1220-OR: Survodutide: Differentiated GLP-1R and Glucagon Receptor (GCGR) Pharmacology Compared with Endogenous Ligands via Time-Resolved Assays
OpenAlex · 2026 · Source ID doi:10.2337/db26-1220-or · DOI 10.2337/db26-1220-or
laboratory-mechanistic
Scientific intelligence record
Experience 2.0
GLP-1/glucagon receptor agonist
Record status
Traceability partial
Last meaningful update: 9/20/2026
Ranked research corpus
224
Categorized publications with transparent machine-proposed ranking; human appraisal pending.
Featured tiered studies
0
global evidence atlas
This is a deduplicated literature screening registry—not a claim that every mention directly proves efficacy or safety. Machine proposals remain visibly separate from governed human appraisal.
224 matching records · ranked 2026-09-18
Page 1 of 9
OpenAlex · 2026 · Source ID doi:10.2337/db26-1220-or · DOI 10.2337/db26-1220-or
laboratory-mechanistic
OpenAlex · 2026 · Source ID doi:10.2337/db26-2551-p · DOI 10.2337/db26-2551-p
preclinical-animal
OpenAlex · 2026 · Source ID doi:10.2337/db26-2565-p · DOI 10.2337/db26-2565-p
preclinical-animal
OpenAlex · 2026 · Source ID doi:10.2337/db26-2577-p · DOI 10.2337/db26-2577-p
preclinical-animal
Europe PMC · 2026 · PMID 41855048 · DOI 10.23736/s2724-6507.26.04406-4
human-interventional
Europe PMC · 2026 · PMID 42590128 · DOI 10.3390/jcm15156026
human-interventional
Europe PMC · 2026 · PMID 42642663 · DOI 10.1038/s41591-026-04650-w
human-interventional
OpenAlex · 2026 · Source ID doi:10.1111/dom.70861/v2/response1 · DOI 10.1111/dom.70861/v2/response1
laboratory-mechanistic
Europe PMC · 2026 · PMID 41216778 · DOI 10.1111/dom.70263
human-interventional
Europe PMC · 2026 · PMID 42208956 · DOI 10.1016/s2213-8587(26)00100-2
human-interventional
Europe PMC · 2026 · PMID 42535526 · DOI 10.1161/jaha.126.049727
human-interventional
Europe PMC · 2026 · PMID 41466530 · DOI 10.1002/edm2.70157
synthesis
Europe PMC · 2026 · PMID 41787737 · DOI 10.1002/edm2.70187
human-interventional
OpenAlex · 2026 · Source ID doi:10.1111/dom.70861/v2/decision1 · DOI 10.1111/dom.70861/v2/decision1
laboratory-mechanistic
OpenAlex · 2026 · Source ID doi:10.1111/dom.70861/v1/decision1 · DOI 10.1111/dom.70861/v1/decision1
laboratory-mechanistic
Europe PMC · 2026 · PMID 42603384 · DOI 10.1016/j.chroma.2026.467288
human-interventional
Europe PMC · 2026 · PMID 42331726 · DOI 10.1111/dom.70861
human-interventional
Europe PMC · 2026 · Source ID doi:10.22541/authorea.15005660/v1 · DOI 10.22541/authorea.15005660/v1
contextual-unclassified
Europe PMC · 2026 · PMID 42529769 · DOI 10.7759/cureus.111728
synthesis
Europe PMC · 2026 · PMID 42192439 · DOI 10.1186/s12967-026-08219-6
synthesis
Europe PMC · 2026 · Source ID doi:10.20944/preprints202604.1748.v1 · DOI 10.20944/preprints202604.1748.v1
preclinical-animal
OpenAlex · 2026 · Source ID doi:10.1016/s0168-8278(26)00570-2 · DOI 10.1016/s0168-8278(26)00570-2
laboratory-mechanistic
OpenAlex · 2026 · Source ID doi:10.1016/s0168-8278(26)01909-4 · DOI 10.1016/s0168-8278(26)01909-4
laboratory-mechanistic
Europe PMC · 2026 · Source ID doi:10.22541/authorea.15008173/v1 · DOI 10.22541/authorea.15008173/v1
preclinical-animal
OpenAlex · 2026 · Source ID doi:10.1007/s12467-026-1631-5 · DOI 10.1007/s12467-026-1631-5
contextual-unclassified
governance and regulatory context
No new outcome conclusion is inferred from discovery metadata. Named accountable approval is required for governed scientific conclusions.
No machine-proposed evidence-strength grades exist yet for this compound; all screening records are unassigned pending further review.
Survodutide evidence · ranking key
A tier describes the evidentiary role and design strength of a source. It is not a popularity score, proof that every conclusion is correct, or a substitute for claim-level review.
Large, well-conducted randomized trials; prespecified major outcomes; rigorous systematic reviews or meta-analyses; and major regulatory assessments.
Smaller randomized trials, strong prospective cohorts, prespecified secondary analyses, and high-quality comparative-effectiveness studies.
Retrospective cohorts, claims-database studies, pharmacovigilance analyses, mechanistic human research, and well-documented case series.
Case reports, conference abstracts, preclinical research, hypothesis-generating analyses, and expert commentary.
APA
World Peptide Foundation. (n.d.). Survodutide — Peptide Scientific Intelligence. World Peptide Foundation. (Updated September 20, 2026.) https://www.worldpeptidefoundation.org/directory/survodutide
AMA / Vancouver
World Peptide Foundation. Survodutide — Peptide Scientific Intelligence. World Peptide Foundation website. Updated September 20, 2026. https://www.worldpeptidefoundation.org/directory/survodutide
Cornerstone publications with study-level interpretation, limitations, and tier disclosure.
Research domains
6
Clinical and scientific questions synthesized independently across the evidence atlas.
Governed reviewed evidence
0
Database records promoted through the governed publication workflow—not the corpus total.
Corpus generated 2026-09-18. Counts remain separately labeled to prevent automated screening from being represented as completed human review.
Human experience · separate evidence stream
Eligible observations remain below the privacy and reliability threshold. WPF will not convert a handful of reports into a percentage, trend, or clinical claim.
Observation is valuable human context. It is not evidence of causation, efficacy, or safety.
Public display gate
n ≥ 20 eligible observations
Exact progress remains private before the threshold.
Intelligence snapshot
A compact view of what is represented, what remains unresolved, and how completely the record can be traced.
Ranked research corpus
224
Categorized screening records; proposed rankings remain pending human appraisal.
Featured tiered studies
0
Cornerstone studies with published study-level interpretation and tier disclosure.
Research domains
6
Independent evidence dossiers covering the major research questions.
Governed reviewed evidence
0
Reviewed database records promoted through the governed publication workflow.
Contradictions
0
Conflicting evidence relationships that remain visible.
Research gaps
3
Questions the current record identifies as unresolved.
Connected media
0
Media records explicitly linked to this scientific record.
What we know
The project separates represented evidence from qualification, contradiction, uncertainty, and what the evidence does not establish.
Reconciled domain conclusions
Survodutide no longer relies on the legacy “no public claim” state. Each research domain publishes a bounded conclusion, confidence level, evidence synthesis, limitations, geographic applicability, regulatory interpretation, and research gaps.
Inspect the reconciled evidence atlasNo reviewed published evidence records are represented for this peptide yet. This is not evidence that no research exists.
Scientific context
Existing reviewed chemistry is preserved as scientific context. Chemistry and mechanism information do not establish clinical efficacy or safety.
No reviewed chemistry record is currently represented for this peptide.
Explore further
Move from this peptide record into the project's broader evidence, research, comparison, and methodology systems.
Research
Chronology, unresolved research questions, opportunities, and researcher activity remain descriptive rather than evaluative.
No peptide-specific research chronology has been represented yet.
The represented chronology reflects records currently included in the governed dataset and does not claim to represent the entire scientific literature.
No verified published evidence records are currently represented for this peptide.
Evidence is missing or not represented as studied; this is not a conclusion that the intervention does not work.
A reviewed chemistry record is not currently represented.
Evidence is missing or not represented as studied; this is not a conclusion that the intervention does not work.
No institutional claim record is currently represented for this peptide.
Evidence is missing or not represented as studied; this is not a conclusion that the intervention does not work.
Connections
Connections appear only when they are represented by the project’s underlying records.
No structured peptide-specific connections are currently represented.
Traceability
The experience makes incomplete links visible instead of presenting a false impression of perfect provenance.
Source publication state
A governed source may be verified and approved for publication while its claim-to-evidence link is still incomplete.
Reviewer provenance state
“Human scientist reviewed: no” means that specific source-path attribution is not recorded. It does not silently negate the separate publication-review state.
Domain conclusion → Evidence
Connected
Evidence → Source
Connected
Source → Original record
Connected
Traceability documents how the project connects statements to records. It does not establish that a source is scientifically valid or that a claim is clinically true.
Reconciled for 6 domain conclusions and 0 featured studies.
Detailed study-to-domain mappings and original-source paths appear in the Survodutide evidence-governance section.
Inspect the ranked source recordsObservational archive
Observational archive data is intentionally separated from published scientific evidence.
Observational boundary
Insufficient eligible observations are available for display under the current filters.
Insufficient eligible observations are currently represented to display aggregated findings for this peptide.
Research + media
Only media explicitly linked through the project’s relationship system appears here.
No scientifically connected media is currently represented for this peptide.
Sources + provenance
Generated: 9/24/2026, 4:00:00 AM
Tier classifies source design and evidentiary role. Confidence reflects risk of bias, sample size, comparator quality, outcome relevance, follow-up, missing data, directness, replication, reporting quality, and whether conclusions stay within the measured results.
Funding and conflicts are disclosed and considered, but sponsorship never automatically changes a tier. Corrections, retractions, and expressions of concern override the original rating.