{"schemaVersion":"wpf-profile-export-v1","exportedAt":"2026-09-18T15:18:28.594Z","profile":{"slug":"carbetocin","name":"Carbetocin","aliases":[],"category":"Oxytocin analog"},"synthesis":{"mechanism":"Carbetocin is a synthetic long-acting oxytocin analog and agonist at the oxytocin receptor. Structural changes—including a thioether bridge and O-methyltyrosine substitution—slow enzymatic degradation relative to oxytocin. In obstetric use it stimulates uterine smooth-muscle contraction after delivery; authorization, route, dose, and eligible population remain product- and jurisdiction-specific. Intranasal developmental research in Prader–Willi syndrome is a distinct investigational context and is not evidence of an obstetric product’s authorization for that use.","evidence":"The governed corpus contains the large heat-stable-carbetocin vaginal-birth trial, randomized cesarean and vaginal-delivery comparisons, dose and cardiovascular-safety studies, high- and low-risk subgroup syntheses, Cochrane and network meta-analyses, and a separately labeled Prader–Willi trial. All 25 source identities, titles, authorship, publication metadata, DOI/PMID links, molecule relevance, active status, and duplication were checked against PubMed. Evidence grading remains provisional pending Owner review, and meta-analyses are not treated as independent replications of their component trials.","safety":"Trials vary in postpartum-haemorrhage thresholds, cesarean urgency, uterotonic regimens, anaesthetic context, and ascertainment of nausea, hypotension, tachycardia, myocardial markers, and other adverse effects. Rare harms and uncommon high-risk obstetric situations are not fully resolved by existing trials. Results from heat-stable formulations or one administration route may not transfer to another. Current regulated labeling and obstetric protocols—not this profile—control contraindications, monitoring, and use.","observationalBoundary":"Across obstetric trials, prophylactic carbetocin has been compared chiefly with oxytocin and other uterotonics for postpartum-haemorrhage prevention and need for additional uterotonics. Results depend on delivery route, baseline haemorrhage risk, comparator dose and stability, outcome definition, and care setting. The archive separately represents efficacy, adverse effects, cardiac-repolarization/troponin research, heat-stable formulation evidence, and the non-obstetric intranasal research program. It does not collapse those indications or formulations into one claim.","openQuestions":"Which women and delivery settings obtain a clinically meaningful advantage over appropriately stored oxytocin? How do heat-stable products perform across low-resource health systems under routine conditions? What dosing best balances uterine effect and cardiovascular adverse events in high-risk cesarean delivery? Which postpartum-haemorrhage definitions and core outcomes should future trials share? Do pharmacogenomic or receptor-level differences predict response? What efficacy and safety conclusions, if any, emerge from larger non-obstetric intranasal programs without being extrapolated from obstetric evidence?"},"completion":{"version":"wpf-profile-v1.0","complete":false,"checks":[{"key":"overview","passed":true,"actual":569,"required":100,"severity":"blocking"},{"key":"evidence_summary","passed":true,"actual":608,"required":100,"severity":"blocking"},{"key":"safety_summary","passed":true,"actual":520,"required":100,"severity":"blocking"},{"key":"archive_boundary","passed":true,"actual":574,"required":75,"severity":"blocking"},{"key":"open_questions","passed":true,"actual":619,"required":75,"severity":"blocking"},{"key":"verified_sources","passed":true,"actual":25,"required":25,"severity":"blocking"},{"key":"reviewed_sources","passed":false,"actual":0,"required":1,"severity":"blocking"},{"key":"chemistry","passed":true,"actual":true,"required":true,"severity":"blocking"},{"key":"regulatory_context","passed":true,"actual":2,"required":2,"severity":"blocking"},{"key":"claims","passed":false,"actual":0,"required":1,"severity":"blocking"},{"key":"claim_traceability","passed":true,"actual":0,"required":0,"severity":"blocking"},{"key":"regulatory_freshness","passed":true,"actual":0,"required":0,"severity":"warning"}],"failures":["reviewed_sources","claims"]},"chemistry":{"id":"6ea16ae737ca63d4e49994b77b5d189e","peptideId":"e1f11a92-3217-4c15-9e09-fb96245c18f7","molecularFormula":"C45H69N11O12S","molecularWeight":988.2,"aminoAcidSequence":"1-deamino-1-monocarba-2-(O-methyltyrosine)-oxytocin; 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