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Carbetocin — Peptide Scientific Intelligence
Scientific intelligence record
Experience 2.0
Oxytocin analog
Carbetocin
Carbetocin is a synthetic long-acting oxytocin analog and agonist at the oxytocin receptor. Structural changes—including a thioether bridge and O-methyltyrosine substitution—slow enzymatic degradation relative to oxytocin. In obstetric use it stimulates uterine smooth-muscle contraction after delivery; authorization, route, dose, and eligible population remain product- and jurisdiction-specific. Intranasal developmental research in Prader–Willi syndrome is a distinct investigational context and is not evidence of an obstetric product’s authorization for that use.
Record status
Traceability partial
Last meaningful update: 9/9/2026
Evidence searched through:
Not recorded
Assessment updated:
9/9/2026
Last human review:
No accountable human review represented
Governed reviewed evidence
25
Governed records, not an efficacy score or total literature count.
Evidence boundary
0 / 25
Claim-linked support versus recorded evidence.
Research gaps
1
Unresolved questions remain visible.
Human experience · separate evidence stream
No community pattern is displayed yet
Eligible observations remain below the privacy and reliability threshold. WPF will not convert a handful of reports into a percentage, trend, or clinical claim.
Observation is valuable human context. It is not evidence of causation, efficacy, or safety.
Public display gate
n ≥ 20 eligible observations
Exact progress remains private before the threshold.
Chronology, unresolved research questions, opportunities, and researcher activity remain descriptive rather than evaluative.
Research chronology
2009 · study · Temporal status not established
Utilization of carbetocin for prevention of postpartum hemorrhage after cesarean section: a randomized clinical trial.
Archives of gynecology and obstetrics
2012 · study · Temporal status not established
Carbetocin for preventing postpartum haemorrhage.
The Cochrane database of systematic reviews
2016 · study · Temporal status not established
Carbetocin for the prevention of postpartum hemorrhage: a systematic review and meta-analysis of randomized controlled trials.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2018 · study · Temporal status not established
Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth.
The New England journal of medicine
Connections
Follow the scientific relationships
Connections appear only when they are represented by the project’s underlying records.
Open 12 represented connections ↓Close represented connections ↑
institution
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
represented evidence source
institution
The journal of obstetrics and gynaecology research
represented evidence source
institution
Archives of gynecology and obstetrics
represented evidence source
Traceability
Follow the record back to its source
The experience makes incomplete links visible instead of presenting a false impression of perfect provenance.
Source publication state
A governed source may be verified and approved for publication while its claim-to-evidence link is still incomplete.
Reviewer provenance state
“Human scientist reviewed: no” means that specific source-path attribution is not recorded. It does not silently negate the separate publication-review state.
Claim → Evidence
Incomplete
Evidence → Source
Connected
Source → Original record
Connected
Traceability documents how the project connects statements to records. It does not establish that a source is scientifically valid or that a claim is clinically true.
Incomplete links: claim-to-evidence
Inspect 25 source paths ↓Close source paths ↑
Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth.
Observational archive
What contributors reported
Observational archive data is intentionally separated from published scientific evidence.
Observational boundary
Insufficient eligible observations are available for display under the current filters.
Insufficient eligible observations are currently represented to display aggregated findings for this peptide.
Regulatory context
Reviewed jurisdictional records
Regulatory status is jurisdiction-specific and time-dependent. It is presented as context, not as a recommendation for use or a substitute for scientific evidence evaluation.
Only media explicitly linked through the project’s relationship system appears here.
No scientifically connected media is currently represented for this peptide.
Sources + provenance
Read the scientific record with its boundaries intact
The public record organizes reviewed evidence; it does not establish scientific truth by itself.
Association, mechanism, observation and regulatory status must not be represented as proof of clinical efficacy or safety.
Observational reports describe contributor experiences and cannot establish causation, effectiveness, safety or clinical benefit.
Contradictory and qualifying evidence must remain visible rather than being silently discarded.
Absence of represented evidence is not evidence that research does not exist.
Research gaps identify unresolved questions; they are not negative conclusions.
Regulatory status is distinct from scientific evidence quality.
Media relationships provide context and explanation; they do not increase the strength of scientific evidence.
A section with no represented records is an incomplete project record, not a scientific conclusion.
Carbetocin evidence · ranking key
How evidence is ranked
A tier describes the evidentiary role and design strength of a source. It is not a popularity score, proof that every conclusion is correct, or a substitute for claim-level review.
A
Practice-defining evidence
Large, well-conducted randomized trials; prespecified major outcomes; rigorous systematic reviews or meta-analyses; and major regulatory assessments.
Retrospective cohorts, claims-database studies, pharmacovigilance analyses, mechanistic human research, and well-documented case series.
D
Signal-generating evidence
Case reports, conference abstracts, preclinical research, hypothesis-generating analyses, and expert commentary.
Tier and confidence answer different questions
Tier classifies source design and evidentiary role. Confidence reflects risk of bias, sample size, comparator quality, outcome relevance, follow-up, missing data, directness, replication, reporting quality, and whether conclusions stay within the measured results.
peptide explorer
Structural visualization and provenance
Evidence-class labeling remains visible even when interactive rendering is unavailable. Representative geometry is not an experimentally determined or predicted biological conformation.
Fully specified molecular identity
Molecular formula
C45H69N11O12S
Molecular weight
988.2 g/mol
Exact identity / sequence notation
1-deamino-1-monocarba-2-(O-methyltyrosine)-oxytocin; cyclic thioether analog
Identity-defining modifications
1-deamino modification
Monocarba cyclic thioether replaces the oxytocin disulfide
O-methyltyrosine2
C-terminal amide
PubChem CID
16681432
InChIKey
NSTRIRCPWQHTIA-DTRKZRJBSA-N
The schematic conveys homologous residue order, not the identity-defining thioether geometry.
Duplicate-safe scientific sources under accountable human review. Identified or pending records do not contribute as approved evidence.
0
Insufficient
WPF-EMM-1.0
Identified sources
6
Governed reviewed
0
Evidence approved for publication
0
Audit view
Evidence integrity map
Human and preclinical evidence remain separate. Source identity, claim-to-source traceability, review dates, conflicts, limitations, and unknowns stay visible rather than being collapsed into one score.
4 unresolved signals
Human evidence
0
Preclinical evidence
0
Human experience
Below display gate
Observations never become clinical evidence.
• Trials vary in postpartum-haemorrhage thresholds, cesarean urgency, uterotonic regimens, anaesthetic context, and ascertainment of nausea, hypotension, tachycardia, myocardial markers, and other adverse effects. Rare harms and uncommon high-risk obstetric situations are not fully resolved by existing trials. Results from heat-stable formulations or one administration route may not transfer to another. Current regulated labeling and obstetric protocols—not this profile—control contraindications, monitoring, and use.
• The presence of published evidence does not by itself establish safety, efficacy, causation or clinical benefit.
Inspect the published evidence record25 governed records · titles, provenance, and original-source linksOpen records ↓Close records ↑
2018Phase 3 human evidence
Evidence strength A · 91/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth.
Postpartum hemorrhage is the most common cause of maternal death.
Authors
Mariana Widmer, Gilda Piaggio, Thi M H Nguyen, Alfred Osoti, Olorunfemi O Owa, Sujata Misra, Arri Coomarasamy, Hany Abdel-Aleem, Ashalata A Mallapur, Zahida Qureshi, Pisake Lumbiganon, Archana B Patel
Evidence strength B · 80/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Intranasal carbetocin reduces hyperphagia in individuals with Prader-Willi syndrome.
Prader-Willi syndrome (PWS) is a genetic neurodevelopmental disorder of life-threatening hyperphagia, obesity, intellectual deficits, compulsivity, and other behavioral problems.
Authors
Elisabeth M Dykens, Jennifer Miller, Moris Angulo, Elizabeth Roof, Michael Reidy, Hind T Hatoum, Richard Willey, Guy Bolton, Paul Korner
Evidence strength B · 80/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Intramyometrial and intravenous oxytocin compared to intravenous carbetocin for prevention of postpartum hemorrhage in elective cesarean section-A quasi-randomized controlled phase IV non-inferiority interventional trial.
Our objective was to assess non-inferiority of the unique approach used in our institution of combined 10 IU IM (intramyometrial) and 10 IU IV (intravenous) oxytocin to carbetocin IV in preventing severe postpartum blood loss in elective cesarean sections.
Authors
Romana Brun, Lea Meier, Elisabeth Kapfhammer, Roland Zimmermann, Nicole Ochsenbein-Kölble, Christian Haslinger
Source
Acta obstetricia et gynecologica Scandinavica
DOI
10.1111/aogs.14893
2024Phase 1–2 human evidence
Evidence strength B · 80/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
A randomized controlled trial on the comparison of two doses of carbetocin with oxytocin for the prevention of postpartum hemorrhage (concert trial).
To compare the effectiveness of 50 and 100 μg of carbetocin with 10 IU of oxytocin for the prevention of postpartum hemorrhage (PPH).
Authors
Rasheedat O Balogun, Olatunji O Lawal, Yusuf O Bello, Tolulope M Odedele, Imran O Morhason-Bello, Adesina Oladokun
Source
The journal of obstetrics and gynaecology research
Evidence strength B · 80/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
The Effect of Carbetocin Dose on Transmural Dispersion of Myocardial Repolarization in Healthy Parturients Scheduled for Elective Cesarean Delivery Under Spinal Anesthesia: A Prospective, Randomized Clinical Trial.
QT interval prolongation is associated with torsade de pointes but remains a poor predictor of drug torsadogenicity.
Authors
Natasha Clunies-Ross, Thomas M Roston, James Taylor, Simon Whyte, Arianne Albert, Matthias Görges, Anthony Chau
Evidence strength B · 80/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Utilization of carbetocin for prevention of postpartum hemorrhage after cesarean section: a randomized clinical trial.
A randomized study involving pregnant women was conducted to compare the effectiveness of a single intravenous (IV) injection of carbetocin with that of a standard 2-h oxytocin IV infusion with respect to intraoperative blood loss in the prevention of uterine atony after cesarean section (CS).
Evidence strength B · 80/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Effect of heat stable carbetocin vs oxytocin for preventing postpartum haemorrhage on post delivery hemoglobin-a randomized controlled trial.
To compare the effect of heat-stable carbetocin 100 μg IM versus oxytocin 10 IU IM on post-delivery hemoglobin level.
Authors
Sunil S Vernekar, Swati S Goudar, Mrityunjay Metgud, Yeshita V Pujar, Manjunath S Somannavar, Gilda Piaggio, José Ferreira D E Carvalho, Amit Revankar, Fernando Althabe, Mariana Widmer, Ahmet Metin Gulmezoglu, Shivaprasad S Goudar
Source
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2021Phase 1–2 human evidence
Evidence strength B · 80/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Intramuscular oxytocin versus Syntometrine® versus carbetocin for prevention of primary postpartum haemorrhage after vaginal birth: a randomised double-blinded clinical trial of effectiveness, side effects and quality of life.
To compare intramuscular oxytocin, Syntometrine® and carbetocin for prevention of postpartum haemorrhage after vaginal birth.
Authors
H van der Nelson, S O'Brien, S Burnard, M Mayer, M Alvarez, J Knowlden, C Winter, N Dailami, E Marques, C Burden, D Siassakos, T Draycott
Source
BJOG : an international journal of obstetrics and gynaecology
DOI
10.1111/1471-0528.16622
PubMed
2025Phase 1–2 human evidence
Evidence strength B · 80/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Effects of Prophylactic Oxytocin or Carbetocin on Troponin Release and Postpartum Haemorrhage at Planned Caesarean Delivery: A Double-Blind Randomised Controlled Trial.
Oxytocin may cause dose-dependent myocardial side effects.
Authors
Maria E Bekkenes, Marte M Jørgensen, Anne F Jacobsen, Morten W Fagerland, Helene Rakstad-Larsen, Lars Aaberge, Olav Klingenberg, Trude Steinsvik, Lars Asphaug, Leiv Arne Rosseland
Source
BJOG : an international journal of obstetrics and gynaecology
Evidence strength B · 80/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Oxytocin versus carbetocin at elective Cesarean delivery in parturients with class III obesity: a double-blind randomized controlled noninferiority trial.
Class III obesity (body mass index [BMI] ≥ 40 kg·m-2) is associated with high rates of Cesarean deliveries and postpartum hemorrhage, with increased maternal and fetal morbidity.
Authors
William Turner, Linda Boonstra, Cynthia Maxwell, Kristy Downey, Mrinalini Balki
Source
Canadian journal of anaesthesia = Journal canadien d'anesthesie
Evidence strength B · 80/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Heat stable carbetocin vs. oxytocin for the prevention of post-partum hemorrhage in emergency caesarean delivery: a randomized controlled trial.
To evaluate the uterotonic effect of carbetocin compared with oxytocin in emergency cesarean delivery in Iraq.
Evidence strength B · 80/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Adverse Effects of Carbetocin versus Oxytocin in the Prevention of Postpartum Haemorrhage after Caesarean Section: A Randomized Controlled Trial.
To compare the incidence of nausea, vomiting, and arterial hypotension between carbetocin and oxytocin to prevent haemorrhage after caesarean section (CS).
Authors
D Mannaerts, L Van der Veeken, H Coppejans, Y Jacquemyn
Evidence strength A · 88/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Carbetocin versus oxytocin for the prevention of postpartum hemorrhage: A meta-analysis of randomized controlled trials in cesarean deliveries.
Postpartum hemorrhage remains the leading cause of maternal mortality in developing countries and a significant proportion of these cases are attributable to uterine atony.
Authors
Hian Yan Voon, Haris Njoo Suharjono, Asrul Akmal Shafie, Mohamad Adam Bujang
Evidence strength A · 88/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
70/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis.
Postpartum haemorrhage (PPH) is the leading cause of maternal mortality worldwide.
Authors
Ioannis D Gallos, Helen M Williams, Malcolm J Price, Abi Merriel, Harold Gee, David Lissauer, Vidhya Moorthy, Aurelio Tobias, Jonathan J Deeks, Mariana Widmer, Özge Tunçalp, Ahmet Metin Gülmezoglu
Evidence strength A · 88/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
The effect of carbetocin compared to misoprostol in management of the third stage of labor and prevention of postpartum hemorrhage: a systematic review.
Postpartum hemorrhage (PPH) and the amount of blood loss are directly related to management of the third stage of labor.
Authors
Mohamed A Abd El Aziz, Ahmed Iraqi, Parvin Abedi, Shayesteh Jahanfar
Evidence strength A · 88/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
A systematic review and meta-analysis of randomized trials comparing carbetocin to oxytocin in prevention of postpartum hemorrhage after cesarean delivery in low-risk women.
To evaluate the efficacy and safety of Carbetocin compared to oxytocin in prevention of postpartum hemorrhage (PPH) after low-risk cesarean delivery (CD).
Authors
Ahmed M Maged, Nour A El-Goly, Doaa Turki, Nehal Bassiouny, Nihal El-Demiry
Source
The journal of obstetrics and gynaecology research
Evidence strength A · 88/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Efficacy of carbetocin in the prevention of postpartum hemorrhage: a systematic review and Bayesian meta-analysis of randomized trials.
To evaluate the efficacy of carbetocin for the prevention of postpartum hemorrhage (PPH) and related events after vaginal or cesarean delivery.
Authors
Erkan Kalafat, Ali Gokce, Pat O'Brien, Can Benlioglu, Acar Koc, Onur Karaaslan, Asma Khalil
Source
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
DOI
10.1080/14767058.2019.1664463
2012Observational human evidence
Evidence strength A · 88/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Carbetocin for preventing postpartum haemorrhage.
Postpartum haemorrhage (PPH) is one of the major contributors to maternal mortality and morbidity worldwide.
Evidence strength A · 88/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Carbetocin versus oxytocin in prevention of postpartum hemorrhage after cesarean delivery in high-risk women. A systematic review and meta-analysis.
To assess the value of carbetocin in prevention of postpartum hemorrhage (PPH) after Cesarean delivery (CD).
Authors
Nour A El-Goly, Ahmed Mohamed Maged, Wafaa M Kamal, Osama Hosny, Doaa Turki, Nadia M Helmy
Evidence strength A · 88/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Carbetocin for the prevention of postpartum hemorrhage: a systematic review and meta-analysis of randomized controlled trials.
To compare the efficacy and safety profile of carbetocin with other uterotonic agents in preventing postpartum hemorrhage.
Authors
Bohong Jin, Yongming Du, Fubin Zhang, Kemei Zhang, Lulu Wang, Lining Cui
Source
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
DOI
10.3109/14767058.2014.1002394
PubMed
2021Observational human evidence
Evidence strength A · 88/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Side-effects of carbetocin to prevent postpartum hemorrhage: A systematic review and meta-analysis of randomized controlled trials.
Postpartum hemorrhage (PPH) increases the risk of maternal death worldwide.
Authors
Wen Ai, Yanfei Zeng, Yubo Ma, Li Liu, Dazhi Fan, Song Wu, Yinghui Zhang
Evidence strength A · 88/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Carbetocin compared with oxytocin in non-elective Cesarean delivery: a systematic review, meta-analysis, and trial sequential analysis of randomized-controlled trials.
Carbetocin has been shown to reduce the requirement for additional uterotonics in women exclusively undergoing elective Cesarean delivery (CD).
Authors
Desire N Onwochei, Adetokunbo Owolabi, Preet Mohinder Singh, David T Monks
Source
Canadian journal of anaesthesia = Journal canadien d'anesthesie
Evidence strength A · 88/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Carbetocin reduces the need for additional uterotonics in elective caesarean delivery: a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials.
Carbetocin has been found to be superior to oxytocin in terms of need for additional uterotonics and prevention of postpartum haemorrhage at caesarean delivery.
Authors
D N Onwochei, J Van Ross, P M Singh, A Salter, D T Monks
Evidence strength A · 88/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Carbetocin vs oxytocin for prevention of postpartum hemorrhage after vaginal delivery: A meta-analysis.
To evaluate the efficacy and safety of carbetocin for prevention of postpartum hemorrhage in women undergoing vaginal delivery compared with oxytocin.
Evidence strength A · 88/100 · ProvisionalHow this is rated
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Directness
85/100
Replication
70/100
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Effect of Carbetocin on Postpartum Hemorrhage after Vaginal Delivery: A Meta-Analysis.
The efficacy of oxytocin and carbetocin in preventing postpartum hemorrhage (PPH) in women with vaginal delivery has been controversial.
Authors
Xiaojuan Huang, Wanxing Xue, Jin Zhou, Cuiyi Zhou, Feiyan Yang
Source
Computational and mathematical methods in medicine
Chemical identity describes the recorded molecular information. It does not establish biological activity, clinical efficacy, safety, or therapeutic suitability.
2018 · study · Temporal status not established
Intranasal carbetocin reduces hyperphagia in individuals with Prader-Willi syndrome.
JCI insight
2018 · study · Temporal status not established
Adverse Effects of Carbetocin versus Oxytocin in the Prevention of Postpartum Haemorrhage after Caesarean Section: A Randomized Controlled Trial.
Journal of pregnancy
2018 · study · Temporal status not established
Carbetocin versus oxytocin for the prevention of postpartum hemorrhage: A meta-analysis of randomized controlled trials in cesarean deliveries.
Taiwanese journal of obstetrics & gynecology
2018 · study · Temporal status not established
Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis.
The Cochrane database of systematic reviews
2018 · study · Temporal status not established
The effect of carbetocin compared to misoprostol in management of the third stage of labor and prevention of postpartum hemorrhage: a systematic review.
Systematic reviews
2019 · study · Temporal status not established
Carbetocin reduces the need for additional uterotonics in elective caesarean delivery: a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials.
International journal of obstetric anesthesia
2019 · study · Temporal status not established
Carbetocin vs oxytocin for prevention of postpartum hemorrhage after vaginal delivery: A meta-analysis.
Medicine
2020 · study · Temporal status not established
Carbetocin compared with oxytocin in non-elective Cesarean delivery: a systematic review, meta-analysis, and trial sequential analysis of randomized-controlled trials.
Canadian journal of anaesthesia = Journal canadien d'anesthesie
2021 · study · Temporal status not established
The Effect of Carbetocin Dose on Transmural Dispersion of Myocardial Repolarization in Healthy Parturients Scheduled for Elective Cesarean Delivery Under Spinal Anesthesia: A Prospective, Randomized Clinical Trial.
Anesthesia and analgesia
2021 · study · Temporal status not established
Intramuscular oxytocin versus Syntometrine® versus carbetocin for prevention of primary postpartum haemorrhage after vaginal birth: a randomised double-blinded clinical trial of effectiveness, side effects and quality of life.
BJOG : an international journal of obstetrics and gynaecology
2021 · study · Temporal status not established
Efficacy of carbetocin in the prevention of postpartum hemorrhage: a systematic review and Bayesian meta-analysis of randomized trials.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2021 · study · Temporal status not established
Side-effects of carbetocin to prevent postpartum hemorrhage: A systematic review and meta-analysis of randomized controlled trials.
Pharmacology research & perspectives
2022 · study · Temporal status not established
Effect of heat stable carbetocin vs oxytocin for preventing postpartum haemorrhage on post delivery hemoglobin-a randomized controlled trial.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2022 · study · Temporal status not established
Heat stable carbetocin vs. oxytocin for the prevention of post-partum hemorrhage in emergency caesarean delivery: a randomized controlled trial.
Journal of perinatal medicine
2022 · study · Temporal status not established
Effect of Carbetocin on Postpartum Hemorrhage after Vaginal Delivery: A Meta-Analysis.
Computational and mathematical methods in medicine
2024 · study · Temporal status not established
Intramyometrial and intravenous oxytocin compared to intravenous carbetocin for prevention of postpartum hemorrhage in elective cesarean section-A quasi-randomized controlled phase IV non-inferiority interventional trial.
Acta obstetricia et gynecologica Scandinavica
2024 · study · Temporal status not established
A randomized controlled trial on the comparison of two doses of carbetocin with oxytocin for the prevention of postpartum hemorrhage (concert trial).
The journal of obstetrics and gynaecology research
2025 · study · Temporal status not established
Effects of Prophylactic Oxytocin or Carbetocin on Troponin Release and Postpartum Haemorrhage at Planned Caesarean Delivery: A Double-Blind Randomised Controlled Trial.
BJOG : an international journal of obstetrics and gynaecology
2025 · study · Temporal status not established
Oxytocin versus carbetocin at elective Cesarean delivery in parturients with class III obesity: a double-blind randomized controlled noninferiority trial.
Canadian journal of anaesthesia = Journal canadien d'anesthesie
2025 · study · Temporal status not established
A systematic review and meta-analysis of randomized trials comparing carbetocin to oxytocin in prevention of postpartum hemorrhage after cesarean delivery in low-risk women.
The journal of obstetrics and gynaecology research
2025 · study · Temporal status not established
Carbetocin versus oxytocin in prevention of postpartum hemorrhage after cesarean delivery in high-risk women. A systematic review and meta-analysis.
Archives of gynecology and obstetrics
2026 · regulatory · Temporal status not established
Regulatory review: approved
Australia (TGA)
2026 · regulatory · Temporal status not established
Regulatory review: approved
Canada (Health Canada)
The represented chronology reflects records currently included in the governed dataset and does not claim to represent the entire scientific literature.
What still needs investigation
Claim traceability
No institutional claim record is currently represented for this peptide.
Evidence is missing or not represented as studied; this is not a conclusion that the intervention does not work.
Researchers represented in the evidence record12 bibliographic identities · open to inspect
These are bibliographic author identities derived from represented records. Name strings are not proof of unique real-world researcher identity, and publishing organizations are not treated as institutional affiliations.
D T Monks
2 represented evidence records
Years represented: 2019, 2020
Publishing organizations appearing in records: Canadian journal of anaesthesia = Journal canadien d'anesthesie, International journal of obstetric anesthesia
Gilda Piaggio
2 represented evidence records
Years represented: 2018, 2022
Publishing organizations appearing in records: The New England journal of medicine, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Mariana Widmer
3 represented evidence records
Years represented: 2018, 2022
Publishing organizations appearing in records: The Cochrane database of systematic reviews, The New England journal of medicine, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
A Salter
1 represented evidence record
Years represented: 2019
Publishing organizations appearing in records: International journal of obstetric anesthesia
Abi Merriel
1 represented evidence record
Years represented: 2018
Publishing organizations appearing in records: The Cochrane database of systematic reviews
Acar Koc
1 represented evidence record
Years represented: 2021
Publishing organizations appearing in records: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Adesina Oladokun
1 represented evidence record
Years represented: 2024
Publishing organizations appearing in records: The journal of obstetrics and gynaecology research
Adetokunbo Owolabi
1 represented evidence record
Years represented: 2020
Publishing organizations appearing in records: Canadian journal of anaesthesia = Journal canadien d'anesthesie
Ahmed Iraqi
1 represented evidence record
Years represented: 2018
Publishing organizations appearing in records: Systematic reviews
Ahmed M Maged
1 represented evidence record
Years represented: 2025
Publishing organizations appearing in records: The journal of obstetrics and gynaecology research
Ahmed Mohamed Maged
1 represented evidence record
Years represented: 2025
Publishing organizations appearing in records: Archives of gynecology and obstetrics
Ahmet Metin Gulmezoglu
1 represented evidence record
Years represented: 2022
Publishing organizations appearing in records: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
institution
BJOG : an international journal of obstetrics and gynaecology
represented evidence source
institution
Canadian journal of anaesthesia = Journal canadien d'anesthesie
represented evidence source
institution
The Cochrane database of systematic reviews
represented evidence source
institution
The New England journal of medicine
represented evidence source
institution
JCI insight
represented evidence source
institution
Acta obstetricia et gynecologica Scandinavica
represented evidence source
institution
Anesthesia and analgesia
represented evidence source
institution
Journal of perinatal medicine
represented evidence source
institution
Journal of pregnancy
represented evidence source
Claim: Not linked · Evidence: 413d39ae9e946b5ca319040460d9210d
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Intramyometrial and intravenous oxytocin compared to intravenous carbetocin for prevention of postpartum hemorrhage in elective cesarean section-A quasi-randomized controlled phase IV non-inferiority interventional trial.
Claim: Not linked · Evidence: 8149daf7d4b3ecb0c39b2a55e919023d
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
The Effect of Carbetocin Dose on Transmural Dispersion of Myocardial Repolarization in Healthy Parturients Scheduled for Elective Cesarean Delivery Under Spinal Anesthesia: A Prospective, Randomized Clinical Trial.
Claim: Not linked · Evidence: f17da328c9afe085d0e5fc9a7d274121
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Intramuscular oxytocin versus Syntometrine® versus carbetocin for prevention of primary postpartum haemorrhage after vaginal birth: a randomised double-blinded clinical trial of effectiveness, side effects and quality of life.
Claim: Not linked · Evidence: ed7a875aac4e7cbd582376911d8213a7
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Effects of Prophylactic Oxytocin or Carbetocin on Troponin Release and Postpartum Haemorrhage at Planned Caesarean Delivery: A Double-Blind Randomised Controlled Trial.
Claim: Not linked · Evidence: 5f168ff82bb9ac9ba18e9cd54140bd60
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Oxytocin versus carbetocin at elective Cesarean delivery in parturients with class III obesity: a double-blind randomized controlled noninferiority trial.
Claim: Not linked · Evidence: 3caa5110cd32d9879d9df96b1bc0de9e
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
The effect of carbetocin compared to misoprostol in management of the third stage of labor and prevention of postpartum hemorrhage: a systematic review.
Claim: Not linked · Evidence: 316bfe4ed0d3c448b6cbffc1944cb497
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
A systematic review and meta-analysis of randomized trials comparing carbetocin to oxytocin in prevention of postpartum hemorrhage after cesarean delivery in low-risk women.
Claim: Not linked · Evidence: 2d92b9e7017fc9be11836b1bfb0f92d4
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Carbetocin compared with oxytocin in non-elective Cesarean delivery: a systematic review, meta-analysis, and trial sequential analysis of randomized-controlled trials.
Claim: Not linked · Evidence: 0a5305e441cf49f26c55ae09124b148a
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Carbetocin reduces the need for additional uterotonics in elective caesarean delivery: a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials.
Claim: Not linked · Evidence: a152056502f2cbb2013457537d31ade4
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Researcher and institutional relationships are shown only when supported by represented records and must not be interpreted as rankings or endorsements.
Generated: 9/18/2026, 3:05:15 PM
Funding and conflicts are disclosed and considered, but sponsorship never automatically changes a tier. Corrections, retractions, and expressions of concern override the original rating.
Structure source
Generated from this record's governed amino-acid sequence
Identifier
Not applicable — not a database structure
Method
Schematic layout ordered by residue position only; not a molecular-dynamics, homology, or fold prediction
Confidence / limitations
Illustrative only. Not physically accurate; carries no structural, binding-site, or activity meaning.
Provenance
WPF governed PeptideChemistry record
Retrieved / last reviewed
2026-09-17
This is a representative, sequence-derived model ordered by residue position only. It is not the peptide's experimentally determined or predicted biological conformation, and it carries no claim about real bond angles, distances, secondary structure, binding sites, or activity.
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Durable source IDs
6/6
Claim-to-source chain
Partial
Evidence searched through: Not recorded
Last accountable review: Not recorded
Inspect unresolved signals (4)
No governed reviewed scientific source is represented.
The last accountable evidence-review date is not recorded.
At least one claim-to-original-source traceability step is not represented.
The literature search-through date is not recorded.
These are documentary and scientific-review signals, not conclusions of harm, ineffectiveness, safety, or absence of research.
Human relevance0
Study design0
Evidence breadth0
Consistency0
Governance quality0
Uncertainty resolution0
Why this rating
No governed reviewed scientific evidence is available.
This maturity index describes evidence-base development and governance. It is not a probability of efficacy, safety, truth, medical advice, or regulatory approval. Read the methodology.