pseudogenization of the <i>Humanin</i> gene is common in the mitochondrial DNA of many vertebrates.\" Abstract excerpt: In the human the peptide Humanin is produced from the small Humanin gene which is embedded as a gene-within-a-gene in the 16S ribosomal molecule of the mitochondrial DNA (mtDNA). The peptide itself appears to be significant in the prevention of cell death in many tissues and improve cognition in animal models. By using simple data mining techniques, it is possible to show that 99.4% of the human H","authors":null,"publishingOrg":null,"publicationYear":2017,"doi":"10.24272/j.issn.2095-8137.2017.049","pubmedId":"28825450","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.24272/j.issn.2095-8137.2017.049","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:36.923Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"09b8a209-1452-45f8-b85a-f01a8d3efa6c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/27783653/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione.\" Abstract excerpt: Humanin (HN) is a small mitochondrial-encoded peptide with neuroprotective properties. We have recently shown protection of retinal pigmented epithelium (RPE) cells by HN in oxidative stress; however, the effect of HN on endoplasmic reticulum (ER) stress has not been evaluated in any cell type. Our aim here was to study the effect of HN on ER stress-induced apoptosis in RPE cells with a specific f","authors":null,"publishingOrg":null,"publicationYear":2016,"doi":"10.1371/journal.pone.0165150","pubmedId":"27783653","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1371/journal.pone.0165150","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:28.998Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"9d9fa73c-0930-4b9c-8f85-cd8a0b56c36c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin exerts cardioprotection against cardiac ischemia/reperfusion injury through attenuation of mitochondrial dysfunction.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/27434747/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin exerts cardioprotection against cardiac ischemia/reperfusion injury through attenuation of mitochondrial dysfunction.\" Abstract excerpt: Myocardial reperfusion via the re-canalization of occluded coronary arteries is gold standard for the treatment of acute myocardial infarction. However, reperfusion itself can cause myocardial damage due to increased reactive oxygen species (ROS) production, a process known as ischemia/reperfusion (I/R) injury. Cardiac mitochondria are the major organelle of ROS production in the heart. Cardiac mi","authors":null,"publishingOrg":null,"publicationYear":2016,"doi":"10.1111/1755-5922.12210","pubmedId":"27434747","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/1755-5922.12210","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:31.438Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"80ec8259-3ef4-422f-8e2a-7a08761ef133","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin prevents brain mitochondrial dysfunction in a cardiac ischaemia-reperfusion injury model.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/27059110/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin prevents brain mitochondrial dysfunction in a cardiac ischaemia-reperfusion injury model.\" Abstract excerpt: What is the central question of this study? Myocardial ischaemia-reperfusion (I/R) injury causes interference in the systemic circulation and damages not only the heart but also several vital organs, including the brain. Recently, a novel peptide called humanin has been shown to exert potent neuroprotective effects. However, the effect of humanin on the brain during cardiac I/R injury has not yet ","authors":null,"publishingOrg":null,"publicationYear":2016,"doi":"10.1113/ep085749","pubmedId":"27059110","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=254, totalMentions=11). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1113/ep085749","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:59.813Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"07a528f5-20c8-457f-bd98-1e37c052f3d0","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/27923980/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism.\" Abstract excerpt: Humanin (HN) is a mitochondrially encoded and secreted peptide linked to glucose metabolism and tissue protecting mechanisms. Whether skeletal muscle HN gene or protein expression is influenced by exercise remains unknown. In this intervention study we show, for the first time, that HN protein levels increase in human skeletal muscle following 12&#xa0;weeks of resistance training in persons with p","authors":null,"publishingOrg":null,"publicationYear":2016,"doi":"10.14814/phy2.13063","pubmedId":"27923980","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=3). Imported evidence lane: human_interventional. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.14814/phy2.13063","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:56.144Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"1828dc8b-f7ea-4a26-905f-e44ef42811ef","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin: Functional Interfaces with IGF-I.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/27082450/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin: Functional Interfaces with IGF-I.\" Abstract excerpt: Humanin is the first newly discovered peptide encoded in the mitochondrial genome in over three decades. It is the first member of a novel class of mitochondrial derived peptides. This small, 24 amino acid peptide was initially discovered to have neuroprotective effects and subsequent experiments have shown that it is beneficial in a diverse number of disease models including stroke, cardiovascula","authors":null,"publishingOrg":null,"publicationYear":2016,"doi":"10.1016/j.ghir.2016.03.005","pubmedId":"27082450","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=6). Imported evidence lane: preclinical_animal. Source provider: WPF seed. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.ghir.2016.03.005","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:59.739Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f9daa259-921e-42b9-aa25-689fc525462d","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/27173674/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress.\" Abstract excerpt: Mitochondrial RNR-2 (mt-RNR2, humanin) has been shown to play a role in protecting several types of cells and tissues from the effects of oxidative stress. Humanin (HN) functions through extracellular and intracellular pathways adjusting mitochondrial oxidative phosphorylation and ATP production. Addition of HN improved insulin sensitivity in animal models of diabetes mellitus but no clinical stud","authors":null,"publishingOrg":null,"publicationYear":2016,"doi":"10.14814/phy2.12796","pubmedId":"27173674","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=30, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.14814/phy2.12796","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:28:59.931Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e0e45b93-6a44-4616-b666-1c05c36518e5","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Potential Roles of Humanin on Apoptosis in the Heart.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/26667157/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Potential Roles of Humanin on Apoptosis in the Heart.\" Abstract excerpt: The process of programmed cell death, or apoptosis, is known as a key player in the development and progression of cardiovascular disease. The proposed mechanism for apoptosis is the activation of two main apoptotic signaling pathways (the extrinsic and intrinsic pathways), which lead to cell death. As the rate and amount of cardiomyocyte loss is the most important determinant of patient morbidity","authors":null,"publishingOrg":null,"publicationYear":2016,"doi":"10.1111/1755-5922.12168","pubmedId":"26667157","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/1755-5922.12168","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:34.564Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"bf5fb3a8-b1f8-406c-a611-a5d1dd18ebe6","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/27475912/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors.\" Abstract excerpt: Rubimetide (Met-Arg-Trp), which had been isolated as an antihypertensive peptide from an enzymatic digest of spinach ribulose-bisphosphate carboxylase/oxygenase (Rubisco), showed anxiolytic-like activity prostaglandin (PG) D2-dependent manner in the elevated plus-maze test after administration at a dose of 0.1mg/kg (ip.) or 1mg/kg (p.o.) in male mice of ddY strain. In this study, we found that rub","authors":null,"publishingOrg":null,"publicationYear":2016,"doi":"10.1016/j.peptides.2016.07.001","pubmedId":"27475912","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.peptides.2016.07.001","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:33.674Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"cc0b4970-73fd-4fa4-a84e-b75a92a8519d","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Solution NMR structure and inhibitory effect against amyloid-β fibrillation of Humanin containing a d-isomerized serine residue.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/27349871/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Solution NMR structure and inhibitory effect against amyloid-β fibrillation of Humanin containing a d-isomerized serine residue.\" Abstract excerpt: Humanin comprising 24 amino acid residues is a bioactive peptide that has been isolated from the brain tissue of patients with Alzheimer's disease. Humanin reportedly suppressed aging-related death of various cells due to amyloid fibrils and oxidative stress. There are reports that the cytoprotective activity of Humanin was remarkably enhanced by optical isomerization of the Ser14 residue from l t","authors":null,"publishingOrg":null,"publicationYear":2016,"doi":"10.1016/j.bbrc.2016.06.114","pubmedId":"27349871","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbrc.2016.06.114","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:43.727Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"98d51746-415a-46e0-91b2-3f3e65ef67de","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/26990160/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.\" Abstract excerpt: To investigate the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effect on oxidative stress-induced cell death, mitochondrial bioenergetics, and senescence. Humanin localization in RPE cells and polarized RPE monolayers was assessed by confocal microscopy. Human RPE cells were treated with 150 &#x3bc;M tert-Butyl hydroperoxide (tBH) in the absence/presence of ","authors":null,"publishingOrg":null,"publicationYear":2016,"doi":"10.1167/iovs.15-17053","pubmedId":"26990160","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1167/iovs.15-17053","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:38.931Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e52ad9e9-6da2-4a5d-bbb5-8b46ec20af98","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/27384491/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus.\" Abstract excerpt: Humanin is a small secreted peptide that is encoded in the mitochondrial genome. Humanin and its analogues have a protective role in multiple age-related diseases including type 2 diabetes and Alzheimer's disease, through cytoprotective and neuroprotective effects both in vitro and in vivo. However, the humanin-mediated signaling pathways are not well understood. In this paper, we demonstrate that","authors":null,"publishingOrg":null,"publicationYear":2016,"doi":"10.18632/oncotarget.10380","pubmedId":"27384491","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.18632/oncotarget.10380","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:39.003Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"00558620-416e-43b7-808a-61e45bd38dfc","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/27306655/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"[Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats.\" Abstract excerpt: Alzheimer disease (AD), a progressive neurodegenerative disorder, is characterized by cognitive decline and the accumulation of senile plaques in the brain. Amyloid &#x3b2; protein (A&#x3b2;) in the plaques is thought to be responsible for the memory loss in AD patients. [Gly14]-humanin (HNG), a derivative of humanin (HN), has much stronger neuroprotective effects than natural HN in vitro. However","authors":null,"publishingOrg":null,"publicationYear":2016,"doi":"10.1007/s12264-016-0041-x","pubmedId":"27306655","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=280, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s12264-016-0041-x","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:02.553Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"59df7b31-c9ad-4c8c-a515-13b898bbedf7","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Central effects of humanin on hepatic triglyceride secretion.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/26058861/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Central effects of humanin on hepatic triglyceride secretion.\" Abstract excerpt: Humanin (HN) is an endogenous mitochondria-associated peptide that has been shown to protect against various Alzheimer's disease-associated insults, myocardial ischemia-reperfusion injury, and reactive oxygen species-induced cell death. We have shown previously that HN improves whole body glucose homeostasis by improving insulin sensitivity and increasing glucose-stimulated insulin secretion (GSIS","authors":null,"publishingOrg":null,"publicationYear":2015,"doi":"10.1152/ajpendo.00043.2015","pubmedId":"26058861","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1152/ajpendo.00043.2015","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:34.639Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"067aa05b-53a2-4b9b-ad1d-438218559681","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Derivatives Inhibit Necrotic Cell Death in Neurons.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/26062019/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Derivatives Inhibit Necrotic Cell Death in Neurons.\" Abstract excerpt: Humanin and its derivatives are peptides known for their protective antiapoptotic effects against Alzheimer's disease. Herein, we identify a novel function of the humanin-derivative AGA(C8R)-HNG17 (namely, protection against cellular necrosis). Necrosis is one of the main modes of cell death, which was until recently considered an unmoderated process. However, recent findings suggest the opposite.","authors":null,"publishingOrg":null,"publicationYear":2015,"doi":"10.2119/molmed.2015.00073","pubmedId":"26062019","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2119/molmed.2015.00073","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:00.081Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"80a6620b-28a3-429a-bf2a-48c3bde22153","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Does Not Protect Against STZ-Induced Spatial Memory Impairment.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25744099/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Does Not Protect Against STZ-Induced Spatial Memory Impairment.\" Abstract excerpt: [Gly14]-Humanin (HNG) is a 24-amino acid peptide which was first identified in the brains of patients diagnosed with Alzheimer's disease (AD). In this region, some neurons were protected against cell damage occurring in this disease. Further studies suggested a neuroprotective role for humanin against A&#x3b2; and some other insults. Intraventricularly administered streptozotocin (STZ) disrupts in","authors":null,"publishingOrg":null,"publicationYear":2015,"doi":"10.1007/s12031-015-0531-8","pubmedId":"25744099","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=8, totalMentions=7). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s12031-015-0531-8","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:00.005Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"41b666cf-a643-4ebc-80fb-86a0c1b1a255","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/26216267/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β.\" Abstract excerpt: Nuclear translocation of IGFBP3 by importin-&#x3b2;1 is a prerequisite for IGFBP3-induced apoptosis. The neuroprotective peptide humanin (HN) counteracts IGFBP3-induced cell death. However, the mechanism by which humanin protects cells is currently unknown. The natural synthesis of this peptide decreases with age, coincident with the likelihood for the development of Alzheimer's Disease, making it","authors":null,"publishingOrg":null,"publicationYear":2015,"doi":"10.2174/0929866522666150728114955","pubmedId":"26216267","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=129, totalMentions=7). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2174/0929866522666150728114955","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:00.152Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"6aa27b5c-4814-4b68-9450-290039bbd584","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin protects against chemotherapy-induced stage-specific male germ cell apoptosis in rats.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25891800/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin protects against chemotherapy-induced stage-specific male germ cell apoptosis in rats.\" Abstract excerpt: Humanin (HN) has cytoprotective action on male germ cells after testicular stress induced by heat and hormonal deprivation. To examine whether HN has protective effects on chemotherapy-induced male germ cell apoptosis, we treated four groups of adult rats with (i) vehicle (control), (ii) HN, (iii) cyclophosphamide (CP); or (iv) HN+CP. To investigate whether the protective effects of HN on germ cel","authors":null,"publishingOrg":null,"publicationYear":2015,"doi":"10.1111/andr.12036","pubmedId":"25891800","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/andr.12036","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:29.071Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"997f5374-7f54-4357-bf1d-903c2189ab33","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Increased oligodendrogenesis by humanin promotes axonal remyelination and neurological recovery in hypoxic/ischemic brains.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25139533/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Increased oligodendrogenesis by humanin promotes axonal remyelination and neurological recovery in hypoxic/ischemic brains.\" Abstract excerpt: Oligodendrocytes are the predominant cell type in white matter and are highly vulnerable to ischemic injury. The role of oligodendrocyte dysfunction in ischemic brain injury is unknown. In this study, we used a 24-amino acid peptide S14G-Humanin (HNG) to examine oligodendrogenesis and neurological functional recovery in a hypoxic/ischemic (H/I) neonatal model. Intraperitoneal HNG pre-treatment dec","authors":null,"publishingOrg":null,"publicationYear":2015,"doi":"10.1002/hipo.22350","pubmedId":"25139533","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1002/hipo.22350","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:38.471Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"addb5e75-45ce-4e35-891e-c5e6f1cb24c6","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Protective effects of Humanin and calmodulin-like skin protein in Alzheimer's disease and broad range of abnormalities.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/24969584/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Protective effects of Humanin and calmodulin-like skin protein in Alzheimer's disease and broad range of abnormalities.\" Abstract excerpt: Humanin is a 24-amino acid, secreted bioactive peptide that prevents various types of cell death and improves some types of cell dysfunction. Humanin inhibits neuronal cell death that is caused by a familial Alzheimer's disease (AD)-linked gene via binding to the heterotrimeric Humanin receptor (htHNR). This suggests that Humanin may play a protective role in AD-related pathogenesis. Calmodulin-li","authors":null,"publishingOrg":null,"publicationYear":2015,"doi":"10.1007/s12035-014-8799-1","pubmedId":"24969584","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: systematic review or meta-analysis. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: synthesis. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"systematic_review_or_meta_analysis","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s12035-014-8799-1","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:35.454Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"4546f211-bcb8-4f62-8d22-445b8ad4d155","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/26116236/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production.\" Abstract excerpt: Evidence for the putative mitochondrial origin of the Humanin (HN) peptide has been lacking, although its cytoprotective activity has been demonstrated in a variety of organismal and cellular systems. We sought to establish proof-of-principle for a mitochondria-derived peptide (MDP) in a rat-derived cellular system as the rat HN sequence is predicted to lack nuclear insertions of mitochondrial ori","authors":null,"publishingOrg":null,"publicationYear":2015,"doi":"10.1016/j.mce.2015.06.015","pubmedId":"26116236","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.mce.2015.06.015","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:32.339Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"8c6c892e-8802-4ac5-91c3-19e178f0867c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/26384090/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.\" Abstract excerpt: Humanin is a peptide that is cytoprotective against stresses in many cell types. We investigated whether a potent humanin analogue S14G-humanin (HNG) would protect against chemotherapy-induced damage to normal cells without interfering with the chemotherapy-induced suppression of cancer cells. Young adult male mice were inoculated iv with murine melanoma cells. After 1 week, cancer-bearing mice we","authors":null,"publishingOrg":null,"publicationYear":2015,"doi":"10.1210/en.2015-1542","pubmedId":"26384090","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=4). Imported evidence lane: human_interventional. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1210/en.2015-1542","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:03.485Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"dbdb90b1-b37c-41df-9a1d-b6a59bc24643","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The effect of sex on humanin levels in healthy adults and patients with uncomplicated type 1 diabetes mellitus.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25615723/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The effect of sex on humanin levels in healthy adults and patients with uncomplicated type 1 diabetes mellitus.\" Abstract excerpt: Diabetes mellitus (DM) is associated with a loss of renal and vascular protection in women compared with men, but the responsible mechanisms are unclear. Recent experimental work implicated humanin (HN) as a novel cytoprotective hormone in DM. Our goal was to measure sex-related differences in HN levels in uncomplicated type 1 DM patients (T1D) and healthy controls (HC), as well as the interaction","authors":null,"publishingOrg":null,"publicationYear":2015,"doi":"10.1139/cjpp-2014-0401","pubmedId":"25615723","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1139/cjpp-2014-0401","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:34.935Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"66fc5f7c-f1b3-4cad-a68e-63ffbb9592ee","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25666707/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs.\" Abstract excerpt: Human (HN) prevents stress-induced apoptosis in many cells/tissues. In this study we showed that HN ameliorated chemotherapy [cyclophosphamide (CP) and Doxorubicin (DOX)]-induced male germ cell apoptosis both ex vivo in seminiferous tubule cultures and in vivo in the testis. HN acts by several putative mechanisms via binding to: an IL-12 like trimeric membrane receptor; BAX; or insulin-like growth","authors":null,"publishingOrg":null,"publicationYear":2015,"doi":"10.1007/s10495-015-1105-5","pubmedId":"25666707","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s10495-015-1105-5","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:34.190Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"1ac0f49f-776b-475d-806d-40eed6b12034","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25360890/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis.\" Abstract excerpt: Humanin (HN) is a 24-amino acid peptide with cytoprotective action in several cell types such as neurons and testicular germ cells. Rattin (HNr), a homologous peptide of HN expressed in several adult rat tissues, also has antiapoptotic action. In the present work, we demonstrated by immunocytochemical analysis and flow cytometry the expression of HNr in the anterior pituitary of female and male ad","authors":null,"publishingOrg":null,"publicationYear":2014,"doi":"10.1371/journal.pone.0111548","pubmedId":"25360890","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1371/journal.pone.0111548","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:35.008Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3af7ccb0-f7dc-431f-8662-1c36c7f2981b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Apollon/Bruce is upregulated by Humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25138702/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Apollon/Bruce is upregulated by Humanin.\" Abstract excerpt: Humanin, a short bioactive peptide, inhibits a variety of cell deaths. Humanin-mediated inhibition of neuronal cell death, caused by an Alzheimer's disease (AD)-linked mutant gene occurs via binding of Humanin to its heterotrimeric Humanin receptor (htHNR), which results in the activation of the Janus-associated kinases (JAKs) and signal transducer and activator and transcription 3 (STAT3) signali","authors":null,"publishingOrg":null,"publicationYear":2014,"doi":"10.1007/s11010-014-2182-4","pubmedId":"25138702","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s11010-014-2182-4","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:38.395Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"6be4e8f4-5948-46ad-b983-2c3965c4777f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin attenuated the change of voltage-dependent potassium currents in hippocampal neurons induced by anoxia.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/24341938/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin attenuated the change of voltage-dependent potassium currents in hippocampal neurons induced by anoxia.\" (identity confirmed; no abstract text available to excerpt.)","authors":null,"publishingOrg":null,"publicationYear":2014,"doi":"10.1111/cns.12211","pubmedId":"24341938","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/cns.12211","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:31.512Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"fd41a69f-2dbe-4fec-b2fc-f98ed583afd1","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25391447/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats.\" Abstract excerpt: Amyloid &#x3b2;-peptide (A&#x3b2;) has been implicated as a key molecule in the neurodegenerative cascades of Alzheimer's disease (AD). Humanin (HN) is a secretory peptide that inhibits the neurotoxicity of A&#x3b2;. However, the mechanism(s) by which HN exerts its neuroprotection against A&#x3b2;-induced AD-like pathological changes and memory deficits are yet to be completely defined. In the pre","authors":null,"publishingOrg":null,"publicationYear":2014,"doi":"10.1007/s12264-014-1479-3","pubmedId":"25391447","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s12264-014-1479-3","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:29.147Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"73809769-8978-4444-8427-562e27bfcc6e","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity not by NMDA receptor.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/24959608/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity not by NMDA receptor.\" Abstract excerpt: Excitatory neurotoxicity has been implicated in many pathological situations and there is no effective treatment available. Humanin is a 24-aa peptide cloned from the brain of patients with Alzheimer's disease (AD). In the present study, excitatory toxicity was induced by N-methyl-D-aspartate (NMDA) in primarily cultured rat cortical neurons. MTT assessment, lactate dehydrogenase (LDH) release, an","authors":null,"publishingOrg":null,"publicationYear":2014,"doi":"10.1155/2014/341529","pubmedId":"24959608","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=124, totalMentions=6). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1155/2014/341529","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:00.266Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e2eb1295-b79a-4326-91aa-ce0e59211141","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin: a possible linkage between Alzheimer's disease and type 2 diabetes.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/24365186/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Humanin: a possible linkage between Alzheimer's disease and type 2 diabetes.\" Abstract excerpt: The prevalence of Alzheimer's disease (AD) is higher among type 2 diabetes mellitus (T2DM) patients. In T2DM patients, the progression of AD is more rapid. Furthermore, several pathophysiological pathways are common to AD and T2DM. Humanin is a recently introduced, mitochondrial-derived peptide with neuroprotective effects. Humanin can alter the mechanisms involved in AD and T2DM pathogenesis. Ins","authors":null,"publishingOrg":null,"publicationYear":2014,"doi":"10.2174/1871527312666131223110147","pubmedId":"24365186","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=232, totalMentions=2). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2174/1871527312666131223110147","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:00.598Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"17e985d9-1609-417a-a53c-5acf6d000e46","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"IGF-I regulates the age-dependent signaling peptide humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25040290/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"IGF-I regulates the age-dependent signaling peptide humanin.\" Abstract excerpt: Aging is influenced by endocrine pathways including the growth hormone/insulin-like growth factor-1 (GH/IGF) axis. Mitochondrial function has also been linked to the aging process, but the relevant mitochondrial signals mediating the effects of mitochondria are poorly understood. Humanin is a novel signaling peptide that acts as a potent regulator of cellular stress responses and protects from a v","authors":null,"publishingOrg":null,"publicationYear":2014,"doi":"10.1111/acel.12243","pubmedId":"25040290","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/acel.12243","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:41.656Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"88a22f07-5ae3-4591-b028-328b7056f2e7","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Inactive C8A‑humanin analog is as stable as a potent S14G‑humanin analog.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/24247787/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Inactive C8A‑humanin analog is as stable as a potent S14G‑humanin analog.\" Abstract excerpt: We have previously shown that the structural stability of humanin&#xa0;(HN), a neuroprotective peptide ligand, is one of the attributes to the observed activity differences between HN analogs. It has been observed that the activity increased consecutively in the S7A&#x2011;HN analog, the parent HN and the S14G&#x2011;HN analog, consistent with the increased stability observed in that order. In the","authors":null,"publishingOrg":null,"publicationYear":2014,"doi":"10.3892/mmr.2013.1797","pubmedId":"24247787","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3892/mmr.2013.1797","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:33.896Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"b289924d-6300-408c-bc1d-71c2410cbfc5","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/24586106/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects.\" (identity confirmed; no abstract text available to excerpt.)","authors":null,"publishingOrg":null,"publicationYear":2014,"doi":"10.1093/jnci/dju006","pubmedId":"24586106","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1093/jnci/dju006","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:40.015Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"d33be5cc-d3c2-440a-8286-acb52f168cf0","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25451915/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells.\" Abstract excerpt: Humanin (HN) is known for its anti-apoptotic functions in neuronal cells. In this study, we sought to investigate the protective effect of [Gly14]-Humanin (HNG) in high glucose (HG)-induced apoptosis of human umbilical vein endothelial cells (HUVECs). 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to examine cell viability, DNA chromatin morphology was assessed u","authors":null,"publishingOrg":null,"publicationYear":2014,"doi":"10.1016/j.diabres.2014.09.020","pubmedId":"25451915","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.diabres.2014.09.020","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:37.384Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"9e4038e9-ce61-4c6b-8fdb-f542ce05a523","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Protective effects of humanin on okadaic Acid-induced neurotoxicities in cultured cortical neurons.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25142935/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Protective effects of humanin on okadaic Acid-induced neurotoxicities in cultured cortical neurons.\" Abstract excerpt: Neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD), which are mostly composed of hyperphosphorylated tau and directly correlate with dementia in AD patients. Okadaic acid (OA), a toxin extracted from marine life, can specifically inhibit protein phosphatases (PPs), including PP1 and Protein phosphatase 2A (PP2A), resulting in tau hyperphosphorylation. Humanin (HN), a pe","authors":null,"publishingOrg":null,"publicationYear":2014,"doi":"10.1007/s11064-014-1410-3","pubmedId":"25142935","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s11064-014-1410-3","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:35.230Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"8a404fa6-b718-4e09-a7f4-9087d940dff5","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/24586107/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment.\" Abstract excerpt: Bortezomib is a proteasome inhibitor currently studied in clinical trials of childhood cancers. So far, no side effects on bone growth have been reported in treated children. However, bortezomib was recently found to induce apoptosis in growth plate chondrocytes and impair linear bone growth in treated mice. We hypothesize that [Gly(14)]-humanin (HNG), a 24-amino acid synthetic antiapoptotic pepti","authors":null,"publishingOrg":null,"publicationYear":2014,"doi":"10.1093/jnci/djt459","pubmedId":"24586107","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: human_interventional. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1093/jnci/djt459","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:34.487Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"0db200cd-a91b-4c74-a67b-ddb8e2ec8687","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23985350/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts.\" Abstract excerpt: A potent analog (HNG) of the endogenous peptide humanin protects against myocardial ischemia-reperfusion (MI-R) injury in vivo, decreasing infarct size and improving cardiac function. Since oxidative stress contributes to the damage from MI-R we tested the hypotheses that: (1) HNG offers cardioprotection through activation of antioxidant defense mechanisms leading to preservation of mitochondrial ","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1016/j.bbrc.2013.08.055","pubmedId":"23985350","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbrc.2013.08.055","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:31.963Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"6ce06ac8-cb06-475e-96ca-5fb0f150b282","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23298615/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin.\" Abstract excerpt: Inhibition of the early intracellular event that triggers neurodegenerative cascades and reversal of neuronal cell death are essential for effective treatment of Alzheimer's disease (AD). In this study, a novel therapeutic for AD, a transducible humanin with an extended caspase-3 cleavage sequence (tHN-C3), was developed and showed multiple mechanisms of therapeutic action. These included targeted","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1016/j.jconrel.2012.12.022","pubmedId":"23298615","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.jconrel.2012.12.022","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:44.246Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"7fa35a67-2b62-4fc7-ba95-895d3aa196af","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Circulating humanin levels are associated with preserved coronary endothelial function.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23220334/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Circulating humanin levels are associated with preserved coronary endothelial function.\" Abstract excerpt: Humanin is a small endogenous antiapoptotic peptide, originally identified as protective against Alzheimer's disease, but subsequently also found on human endothelium as well as carotid artery plaques. Endothelial dysfunction is a precursor to the development of atherosclerotic plaques, which are characterized by a highly proinflammatory, reactive oxygen species, and apoptotic milieu. Previous ani","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1152/ajpheart.00765.2012","pubmedId":"23220334","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1152/ajpheart.00765.2012","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:33.748Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"401e953e-ce9d-436c-b03b-645ada9f6478","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin binds MPP8: mapping interaction sites of the peptide and protein.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23532874/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Humanin binds MPP8: mapping interaction sites of the peptide and protein.\" Abstract excerpt: Humanin (HN), a 24-amino acid peptide encoded by the mitochondrial 16S rRNA gene, was discovered by screening a cDNA library from the occipital cortex of a patient with Alzheimer's disease (AD) for a protection factor against AD-relevant insults. Earlier, using the yeast two-hybrid system, we have identified the M-phase phosphoprotein 8 (MPP8) as a binding partner for HN. In the present work, we f","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1002/psc.2500","pubmedId":"23532874","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1002/psc.2500","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:30.775Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e894983c-d707-4fc4-bc1b-52bb3e8ac8fb","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin: a harbinger of mitochondrial-derived peptides?","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23402768/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin: a harbinger of mitochondrial-derived peptides?\" Abstract excerpt: Mitochondria have been largely considered as 'end-function' organelles, servicing the cell by producing energy and regulating cell death in response to complex signals. Being cellular entities with vital roles, mitochondria communicate back to the cell and actively engage in determining major cellular policies. These signals, collectively referred to as retrograde signals, are encoded in the nucle","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1016/j.tem.2013.01.005","pubmedId":"23402768","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.tem.2013.01.005","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:31.587Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"c2287c23-7649-4dc5-b8b3-1c34143c5df2","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin: a novel functional molecule for the green synthesis of graphene.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23850746/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin: a novel functional molecule for the green synthesis of graphene.\" Abstract excerpt: The synthesis of graphene nanosheets from graphene oxide is an interesting area of nanobiotechnology because graphene-based nanomaterials have potential applications in the biomedical field. In this study, we developed a green, rapid, and simple method for the synthesis of graphene from graphene oxide, which uses the mitochondrial polypeptide humanin as a reducing agent. Graphene was prepared via ","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1016/j.colsurfb.2013.06.018","pubmedId":"23850746","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=345, totalMentions=2). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.colsurfb.2013.06.018","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:00.874Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"856138e4-d744-459c-97d1-dae6fa6a9346","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Neuroprotective Peptide humanin inhibits inflammatory response in astrocytes induced by lipopolysaccharide.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23277413/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Neuroprotective Peptide humanin inhibits inflammatory response in astrocytes induced by lipopolysaccharide.\" Abstract excerpt: Humanin (HN) has been proved to be an extensive neuroprotective peptide against AD-related and unrelated insults, but little is know about the effect of HN in inflammation response. Current studies indicated the receptors of HN have a close relationship with immune system, which led us to hypothesize HN might have a role in inflammatory response. In this study, we used lipopolysaccharide (LPS) to ","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1007/s11064-012-0951-6","pubmedId":"23277413","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s11064-012-0951-6","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:36.107Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"81436eb7-031c-407b-80c5-ce64dd8253ad","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23836030/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents.\" Abstract excerpt: Humanin (HN) is a novel 24-amino acid mitochondrial-derived peptide that has demonstrated diverse cytoprotective effects, including an emerging role in diabetes. The purpose of this study was to examine the pharmacokinetics of humanin analogues, which show great potential as therapeutic agents (HNG and the non-IGFBP-3 binding, HNGF6A). 11-week-old male IGFBP-3(-/-) and wild type (WT) mice were div","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1210/en.2012-2004","pubmedId":"23836030","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1210/en.2012-2004","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:40.694Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"56ef9b7c-1e94-45fe-b9d3-bb1809308900","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23995290/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell.\" Abstract excerpt: Humanin (HN) is a 24-aa polypeptide that offers protection from Alzheimer's disease and myocardial infarction, increases insulin sensitivity, improves survival of &#x3b2; cells, and delays onset of diabetes. Here we examined the acute effects of HN on insulin secretion and potential mechanisms through which they are mediated. Effects of a potent HN analog, HNGF6A, on glucose-stimulated insulin sec","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1096/fj.13-231092","pubmedId":"23995290","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1096/fj.13-231092","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:32.935Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"29605b9e-9afc-421a-a197-b659da1720ca","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25206568/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein.\" Abstract excerpt: Humanin is a potential therapeutic agent for Alzheimer's disease, and its derivative, S14G-humanin, is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults. Al-though effective, the detailed molecular mechanism through which S14G-humanin exerts its effects remains unclear. Data from this study showed that fibrillar amyloid-beta 40 disturbed cellular ho-meo","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.3969/j.issn.1673-5374.2013.27.009","pubmedId":"25206568","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=5). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3969/j.issn.1673-5374.2013.27.009","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:01.648Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"b18c5aa4-5007-41b0-b640-b3137330eee9","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23861391/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase.\" Abstract excerpt: Humanin is a secreted bioactive peptide that suppresses cell toxicity caused by a variety of insults. The neuroprotective effect of Humanin against Alzheimer disease (AD)-related death is mediated by the binding of Humanin to its heterotrimeric Humanin receptor composed of ciliary neurotrophic receptor &#x3b1;, WSX-1, and gp130, as well as the activation of intracellular signaling pathways includi","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1074/jbc.m113.469692","pubmedId":"23861391","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1074/jbc.m113.469692","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:44.395Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"5c119dd0-7199-467f-8c71-c62ed333ead6","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23519124/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor.\" Abstract excerpt: Humanin is a secreted bioactive peptide that is protective in a variety of death models, including cell-based neuronal death models related to Alzheimer's disease (AD). To mediate the protective effect in AD-related death models, Humanin signals via a cell-surface receptor that is generally composed of three subunits: ciliary neurotrophic factor receptor &#x3b1;, WSX-1 and gp130 (heterotrimeric Hu","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1038/cddis.2013.80","pubmedId":"23519124","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1038/cddis.2013.80","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:44.691Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3d7b3815-fd46-41d2-b7a0-b5e469b05569","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23686888/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis.\" Abstract excerpt: We have previously demonstrated that the mitochondria-derived cytoprotective peptide humanin (HN), when administered intratesticularly to rats, rescues germ cells from apoptosis secondary to testicular stress of hormonal deprivation induced by gonadotropin-releasing hormone antagonist (GnRH-A). To decipher the cellular mechanisms of HN action in the amelioration of GnRH-A-induced germ cell apoptos","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1111/j.2047-2927.2013.00091.x","pubmedId":"23686888","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/j.2047-2927.2013.00091.x","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:36.999Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"27b6e020-dd8d-46ac-828b-1a2c8b380d0d","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The emerging role of the mitochondrial-derived peptide humanin in stress resistance.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23239898/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The emerging role of the mitochondrial-derived peptide humanin in stress resistance.\" Abstract excerpt: The discovery of humanin, a novel, mitochondrial-derived peptide, has created a potentially new category of biologically active peptide. As more research unravels the endogenous role of humanin as well as its potential pharmacological use, its role in stress resistance has become clearer. Humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults in vitro and also i","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1530/jme-12-0203","pubmedId":"23239898","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1530/jme-12-0203","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:41.874Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3b4388df-804d-40e1-8cdb-7e85a0a70cae","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Gly14]-Humanin offers neuroprotection through glycogen synthase kinase-3β inhibition in a mouse model of intracerebral hemorrhage.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23538063/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"[Gly14]-Humanin offers neuroprotection through glycogen synthase kinase-3β inhibition in a mouse model of intracerebral hemorrhage.\" Abstract excerpt: Perihematomal brain edema formation and consequent cell death contribute to second brain injury resulting in severe neurological deficits and sometimes delayed fatality after intracerebral hemorrhage (ICH). [Gly14]-Humanin (HNG), a variant of Humanin (HN) in which the 14th amino acid serine is replaced with glycine, reduced Alzheimer's disease-relevant insults and improved neurological deficits in","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1016/j.bbr.2013.03.023","pubmedId":"23538063","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=215, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbr.2013.03.023","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:02.625Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"4fb29401-1052-40e8-aca9-093c88c45fb4","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23178909/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"[Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice.\" Abstract excerpt: Humanin (HN) has been identified as an endogenous peptide that inhibited AD-relevant neuronal cell death. HNG, a variant of HN in which the 14th amino acid serine was replaced with glycine, can reduce infarct volume and improve neurological deficits after ischemia/reperfusion injury. In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and ex","authors":null,"publishingOrg":null,"publicationYear":2013,"doi":"10.1016/j.neuroscience.2012.11.019","pubmedId":"23178909","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.neuroscience.2012.11.019","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:33.087Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"4e95b4f5-be4a-4a82-bb4f-916e7594bef7","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"D-Ser-containing humanin shows promotion of fibril formation.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/21735222/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"D-Ser-containing humanin shows promotion of fibril formation.\" Abstract excerpt: Humanin (HN), a peptide of 24 amino acid residues, suppresses the neuronal cell death that is induced by the gene products of Alzheimer's disease. HN contains two Ser residues at positions 7 and 14. Because the proportion of D-Ser isomerized from L-Ser in proteins appears to increase as cellular organs age, we explored the structural effects of the isomerization of each Ser residue in HN. By using","authors":null,"publishingOrg":null,"publicationYear":2012,"doi":"10.1007/s00726-011-0971-6","pubmedId":"21735222","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s00726-011-0971-6","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:34.338Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"bf334415-59b1-4cb2-a75f-4affae7e4a20","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/22820173/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice.\" Abstract excerpt: Humanin (HN) is an endogenous mitochondrial-derived cytoprotective peptide that has shown protective effects against atherosclerosis and is expressed in human vessels. However, its effects on the progression of kidney disease are unknown. We hypothesized that HN would protect the kidney in the early phase of atherogenesis. Forty-eight mice were studied in four groups (n=12 each). Twenty-four ApoE ","authors":null,"publishingOrg":null,"publicationYear":2012,"doi":"10.1016/j.lfs.2012.07.010","pubmedId":"22820173","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.lfs.2012.07.010","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:29.296Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"372fabc7-0398-452b-863c-474f331729b0","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/21935731/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase.\" Abstract excerpt: The neuroprotective effects of superoxide dismutase (SOD) against hypoxia/reperfusion (I/R) injury and of humanin (HN) against toxicity by familial amyotrophic lateral sclerosis (ALS)-related mutant SOD led us to hypothesize that HN might have a role to increase the activity of SOD, which might be involved in the protective effects of HN on neuron against Alzheimer's disease-unrelated neurotoxicit","authors":null,"publishingOrg":null,"publicationYear":2012,"doi":"10.1007/s11064-011-0593-0","pubmedId":"21935731","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s11064-011-0593-0","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:29.222Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"bd2dd26b-08d7-4cc3-abf2-d516de1138e0","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/22328926/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans.\" Abstract excerpt: The mechanism of atherosclerotic plaque progression leading to instability, rupture, and ischemic manifestation involves oxidative stress and apoptosis. Humanin (HN) is a newly emerging endogenously expressed cytoprotective peptide. Our goal was to determine the presence and localization of HN in carotid atherosclerotic plaques. Plaque specimens from 34 patients undergoing carotid endarterectomy w","authors":null,"publishingOrg":null,"publicationYear":2012,"doi":"10.1371/journal.pone.0031065","pubmedId":"22328926","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1371/journal.pone.0031065","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:29.372Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"68a086c1-8f3b-49da-8796-bba39fa80316","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Interaction structure of the complex between neuroprotective factor humanin and Alzheimer's β-amyloid peptide revealed by affinity mass spectrometry and molecular modeling.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/22522311/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Interaction structure of the complex between neuroprotective factor humanin and Alzheimer's β-amyloid peptide revealed by affinity mass spectrometry and molecular modeling.\" Abstract excerpt: Humanin (HN) is a linear 24-aa peptide recently detected in human Alzheimer's disease (AD) brain. HN specifically inhibits neuronal cell death in vitro induced by &#xdf;-amyloid (A&#xdf;) peptides and by amyloid precursor protein and its gene mutations in familial AD, thereby representing a potential therapeutic lead structure for AD; however, its molecular mechanism of action is not well understo","authors":null,"publishingOrg":null,"publicationYear":2012,"doi":"10.1002/psc.2404","pubmedId":"22522311","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1002/psc.2404","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:43.211Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"21584b62-37c6-4d8c-beee-ba55f7eb274a","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/21993310/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice.\" Abstract excerpt: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by clinical cognitive decline and pathological deposition of amyloid-beta protein (A&#x3b2;) in the brain. So far, there has been no causative therapy for this devastating disease. S14G-Humanin (HNG), a synthetic derivative of Humanin (HN), has been shown to have strong neuroprotective ability against AD-related ins","authors":null,"publishingOrg":null,"publicationYear":2012,"doi":"10.1016/j.pbb.2011.09.012","pubmedId":"21993310","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=269, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.pbb.2011.09.012","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:01.721Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"34ecd545-4cd6-409a-88ba-a79a3fc5835f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[[Gly14]-humanin protects against Aβ₃₁₋₃₅-induced impairment of spatial learning and memory in rats].","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/23258324/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"[[Gly14]-humanin protects against Aβ₃₁₋₃₅-induced impairment of spatial learning and memory in rats].\" Abstract excerpt: Amyloid &#x3b2; protein (A&#x3b2;) is closely involved in the pathogenesis of Alzheimer's disease (AD), and one of the main strategies for AD treatment is antagonizing the neurotoxicity of A&#x3b2; or even clearing the A&#x3b2; deposited in the brain. The present study was aimed to observe the effects of intrahippocampal injection of A&#x3b2;&#x2083;&#x2081;&#x208b;&#x2083;&#x2085; on the spatial ","authors":null,"publishingOrg":null,"publicationYear":2012,"doi":null,"pubmedId":"23258324","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"pmid:23258324","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:33.158Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"cb6f3891-fec8-43f9-a781-744f0a105567","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/21264226/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice.\" Abstract excerpt: Humanin (HN), a 24-residue peptide, was identified as a novel neuroprotective factor and shows anti-cell death activity against a wide spectrum of Alzheimer's disease (AD)-related cytotoxicities, including exposure to amyloid beta (Abeta), in vitro. We previously demonstrated that the injection of S14G-HN, a highly potent HN derivative, into brain ameliorated memory loss in an Abeta-injection mous","authors":null,"publishingOrg":null,"publicationYear":2011,"doi":"10.1371/journal.pone.0016259","pubmedId":"21264226","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1371/journal.pone.0016259","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:32.039Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"afc6ce96-c4eb-4389-8898-8bf1bd9bca18","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Advances in characterization of neuroprotective peptide, humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/22172065/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Advances in characterization of neuroprotective peptide, humanin.\" Abstract excerpt: Humanin (HN), a short amino acid peptide, protects neurons as well as other cells from amyloid &#x3b2;-induced toxicities and other stresses. A number of HN binding proteins have been identified and their involvements in HN-mediated neuroprotection have been suggested in some cases. However, the way HN binds to the target molecules has never been clarified. Here we will review the structures of HN","authors":null,"publishingOrg":null,"publicationYear":2011,"doi":"10.2174/092986711798347261","pubmedId":"22172065","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: systematic review or meta-analysis. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: synthesis. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"systematic_review_or_meta_analysis","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2174/092986711798347261","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:42.181Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"c268c2df-0a58-4feb-8a0f-05003cf51add","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/21763658/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice.\" Abstract excerpt: Humanin (HN) is a cytoprotective peptide derived from endogenous mitochondria, expressed in the endothelial layer of human vessels, but its role in atherogenesis in vivo is not known. In vitro study, however, HN reduced oxidized low-density lipoprotein induced formation of reactive oxygen species and apoptosis. The present study tested the hypothesis that long term treatment with HN will have a pr","authors":null,"publishingOrg":null,"publicationYear":2011,"doi":"10.1016/j.atherosclerosis.2011.06.038","pubmedId":"21763658","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.atherosclerosis.2011.06.038","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:29.447Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"0413238b-fade-4857-ab6d-ca61c7660f25","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin signal for Alzheimer's disease.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/21335658/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin signal for Alzheimer's disease.\" Abstract excerpt: Despite a bulk of evidence supporting the idea that increased neurotoxic insults lead to Alzheimer's disease (AD), the possibility still remains that insufficiency of an endogenous defense system contributes to the disease progression. Humanin is a bioactive peptide that is likely to inhibit both neuronal death and dysfunction only related to AD by binding to a Humanin receptor on the cell-surface","authors":null,"publishingOrg":null,"publicationYear":2011,"doi":"10.3233/jad-2011-102076","pubmedId":"21335658","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=236, totalMentions=4). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.3233/jad-2011-102076","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:00.338Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f71042ad-e3ad-443c-8948-5ce245f37ce2","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Structure of three Humanin peptides with different activities upon interaction with liposome.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/21215775/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Structure of three Humanin peptides with different activities upon interaction with liposome.\" Abstract excerpt: We have recently shown that a 24 amino acid Humanin (HN) adopts an anti-parallel &#x3b2;-sheet structure in the presence of a negatively charged 1,2-dioleoyl-sn-glycero-3-phosphoglycerol (DOPG) and suggested a possibility that it interacts with lipid membranes and thereby exerts neuroprotective effects through the target cell surface receptors or the intracellular signaling molecules following mem","authors":null,"publishingOrg":null,"publicationYear":2011,"doi":"10.1016/j.ijbiomac.2010.12.017","pubmedId":"21215775","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.ijbiomac.2010.12.017","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:34.712Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"993fab4e-00d0-423a-a0c4-230529f76aa1","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The biological activity of Humanin analogs correlates with structure stabilities in solution.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/21510972/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The biological activity of Humanin analogs correlates with structure stabilities in solution.\" Abstract excerpt: A single mutation has resulted in large differences in neuroprotective activity of a 24 amino acid Humanin (HN). A mutation of Ser7Ala (S7A-HN) resulted in loss of activity, while a mutation of Ser14Gly (S14G-HN) resulted in about 1000-fold increase. The mechanism of the effects conferred by these mutations have been totally unclear, although our recent structure analysis suggested a possibility o","authors":null,"publishingOrg":null,"publicationYear":2011,"doi":"10.1016/j.ijbiomac.2011.04.003","pubmedId":"21510972","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.ijbiomac.2011.04.003","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:37.075Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"653e9347-0c66-4ccb-ab3f-4dcb846fa5d4","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/21393573/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin.\" Abstract excerpt: Humanin (HN) is a 24-residue peptide displaying a protective activity in vitro against a range of cytotoxic and neurotoxic insults, as well as mediating in vivo amelioration of Alzheimer disease (AD)-related memory impairment in experimental models. Published evidence suggests that the mechanisms through which HN exerts its cyto- and neuroprotective activity may include its secretion and binding t","authors":null,"publishingOrg":null,"publicationYear":2011,"doi":"10.1096/fj.10-163535","pubmedId":"21393573","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1096/fj.10-163535","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:43.435Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"075d3484-0062-43a0-8da4-2a36de229274","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities].","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/22010475/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"[Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities].\" Abstract excerpt: Humanin (HN) is a newly discovered 24-amino acid peptide, which may suppress neuronal cell death. HN cDNA includes the open reading frame (HN-ORF) of 75 bases, located 950 bases downstream of the 5' end of the HN cDNA. It was demonstrated that HN cDNA is 99% identical with mitochondrial DNA (mtDNA) sequence. HN homologues have been identified as expressed sequence tags (ESTs) in rat and nematode. ","authors":null,"publishingOrg":null,"publicationYear":2011,"doi":null,"pubmedId":"22010475","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"pmid:22010475","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:00.979Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"da14ca38-3964-4853-94db-8a7f775d7dfa","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/20651283/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice.\" Abstract excerpt: Humanin (HN), an endogenous antiapoptotic peptide, has previously been shown to protect against Alzheimer's disease and a variety of cellular insults. We evaluated the effects of a potent analog of HN (HNG) in an in vivo murine model of myocardial ischemia and reperfusion. Male C57BL6/J mice (8 to 10 week old) were subjected to 45 minutes of left coronary artery occlusion followed by a 24-hour rep","authors":null,"publishingOrg":null,"publicationYear":2010,"doi":"10.1161/atvbaha.110.205997","pubmedId":"20651283","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1161/atvbaha.110.205997","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:32.712Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"dc844a76-81b3-46b6-a11e-44039e2327a5","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin and the receptors for humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/19997871/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin and the receptors for humanin.\" Abstract excerpt: Alzheimer's disease (AD) is a prevalent dementia-causing neurodegenerative disease. Neuronal death is closely linked to the progression of AD-associated dementia. Accumulating evidence has established that a 24-amino-acid bioactive peptide, Humanin, protects neurons from AD-related neuronal death. A series of studies using various murine AD models including familial AD gene-expressing transgenic m","authors":null,"publishingOrg":null,"publicationYear":2010,"doi":"10.1007/s12035-009-8090-z","pubmedId":"19997871","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=241, totalMentions=5). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s12035-009-8090-z","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:00.454Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"9b0aa80d-4801-4dd5-81dc-88f779502ee1","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/20562421/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress.\" Abstract excerpt: Humanin (HN) is a 24-amino acid peptide that has been shown to have an anti-apoptotic function against neuronal cell death caused by Alzheimer's disease. Increased oxidative stress, one of the major factors contributing to this cell death, also plays an important role in the inflammatory process of atherosclerosis. The current study was designed to test the hypothesis that HN is expressed in the h","authors":null,"publishingOrg":null,"publicationYear":2010,"doi":"10.1093/cvr/cvq191","pubmedId":"20562421","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1093/cvr/cvq191","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:29.670Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"5545228f-09c1-4ff7-b0d3-e6aeae1b9749","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin protects neurons against apoptosis induced by Abeta31-35 through suppression of intrinsic pathway.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/20401442/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin protects neurons against apoptosis induced by Abeta31-35 through suppression of intrinsic pathway.\" Abstract excerpt: The present study aimed to investigate the effects of humanin (HN) on primary cortical neuronal apoptosis induced by Abeta31-35, and explore the potential mechanisms. Cultured cortical neurons were pretreated with different concentrations of HN (5, 10, 20 micromol/L) for different time period (0, 8 and 16 h) respectively, and then exposed to Abeta31-35 (25 micromol/L) for additional 24 h and the n","authors":null,"publishingOrg":null,"publicationYear":2010,"doi":null,"pubmedId":"20401442","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"pmid:20401442","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:29.521Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"50fcac3c-e08a-4461-9d4b-8d37f2972218","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties","sourceUrl":"https://doi.org/10.1016/s1734-1140(10)70337-6","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties\" Abstract excerpt: Humanin (HN) is a newly discovered 24-amino acid peptide, which may suppress neuronal cell death. HN cDNA includes an open reading frame (HN-ORF) of 75 bases located 950 bases downstream of the 5' end of the HN cDNA. It has been demonstrated that HN cDNA is 99% identical to the mitochondrial DNA (mtDNA) sequence. HN homologs have been identified as expressed sequence tags (ESTs) in both rats and n","authors":null,"publishingOrg":null,"publicationYear":2010,"doi":"10.1016/s1734-1140(10)70337-6","pubmedId":"21098860","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/s1734-1140(10)70337-6","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:29.596Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f04781b8-5f3c-4a6f-b8eb-bff7decd063f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Immunolocalization of humanin in human sperm and testis.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/20542501/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Immunolocalization of humanin in human sperm and testis.\" Abstract excerpt: We have discovered, by immunocytochemistry and immunoelectronmicroscopy, that humanin (HN) is expressed in human ejaculated sperm and testis. In sperm, the HN immunolabeling pattern depends on sperm morphology; in particular, HN is mainly localized in the midpiece of sperm in semen samples with normal morphology and in cytoplasmic residues and entire tail in those with abnormal morphology. We also","authors":null,"publishingOrg":null,"publicationYear":2010,"doi":"10.1016/j.fertnstert.2010.04.075","pubmedId":"20542501","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.fertnstert.2010.04.075","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:35.526Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"4f72ee6d-9d15-4445-ad6c-3972ecbb12e9","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Protective effects of [Gly14]-Humanin on beta-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/19941922/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Protective effects of [Gly14]-Humanin on beta-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction.\" Abstract excerpt: Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD), and is considered as an early event in AD pathology. Humanin (HN) and its derivative, [Gly14]-Humanin (HNG), are known for their ability to suppress neuronal death induced by AD-related insults in vitro and in vivo. In the present study, we investigated the neuroprotective effects","authors":null,"publishingOrg":null,"publicationYear":2010,"doi":"10.1016/j.neuint.2009.11.015","pubmedId":"19941922","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.neuint.2009.11.015","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:37.807Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"0cc1564c-abe8-4815-a323-e7c0acba936f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Structure changes of natively disordered Humanin in the presence of lipid.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/20116397/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Structure changes of natively disordered Humanin in the presence of lipid.\" Abstract excerpt: While neuroprotective activities of Humanin peptides have been clearly demonstrated, the functional mechanism has not been fully understood. Humanin and a majority of Humanin analogs showed a disordered structure at low peptide concentrations and aggregation at higher concentrations in aqueous solution at pH 7.0. Here we have examined the structure in lipid environments, i.e., in the presence of l","authors":null,"publishingOrg":null,"publicationYear":2010,"doi":"10.1016/j.ijbiomac.2010.01.012","pubmedId":"20116397","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.ijbiomac.2010.01.012","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:40.244Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f7649a71-336e-4d4d-904d-f2c6a745742a","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/20682300/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury.\" Abstract excerpt: Since several different pathways are involved in cerebral ischemia/reperfusion injury, combination therapy rather than monotherapy may be required for efficient neuroprotection. In this study, we examined the protective effects of an apoptosis inhibitor Gly(14)-humanin (HNG) and a necroptosis inhibitor necrostatin-1 (Nec-1) on hypoxia/ischemia/reperfusion injury. Cultured mouse primary cortical ne","authors":null,"publishingOrg":null,"publicationYear":2010,"doi":"10.1016/j.brainres.2010.07.080","pubmedId":"20682300","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.brainres.2010.07.080","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:39.079Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"080018d3-8f74-42f8-9436-7f58d12c412b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/19800083/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice.\" Abstract excerpt: Pancreatic beta-cell apoptosis is important in the pathogenesis and potential treatment of type 1 diabetes mellitus. We investigated whether Humanin, a recently described survival factor for neurons, could improve the survival of beta-cells and delay or treat diabetes in the nonobese diabetic (NOD) model. Humanin reduced apoptosis induced by serum starvation in NIT-1 cells and decreased apoptosis ","authors":null,"publishingOrg":null,"publicationYear":2010,"doi":"10.1016/j.metabol.2009.08.001","pubmedId":"19800083","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.metabol.2009.08.001","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:36.327Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"20ba7c1f-6407-427c-95d2-6bd2d84c8fe3","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Effect of [Gly14]-Humanin on Abeta(25-35)-induced PC12 cell apoptosis].","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/20423647/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"[Effect of [Gly14]-Humanin on Abeta(25-35)-induced PC12 cell apoptosis].\" Abstract excerpt: To investigate the effect of [Gly14]-Humanin overexpression on Abeta(25-35);-induced PC12 cell apoptosis. Recombinant plasmid pcDNA3.1(-)/HNG-FLAG was transfected into PC12 cells by liposome method. The subclone cell lines were obtained by persistent G418 selection. The HNG gene expression of PC12 cells was detected by immunocytochemistry. After being treated with 25 micromol/L Abeta(25-35); for 2","authors":null,"publishingOrg":null,"publicationYear":2010,"doi":null,"pubmedId":"20423647","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"pmid:20423647","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:34.787Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3afba23c-2800-4977-bf00-ed76f36fb05e","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Gly(14)]-humanin rescues long-term potentiation from amyloid beta protein-induced impairment in the rat hippocampal CA1 region in vivo.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/19768812/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"[Gly(14)]-humanin rescues long-term potentiation from amyloid beta protein-induced impairment in the rat hippocampal CA1 region in vivo.\" Abstract excerpt: The novel neuroprotective action of Humanin (HN), especially its derivative [Gly(14)]-humanin (HNG), against Alzheimer's disease (AD)-related insults has been reported. However, it is still short of electrophysiological evidence for the protection of HN on synaptic plasticity, and the molecular mechanisms that underlie the neuroprotective function of HN remain largely unknown. The present study ex","authors":null,"publishingOrg":null,"publicationYear":2010,"doi":"10.1002/syn.20707","pubmedId":"19768812","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=36, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1002/syn.20707","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:03.221Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e4cabf72-f6d7-40f8-a5b9-5307bce49add","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Evidence for potential functionality of nuclearly-encoded humanin isoforms.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/19477263/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Evidence for potential functionality of nuclearly-encoded humanin isoforms.\" Abstract excerpt: Humanin (HN) is a recently identified neuroprotective and antiapoptotic peptide derived from a portion of the mitochondrial MT-RNR2 gene. We provide bioinformatic and expression data suggesting the existence of 13 MT-RNR2-like nuclear loci predicted to maintain the open reading frames of 15 distinct full-length HN-like peptides. At least ten of these nuclear genes are expressed in human tissues, a","authors":null,"publishingOrg":null,"publicationYear":2009,"doi":"10.1016/j.ygeno.2009.05.006","pubmedId":"19477263","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.ygeno.2009.05.006","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:42.328Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"bc64c07a-2aa8-4bc7-ae44-beeac1d8ac1a","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/19386761/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.\" Abstract excerpt: Humanin (HN) inhibits neuronal death induced by various Alzheimer's disease (AD)-related insults via an unknown receptor on cell membranes. Our earlier study indicated that the activation of STAT3 was essential for HN-induced neuroprotection, suggesting that the HN receptor may belong to the cytokine receptor family. In this study, a series of loss-of-function tests indicated that gp130, the commo","authors":null,"publishingOrg":null,"publicationYear":2009,"doi":"10.1091/mbc.e09-02-0168","pubmedId":"19386761","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1091/mbc.e09-02-0168","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:30.847Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"961e916d-5656-4e6f-a352-40615ceb9891","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin structural versatility and interaction with model cerebral cortex membranes.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/19378954/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin structural versatility and interaction with model cerebral cortex membranes.\" Abstract excerpt: Humanin (HN) is a recently identified neuroprotective peptide able to inhibit neurotoxicity induced by various insults which can be related to Alzheimer disease (AD) as well as to cell death induced by other stimuli. Previous CD and NMR studies demonstrated that HN adopts an unordered conformation in water, a alpha-helix conformation in 30% TFE, and a beta-sheet structure in PBS. Furthermore, othe","authors":null,"publishingOrg":null,"publicationYear":2009,"doi":"10.1021/bi900187s","pubmedId":"19378954","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1021/bi900187s","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:29.742Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"8cc39a8b-93fa-4bfc-9bb6-876d5ea6296c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin: a novel central regulator of peripheral insulin action.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/19623253/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin: a novel central regulator of peripheral insulin action.\" Abstract excerpt: Decline in insulin action is a metabolic feature of aging and is involved in the development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD). A novel mitochondria-associated peptide, Humanin (HN), has a neuroprotective role against AD-related neurotoxicity. Considering the association between insulin resistance and AD, we investigated if HN influences","authors":null,"publishingOrg":null,"publicationYear":2009,"doi":"10.1371/journal.pone.0006334","pubmedId":"19623253","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1371/journal.pone.0006334","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:29.815Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"8095ce65-0322-48cd-8c0a-983efa11f19f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin; a defender against Alzheimer's disease?","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/19149712/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin; a defender against Alzheimer's disease?\" Abstract excerpt: Alzheimer's disease (AD) is the most prevalent neurological disease with dementia. AD-related dementia is caused by death and dysfunction of neurons involved in cognitive function. It has been generally believed that increased levels of toxic amyloid-betas (Abetas) are linked to the occurrence of neuronal death as well as dysfunction (Abeta cascade theory). Consequently, lowering levels of toxic A","authors":null,"publishingOrg":null,"publicationYear":2009,"doi":"10.2174/157488909787002609","pubmedId":"19149712","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2174/157488909787002609","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:29.890Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"b60923bf-7eb4-485c-beca-e7bd332e0ca4","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/19703422/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin.\" Abstract excerpt: Humanin (HN) inhibits Alzheimer's disease (AD)-relevant neuronal death and dysfunction, by interacting with a receptor (s) involving ciliary neurotrophic factor receptor alpha (CNTFR), WSX-1, and gp130. It remains unknown whether this complex is the sole HN receptor that mediates HN-induced anti-AD activity. We here report that an alternatively spliced WSX-1 isoform, encoding an extracellular 270-","authors":null,"publishingOrg":null,"publicationYear":2009,"doi":"10.1016/j.bbrc.2009.08.095","pubmedId":"19703422","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbrc.2009.08.095","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:44.918Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"1de3c87e-565f-429a-8fb6-0a478792cc52","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/19666070/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives.\" Abstract excerpt: Humanin (HN) and HN-derivatives are a family of peptides first reported in the last decade with potent in vitro and in vivo neuroprotective activity, which is mediated through a not completely elucidated mechanism. Recently, our group has evaluated the effect of various HN-derivatives on the 3-quinuclidinyl benzilate (QNB)-induced impairment of spatial orientation and memory in rats, by employing ","authors":null,"publishingOrg":null,"publicationYear":2009,"doi":"10.1016/j.peptides.2009.07.028","pubmedId":"19666070","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.peptides.2009.07.028","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:44.030Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"44ec4af2-1426-4351-880c-99036631e06c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Opposing Roles of Insulin-Like Growth Factor Binding Protein 3 and Humanin in the Regulation of Testicular Germ Cell Apoptosis","sourceUrl":"https://doi.org/10.1210/en.2009-0577","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Opposing Roles of Insulin-Like Growth Factor Binding Protein 3 and Humanin in the Regulation of Testicular Germ Cell Apoptosis\" Abstract excerpt: Modulating germ cell death and survival have significant therapeutic potential for male infertility and contraception. We have shown previously that IGF binding protein 3 (IGFBP3) gene expression is up-regulated in human testis when germ cell apoptosis is induced by intratesticular hormonal deprivation created by testosterone administration. Humanin (HN) is a binding partner of IGFBP3, and both ar","authors":null,"publishingOrg":null,"publicationYear":2009,"doi":"10.1210/en.2009-0577","pubmedId":"19952275","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1210/en.2009-0577","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:43.067Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"ca10dda3-b732-4621-bdea-6c5382cf8b8b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Activity-dependent neurotrophic factor, ADNF, determines the structure characteristics of Colivelin, a fusion protein of ADNF9 and Humanin analog.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/17994638/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Activity-dependent neurotrophic factor, ADNF, determines the structure characteristics of Colivelin, a fusion protein of ADNF9 and Humanin analog.\" Abstract excerpt: A 24-amino acid long peptide, Humanin, protects neurons from Alzheimer's disease (AD)-related cell toxicities at sub-nM-uM concentrations. Activity-dependent neurotrophic factor (ADNF) is a glia-derived neurotrophic peptide, which protects neurons from tetrodoxin treatment and AD-related and amyotrophic lateral sclerosis-related insults at fM concentrations. An attempt was made to further improve ","authors":null,"publishingOrg":null,"publicationYear":2008,"doi":"10.1002/psc.959","pubmedId":"17994638","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1002/psc.959","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:44.770Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"eff78bdd-2cae-4f64-804d-246f723362a8","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway","sourceUrl":"https://doi.org/10.1016/j.brainres.2008.06.018","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway\" Abstract excerpt: Humanin (HN) is an anti-apoptotic peptide that suppresses neuronal cell death induced by Alzheimer's disease, prion protein fragments, and serum deprivation. Recently, we demonstrated that Gly14-HN (HNG), a variant of HN in which the 14th amino acid serine is replaced with glycine, can decrease apoptotic neuronal death and reduce infarct volume in a focal cerebral ischemia/reperfusion mouse model.","authors":null,"publishingOrg":null,"publicationYear":2008,"doi":"10.1016/j.brainres.2008.06.018","pubmedId":"18590709","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.brainres.2008.06.018","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:36.626Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"8aa80cf3-63b5-474b-905e-67f6326ecaaf","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Structural and dynamical studies of Humanin in water and TFE/water mixture: a molecular dynamics simulation.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/18597547/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Structural and dynamical studies of Humanin in water and TFE/water mixture: a molecular dynamics simulation.\" Abstract excerpt: The structural and dynamical properties of Humanin, a small peptide with neuroprotective activity against the insults of the Alzheimer's disease-related genes and the neurotoxic amyloid peptide, are studied in two different environments by molecular dynamics simulation. In this study, we have performed comparative molecular dynamics simulations in the absence and in the presence of TFE. The result","authors":null,"publishingOrg":null,"publicationYear":2008,"doi":"10.1080/07391102.2008.10507241","pubmedId":"18597547","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1080/07391102.2008.10507241","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:39.388Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"58525b9e-d733-482b-b8fa-86188eef2721","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The complex structure transition of Humanin peptides by sodium dodecylsulfate and trifluoroethanol.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/18537742/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The complex structure transition of Humanin peptides by sodium dodecylsulfate and trifluoroethanol.\" Abstract excerpt: We have examined the structure of two Humanin (HN) analog peptides, HNG and AGA-(C8R)HNG17, in the presence of sodium dodecylsulfate (SDS) and trifluoroethanol (TFE) using CD and sedimentation velocity. Both HNG and AGA-(C8R)HNG17 underwent complex conformational changes with increasing concentrations of SDS and TFE, in contrast to general trend of increasing alpha-helix with their concentration. ","authors":null,"publishingOrg":null,"publicationYear":2008,"doi":"10.2174/092986608784567555","pubmedId":"18537742","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2174/092986608784567555","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:39.470Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"ab5c5ce7-ef68-4169-84fd-51d5202b31e0","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues","sourceUrl":"https://doi.org/10.1016/j.peptides.2008.06.019","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues\" Abstract excerpt: Humanin (HN) and its analogues have been shown to protect cells against death induced by various Alzheimer's disease (AD) genes and amyloid-beta-peptides in vitro; the analogues [Gly(14)]-HN and colivelin have also been shown to be potent in reversing learning and memory impairment induced by scopolamine or quinuclidinyl benzilate (QNB) in mice or rats in vivo using the Y-maze or multiple T-maze t","authors":null,"publishingOrg":null,"publicationYear":2008,"doi":"10.1016/j.peptides.2008.06.019","pubmedId":"18647630","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.peptides.2008.06.019","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:43.510Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e076f3bb-368c-45c0-b2f2-ab078c1ec99e","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Mapping the specific cytoprotective interaction of humanin with the pro-apoptotic protein bid.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/17927731/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Mapping the specific cytoprotective interaction of humanin with the pro-apoptotic protein bid.\" Abstract excerpt: Humanin is a short endogenous peptide, which can provide protection from cell death through its association with various receptors, including the pro-apoptotic Bcl-2 family proteins Bid, Bim, and Bax. By using NMR chemical shift mapping experiments, we demonstrate that the interaction between Humanin-derived peptides and Bid is specific, and we localize the binding site to a region on the surface ","authors":null,"publishingOrg":null,"publicationYear":2007,"doi":"10.1111/j.1747-0285.2007.00576.x","pubmedId":"17927731","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/j.1747-0285.2007.00576.x","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:41.431Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"9f581209-e3a1-416e-961e-1853cbe473e1","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Structural preferences of neuroprotective S14G-humanin peptide analyzed by molecular modeling and circular dichroism.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/17627606/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Structural preferences of neuroprotective S14G-humanin peptide analyzed by molecular modeling and circular dichroism.\" Abstract excerpt: S14G-humanin (S14G-HN) is one of the latest of a new family of neuropeptides with protective action against Alzheimer's disease insults. The structure of S14G-HN was studied with both spectroscopic techniques and molecular dynamics simulation. Secondary structure predictions and modeling of backbone conformation were carried out. Side chain reconstruction, homology modeling and molecular dynamics ","authors":null,"publishingOrg":null,"publicationYear":2007,"doi":"10.2174/092986607780989903","pubmedId":"17627606","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2174/092986607780989903","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:41.143Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"182b16e6-5c79-4cbb-a071-99526fb45b4c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/16619233/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis.\" Abstract excerpt: Humanin (HN) is a 24 amino acids peptide with potent neuro-survival properties that protects against damage associated with Alzheimer's disease. In the present report, we have demonstrated by immunohistochemical analysis and Western blotting the pattern of expression of rat humanin (HNr) in the testis of 10- to 60-day-old rats. The Leydig cells of 10- and 40- day-old rats expressed this peptide at","authors":null,"publishingOrg":null,"publicationYear":2006,"doi":"10.1002/jcp.20672","pubmedId":"16619233","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1002/jcp.20672","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:35.303Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"dd63bede-384d-4f2f-8cc1-f588c3eda1c1","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Is a Novel Neuroprotective Agent Against Stroke","sourceUrl":"https://doi.org/10.1161/01.str.0000242772.94277.1f","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin Is a Novel Neuroprotective Agent Against Stroke\" Abstract excerpt: Humanin (HN) is a 24-amino acid peptide best known for its ability to protect neurons from damage caused by Alzheimer disease-related proteins. This study examines the neuroprotective effects of HNG (a potent form of HN) on focal cerebral ischemia/reperfusion injury in mice. Mice underwent middle cerebral artery occlusion for 75 minutes followed by 24-hour reperfusion. Mice were pretreated with 0.","authors":null,"publishingOrg":null,"publicationYear":2006,"doi":"10.1161/01.str.0000242772.94277.1f","pubmedId":"16960089","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"Gly(14)-Humanin\"). Imported evidence lane: contextual_unclassified. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1161/01.str.0000242772.94277.1f","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:31.664Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3633bc53-6645-411b-8608-ecee85a9de8a","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/16958985/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis.\" Abstract excerpt: Humanin (HN), a 24-amino-acid neuroprotective peptide, was originally found in the occipital lobe of an autopsied Alzheimer's disease (AD) patient. HN inhibits neuronal death by binding to its specific receptor on the cell membrane and triggering a Jak2/STAT3 prosurvival pathway. The activation of this pathway may represent a therapeutic approach to AD. HN also exhibits neuroprotective activity ag","authors":null,"publishingOrg":null,"publicationYear":2006,"doi":"10.1111/j.1527-3458.2006.00113.x","pubmedId":"16958985","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/j.1527-3458.2006.00113.x","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:30.038Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"22ad52b3-7a29-4059-9233-053a0445a45b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia","sourceUrl":"https://doi.org/10.1007/s10038-006-0397-2","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia\" Abstract excerpt: We showed that humanin (HN), an endogenous peptide against Alzheimer disease-related insults, was expressed in muscles of patients with chronic progressive external ophthalmoplegia (CPEO), a major mitochondrial disease. Because HN was recently found to block proapoptotic Bax function and exert its versatile cytoprotective effects in association with an increase in ATP levels, HN expression may thu","authors":null,"publishingOrg":null,"publicationYear":2006,"doi":"10.1007/s10038-006-0397-2","pubmedId":"16639504","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s10038-006-0397-2","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:29.963Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f635454f-dd83-476a-9b99-a47f743a755c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits an unknown post-cysteine cleavage specificity.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/16700513/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits an unknown post-cysteine cleavage specificity.\" (identity confirmed; no abstract text available to excerpt.)","authors":null,"publishingOrg":null,"publicationYear":2006,"doi":"10.1007/0-387-32824-6_11","pubmedId":"16700513","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/0-387-32824-6_11","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:42.403Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3eb1e54d-dee2-4381-bce3-bde261c4f4a3","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/16945331/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease.\" Abstract excerpt: The NMR solution study of Ser14Gly-humanin (S14G-HN), a 1000-fold more potent derivative of humanin (HN), is reported. HN is 24-residue peptide that selectively suppresses neuronal cell death caused by Alzheimer's disease (AD)-specific insults and offers hope for the development of a cure against AD. In aqueous solution the NMR data show that S14G-HN is a flexible peptide with turn-like structures","authors":null,"publishingOrg":null,"publicationYear":2006,"doi":"10.1016/j.bbrc.2006.08.087","pubmedId":"16945331","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbrc.2006.08.087","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:38.102Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"85567766-6109-4101-bb3c-06d9d2e5fbdb","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"The secondary structure analysis of a potent Ser14Gly analog of antiAlzheimer peptide, Humanin, by circular dichroism.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/16835886/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"The secondary structure analysis of a potent Ser14Gly analog of antiAlzheimer peptide, Humanin, by circular dichroism.\" Abstract excerpt: The structure of a highly potent Ser14Gly analog of antiAlzheimer peptide, Humanin, was examined by circular dichroism (CD). The secondary structure is more disordered in water than in phosphate-buffered saline (PBS). The peptide structure in water is little dependent on both peptide concentration and temperature. On the contrary, the peptide structure was significantly different in PBS from the s","authors":null,"publishingOrg":null,"publicationYear":2006,"doi":"10.1002/psc.773","pubmedId":"16835886","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1002/psc.773","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:44.174Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"56481087-fe0b-446a-9e6f-86672086b451","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Zinc(II) binds to the neuroprotective peptide humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/16844225/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Zinc(II) binds to the neuroprotective peptide humanin.\" Abstract excerpt: The abnormal accumulation of the peptide amyloid-beta in the form of senile (or amyloid) plaques is one of the hallmarks of Alzheimer's disease (AD). Zinc ions have been implicated in AD and plaques formation. Recently, the peptide humanin has been discovered. Humanin showed neuroprotective activity against amyloid-beta insults. Here the question investigated is if humanin could interact directly ","authors":null,"publishingOrg":null,"publicationYear":2006,"doi":"10.1016/j.jinorgbio.2006.06.002","pubmedId":"16844225","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.jinorgbio.2006.06.002","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:40.987Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"2cc6b240-0910-44bc-8869-7fc935fbdff8","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system].","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/16583711/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system].\" Abstract excerpt: Humanine is a human neuroprotective peptide with a wide action spectrum. To analyze molecular mechanisms of humanin functioning, a search for proteins interacting with this peptide was conducted using yeast two-hybrid system. Screening of human fetal brain cDNA library identified seven proteins with different functions that specifically interacted with humanin.","authors":null,"publishingOrg":null,"publicationYear":2006,"doi":"10.1134/s1022795406020141","pubmedId":"16583711","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1134/s1022795406020141","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:43.653Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"7e2033f0-22c0-45d2-8f56-ec2811753dcd","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Recent progress in neuroprotection of humanin against Alzheimer's disease-relevant neurotoxicity].","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/17262962/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"[Recent progress in neuroprotection of humanin against Alzheimer's disease-relevant neurotoxicity].\" Abstract excerpt: Alzheimer's disease (AD) is the leading cause of dementia for aging people, and far from control due to its obscure mechanism. Humanin, a 24-aa peptide encoded by a newly identified gene cloned from an apparently normal region of AD brain, can specifically attenuate AD-related neurotoxicity. It protects neurons from insults of various AD genes, anti-APP antibodies and Abeta by forming a homodimer ","authors":null,"publishingOrg":null,"publicationYear":2006,"doi":null,"pubmedId":"17262962","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"pmid:17262962","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:39.939Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"c08b67c4-ad6d-46f9-8f31-f728be76420f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"A humanin derivative, S14G‐HN, prevents amyloid‐β‐induced memory impairment in mice","sourceUrl":"https://doi.org/10.1002/jnr.20391","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"A humanin derivative, S14G‐HN, prevents amyloid‐β‐induced memory impairment in mice\" Abstract excerpt: Humanin (HN) is a 24-amino acid peptide that protects neuronal cells from death caused by Alzheimer's disease (AD)-related genes and amyloid-beta (Abeta). Multiple studies have revealed its biochemical and neuroprotective characteristics in vitro; however, little has been known regarding whether HN is effective in vivo in AD model systems. We examined the effect of S14G-HN, a 1,000-fold more poten","authors":null,"publishingOrg":null,"publicationYear":2005,"doi":"10.1002/jnr.20391","pubmedId":"15678515","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1002/jnr.20391","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:32.111Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"1d4d9e59-f900-4a44-a4a9-2c735c75acb6","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Construction of a eukaryotic expression plasmid of Humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/15593385/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Construction of a eukaryotic expression plasmid of Humanin.\" Abstract excerpt: To construct a eukaryotic expression plasmid pcDNA3.1(-)-Humanin. The recombinant plasmid pGEMEX-1-Humanin was digested with restriction endonucleases BamH I and Hind III and the Humanin gene fragments, about 100 bp length, were obtained. Then the Humanin gene fragments were inserted into eukaryotic expression vector pcDNA3.1(-) and the recombinant plasmids pcDNA3.1(-)-Humanin were identified by s","authors":null,"publishingOrg":null,"publicationYear":2005,"doi":"10.1631/jzus.2005.b0011","pubmedId":"15593385","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1631/jzus.2005.b0011","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:41.583Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"69a27562-fdbf-47a8-a821-e2438cf291ca","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL","sourceUrl":"https://doi.org/10.1074/jbc.m413062200","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL\" Abstract excerpt: Humanin (HN) is a recently identified endogenous peptide that protects cells against cytotoxicity induced by various stimuli. Recently, we showed that HN binds to and inhibits Bax, a proapoptotic Bcl-2 family protein, suggesting a mechanism for HN action. In this study, we identified Bim, a Bcl-2 homology 3-only member of the Bcl-2/Bax family, as an additional HN target protein. Using in vitro pro","authors":null,"publishingOrg":null,"publicationYear":2005,"doi":"10.1074/jbc.m413062200","pubmedId":"15661735","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1074/jbc.m413062200","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:35.886Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"95bc6994-eb96-4b0f-92ae-f568c75d52f1","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Development of a Femtomolar-Acting Humanin Derivative Named Colivelin by Attaching Activity-Dependent Neurotrophic Factor to Its N Terminus: Characterization of Colivelin-Mediated Neuroprotection against Alzheimer's Disease-Relevant InsultsIn VitroandIn Vivo","sourceUrl":"https://doi.org/10.1523/jneurosci.3348-05.2005","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Development of a Femtomolar-Acting Humanin Derivative Named Colivelin by Attaching Activity-Dependent Neurotrophic Factor to Its N Terminus: Characterization of Colivelin-Mediated Neuroprotection against Alzheimer's Disease-Relevant InsultsIn VitroandIn Vivo\" Abstract excerpt: Alzheimer's disease (AD) is the most common cause of dementia. Humanin (HN) is a short bioactive peptide abolishing neuronal cell death induced by various familial AD (FAD)-causative genes and amyloid-beta (Abeta) in vitro. It has been shown that HN suppresses memory impairment of mice induced by intracerebroventricular administration of Abeta. To potentiate the neuroprotective effect of HN, we sy","authors":null,"publishingOrg":null,"publicationYear":2005,"doi":"10.1523/jneurosci.3348-05.2005","pubmedId":"16267233","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1523/jneurosci.3348-05.2005","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:39.152Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"ca693e68-c22f-4ab9-8c0f-5774f65864b1","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Effect of humanin on decreased ATP levels of human lymphocytes harboring A3243G mutant mitochondrial DNA","sourceUrl":"https://doi.org/10.1016/j.npep.2004.11.004","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Effect of humanin on decreased ATP levels of human lymphocytes harboring A3243G mutant mitochondrial DNA\" Abstract excerpt: Humanin (HN) was originally identified as an endogenous peptide that protects neuronal cells from apoptosis by mutant Alzheimer's disease genes. This 24-residue peptide has been recently shown to suppress apoptosis by interfering with activation of Bcl-2-associated X protein (Bax) in cytosol. In the present study, we showed that HN increases ATP levels in human lymphocytes, muscular TE671 cells, a","authors":null,"publishingOrg":null,"publicationYear":2005,"doi":"10.1016/j.npep.2004.11.004","pubmedId":"15752543","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.npep.2004.11.004","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:33.231Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"fcf8a1e0-0cb4-46bd-8119-00ef05ee1a38","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Attenuates Apoptosis Induced by DRPLA Proteins With Expanded Polyglutamine Stretches","sourceUrl":"https://doi.org/10.1385/jmn:25:2:165","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin Attenuates Apoptosis Induced by DRPLA Proteins With Expanded Polyglutamine Stretches\" Abstract excerpt: Dentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal-dominant neurodegenerative disorder caused by expansion of CAG repeats in the DRPLA gene, which codes for a polyglutamine (polyQ) stretch. The expanded polyQs are known to form intracellular aggregates and to confer neurotoxic activity. Recent studies have indicated that activation of apoptosis signal-regulating kinase 1 (ASK1) is involv","authors":null,"publishingOrg":null,"publicationYear":2005,"doi":"10.1385/jmn:25:2:165","pubmedId":"15784964","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1385/jmn:25:2:165","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:30.110Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"05e3eadb-028f-461d-90b7-56693f48ec8b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak","sourceUrl":"https://doi.org/10.1074/jbc.m411902200","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak\" Abstract excerpt: Recently, we discovered that Humanin (HN), a small endogenous peptide of 24 amino acids, binds to and inhibits the proapoptotic protein Bax. We show here that HN also interacts with the BH3-only Bcl-2/Bax family protein, Bid, as well as a truncated form of Bid (tBid) associated with protease-mediated activation of this proapoptotic protein. Synthetic HN peptide binds purified Bid and tBid in vitro","authors":null,"publishingOrg":null,"publicationYear":2005,"doi":"10.1074/jbc.m411902200","pubmedId":"15661737","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1074/jbc.m411902200","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:30.995Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3d552e88-9758-4fa2-a981-919fa37215f1","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase","sourceUrl":"https://doi.org/10.1007/s10495-005-1191-x","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase\" Abstract excerpt: Humanin (HN) is a newly identified neuroprotective peptide. In this study, we investigated its antiapoptotic effect and the potential mechanisms in K562 cells. Upon serum deprivation, expression of HN in K562 cells decreased and its intracellular distribution changed from cytoplasm to cell membrane. In HN stably transfected K562 cells, apoptosis was delayed compared with control vector transfected","authors":null,"publishingOrg":null,"publicationYear":2005,"doi":"10.1007/s10495-005-1191-x","pubmedId":"16151632","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s10495-005-1191-x","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:30.923Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e34742fb-5811-42d1-a255-08c5c500ec4b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent","sourceUrl":"https://doi.org/10.1007/s00401-004-0965-5","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent\" Abstract excerpt: Humanin (HN) was originally identified as an endogenous peptide that protects neuronal cells from apoptosis induced by various types of Alzheimer's disease-related insults. We have previously indicated that HN increases cellular ATP levels and speculated that this peptide may rescue energy-deficient cells in mitochondrial disorders. Here, we report, for the first time, increased HN expression in s","authors":null,"publishingOrg":null,"publicationYear":2005,"doi":"10.1007/s00401-004-0965-5","pubmedId":"15759134","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s00401-004-0965-5","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:31.738Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f2690347-1d9e-4cfb-9d00-46ae1676f544","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/15567815/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality.\" Abstract excerpt: To define the pathogenesis of pigmented villonodular synovitis (PVNS), by searching for highly expressed genes in primary synovial cells from patients with PVNS. A combination of subtraction cloning and Southern colony hybridisation was used to detect highly expressed genes in PVNS in comparison with rheumatoid synovial cells. Northern hybridisation was performed to confirm the differential expres","authors":null,"publishingOrg":null,"publicationYear":2005,"doi":"10.1136/ard.2004.025445","pubmedId":"15567815","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1136/ard.2004.025445","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:36.255Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f4a69342-22a1-4673-9814-f7a53582488d","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/16005025/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.\" Abstract excerpt: Humanin (HN) inhibits neuronal cell death induced by various Alzheimer's disease (AD)-related insults. It has been proposed that HN binds to a putative receptor on the cell membrane and triggers a signal transduction cascade linked to neuroprotection. Recently, it was shown that HN binds to pertussis toxin (PTX)-sensitive G protein-coupled formylpeptide receptor-like-1 molecule (FPRL-1), reduces A","authors":null,"publishingOrg":null,"publicationYear":2005,"doi":"10.1016/j.lfs.2005.03.031","pubmedId":"16005025","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.lfs.2005.03.031","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:40.838Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"53fee145-a86f-44f4-a9e4-63ca16d429a4","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/15721287/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity.\" Abstract excerpt: Humanin is a newly identified 24-residue peptide that suppresses neuronal cell death caused by a wide spectrum of familial Alzheimer's disease genes and the beta-amyloid peptide. In this study, NMR and circular dichroism studies of synthetic humanin in aqueous and 30% 2,2,2-trifluoroethanol (TFE) solutions are reported. In aqueous solution, humanin exists predominantly in an unstructured conformat","authors":null,"publishingOrg":null,"publicationYear":2005,"doi":"10.1016/j.bbrc.2005.01.100","pubmedId":"15721287","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbrc.2005.01.100","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:35.380Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"ad5eae8d-26c4-4ff9-adb9-d6a6edbdddbd","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Effect of humanin analogues on experimentally induced impairment of spatial memory in rats.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/15526713/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Effect of humanin analogues on experimentally induced impairment of spatial memory in rats.\" Abstract excerpt: Humanin and its analogues have been shown to protect cells against death induced by various Alzheimer's disease genes and amyloid-beta-peptides in vitro: the analogue [Gly14]-humanin has also been shown to be potent in reversing learning and memory impairment induced by scopolamine in mice in vivo. It is important to validate these results by using other behavioral methods. In this study, the effe","authors":null,"publishingOrg":null,"publicationYear":2004,"doi":"10.1002/psc.569","pubmedId":"15526713","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=4). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1002/psc.569","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:03.292Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"cba9b59e-d0ae-4dc9-b614-8f007ac6f9ba","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"High-yield, solid-phase synthesis of humanin, an Alzheimer's disease associated, novel 24-mer peptide which contains a difficult sequence.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/15526712/","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"High-yield, solid-phase synthesis of humanin, an Alzheimer's disease associated, novel 24-mer peptide which contains a difficult sequence.\" Abstract excerpt: Humanin is a novel, 24-mer residue bioactive peptide, which antagonizes Alzheimer's disease (AD) related neurotoxicity and offers a hope for developing new therapeutics against AD. Access to adequate amounts of pure humanin is a prerequisite for further, thorough, investigation of the pharmacological properties and therapeutic potency of the peptide. Until now, humanin has been obtained mainly by ","authors":null,"publishingOrg":null,"publicationYear":2004,"doi":"10.1002/psc.572","pubmedId":"15526712","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1002/psc.572","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:39.708Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"f2df4ab7-9f47-4cf1-aaea-a2b08d0288a2","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/15128389/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin.\" Abstract excerpt: The 24-residue peptide Humanin (HN) protects neuronal cells from insults of various Alzheimer's disease (AD) genes and Abeta by forming a homodimer. We have previously shown that P3A, S7A, C8A, L9A, L12A, T13A, S14A and P19A mutations nullify the neuroprotective function of HN [Yamagishi, Y., Hashimoto, Y., Niikura, T. & Nishimoto, I. (2003) Peptides, 24, 585-595]. Here we examined whether any of ","authors":null,"publishingOrg":null,"publicationYear":2004,"doi":"10.1111/j.0953-816x.2004.03298.x","pubmedId":"15128389","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1111/j.0953-816x.2004.03298.x","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:30.183Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"ca346296-7616-401c-a68d-270f81d7c0e2","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/15153530/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor.\" Abstract excerpt: Alzheimer's disease (AD) is characterized by overproduction of beta amyloid peptides in the brain with progressive loss of neuronal cells. The 42-aa form of the beta amyloid peptide (Abeta(42)) is implied as a major causative factor, because it is toxic to neurons and elicits inflammatory responses in the brain by activating microglial cells. Despite the overproduction of Abeta(42), AD brain tissu","authors":null,"publishingOrg":null,"publicationYear":2004,"doi":"10.4049/jimmunol.172.11.7078","pubmedId":"15153530","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.4049/jimmunol.172.11.7078","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:30.327Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"d03e6106-bb61-402b-8d16-1093e737144c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin: After the Discovery","sourceUrl":"https://doi.org/10.1385/mn:30:3:327","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin: After the Discovery\" Abstract excerpt: Humanin (HN) is a novel neuroprotective factor that consists of 24 amino acid residues. HN suppresses neuronal cell death caused by Alzheimer's disease (AD)-specific insults, including both amyloid-beta (betaAbeta) peptides and familial AD-causative genes. Cerebrovascular smooth muscle cells are also protected from Abeta toxicity by HN, suggesting that HN affects both neuronal and non-neuronal cel","authors":null,"publishingOrg":null,"publicationYear":2004,"doi":"10.1385/mn:30:3:327","pubmedId":"15655255","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1385/mn:30:3:327","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:30.255Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"983269c3-ff96-4898-b45d-bcb124d92582","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/15619032/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide.\" Abstract excerpt: Podocyte alpha-actinin-4 (actinin-4) is an essential component of the glomerular filtration barrier. We recently reported that the central rod spectrin-like repeats (R1-R4) of actinin-4 have a high affinity to puromycin aminonucleoside (PAN), which can induce nephro-sis in animals. The aim of this study was to identify endogenous molecules that interact with the actinin-4 R1-R4 domain. To identify","authors":null,"publishingOrg":null,"publicationYear":2004,"doi":"10.1007/s10157-004-0322-y","pubmedId":"15619032","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s10157-004-0322-y","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:42.994Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"87230c1a-ed5b-4f34-b894-de576aeb74e5","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"N-Formylated humanin activates both formyl peptide receptor-like 1 and 2","sourceUrl":"https://doi.org/10.1016/j.bbrc.2004.09.046","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"N-Formylated humanin activates both formyl peptide receptor-like 1 and 2\" Abstract excerpt: We have discovered that humanin (HN) acts as a ligand for formyl peptide receptor-like 1 (FPRL1) and 2 (FPRL2). This discovery was based on our finding that HN suppressed forskolin-induced cAMP production in Chinese hamster ovary (CHO) cells expressing human FPRL1 (CHO-hFPRL1) or human FPRL2 (CHO-hFPRL2). In addition, we found that N-formylated HN (fHN) performed more potently as a ligand for FPRL","authors":null,"publishingOrg":null,"publicationYear":2004,"doi":"10.1016/j.bbrc.2004.09.046","pubmedId":"15465011","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.bbrc.2004.09.046","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:33.970Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"c83908b5-97f4-43b2-8cd4-afc14c644c22","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Unravelling the role of Humanin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/15106598/","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Unravelling the role of Humanin.\" Abstract excerpt: Humanin (HN), a recently identified neuroprotective factor against Alzheimer's disease-related insults, has been reported to function as an anti cell-death factor through multiple mechanisms. One mechanism, revealed in a glioblastoma cell line, involves the apoptosis-inducing protein Bax. This, in addition to the fact that HN is produced in certain normal tissues, such as testis, implies a potenti","authors":null,"publishingOrg":null,"publicationYear":2004,"doi":"10.1016/j.molmed.2004.01.001","pubmedId":"15106598","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.molmed.2004.01.001","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:36.179Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"2a31a348-0274-4644-851d-8f87bb0ddfda","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease‐relevant insults","sourceUrl":"https://doi.org/10.1046/j.1460-9568.2003.02553.x","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease‐relevant insults\" Abstract excerpt: Humanin (HN) is a newly identified neuroprotective peptide that specifically suppresses Alzheimer's disease (AD)-related neurotoxicity. HN peptide has been detected in the human AD brain as well as in mouse testis and colon by immunoblot and immunohistochemical analyses. By means of yeast two-hybrid screening, we identified TRIM11 as a novel HN-interacting protein. TRIM11, which is a member of pro","authors":null,"publishingOrg":null,"publicationYear":2003,"doi":"10.1046/j.1460-9568.2003.02553.x","pubmedId":"12670303","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1046/j.1460-9568.2003.02553.x","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:42.255Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"73038efc-ac23-41e9-a195-37249f076755","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin improves impaired metabolic activity and prolongs survival of serum-deprived human lymphocytes","sourceUrl":"https://doi.org/10.1023/a:1027372519726","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Humanin improves impaired metabolic activity and prolongs survival of serum-deprived human lymphocytes\" Abstract excerpt: Humanin (HN) has been reported to be an endogenous peptide that exerts highly selective neuroprotection against cell death induced by various types of Alzheimer's disease-related insults. We previously proposed the much broader cytoprotective potential of HN from the result that HN suppressed serum-deprivation-induced death of rat pheochromocytoma cells. In this study, we showed that HN also suppr","authors":null,"publishingOrg":null,"publicationYear":2003,"doi":"10.1023/a:1027372519726","pubmedId":"14674685","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1023/a:1027372519726","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:31.067Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3704a24c-10ae-4994-9810-9c5d4c8f7aff","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin peptide suppresses apoptosis by interfering with Bax activation","sourceUrl":"https://doi.org/10.1038/nature01627","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin peptide suppresses apoptosis by interfering with Bax activation\" Abstract excerpt: Bax (Bcl2-associated X protein) is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases. Bax resides in an inactive state in the cytosol of many cells. In response to death stimuli, Bax protein undergoes conformational changes that expose membrane-targeting domains, resulting in its translocation to mitochondrial membranes, where Bax inser","authors":null,"publishingOrg":null,"publicationYear":2003,"doi":"10.1038/nature01627","pubmedId":"12732850","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1038/nature01627","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:31.884Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"62b467e7-d211-4eff-b4bc-11f15c1c9cf4","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Aβ1–40","sourceUrl":"https://doi.org/10.1016/s0196-9781(03)00131-1","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Aβ1–40\" Abstract excerpt: Humanin peptides (including HN, HNG and other mutants) were reported previously that antagonize neurotoxicity caused by various familial Alzheimer's disease (FAD) genes and Abeta derivatives. Herein, we describe the aggregation dynamics and the representative morphological characteristics of Abeta(1-40) after different time of addition humanin peptides, which revealed that (a) the interactions of ","authors":null,"publishingOrg":null,"publicationYear":2003,"doi":"10.1016/s0196-9781(03)00131-1","pubmedId":"12895653","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=2). Imported evidence lane: preclinical_animal. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/s0196-9781(03)00131-1","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:00.524Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"e66e3172-fde5-4a2b-a7b8-f9ec18bd1e1f","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin rescues cortical neurons from prion-peptide-induced apoptosis","sourceUrl":"https://doi.org/10.1016/j.mcn.2003.09.017","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Humanin rescues cortical neurons from prion-peptide-induced apoptosis\" Abstract excerpt: We recently demonstrated that a soluble oligomeric prion peptide, the putative 118-135 transmembrane domain of prion protein (PrP), exhibited membrane fusogenic properties and induced apoptotic cell death both in vitro and in vivo. A recently discovered rescue factor humanin (HN) was shown to protect neuronal cells from various insults involved in human neurodegenerative diseases. We thus addresse","authors":null,"publishingOrg":null,"publicationYear":2003,"doi":"10.1016/j.mcn.2003.09.017","pubmedId":"14962743","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.mcn.2003.09.017","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:31.811Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"0bb000f1-ed31-4835-9698-bed68ccd5cef","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin rescues human cerebrovascular smooth muscle cells from Aβ‐induced toxicity","sourceUrl":"https://doi.org/10.1046/j.1471-4159.2003.01524.x","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Humanin rescues human cerebrovascular smooth muscle cells from Aβ‐induced toxicity\" Abstract excerpt: Cerebral amyloid beta-protein (Abeta) angiopathy (CAA) is a key pathological feature of Alzheimer's disease (AD) and related disorders. We have used human cerebrovascular smooth muscle (HCSM) cells as an in vitro model system to investigate the pathogenic mechanisms of the pathology of CAA. It was previously demonstrated that certain pathogenic forms of Abeta induce several pathologic responses in","authors":null,"publishingOrg":null,"publicationYear":2003,"doi":"10.1046/j.1471-4159.2003.01524.x","pubmedId":"12558989","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1046/j.1471-4159.2003.01524.x","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:30.403Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"6222f82d-8d24-4da6-8746-91fcccac2f2c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults","sourceUrl":"https://doi.org/10.1016/s0196-9781(03)00106-2","evidenceTier":"insufficient","summary":"Content-verified record concerning Humanin: \"Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults\" Abstract excerpt: Humanin (HN) is a secretory peptide that inhibits neurotoxicity by various Alzheimer's disease-relevant insults. We have so far identified that the substitution of Leu9 for Arg nullifies the extracellular secretion of HN. Here we comprehensively investigate the amino acid requirement of HN essential for its secretion and for its neuroprotective function. Intracellulary expressed HN-EGFP (EGFP N-te","authors":null,"publishingOrg":null,"publicationYear":2003,"doi":"10.1016/s0196-9781(03)00106-2","pubmedId":"12860203","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: contextual_unclassified. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/s0196-9781(03)00106-2","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:40.546Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"5b15593d-d745-4bdb-9bcc-22371387792e","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis","sourceUrl":"https://doi.org/10.1073/pnas.2135111100","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis\" Abstract excerpt: Insulin-like growth factor-binding protein-3 (IGFBP-3) regulates IGF bioactivity and also independently modulates cell growth and survival. By using a yeast two-hybrid screen to identify IGFBP-3-interacting proteins, we cloned humanin (HN) as an IGFBP-3-binding partner. HN is a 24-aa peptide that has been shown to specifically inhibit neuronal cell death induced by familial Alzheimer's disease mut","authors":null,"publishingOrg":null,"publicationYear":2003,"doi":"10.1073/pnas.2135111100","pubmedId":"14561895","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1073/pnas.2135111100","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:41.730Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"22a2aa8c-168e-4677-b1b5-c27cca8e9d27","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease‐related neurotoxicity: functional potentiation by isomerization and dimerization","sourceUrl":"https://doi.org/10.1046/j.1471-4159.2003.01797.x","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease‐related neurotoxicity: functional potentiation by isomerization and dimerization\" Abstract excerpt: The 24-residue peptide Humanin (HN), containing two Ser residues at positions 7 and 14, protects neuronal cells from insults of various Alzheimer's disease (AD) genes and A beta. It was not known why the rescue function of (S14G)HN is more potent than HN by two to three orders of magnitude. Investigating the possibility that the post-translational modification of Ser14 might play a role, we found ","authors":null,"publishingOrg":null,"publicationYear":2003,"doi":"10.1046/j.1471-4159.2003.01797.x","pubmedId":"12787071","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1046/j.1471-4159.2003.01797.x","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:42.698Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3c27f939-9274-4618-8716-ea8ab40d9022","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/12154011/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity.\" Abstract excerpt: We report the identification of a novel rat cDNA encoding a peptide homologous to Humanin, a secreted peptide that specifically protects against neuronal cell death induced by beta-amyloid peptide (Ab) or by mutations causing early-onset familial Alzheimer's disease. The rat gene, which we termed Rattin, encodes a peptide of 38 residues (15 residues longer than Humanin) showing 73% identity in the","authors":null,"publishingOrg":null,"publicationYear":2002,"doi":"10.1096/fj.02-0018fje","pubmedId":"12154011","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1096/fj.02-0018fje","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:37.310Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"8d4ffebf-2a90-4bef-8a7a-1beac95d0601","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults","sourceUrl":"https://doi.org/10.1016/s0304-3940(02)00199-4","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults\" Abstract excerpt: An unbiased functional screening with brain cDNA library from an Alzheimer's disease (AD) brain identified a novel 24-residue peptide Humanin (HN), which suppresses AD-related neurotoxicity. As the 1567-base cDNA containing the open reading frame (ORF) of HN is 99% identical to mitochondrial 16S ribosomal RNA as well as registered human mRNA, it was elusive whether HN is produced in vivo. Here, we","authors":null,"publishingOrg":null,"publicationYear":2002,"doi":"10.1016/s0304-3940(02)00199-4","pubmedId":"12009529","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/s0304-3940(02)00199-4","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:39.229Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"3a52bb97-aeee-4966-917b-b448cb8c8a9c","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Humanin inhibits cell death of serum-deprived PC12h cells","sourceUrl":"https://doi.org/10.1097/00001756-200205070-00034","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Humanin inhibits cell death of serum-deprived PC12h cells\" Abstract excerpt: Humanin (HN) and S14G HN (HNG) are recently discovered polypeptides that rescue cells from death induced by multiple different types of familial Alzheimer's disease genes and by amyloid-beta. However, the cytoprotective activity of these peptides against other cell death-inducing stimuli remains unclear. In this study, we demonstrated, using three different methods (MTS assay, caspase-3 assay, and","authors":null,"publishingOrg":null,"publicationYear":2002,"doi":"10.1097/00001756-200205070-00034","pubmedId":"11997711","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1097/00001756-200205070-00034","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:31.143Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"522db321-b912-48cc-873e-a35332f81c09","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults","sourceUrl":"https://doi.org/10.1523/jneurosci.21-23-09235.2001","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults\" Abstract excerpt: A novel factor, termed Humanin (HN), antagonizes against neurotoxicity by various types of familial Alzheimer's disease (AD) genes [V642I and K595N/M596L (NL) mutants of amyloid precursor protein (APP), M146L-presenilin (PS) 1, and N141I-PS2] and by Abeta1-43 with clear action specificity ineffective on neurotoxicity by polyglutamine repeat Q79 or superoxide dismutase 1 mutants. Here we report tha","authors":null,"publishingOrg":null,"publicationYear":2001,"doi":"10.1523/jneurosci.21-23-09235.2001","pubmedId":"11717357","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: preclinical_animal. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1523/jneurosci.21-23-09235.2001","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:42.848Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"55f29ff9-4a02-4314-8f1e-d2c95913c344","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"Mechanisms of Neuroprotection by a Novel Rescue Factor Humanin from Swedish Mutant Amyloid Precursor Protein","sourceUrl":"https://doi.org/10.1006/bbrc.2001.4765","evidenceTier":"laboratory","summary":"Content-verified record concerning Humanin: \"Mechanisms of Neuroprotection by a Novel Rescue Factor Humanin from Swedish Mutant Amyloid Precursor Protein\" Abstract excerpt: We report a novel gene, designated Humanin (HN) cDNA, that suppresses neuronal cell death by K595N/M596L-APP (NL-APP), a mutant causing familial Alzheimer's disease (FAD), termed Swedish mutant. Transfection of neuronal cells with HN cDNA or treatment with the coding HN polypeptide abrogated cytotoxicity by NL-APP. HN suppressed neurotoxicity by Abeta1-43 in the absence of N2 supplement, but could","authors":null,"publishingOrg":null,"publicationYear":2001,"doi":"10.1006/bbrc.2001.4765","pubmedId":"11327724","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: pubmed_curated_indexing_confirms_subject (matched: \"humanin\"). Imported evidence lane: laboratory_mechanistic. Source provider: OpenAlex. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1006/bbrc.2001.4765","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:43:41.947Z","updatedAt":"2026-09-23T23:29:30.365Z"},{"id":"6e219d2d-cf14-4e78-ac32-cfa3d5aa054b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","title":"[Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/11739234/","evidenceTier":"animal","summary":"Content-verified record concerning Humanin: \"[Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo.\" Abstract excerpt: Humanin is a very recently discovered 24 amino acid linear polypeptide, which protects against cell death induced by either familial Alzheimer's disease mutant of amyloid precursor protein, presenilin-1 or presenilin-2 in vitro. However, it has remained uncertain whether humanin is a useful drug for the animal model of learning and memory deficit. In this study, we evaluated the effects of [Gly(14","authors":null,"publishingOrg":null,"publicationYear":2001,"doi":"10.1038/sj.bjp.0704429","pubmedId":"11739234","jurisdiction":null,"dateAccessed":null,"editorialNotes":"Category: primary research record. Verified by content, not title or identifier alone: abstract_confirms_peptide_as_subject (firstMentionChar=0, totalMentions=6). Imported evidence lane: preclinical_animal. Source provider: Europe PMC. Content-verified for the 13-profile directory completion effort (2026-09) using free NCBI PubMed E-utilities; no paid API used.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"wpf-directory-completion-content-verified-2026-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1038/sj.bjp.0704429","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":null,"retrievalProvider":null,"retrievalPayloadRef":null,"evidenceLane":null,"extractionPayload":null,"provenancePayload":null,"validationGates":null,"engineState":"manual","engineRunId":null,"createdAt":"2026-09-23T22:29:03.411Z","updatedAt":"2026-09-23T23:29:30.365Z"}],"regulatory":[{"id":"8e7b2ee3-5ed3-418a-b937-069649b0b80b","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","jurisdiction":"European Union — EMA","status":"not_approved","approvedIndication":null,"rationale":"No centrally authorized EMA medicine containing humanin was identified in the EMA medicines database as of 2026-09-23. Humanin remains an investigational research-stage compound with no completed EU marketing review. Absence of a record in this search is not proof that no authorization exists via another regulatory pathway (e.g. national member-state authorization outside the centralized procedure). Status remains jurisdiction-, product-, and date-specific.","sourceTitle":"European Medicines Agency medicines database","sourceUrl":"https://www.ema.europa.eu/en/medicines","dateChecked":"2026-09-23T00:00:00.000Z","reviewDueAt":"2026-12-22T00:00:00.000Z","enteredById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","publicationStatus":"published","factualObservationId":null,"createdAt":"2026-09-23T02:42:18.498Z","updatedAt":"2026-09-23T23:29:30.479Z"},{"id":"721a0587-b36b-440b-952b-5c6ff04d2cba","peptideId":"f2de558f-b385-4121-9f20-5c234f30faf9","jurisdiction":"United States — FDA","status":"not_approved","approvedIndication":null,"rationale":"No FDA-approved product containing humanin was identified in the FDA Drugs@FDA database as of 2026-09-23. Humanin remains an investigational, laboratory- and animal-research-stage mitochondrial-derived peptide with no completed FDA marketing review. Absence of a record in this search is not proof that no authorization exists under a different product name or application. Status remains product- and date-specific.","sourceTitle":"FDA Drugs@FDA database","sourceUrl":"https://www.accessdata.fda.gov/scripts/cder/daf/","dateChecked":"2026-09-23T00:00:00.000Z","reviewDueAt":"2026-12-22T00:00:00.000Z","enteredById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","publicationStatus":"published","factualObservationId":null,"createdAt":"2026-09-23T02:42:18.421Z","updatedAt":"2026-09-23T23:29:30.479Z"}],"claims":[],"correctionHistory":[],"boundaries":{"observationsAreEvidence":false,"completionIsPublicationApproval":false,"medicalAdvice":false}}