Scientific intelligence record
Experience 2.0
Endogenous neurohypophyseal nonapeptide / vasopressor medicine
Arginine vasopressin, also called argipressin or antidiuretic hormone, is an endogenous cyclic nonapeptide synthesized in hypothalamic neurons and released from the posterior pituitary. V1a-receptor activation constricts vascular smooth muscle, V2-receptor activation promotes renal water reabsorption through aquaporin-2 trafficking, and additional receptor signaling contributes to pituitary, hemostatic, and central effects. Pharmaceutical vasopressin is used in tightly defined clinical contexts, notably as an intravenous vasopressor for vasodilatory shock in the United States; endogenous physiology, diagnostic biomarkers, receptor antagonists, analogs, and investigational intranasal research must remain distinct.
Record status
Traceability partial
Last meaningful update: 9/10/2026
Governed reviewed evidence
25
Governed records, not an efficacy score or total literature count.
Evidence boundary
0 / 25
Claim-linked support versus recorded evidence.
Human experience · separate evidence stream
Eligible observations remain below the privacy and reliability threshold. WPF will not convert a handful of reports into a percentage, trend, or clinical claim.
Observation is valuable human context. It is not evidence of causation, efficacy, or safety.
Public display gate
n ≥ 20 eligible observations
Exact progress remains private before the threshold.
Intelligence snapshot
A compact view of what is represented, what remains unresolved, and how completely the record can be traced.
Governed reviewed evidence
25
Reviewed database records promoted through the governed publication workflow.
Contradictions
0
Conflicting evidence relationships that remain visible.
Research gaps
1
Questions the current record identifies as unresolved.
Connected media
0
Media records explicitly linked to this scientific record.
What we know
The project separates represented evidence from qualification, contradiction, uncertainty, and what the evidence does not establish.
This does not mean the scientific literature contains no findings. It means no reviewed institutional claim has been represented here.
Scientific context
Existing reviewed chemistry is preserved as scientific context. Chemistry and mechanism information do not establish clinical efficacy or safety.
Explore further
Move from this peptide record into the project's broader evidence, research, comparison, and methodology systems.
Research
Chronology, unresolved research questions, opportunities, and researcher activity remain descriptive rather than evaluative.
1975 · study · Temporal status not established
Gastroenterology
1984 · study · Temporal status not established
Hepatology (Baltimore, Md.)
1996 · study · Temporal status not established
Obstetrics and gynecology
2001 · study · Temporal status not established
Lancet (London, England)
Connections
Connections appear only when they are represented by the project’s underlying records.
institution
institution
institution
institution
Traceability
The experience makes incomplete links visible instead of presenting a false impression of perfect provenance.
Source publication state
A governed source may be verified and approved for publication while its claim-to-evidence link is still incomplete.
Reviewer provenance state
“Human scientist reviewed: no” means that specific source-path attribution is not recorded. It does not silently negate the separate publication-review state.
Claim → Evidence
Incomplete
Evidence → Source
Connected
Source → Original record
Connected
Traceability documents how the project connects statements to records. It does not establish that a source is scientifically valid or that a claim is clinically true.
Incomplete links: claim-to-evidence
Intra-arterial vasopressin in the human forearm: pharmacodynamics and the role of nitric oxide.
Observational archive
Observational archive data is intentionally separated from published scientific evidence.
Observational boundary
Insufficient eligible observations are available for display under the current filters.
Insufficient eligible observations are currently represented to display aggregated findings for this peptide.
Regulatory context
Regulatory status is jurisdiction-specific and time-dependent. It is presented as context, not as a recommendation for use or a substitute for scientific evidence evaluation.
Canada (Health Canada — Vasopressin Injection USP DIN 02139502)
Regulator: Vasopressin Injection USP DIN 02139502)
As of: 9/10/2026 · Temporal status not established
Health Canada — Importation of US-Authorized Vasopressin Injection during Canadian shortage
United States (FDA — VASOSTRICT)
Regulator: VASOSTRICT)
As of: 9/10/2026 · Temporal status not established
Research + media
Only media explicitly linked through the project’s relationship system appears here.
No scientifically connected media is currently represented for this peptide.
Sources + provenance
Vasopressin evidence · ranking key
A tier describes the evidentiary role and design strength of a source. It is not a popularity score, proof that every conclusion is correct, or a substitute for claim-level review.
Large, well-conducted randomized trials; prespecified major outcomes; rigorous systematic reviews or meta-analyses; and major regulatory assessments.
Smaller randomized trials, strong prospective cohorts, prespecified secondary analyses, and high-quality comparative-effectiveness studies.
Retrospective cohorts, claims-database studies, pharmacovigilance analyses, mechanistic human research, and well-documented case series.
Case reports, conference abstracts, preclinical research, hypothesis-generating analyses, and expert commentary.
Tier classifies source design and evidentiary role. Confidence reflects risk of bias, sample size, comparator quality, outcome relevance, follow-up, missing data, directness, replication, reporting quality, and whether conclusions stay within the measured results.
Governed scientific evidence
Duplicate-safe scientific sources under accountable human review. Identified or pending records do not contribute as approved evidence.
Audit view
Human and preclinical evidence remain separate. Source identity, claim-to-source traceability, review dates, conflicts, limitations, and unknowns stay visible rather than being collapsed into one score.
Research gaps
1
Unresolved questions remain visible.
Human experience
Below display gate
Observations never become clinical evidence.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Diverse vascular effects have been ascribed to vasopressin, including the potential to cause vasodilation, vasoconstriction, and nitric oxide release.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
To compare the effects of two arginine vasopressin (AVP) dose regimens on the hemodynamic response, catecholamine requirements, AVP plasma concentrations, organ function and adverse events in advanced vasodilatory shock.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Vasopressin has been proposed as a potent vasoactive agent in the treatment of vasodilatory shock in adults and children.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Survival rates for cardiac arrest patients, both in and out of hospital, are poor.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Vasopressin is commonly used as an adjunct to catecholamines to support blood pressure in refractory septic shock, but its effect on mortality is unknown.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Vasoplegic syndrome is a common complication after cardiac surgery and impacts negatively on patient outcomes.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Norepinephrine is currently recommended as the first-line vasopressor in septic shock; however, early vasopressin use has been proposed as an alternative.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Previous trials suggest that vasopressin may improve outcomes in patients with vasodilatory shock.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Evaluate the incidence of hypotension during the weaning phase of vasopressors.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Intraarterial vasopressin has been reported to be effective in the treatment of massive upper gastrointestinal hemorrhage.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
To determine if higher-volume, fixed-dose administration of vasopressin further reduces blood loss at the time of minimally invasive myomectomy.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Arginine vasopressin is a nonapeptide hormone with effects on intracellular water transport and arterial tone that is used in distributive shock and following cardiopulmonary bypass.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
To compare the efficacy and safety of intramyometrial vasopressin plus rectal misoprostol with intramyometrial vasopressin alone to reduce blood loss during laparoscopic myomectomy.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
To assess the comparative efficacy of perivascular vasopressin and tourniquet in minimizing bleeding and its sequelae at myomectomy.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
In a randomized controlled trial, the effect of continuous intravenous administration of vasopressin was compared with Sengstaken-Blakemore balloon tamponade in 37 episodes of bleeding esophageal varices in patients with cirrhosis.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
The aim of this study was to investigate the relationship between intraoperative vasopressin infusion and postoperative cardiac enzymes.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Inhibition of angiotensin-converting enzyme (ACE) predisposes patients to vasodilatory hypotension after cardiopulmonary bypass (CPB).
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
To assess the safety of low-dose vasopressin infusion in critically ill children requiring prolonged mechanical ventilation (MV) at risk of developing sedation/analgesia-related hypotension.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Disturbances in microcirculatory homeostasis have been hypothesized to play a key role in the pathophysiology of multiple organ dysfunction syndrome and vasopressor-associated ischemic skin lesions.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
To compare the effects of arginine-vasopressin (AVP) and norepinephrine (NE) on hemodynamic variables, organ dysfunction, and adverse events in early hyperdynamic septic shock.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
To summarize the results of randomized controlled trials on the use of vasopressin as a vasopressor agent in cardiac surgery.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Background: Septic shock is a distributive shock with decreased systemic vascular resistance and MAP.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
International guidelines recommend dopamine or norepinephrine as first-line vasopressor agents in septic shock.
This score estimates how strongly this source can support scientific claims. It is not a prestige score, and the grade does not transfer automatically to every claim that cites the source.
Grade guide: A+/A is the strongest represented support; B+/B is substantial but qualified; C is limited, indirect, observational, or preclinical; D/E is weak, mechanistic-only, anecdotal, or insufficient.
Provisional ratings are automated baselines from structured metadata. They are not completed full-text risk-of-bias reviews and may change after editorial assessment.
Methodology: WPF-ESR-1.0
Excessive exposure to adrenergic vasopressors may be harmful.
We performed an individual patient data meta-analysis to investigate the possible benefits and harms of vasopressin therapy in adults with septic shock both overall and in pre-defined subgroups.
Chemical identity describes the recorded molecular information. It does not establish biological activity, clinical efficacy, safety, or therapeutic suitability.
2003 · study · Temporal status not established
Clinical pharmacology and therapeutics
2003 · study · Temporal status not established
The Annals of thoracic surgery
2006 · study · Temporal status not established
Critical care (London, England)
2006 · study · Temporal status not established
Intensive care medicine
2008 · study · Temporal status not established
The New England journal of medicine
2009 · study · Temporal status not established
American journal of respiratory and critical care medicine
2009 · study · Temporal status not established
Intensive care medicine
2010 · study · Temporal status not established
Intensive care medicine
2015 · study · Temporal status not established
Journal of cardiothoracic and vascular anesthesia
2015 · study · Temporal status not established
PloS one
2016 · study · Temporal status not established
JAMA
2017 · study · Temporal status not established
Anesthesiology
2017 · study · Temporal status not established
BJOG : an international journal of obstetrics and gynaecology
2018 · study · Temporal status not established
European journal of obstetrics, gynecology, and reproductive biology
2018 · study · Temporal status not established
Journal of cardiothoracic and vascular anesthesia
2019 · study · Temporal status not established
Critical care medicine
2019 · study · Temporal status not established
The Annals of thoracic surgery
2019 · study · Temporal status not established
Intensive care medicine
2023 · study · Temporal status not established
Shock (Augusta, Ga.)
2024 · study · Temporal status not established
Critical care (London, England)
2025 · study · Temporal status not established
Medicina intensiva
2026 · regulatory · Temporal status not established
Canada (Health Canada — Vasopressin Injection USP DIN 02139502)
2026 · regulatory · Temporal status not established
United States (FDA — VASOSTRICT)
The represented chronology reflects records currently included in the governed dataset and does not claim to represent the entire scientific literature.
No institutional claim record is currently represented for this peptide.
Evidence is missing or not represented as studied; this is not a conclusion that the intervention does not work.
These are bibliographic author identities derived from represented records. Name strings are not proof of unique real-world researcher identity, and publishing organizations are not treated as institutional affiliations.
4 represented evidence records
Years represented: 2008, 2016, 2019
Publishing organizations appearing in records: Critical care medicine, Intensive care medicine, JAMA, The New England journal of medicine
3 represented evidence records
Years represented: 2006, 2010, 2018
Publishing organizations appearing in records: Critical care (London, England), Intensive care medicine, Journal of cardiothoracic and vascular anesthesia
2 represented evidence records
Years represented: 2019, 2024
Publishing organizations appearing in records: Critical care (London, England), Critical care medicine
2 represented evidence records
Years represented: 2016, 2019
Publishing organizations appearing in records: Intensive care medicine, JAMA
2 represented evidence records
Years represented: 2016, 2019
Publishing organizations appearing in records: Intensive care medicine, JAMA
2 represented evidence records
Years represented: 2016, 2019
Publishing organizations appearing in records: Intensive care medicine, JAMA
2 represented evidence records
Years represented: 2017, 2024
Publishing organizations appearing in records: Anesthesiology, Critical care (London, England)
2 represented evidence records
Years represented: 2006, 2010
Publishing organizations appearing in records: Critical care (London, England), Intensive care medicine
2 represented evidence records
Years represented: 2006, 2018
Publishing organizations appearing in records: Critical care (London, England), Journal of cardiothoracic and vascular anesthesia
2 represented evidence records
Years represented: 2006, 2018
Publishing organizations appearing in records: Critical care (London, England), Journal of cardiothoracic and vascular anesthesia
2 represented evidence records
Years represented: 2008, 2019
Publishing organizations appearing in records: Intensive care medicine, The New England journal of medicine
2 represented evidence records
Years represented: 2008, 2019
Publishing organizations appearing in records: Intensive care medicine, The New England journal of medicine
institution
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Claim: Not linked · Evidence: b0320bdbdaf26c2ac7e29d7bd56239a4
PMID: 12844130 · DOI: 10.1016/s0009-9236(03)00065-1
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Comparing two different arginine vasopressin doses in advanced vasodilatory shock: a randomized, controlled, open-label trial.
Claim: Not linked · Evidence: 6567931721af466a767c742d741124bc
PMID: 19756505 · DOI: 10.1007/s00134-009-1630-1
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Vasopressin in pediatric vasodilatory shock: a multicenter randomized controlled trial.
Claim: Not linked · Evidence: ffcae151c3b7ece1aa3f1f64ca1f4784
PMID: 19608718 · DOI: 10.1164/rccm.200902-0221oc
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Vasopressin versus epinephrine for inhospital cardiac arrest: a randomised controlled trial.
Claim: Not linked · Evidence: f535e87dfe3e51cd2d61a35250538cac
PMID: 11463411 · DOI: 10.1016/s0140-6736(01)05328-4
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Vasopressin versus norepinephrine infusion in patients with septic shock.
Claim: Not linked · Evidence: 3eee715da45f12fa32a4359c9e0ef586
PMID: 18305265 · DOI: 10.1056/nejmoa067373
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Vasopressin versus Norepinephrine in Patients with Vasoplegic Shock after Cardiac Surgery: The VANCS Randomized Controlled Trial.
Claim: Not linked · Evidence: 750e149391a546a1bda2292fccb74c12
PMID: 27841822 · DOI: 10.1097/aln.0000000000001434
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial.
Claim: Not linked · Evidence: efbf7e77fcde25df28a4ff6d9d37adf5
PMID: 27483065 · DOI: 10.1001/jama.2016.10485
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients: The VANCS II Randomized Clinical Trial.
Claim: Not linked · Evidence: aedca690c591cf283e8d5b8c0d269367
PMID: 31609774 · DOI: 10.1097/ccm.0000000000004023
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Reduction of norepinephrine versus vasopressin in the stabilization phase of septic shock: RENOVA clinical trial.
Claim: Not linked · Evidence: 0db444cb714014e8c71a4af42af5789c
PMID: 39890531 · DOI: 10.1016/j.medine.2025.502147
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Intraarterial vasopressin in the treatment of upper gastrointestinal hemorrhage: a prospective, controlled clinical trial.
Claim: Not linked · Evidence: b509b33c15ffe6243a43ffe1b59a32cd
PMID: 803910 · DOI: Unavailable
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Dilute versus concentrated vasopressin administration during laparoscopic myomectomy: a randomised controlled trial.
Claim: Not linked · Evidence: b4ec1a37e16a679dc96c7df06ca5b763
PMID: 27362908 · DOI: 10.1111/1471-0528.14179
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Safety and Efficacy of Vasopressin After Fontan Completion: A Randomized Pilot Study.
Claim: Not linked · Evidence: a4f946599f66f1f621e1898a8f1ae9d0
PMID: 31400337 · DOI: 10.1016/j.athoracsur.2019.06.053
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Comparison of intramyometrial vasopressin plus rectal misoprostol with intramyometrial vasopressin alone to decrease blood loss during laparoscopic myomectomy: Randomized clinical trial.
Claim: Not linked · Evidence: 983c86fa413b447cc5db88356e795ec7
PMID: 30056355 · DOI: 10.1016/j.ejogrb.2018.07.006
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
A randomized comparison of vasopressin and tourniquet as hemostatic agents during myomectomy.
Claim: Not linked · Evidence: 1d3ad17ac8c78262cf1778e51c4dd052
PMID: 8649682 · DOI: 10.1016/0029-7844(96)00071-3
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Controlled trial of vasopressin and balloon tamponade in bleeding esophageal varices.
Claim: Not linked · Evidence: 07e70e2e2763cd412b40bb92d57f3728
PMID: 6383998 · DOI: 10.1002/hep.1840040515
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Vasopressin does not raise cardiac enzymes following cardiac surgery: a randomized double-blind clinical trial.
Claim: Not linked · Evidence: 7649005da9c75dcc3524f6d39c4ebfe6
PMID: 25440643 · DOI: 10.1053/j.jvca.2014.07.007
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
A double-blind randomized trial: prophylactic vasopressin reduces hypotension after cardiopulmonary bypass.
Claim: Not linked · Evidence: 9c4c7b6190d13fec0c77b95bdc9a894f
PMID: 12645718 · DOI: 10.1016/s0003-4975(02)04408-9
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Pilot safety study of low-dose vasopressin in non-septic critically ill children.
Claim: Not linked · Evidence: 13f7cc3d7d8a06be864ef563b99e05fa
PMID: 19132338 · DOI: 10.1007/s00134-008-1392-1
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Cutaneous vascular reactivity and flow motion response to vasopressin in advanced vasodilatory shock and severe postoperative multiple organ dysfunction syndrome.
Claim: Not linked · Evidence: dfa29ba58f4b3949a074edb1e465d30d
PMID: 16542484 · DOI: 10.1186/cc4845
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Vasopressin or norepinephrine in early hyperdynamic septic shock: a randomized clinical trial.
Claim: Not linked · Evidence: 99134629a26c6994f8aa58c17209c32c
PMID: 17019548 · DOI: 10.1007/s00134-006-0378-0
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Vasopressin in Cardiac Surgery: A Meta-analysis of Randomized Controlled Trials.
Claim: Not linked · Evidence: 349ba1474e7688736ac98f0accc9ef3e
PMID: 29748077 · DOI: 10.1053/j.jvca.2018.04.006
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
THE EFFICACY AND SAFETY OF VASOPRESSORS FOR SEPTIC SHOCK PATIENTS: A SYSTEMIC REVIEW AND NETWORK META-ANALYSIS.
Claim: Not linked · Evidence: 483700eb0a1c38960b50b6cad79662d7
PMID: 37548686 · DOI: 10.1097/shk.0000000000002193
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Vasopressors for the Treatment of Septic Shock: Systematic Review and Meta-Analysis.
Claim: Not linked · Evidence: 2dc33d687ee9740e935f7b97d613cca0
PMID: 26237037 · DOI: 10.1371/journal.pone.0129305
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Non-adrenergic vasopressors for vasodilatory shock or perioperative vasoplegia: a meta-analysis of randomized controlled trials.
Claim: Not linked · Evidence: 19a68dd008b2e767d5e97002386206c6
PMID: 39736782 · DOI: 10.1186/s13054-024-05212-7
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Vasopressin in septic shock: an individual patient data meta-analysis of randomised controlled trials.
Claim: Not linked · Evidence: e296262a3815c3bbcad086b0dc87cd4e
PMID: 31062052 · DOI: 10.1007/s00134-019-05620-2
Extraction: not-recorded · Review: verified · Source state: unknown
Machine extracted: no · Human scientist reviewed: no · Externally validated: no
Incomplete path: claim, extraction-status
Generated: 9/18/2026, 3:04:07 PM
Funding and conflicts are disclosed and considered, but sponsorship never automatically changes a tier. Corrections, retractions, and expressions of concern override the original rating.
Evidence searched through: Not recorded
Last accountable review: Not recorded
These are documentary and scientific-review signals, not conclusions of harm, ineffectiveness, safety, or absence of research.
This maturity index describes evidence-base development and governance. It is not a probability of efficacy, safety, truth, medical advice, or regulatory approval. Read the methodology.