Flagship record · Ghrelin

Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite.

human primarycontrolled human primarysecondary multi agent subject

Scientific attribution

The sleep-curtailment study evaluates ghrelin together with leptin and appetite-related outcomes; ghrelin is a measured biological subject rather than the experimental intervention.

PMID: 15583226
DOI: 10.7326/0003-4819-141-11-200412070-00008
Sample size: Not captured in the structured review record
Population / model: Not captured in the structured review record

Key findings

Total sleep deprivation in rodents and in humans has been associated with hyperphagia.
Over the past 40 years, self-reported sleep duration in the United States has decreased by almost 2 hours.
Sleep restriction was associated with average reductions in the anorexigenic hormone leptin (decrease, 18%; P = 0.04), elevations in the orexigenic factor ghrelin (increase, 28%; P < 0.04), and increased hunger (increase, 24%; P < 0.01) and appetite (increase, 23%; P = 0.01), especially for calorie-dense foods with high carbohydrate content (increase, 33% to 45%; P = 0.02).
Short sleep duration in young, healthy men is associated with decreased leptin levels, increased ghrelin levels, and increased hunger and appetite.

Contradiction / qualification signals

The study included only 12 young men and did not measure energy expenditure.

Review status

This research library contains structured AI-assisted scientific review. AI-assisted review is not accountable human scientific approval. Inclusion here does not constitute publication approval, clinical guidance, efficacy proof, or automatic promotion of a scientific conclusion.

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