archived version — not current
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Kisspeptin-10
Snapshot captured 2026-09-27 — Evidence added or removed
Overview
Bioactive C-terminal kisspeptin fragment that activates KISS1R and hypothalamic-pituitary-gonadal signaling.
Evidence quality
Source identities are PubMed-resolved and provisionally graded by study design. Full-text findings, bias, applicability, contradictions, and regulatory interpretation remain pending.
Safety concerns
Acute endocrine responses do not establish long-term safety or therapeutic effectiveness.
Citations as of this version
- GPR54 and kisspeptin in reproduction.
- Role of Kisspeptin and NKB in Puberty in Nonhuman Primates: Sex Differences.
- Kisspeptin and Cancer: Molecular Interaction, Biological Functions, and Future Perspectives.
- Roles of the kisspeptin/GPR54 system in pathomechanisms of atherosclerosis.
- New Insights in Bovine Follicular Cysts. — Reproduction in domestic animals = Zuchthygiene (2025)
- Kisspeptin-10 protects against HIV-1 Tat-induced blood-brain barrier dysfunction and neuroinflammation via RhoA/ROCK pathway: Implications for HAND therapy. — Neurotoxicology (2025)
- Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice. — Biomolecules (2025)
- Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. — Nature communications (2024)
- Author Correction: Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. — Nature communications (2024)
- [Not Available]. — Biomedical chromatography : BMC (2024)
- Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity. — Scientific reports (2023)
- Kisspeptin regulates airway hyperresponsiveness and remodeling in a mouse model of asthma. — The Journal of pathology (2023)
- Kisspeptin-10 Promotes Progesterone Synthesis in Bovine Ovarian Granulosa Cells via Downregulation of microRNA-1246. — Genes (2022)
- Kisspeptin-10 in cryodiluent improves the post-thaw quality of Nili-Ravi buffalo (Bubalus bubalis) bull spermatozoa. — Andrologia (2022)
- Effects of kisspeptin-10 on the reproductive performance of sows in a fixed-time artificial insemination programme. — Animal : an international journal of animal bioscience (2022)
- Kisspeptins inhibit human airway smooth muscle proliferation. — JCI insight (2022)
- Kisspeptin-10 Rescues Cholinergic Differentiated SHSY-5Y Cells from α-Synuclein-Induced Toxicity In Vitro. — International journal of molecular sciences (2022)
- Safety Evaluation of KP-10 (Metastin 45-54) Following once Daily Intravenous Administration for 14 Days in Dog. — International journal of toxicology (2021)
- Mutual Interactions Between GnRH and Kisspeptin in GnRH- and Kiss-1-Expressing Immortalized Hypothalamic Cell Models. — Reproductive sciences (Thousand Oaks, Calif.) (2021)
- Effects of Kisspeptin-10 on Hypothalamic Neuropeptides and Neurotransmitters Involved in Appetite Control. — Molecules (Basel, Switzerland) (2018)
- Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. — Scientific reports (2018)
- Stimulation of growth hormone by kisspeptin antagonists in ewes. — The Journal of endocrinology (2018)
- The effects of kisspeptin-10 on serum metabolism and myocardium in rats. — PloS one (2017)
- Hypothalamic-Pituitary-Ovarian Axis Reactivation by Kisspeptin-10 in Hyperprolactinemic Women With Chronic Amenorrhea. — Journal of the Endocrine Society (2017)
- Kisspeptin-10 inhibits OHSS by suppressing VEGF secretion. — Reproduction (Cambridge, England) (2017)
- Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo. — PloS one (2017)
- The effects of kisspeptin-10 on migration and proliferation of endothelial cell. — Advanced biomedical research (2015)
- Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition. — Oncology reports (2015)
- Kisspeptin-10 potentiates miniature excitatory postsynaptic currents in the rat supraoptic nucleus. — Brain research (2014)
Regulatory status as of this version
- United States: not_approved
- European Union: not_approved
Content hash: 62f4d27bf06e188cd44b6c08f5d333988987c6b009600193d7d465815642f038