Kisspeptin

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Kisspeptin — Peptide Scientific Intelligence

What we know

Evidence, claims, and boundaries

The project separates represented evidence from qualification, contradiction, uncertainty, and what the evidence does not establish.

Reconciled domain conclusions

6 conclusions connected to 0 featured studies

Kisspeptin no longer relies on the legacy “no public claim” state. Each research domain publishes a bounded conclusion, confidence level, evidence synthesis, limitations, geographic applicability, regulatory interpretation, and research gaps.

Inspect the reconciled evidence atlas

Inspect the published evidence record444 governed records · titles, provenance, and original-source linksOpen records ↓

2025Phase 1–2 human evidence

Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study.

Content-verified record concerning Kisspeptin: "Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study." Abstract excerpt: Kisspeptin plays a major role in the onset of puberty by stimulating the gonadotropin-releasing hormone (GnRH) neurons. The aim of this study was to investigate whether GnRH inhibits kisspeptin secretion via a negative feedback mechanism and potential associations between kisspeptin levels and other hormones of importance for pubertal onset. Thirteen girls with suspected central precocious puberty

Source: peer_reviewed_research
DOI: 10.1515/jpem-2024-0606
PubMed: 39847034

Open original source

2024Phase 1–2 human evidence

Kisspeptin expression levels in patients with placenta previa: A randomized trial.

Scientific context

Chemistry and represented biological context

Existing reviewed chemistry is preserved as scientific context. Chemistry and mechanism information do not establish clinical efficacy or safety.

Open chemistry and biological context ↓

Chemical identity

Molecular and structural record

Structured record

Molecular formula: C258H401N79O78
Molecular weight: 5857
SMILES: CCC(C)C(C(=O)N1CCCC1C(=O)NC(C)C(=O)N2CCCC2C(=O)NC(CCC(=O)N)C(=O)NCC(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)N3CCCC3C(=O)NC(CC(=O)N)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CC(=O)N)C(=O)NC(CC5=CNC6=CC=CC=C65)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CC7=CC=CC=C7)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC8=CC=CC=C8)C(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(CC9=CN=CN9)NC(=O)C1CCCN1C(=O)C(C)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C1CCCN1C(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)CNC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCC(=O)O)NC(=O)C1CCCN1C(=O)C1CCCN1C(=O)C1CCCN1C(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)CN
InChI: InChI=1S/C258H401N79O78/c1-21-131(16)204(329-220(381)152(70-77-189(264)351)301-213(374)147(53-34-84-281-257(274)275)299-234(395)173(118-341)322-226(387)164(103-140-110-278-123-288-140)315-242(403)181-58-38-87-331(181)247(408)133(18)290-232(393)172(117-340)321-222(383)158(95-125(4)5)293-197(359)114-287-238(399)178-55-36-88-332(178)249(410)155(71-78-190(265)352)306-218(379)150(68-75-187(262)349)300-212(373)146(52-33-83-280-256(272)273)298-233(394)171(116-339)294-198(360)113-286-210(371)170(115-338)319-237(398)175(120-343)320-219(380)154(73-80-200(363)364)304-241(402)183-60-40-90-334(183)252(413)185-62-43-93-337(185)253(414)184-61-42-92-336(184)251(412)177(122-345)325-223(384)159(96-126(6)7)308-236(397)176(121-344)324-246(407)205(135(20)346)326-194(356)108-260)254(415)335-91-41-56-179(335)239(400)291-134(19)248(409)330-86-37-57-180(330)240(401)303-149(67-74-186(261)348)208(369)284-111-195(357)289-132(17)207(368)327-202(129(12)13)245(406)317-160(97-127(8)9)231(392)328-203(130(14)15)244(405)305-151(69-76-188(263)350)216(377)296-145(51-32-82-279-255(270)271)211(372)302-153(72-79-199(361)362)217(378)295-144(50-30-31-81-259)215(376)314-168(107-201(365)366)230(391)318-169(98-128(10)11)250(411)333-89-39-59-182(333)243(404)316-167(106-193(268)355)228(389)310-162(101-138-63-65-141(347)66-64-138)224(385)312-165(104-191(266)353)227(388)311-163(102-139-109-283-143-49-29-28-48-142(139)143)225(386)313-166(105-192(267)354)229(390)323-174(119-342)235(396)309-161(100-137-46-26-23-27-47-137)209(370)285-112-196(358)292-157(94-124(2)3)221(382)297-148(54-35-85-282-258(276)277)214(375)307-156(206(269)367)99-136-44-24-22-25-45-136/h22-29,44-49,63-66,109-110,123-135,144-185,202-205,283,338-347H,21,30-43,50-62,67-108,111-122,259-260H2,1-20H3,(H2,261,348)(H2,262,349)(H2,263,350)(H2,264,351)(H2,265,352)(H2,266,353)(H2,267,354)(H2,268,355)(H2,269,367)(H,278,288)(H,284,369)(H,285,370)(H,286,371)(H,287,399)(H,289,357)(H,290,393)(H,291,400)(H,292,358)(H,293,359)(H,294,360)(H,295,378)(H,296,377)(H,297,382)(H,298,394)(H,299,395)(H,300,373)(H,301,374)(H,302,372)(H,303,401)(H,304,402)(H,305,405)(H,306,379)(H,307,375)(H,308,397)(H,309,396)(H,310,389)(H,311,388)(H,312,385)(H,313,386)(H,314,376)(H,315,403)(H,316,404)(H,317,406)(H,318,391)(H,319,398)(H,320,380)(H,321,383)(H,322,387)(H,323,390)(H,324,407)(H,325,384)(H,326,356)(H,327,368)(H,328,392)(H,329,381)(H,361,362)(H,363,364)(H,365,366)(H4,270,271,279)(H4,272,273,280)(H4,274,275,281)(H4,276,277,282)/t131-,132-,133-,134-,135+,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,202-,203-,204-,205-/m0/s1
InChIKey: KAHDONZOCXSKII-NJVVDGNHSA-N

Chemical identity describes the recorded molecular information. It does not establish biological activity, clinical efficacy, safety, or therapeutic suitability.

Research

How the scientific record is developing

Chronology, unresolved research questions, opportunities, and researcher activity remain descriptive rather than evaluative.

Research chronology

2001 · study · Temporal status not established
The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54
peer_reviewed_research
2004 · study · Temporal status not established
A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse
peer_reviewed_research
2004 · study · Temporal status not established
Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat
peer_reviewed_research
2004 · study · Temporal status not established
Central and Peripheral Administration of Kisspeptin‐10 Stimulates the Hypothalamic‐Pituitary‐Gonadal Axis
peer_reviewed_research
2004 · study · Temporal status not established
Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts
peer_reviewed_research
2005 · study · Temporal status not established
Changes in Hypothalamic KiSS-1 System and Restoration of Pubertal Activation of the Reproductive Axis by Kisspeptin in Undernutrition
peer_reviewed_research
2005 · study · Temporal status not established
Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
peer_reviewed_research
2005 · study · Temporal status not established
Kisspeptin-10-Induced Signaling of GPR54 Negatively Regulates Chemotactic Responses Mediated by CXCR4: a Potential Mechanism for the Metastasis Suppressor Activity of Kisspeptins
peer_reviewed_research
2005 · study · Temporal status not established
Repetitive Activation of Hypothalamic G Protein-Coupled Receptor 54 with Intravenous Pulses of Kisspeptin in the Juvenile Monkey (Macaca mulatta) Elicits a Sustained Train of Gonadotropin-Releasing Hormone Discharges
peer_reviewed_research
2005 · study · Temporal status not established
Minireview: Kisspeptin Neurons as Central Processors in the Regulation of Gonadotropin-Releasing Hormone Secretion
systematic_review_or_meta_analysis
2005 · study · Temporal status not established
Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty
peer_reviewed_research
2005 · study · Temporal status not established
Kisspeptin-54 Stimulates the Hypothalamic-Pituitary Gonadal Axis in Human Males
peer_reviewed_research
2006 · study · Temporal status not established
Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats
peer_reviewed_research
2006 · study · Temporal status not established
Hypothalamic Expression of KiSS-1 System and Gonadotropin-Releasing Effects of Kisspeptin in Different Reproductive States of the Female Rat
peer_reviewed_research
2006 · study · Temporal status not established
Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat
peer_reviewed_research
2006 · study · Temporal status not established
Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats
peer_reviewed_research
2006 · study · Temporal status not established
Postnatal Development of Kisspeptin Neurons in Mouse Hypothalamus; Sexual Dimorphism and Projections to Gonadotropin-Releasing Hormone Neurons
peer_reviewed_research
2006 · study · Temporal status not established
Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha
peer_reviewed_research
2006 · study · Temporal status not established
A role for kisspeptin in islet function
peer_reviewed_research
2006 · study · Temporal status not established
Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling
peer_reviewed_research
2006 · study · Temporal status not established
Kisspeptin Mediates the Photoperiodic Control of Reproduction in Hamsters
peer_reviewed_research
2006 · study · Temporal status not established
GPR54 and kisspeptin in reproduction
peer_reviewed_research
2007 · study · Temporal status not established
Metastin/Kisspeptin and control of estrous cycle in rats
peer_reviewed_research
2007 · study · Temporal status not established
Kisspeptin Is Present in Ovine Hypophysial Portal Blood But Does Not Increase during the Preovulatory Luteinizing Hormone Surge: Evidence that Gonadotropes Are Not Direct Targets of Kisspeptin in Vivo
peer_reviewed_research
2007 · study · Temporal status not established
Involvement of Anteroventral Periventricular Metastin/Kisspeptin Neurons in Estrogen Positive Feedback Action on Luteinizing Hormone Release in Female Rats
peer_reviewed_research
2007 · study · Temporal status not established
The Kisspeptin Receptor GPR54 Is Required for Sexual Differentiation of the Brain and Behavior
peer_reviewed_research
2007 · study · Temporal status not established
Hypertrophy and Increased Kisspeptin Gene Expression in the Hypothalamic Infundibular Nucleus of Postmenopausal Women and Ovariectomized Monkeys
peer_reviewed_research
2007 · study · Temporal status not established
Emerging ideas about kisspeptin– GPR54 signaling in the neuroendocrine regulation of reproduction
systematic_review_or_meta_analysis
2007 · study · Temporal status not established
New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function
peer_reviewed_research
2007 · study · Temporal status not established
The Role of Kisspeptin–GPR54 Signaling in the Tonic Regulation and Surge Release of Gonadotropin-Releasing Hormone/Luteinizing Hormone
peer_reviewed_research
2007 · study · Temporal status not established
The Role of Kisspeptins and GPR54 in the Neuroendocrine Regulation of Reproduction
systematic_review_or_meta_analysis
2007 · study · Temporal status not established
The Kisspeptin/Gonadotropin-Releasing Hormone Pathway and Molecular Signaling of Puberty in Fish1
peer_reviewed_research
2007 · study · Temporal status not established
Kisspeptin-54 Stimulates Gonadotropin Release Most Potently during the Preovulatory Phase of the Menstrual Cycle in Women
peer_reviewed_research
2007 · study · Temporal status not established
Kisspeptin Acts Directly and Indirectly to Increase Gonadotropin-Releasing Hormone Neuron Activity and Its Effects Are Modulated by Estradiol
peer_reviewed_research
2007 · study · Temporal status not established
Kisspeptin Neurons in the Arcuate Nucleus of the Ewe Express Both Dynorphin A and Neurokinin B
peer_reviewed_research
2007 · study · Temporal status not established
Kisspeptin Synchronizes Preovulatory Surges in Cyclical Ewes and Causes Ovulation in Seasonally Acyclic Ewes
peer_reviewed_research
2007 · study · Temporal status not established
Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system
peer_reviewed_research
2007 · study · Temporal status not established
Kisspeptin signalling in the brain: Steroid regulation in the rodent and ewe
peer_reviewed_research
2007 · study · Temporal status not established
Kisspeptin: A key link to seasonal breeding
peer_reviewed_research
2007 · study · Temporal status not established
Kisspeptins and the placenta: Regulation of trophoblast invasion
peer_reviewed_research
2007 · study · Temporal status not established
Kisspeptin expression in the brain: Catalyst for the initiation of puberty
peer_reviewed_research
2007 · study · Temporal status not established
Neuroendocrine factors in the initiation of puberty: The emergent role of kisspeptin
peer_reviewed_research
2007 · study · Temporal status not established
Direct Pituitary Effects of Kisspeptin: Activation of Gonadotrophs and Somatotrophs and Stimulation of Luteinising Hormone and Growth Hormone Secretion
peer_reviewed_research
2008 · study · Temporal status not established
Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals
peer_reviewed_research
2008 · study · Temporal status not established
Molecular Identification and Functional Characterization of the Kisspeptin/Kisspeptin Receptor System in Lower Vertebrates1
peer_reviewed_research
2008 · study · Temporal status not established
An Increase in Kisspeptin-54 Release Occurs with the Pubertal Increase in Luteinizing Hormone-Releasing Hormone-1 Release in the Stalk-Median Eminence of Female Rhesus Monkeys in Vivo
peer_reviewed_research
2008 · study · Temporal status not established
Central and peripheral administration of kisspeptin activates gonadotropin but not somatotropin secretion in prepubertal gilts
peer_reviewed_research
2008 · study · Temporal status not established
Kisspeptin Depolarizes Gonadotropin-Releasing Hormone Neurons through Activation of TRPC-Like Cationic Channels
peer_reviewed_research
2008 · study · Temporal status not established
The neuroanatomy of the kisspeptin system in the mammalian brain
peer_reviewed_research
2008 · study · Temporal status not established
The role of kisspeptin in the control of gonadotrophin secretion
peer_reviewed_research
2008 · study · Temporal status not established
GPR54 and Kisspeptins
peer_reviewed_research
2008 · study · Temporal status not established
Comparison of the effects of peripherally administered kisspeptins
peer_reviewed_research
2008 · study · Temporal status not established
From KISS1 to kisspeptins: An historical perspective and suggested nomenclature
peer_reviewed_research
2008 · study · Temporal status not established
The kisspeptin (KiSS-1)/GPR54 system in cancer biology
peer_reviewed_research
2008 · study · Temporal status not established
Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback
peer_reviewed_research
2008 · study · Temporal status not established
Kisspeptin–GPR54 Signaling Is Essential for Preovulatory Gonadotropin-Releasing Hormone Neuron Activation and the Luteinizing Hormone Surge
peer_reviewed_research
2008 · study · Temporal status not established
Kisspeptins and GnRH neuronal signalling
systematic_review_or_meta_analysis
2008 · study · Temporal status not established
Kisspeptin Excites Gonadotropin-Releasing Hormone Neurons through a Phospholipase C/Calcium-Dependent Pathway Regulating Multiple Ion Channels
peer_reviewed_research
2008 · study · Temporal status not established
Kisspeptin Can Stimulate Gonadotropin-Releasing Hormone (GnRH) Release by a Direct Action at GnRH Nerve Terminals
peer_reviewed_research
2008 · study · Temporal status not established
Kisspeptin and GPR54: Discovery of a Novel Pathway in Reproduction
peer_reviewed_research
2008 · study · Temporal status not established
Kisspeptins and the control of gonadotropin secretion in male and female rodents
peer_reviewed_research
2008 · study · Temporal status not established
Identification of KiSS-1 Product Kisspeptin and Steroid-Sensitive Sexually Dimorphic Kisspeptin Neurons in Medaka (Oryzias latipes)
peer_reviewed_research
2009 · study · Temporal status not established
A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10
peer_reviewed_research
2009 · study · Temporal status not established
Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse
peer_reviewed_research
2009 · study · Temporal status not established
Kisspeptin Signalling in the Hypothalamic Arcuate Nucleus Regulates GnRH Pulse Generator Frequency in the Rat
peer_reviewed_research
2009 · study · Temporal status not established
Distribution of Kisspeptin Neurones in the Adult Female Mouse Brain
peer_reviewed_research
2009 · study · Temporal status not established
Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women with Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis
peer_reviewed_research
2009 · study · Temporal status not established
Molecular Evolution of Multiple Forms of Kisspeptins and GPR54 Receptors in Vertebrates
peer_reviewed_research
2009 · study · Temporal status not established
Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines
peer_reviewed_research
2009 · study · Temporal status not established
The Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cell Population of the Arcuate Nucleus: Sex Differences and Effects of Prenatal Testosterone in Sheep
peer_reviewed_research
2009 · study · Temporal status not established
Discovery of Potent Kisspeptin Antagonists Delineate Physiological Mechanisms of Gonadotropin Regulation
peer_reviewed_research
2009 · study · Temporal status not established
Postnatal Development of an Estradiol-Kisspeptin Positive Feedback Mechanism Implicated in Puberty Onset
peer_reviewed_research
2009 · study · Temporal status not established
Critical Roles of Kisspeptins in Female Puberty and Preovulatory Gonadotropin Surges as Revealed by a Novel Antagonist
peer_reviewed_research
2009 · study · Temporal status not established
Oestrogen, Kisspeptin, GPR54 and the Pre‐Ovulatory Luteinising Hormone Surge
peer_reviewed_research
2009 · study · Temporal status not established
Characteristics of stimulation of gonadotropin secretion by kisspeptin-10 in female goats
peer_reviewed_research
2009 · study · Temporal status not established
Kisspeptin Signaling in the Brain
peer_reviewed_research
2010 · study · Temporal status not established
Timing and completion of puberty in female mice depend on estrogen receptor α-signaling in kisspeptin neurons
peer_reviewed_research
2010 · study · Temporal status not established
Mapping of Kisspeptin Fibres in the Brain of the Pro‐Oestrous Rat
peer_reviewed_research
2010 · study · Temporal status not established
Identification of Prolactin-Sensitive GABA and Kisspeptin Neurons in Regions of the Rat Hypothalamus Involved in the Control of Fertility
peer_reviewed_research
2010 · study · Temporal status not established
Developmental Changes in the Expression of Kisspeptin mRNA in Rat Hypothalamus
peer_reviewed_research
2010 · study · Temporal status not established
Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat
peer_reviewed_research
2010 · study · Temporal status not established
Characterisation of Arcuate Nucleus Kisspeptin/Neurokinin B Neuronal Projections and Regulation during Lactation in the Rat
peer_reviewed_research
2010 · study · Temporal status not established
Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat
peer_reviewed_research
2010 · study · Temporal status not established
Kisspeptin Cells in the Ewe Brain Respond to Leptin and Communicate with Neuropeptide Y and Proopiomelanocortin Cells
peer_reviewed_research
2010 · study · Temporal status not established
Kisspeptin Directly Excites Anorexigenic Proopiomelanocortin Neurons but Inhibits Orexigenic Neuropeptide Y Cells by an Indirect Synaptic Mechanism
peer_reviewed_research
2010 · study · Temporal status not established
Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion
peer_reviewed_research
2010 · study · Temporal status not established
Molecular coevolution of kisspeptins and their receptors from fish to mammals
peer_reviewed_research
2010 · study · Temporal status not established
Anatomy of the kisspeptin neural network in mammals
peer_reviewed_research
2010 · study · Temporal status not established
Hypothesis: Kisspeptin Mediates Male Hypogonadism in Obesity and Type 2 Diabetes
peer_reviewed_research
2010 · study · Temporal status not established
The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin‐releasing hormone and neurokinin B neurons
peer_reviewed_research
2010 · study · Temporal status not established
Kisspeptin and fertility
peer_reviewed_research
2010 · study · Temporal status not established
Kisspeptin Regulates Prolactin Release through Hypothalamic Dopaminergic Neurons
peer_reviewed_research
2010 · study · Temporal status not established
Kisspeptin antagonists: Unraveling the role of kisspeptin in reproductive physiology
peer_reviewed_research
2010 · study · Temporal status not established
Kisspeptins: Bridging energy homeostasis and reproduction
peer_reviewed_research
2010 · study · Temporal status not established
The Role of Kisspeptin Signaling in Reproduction
peer_reviewed_research
2010 · study · Temporal status not established
Neurokinin B Stimulates GnRH Release in the Male Monkey (Macaca mulatta) and Is Colocalized with Kisspeptin in the Arcuate Nucleus
peer_reviewed_research
2011 · study · Temporal status not established
Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice
peer_reviewed_research
2011 · study · Temporal status not established
Kisspeptin Signaling Is Indispensable for Neurokinin B, but not Glutamate, Stimulation of Gonadotropin Secretion in Mice
peer_reviewed_research
2011 · study · Temporal status not established
Projections of Arcuate Nucleus and Rostral Periventricular Kisspeptin Neurons in the Adult Female Mouse Brain
peer_reviewed_research
2011 · study · Temporal status not established
Female reproductive maturation in the absence of kisspeptin/GPR54 signaling
peer_reviewed_research
2011 · study · Temporal status not established
Comparative insights of the kisspeptin/kisspeptin receptor system: Lessons from non-mammalian vertebrates
peer_reviewed_research
2011 · study · Temporal status not established
Organization of Two Independent Kisspeptin Systems Derived from Evolutionary-Ancient Kiss Genes in the Brain of Zebrafish
peer_reviewed_research
2011 · study · Temporal status not established
Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility
systematic_review_or_meta_analysis
2011 · study · Temporal status not established
Characterization of the kisspeptin system in human spermatozoa
peer_reviewed_research
2011 · study · Temporal status not established
The Effects of Kisspeptin-10 on Reproductive Hormone Release Show Sexual Dimorphism in Humans
peer_reviewed_research
2011 · study · Temporal status not established
Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men
peer_reviewed_research
2011 · study · Temporal status not established
Kisspeptin Resets the Hypothalamic GnRH Clock in Men
peer_reviewed_research
2011 · study · Temporal status not established
Kisspeptin Is Essential for the Full Preovulatory LH Surge and Stimulates GnRH Release from the Isolated Ovine Median Eminence
peer_reviewed_research
2011 · study · Temporal status not established
Kisspeptins in Reproductive Biology: Consensus Knowledge and Recent Developments1
peer_reviewed_research
2011 · study · Temporal status not established
Early Metabolic Programming of Puberty Onset: Impact of Changes in Postnatal Feeding and Rearing Conditions on the Timing of Puberty and Development of the Hypothalamic Kisspeptin System
peer_reviewed_research
2012 · study · Temporal status not established
Kisspeptin Neurons from Mice to Men: Similarities and Differences
peer_reviewed_research
2012 · study · Temporal status not established
Kisspeptin Administration to Women: A Window into Endogenous Kisspeptin Secretion and GnRH Responsiveness across the Menstrual Cycle
peer_reviewed_research
2012 · study · Temporal status not established
Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration
peer_reviewed_research
2012 · study · Temporal status not established
Kisspeptin-GPR54 Signaling in Mouse NO-Synthesizing Neurons Participates in the Hypothalamic Control of Ovulation
peer_reviewed_research
2012 · study · Temporal status not established
Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature
peer_reviewed_research
2012 · study · Temporal status not established
Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
peer_reviewed_research
2012 · study · Temporal status not established
RFamide-Related Peptide-3 Receptor Gene Expression in GnRH and Kisspeptin Neurons and GnRH-Dependent Mechanism of Action
peer_reviewed_research
2012 · study · Temporal status not established
Seasonal Variation in the Gonadotropin-Releasing Hormone Response to Kisspeptin in Sheep: Possible Kisspeptin Regulation of the Kisspeptin Receptor
peer_reviewed_research
2012 · study · Temporal status not established
Evidence of a Role for Kisspeptin and Neurokinin B in Puberty of Female Sheep
peer_reviewed_research
2012 · study · Temporal status not established
Arcuate Kisspeptin/Neurokinin B/Dynorphin (KNDy) Neurons Mediate the Estrogen Suppression of Gonadotropin Secretion and Body Weight
peer_reviewed_research
2012 · study · Temporal status not established
Cloning and expression of tachykinins and their association with kisspeptins in the brains of zebrafish
peer_reviewed_research
2013 · study · Temporal status not established
Kisspeptin Neurones do not Directly Signal to RFRP ‐3 Neurones but RFRP ‐3 may Directly Modulate a Subset of Hypothalamic Kisspeptin Cells in Mice
peer_reviewed_research
2013 · study · Temporal status not established
Kisspeptin and GnRH Pulse Generation
peer_reviewed_research
2013 · study · Temporal status not established
Kisspeptin, Neurokinin B, and Dynorphin Act in the Arcuate Nucleus to Control Activity of the GnRH Pulse Generator in Ewes
peer_reviewed_research
2013 · study · Temporal status not established
Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes
peer_reviewed_research
2013 · study · Temporal status not established
Neuroanatomy of the Kisspeptin Signaling System in Mammals: Comparative and Developmental Aspects
peer_reviewed_research
2013 · study · Temporal status not established
Neurokinin B Activates Arcuate Kisspeptin Neurons Through Multiple Tachykinin Receptors in the Male Mouse
peer_reviewed_research
2013 · study · Temporal status not established
Expression of Kisspeptins and Kiss Receptors Suggests a Large Range of Functions for Kisspeptin Systems in the Brain of the European Sea Bass
peer_reviewed_research
2013 · study · Temporal status not established
Sex Steroid Regulation of Kisspeptin Circuits
peer_reviewed_research
2013 · study · Temporal status not established
Neuroanatomy of the Human Hypothalamic Kisspeptin System
peer_reviewed_research
2013 · study · Temporal status not established
Interactions Between Kisspeptins and Neurokinin B
peer_reviewed_research
2013 · study · Temporal status not established
Current and future applications of GnRH, kisspeptin and neurokinin B analogues
systematic_review_or_meta_analysis
2013 · study · Temporal status not established
Kisspeptin and energy balance in reproduction
peer_reviewed_research
2013 · study · Temporal status not established
Kisspeptin and Puberty in Mammals
peer_reviewed_research
2013 · study · Temporal status not established
Metabolic control of puberty: Roles of leptin and kisspeptins
peer_reviewed_research
2013 · study · Temporal status not established
Neuroanatomical Evidence That Kisspeptin Directly Regulates Isotocin and Vasotocin Neurons
peer_reviewed_research
2013 · study · Temporal status not established
Dependence of fertility on kisspeptin–Gpr54 signaling at the GnRH neuron
peer_reviewed_research
2014 · study · Temporal status not established
Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization
peer_reviewed_research
2014 · study · Temporal status not established
Kisspeptin modulates fertilization capacity of mouse spermatozoa
peer_reviewed_research
2014 · study · Temporal status not established
Positive, But Not Negative Feedback Actions of Estradiol in Adult Female Mice Require Estrogen Receptor α in Kisspeptin Neurons
peer_reviewed_research
2014 · study · Temporal status not established
Prolactin Regulation of Kisspeptin Neurones in the Mouse Brain and its Role in the Lactation‐Induced Suppression of Kisspeptin Expression
peer_reviewed_research
2014 · study · Temporal status not established
The Integrated Hypothalamic Tachykinin-Kisspeptin System as a Central Coordinator for Reproduction
peer_reviewed_research
2014 · study · Temporal status not established
MOLECULAR EVOLUTION OF GPCRS: Kisspeptin/kisspeptin receptors
peer_reviewed_research
2014 · study · Temporal status not established
Coevolution of the Spexin/Galanin/Kisspeptin Family: Spexin Activates Galanin Receptor Type II and III
peer_reviewed_research
2014 · study · Temporal status not established
Disrupted Kisspeptin Signaling in GnRH Neurons Leads to Hypogonadotrophic Hypogonadism
peer_reviewed_research
2014 · study · Temporal status not established
Habenular kisspeptin modulates fear in the zebrafish
peer_reviewed_research
2014 · study · Temporal status not established
Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity
peer_reviewed_research
2014 · study · Temporal status not established
The kisspeptin-GnRH pathway in human reproductive health and disease
peer_reviewed_research
2014 · study · Temporal status not established
Increasing LH Pulsatility in Women With Hypothalamic Amenorrhoea Using Intravenous Infusion of Kisspeptin-54
peer_reviewed_research
2014 · study · Temporal status not established
Glucagon Regulates Hepatic Kisspeptin to Impair Insulin Secretion
peer_reviewed_research
2015 · study · Temporal status not established
Selective optogenetic activation of arcuate kisspeptin neurons generates pulsatile luteinizing hormone secretion
peer_reviewed_research
2015 · study · Temporal status not established
There is Kisspeptin – And Then There is Kisspeptin
systematic_review_or_meta_analysis
2015 · study · Temporal status not established
Kisspeptin: Beyond the Brain
peer_reviewed_research
2015 · study · Temporal status not established
Kisspeptin signalling and its roles in humans
peer_reviewed_research
2015 · study · Temporal status not established
Kisspeptin Antagonists Reveal Kisspeptin 1 and Kisspeptin 2 Differential Regulation of Reproduction in the Teleost, Morone saxatilis1
peer_reviewed_research
2015 · study · Temporal status not established
Kisspeptin signaling in the amygdala modulates reproductive hormone secretion
peer_reviewed_research
2016 · study · Temporal status not established
The localization of kisspeptin and kisspeptin receptor in the canine ovary during different stages of the reproductive cycle
peer_reviewed_research
2016 · study · Temporal status not established
Phoenixin Activates Immortalized GnRH and Kisspeptin Neurons Through the Novel Receptor GPR173
peer_reviewed_research
2016 · study · Temporal status not established
High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons
peer_reviewed_research
2016 · study · Temporal status not established
Kisspeptins, Estrogens and Male Fertility
peer_reviewed_research
2017 · study · Temporal status not established
Is there a role for kisspeptin in pathogenesis of polycystic ovary syndrome?
peer_reviewed_research
2017 · study · Temporal status not established
Kisspeptin modulates sexual and emotional brain processing in humans
peer_reviewed_research
2018 · study · Temporal status not established
Female sexual behavior in mice is controlled by kisspeptin neurons
peer_reviewed_research
2018 · study · Temporal status not established
Kisspeptin/Kisspeptin Receptor System in the Ovary
peer_reviewed_research
2018 · study · Temporal status not established
Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation
peer_reviewed_research
2018 · study · Temporal status not established
Kisspeptin and LH pulsatile temporal coupling in PCOS patients
peer_reviewed_research
2018 · study · Temporal status not established
The role of kisspeptin neurons in reproduction and metabolism
peer_reviewed_research
2018 · study · Temporal status not established
Serum Levels of Spexin and Kisspeptin Negatively Correlate With Obesity and Insulin Resistance in Women
peer_reviewed_research
2019 · study · Temporal status not established
Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism
peer_reviewed_research
2019 · study · Temporal status not established
Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery
peer_reviewed_research
2020 · study · Temporal status not established
Metabolic regulation of kisspeptin - the link between energy balance and reproduction.
peer_reviewed_research
2020 · study · Temporal status not established
Kisspeptin and Testicular Function—Is It Necessary?
peer_reviewed_research
2020 · study · Temporal status not established
Kisspeptin and GnRH interactions in the reproductive brain of teleosts
peer_reviewed_research
2020 · study · Temporal status not established
Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour
systematic_review_or_meta_analysis
2022 · study · Temporal status not established
Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.
peer_reviewed_research
2022 · study · Temporal status not established
Gestational exposure to bisphenol analogues and kisspeptin levels in pregnant women and their children: A pregnancy-birth cohort study.
peer_reviewed_research
2022 · study · Temporal status not established
Kisspeptin-10 in cryodiluent improves the post-thaw quality of Nili-Ravi buffalo (Bubalus bubalis) bull spermatozoa.
peer_reviewed_research
2022 · study · Temporal status not established
Kisspeptin in the Prediction of Pregnancy Complications.
peer_reviewed_research
2022 · study · Temporal status not established
Morphometric and Myelin Basic Protein Expression Changes in Arcuate Nucleus Kisspeptin Neurons Underlie Activation of Hypothalamic Pituitary Gonadal-axis in Monkeys (Macaca Mulatta) during the Breeding Season.
peer_reviewed_research
2022 · study · Temporal status not established
Effects of intracerebroventricular and intravenous administration of Kisspeptin-54 and Gonadotropin-releasing hormone agonist in rats with ovarian hyperstimulation.
peer_reviewed_research
2022 · study · Temporal status not established
Mechanism of LH release after peripheral administration of kisspeptin in cattle.
peer_reviewed_research
2022 · study · Temporal status not established
Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides.
peer_reviewed_research
2022 · study · Temporal status not established
Stereology of gonadotropin-releasing hormone and kisspeptin neurons in PACAP gene-deficient female mice.
peer_reviewed_research
2022 · study · Temporal status not established
GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice.
peer_reviewed_research
2022 · study · Temporal status not established
Effects of empagliflozin on the expression of kisspeptin gene and reproductive system function in streptozotocin-induced diabetic male rats.
peer_reviewed_research
2022 · study · Temporal status not established
What is the protective effect of preischemic kisspeptin-10 administration against ischemia/reperfusion injury of striatum on mice?
peer_reviewed_research
2022 · study · Temporal status not established
Socs3 ablation in kisspeptin cells partially prevents lipopolysaccharide-induced body weight loss.
peer_reviewed_research
2022 · study · Temporal status not established
Sex-specific hypothalamic expression of kisspeptin, gonadotropin releasing hormone, and kisspeptin receptor in progressive demyelination model.
peer_reviewed_research
2022 · study · Temporal status not established
Current Perspectives on Kisspeptins Role in Behaviour.
peer_reviewed_research
2022 · study · Temporal status not established
Invited review: Translating kisspeptin and neurokinin B biology into new therapies for reproductive health.
peer_reviewed_research
2022 · study · Temporal status not established
Novel therapeutic avenues for kisspeptin.
peer_reviewed_research
2022 · study · Temporal status not established
The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction.
peer_reviewed_research
2022 · study · Temporal status not established
Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction.
peer_reviewed_research
2022 · study · Temporal status not established
Acute Effects of Kisspeptin Administration on Bone Metabolism in Healthy Men.
peer_reviewed_research
2022 · study · Temporal status not established
Stress, kisspeptin, and functional hypothalamic amenorrhea.
peer_reviewed_research
2022 · study · Temporal status not established
Kisspeptins and the neuroendocrine control of reproduction: Recent progress and new frontiers in kisspeptin research
peer_reviewed_research
2023 · study · Temporal status not established
Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.
peer_reviewed_research
2023 · study · Temporal status not established
Kisspeptin: a potential therapeutic target in patients with unexplained infertility?
peer_reviewed_research
2023 · study · Temporal status not established
Kisspeptin neuron projections to oxytocin neurons are not necessary for parturition in the mouse.
peer_reviewed_research
2023 · study · Temporal status not established
Kisspeptin and lactational anestrus: Current understanding and future prospects.
peer_reviewed_research
2023 · study · Temporal status not established
Kisspeptin induces Kiss-1 and GnRH gene expression in mHypoA-55 hypothalamic cell models: Involvement of the ERK and PKA signaling pathways.
peer_reviewed_research
2023 · study · Temporal status not established
Kisspeptin decreases the adverse effects of human ovarian vitrification by regulating ROS-related apoptotic occurrences.
peer_reviewed_research
2023 · study · Temporal status not established
Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity.
peer_reviewed_research
2023 · study · Temporal status not established
Kisspeptin regulates the proliferation and apoptosis of ovary granulosa cells in polycystic ovary syndrome by modulating the PI3K/AKT/ERK signalling pathway.
peer_reviewed_research
2023 · study · Temporal status not established
Kisspeptin Suppresses Inflammasome-NLRP3 Activation and Pyroptosis Caused by Hypothyroidism at the Maternal-Fetal Interface of Rats.
peer_reviewed_research
2023 · study · Temporal status not established
Treadmill exercise has healing effects on obesity-induced sexual behavior disorder through kisspeptin and kiss1R expression in male rats.
peer_reviewed_research
2023 · study · Temporal status not established
[Effects of electroacupuncture on the secretion function of ovarian cells and kisspeptin/kiss1r system in rats with polycystic ovarian syndrome].
peer_reviewed_research
2023 · study · Temporal status not established
Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse model.
peer_reviewed_research
2023 · study · Temporal status not established
Fasting Modulates GABAergic Synaptic Transmission to Arcuate Kisspeptin Neurons in Female Mice.
peer_reviewed_research
2023 · study · Temporal status not established
The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin.
peer_reviewed_research
2023 · study · Temporal status not established
Physiological and pathological roles of locally expressed kisspeptin and KISS1R in the endometrium.
peer_reviewed_research
2023 · study · Temporal status not established
Serum kisspeptin, neurokinin B and inhibin B levels can be used as alternative parameters to distinguish idiopathic CPP from premature thelarche in the early stages of puberty.
peer_reviewed_research
2023 · study · Temporal status not established
Role of kisspeptin in decidualization and unexplained recurrent spontaneous abortion via the ERK1/2 signalling pathway.
peer_reviewed_research
2023 · study · Temporal status not established
Role of kisspeptin in polycystic ovarian syndrome: A metabolomics study.
peer_reviewed_research
2023 · study · Temporal status not established
The impact of inflammatory stress on hypothalamic kisspeptin neurons: Mechanisms underlying inflammation-associated infertility in humans and domestic animals.
peer_reviewed_research
2023 · study · Temporal status not established
Effects of Kisspeptin on the reproductive function in the Dabry's sturgeon (Acipenser dabrynus).
peer_reviewed_research
2023 · study · Temporal status not established
The role of kisspeptin in the pathogenesis of a polycystic ovary syndrome.
peer_reviewed_research
2023 · study · Temporal status not established
CRISPR-Cas9 knockdown of ESR1 in preoptic GABA-kisspeptin neurons suppresses the preovulatory surge and estrous cycles in female mice.
peer_reviewed_research
2023 · study · Temporal status not established
Hypothalamic Kisspeptin Neurons as a Target for Whole-Cell Patch-Clamp Recordings.
peer_reviewed_research
2023 · study · Temporal status not established
Effects of KISS1 structural polymorphism on the risk of polycystic ovary syndrome and reproductive hormones in Iraqi women who take metformin.
peer_reviewed_research
2023 · study · Temporal status not established
Hindbrain Adenosine 5-Triphosphate (ATP)-Purinergic Signaling Triggers LH Surge and Ovulation via Activation of AVPV Kisspeptin Neurons in Rats.
peer_reviewed_research
2023 · study · Temporal status not established
Mechanism of Arcuate Kisspeptin Neuron Synchronization in Acute Brain Slices From Female Mice.
peer_reviewed_research
2023 · study · Temporal status not established
Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovary syndrome.
peer_reviewed_research
2023 · study · Temporal status not established
The interplay between kisspeptin and endocannabinoid systems modulates male hypothalamic and gonadic control of reproduction in vivo.
peer_reviewed_research
2023 · study · Temporal status not established
Optogenetics studies of kisspeptin neurons.
peer_reviewed_research
2023 · study · Temporal status not established
Effects of electroacupuncture on the kisspeptin-gonadotropin-releasing hormone (GnRH) /luteinizing hormone (LH) neural circuit abnormalities and androgen receptor expression of kisspeptin/neurokinin B/dynorphin neurons in PCOS rats.
peer_reviewed_research
2023 · study · Temporal status not established
Deletion of Androgen Receptors From Kisspeptin Neurons Prevents PCOS Features in a Letrozole Mouse Model.
peer_reviewed_research
2023 · study · Temporal status not established
Deletion of GABAB receptors from Kiss1 cells affects glucose homeostasis without altering reproduction in male mice.
peer_reviewed_research
2023 · study · Temporal status not established
Conditional Oprk1-dependent Kiss1 deletion in kisspeptin neurons caused estrogen-dependent LH pulse disruption and LH surge attenuation in female rats.
peer_reviewed_research
2023 · study · Temporal status not established
Correlation between kisspeptin and biochemical markers in obese and non-obese women with polycystic ovary syndrome.
peer_reviewed_research
2023 · study · Temporal status not established
Editorial: The versatile kisspeptin: advances in cancer, metabolism, and reproduction.
peer_reviewed_research
2023 · study · Temporal status not established
Oral sodium oxybate does not alter plasma kisspeptin levels in healthy male volunteers.
peer_reviewed_research
2023 · study · Temporal status not established
Is There an Association Between Circulating Kisspeptin Levels and Ovarian Reserve in Women of Reproductive Age?
peer_reviewed_research
2023 · study · Temporal status not established
The effects of kisspeptin on food intake in women with overweight or obesity.
peer_reviewed_research
2023 · study · Temporal status not established
A fresh look at kisspeptin neuron synchronization.
peer_reviewed_research
2023 · study · Temporal status not established
Kisspeptin as a predictor of miscarriage: a systematic review.
systematic_review_or_meta_analysis
2024 · study · Temporal status not established
Kisspeptin expression levels in patients with placenta previa: A randomized trial.
peer_reviewed_research
2024 · study · Temporal status not established
A prospective study to evaluate whether serum kisspeptin is a marker predictive of the first-trimester miscarriage of women who conceive in IVF.
peer_reviewed_research
2024 · study · Temporal status not established
[Notch1/Akt/Foxo1 Pathway Regulated by Kisspeptin Is Involved in Endometrial Decidualization in Patients With Recurrent Spontaneous Abortion].
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin signalling and its correlation with placental ultrastructure and clinical outcomes in pregnant South African women with obesity and gestational diabetes.
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin and DLK1 levels for monitoring treatment of girls with central precocious puberty.
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin expression during menstruation in PCOS patients undergoing ovulation induction and the correlation with early pregnancy.
peer_reviewed_research
2024 · study · Temporal status not established
Associations between maternal urinary kisspeptin in late pregnancy and decreased fetal growth: a pregnancy-birth cohort study.
peer_reviewed_research
2024 · study · Temporal status not established
Urinary phthalate/DINCH metabolites associations with kisspeptin and reproductive hormones in teenagers: A cross-sectional study from the HBM4EU aligned studies.
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin administration may promote precopulatory behavior in male rats independently or supplementally to testosterone and contribute to proceptive behavior in female partners, reducing mating failure.
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin prevents pregnancy loss by modulating the immune microenvironment at the maternal-fetal interface in recurrent spontaneous abortion.
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin/KISS1R Signaling Modulates Human Airway Smooth Muscle Cell Migration.
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin signaling in astrocytes modulates the reproductive axis.
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin Regulates Cell Invasion and Migration in Endometrial Cancer.
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin Alleviates Human Hepatic Fibrogenesis by Inhibiting TGFβ Signaling in Hepatic Stellate Cells.
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin and Endometriosis-Is There a Link?
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin is elevated in the brain after intracerebral haemorrhagic stroke.
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin in functional hypothalamic amenorrhea: Pathophysiology and therapeutic potential.
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin upregulates β-cell serotonin production during pregnancy.
peer_reviewed_research
2024 · study · Temporal status not established
Elevated temperature impairs gonadal development by suppressing the expression of the genes for kisspeptin, GnRH1 and GTH subunits in Nile tilapia Oreochromis niloticus.
peer_reviewed_research
2024 · study · Temporal status not established
Jiawei Buzhong Yiqi Decoction attenuates polycystic ovary syndrome through regulating kisspeptin-GPR54-AKT-SHBG system.
peer_reviewed_research
2024 · study · Temporal status not established
Chronic estradiol exposure suppresses luteinizing hormone surge without affecting kisspeptin neurons and estrogen receptor alpha in anteroventral periventricular nucleus†.
peer_reviewed_research
2024 · study · Temporal status not established
Structural basis for the ligand recognition and G protein subtype selectivity of kisspeptin receptor.
peer_reviewed_research
2024 · study · Temporal status not established
The effect of coadministration of vitamin D and tramadol on serum kisspeptin, testosterone, oxidative stress levels and testicular histology in Wistar rats: a preliminary report.
peer_reviewed_research
2024 · study · Temporal status not established
Investigating the detection of the novel doping‐relevant peptide kisspeptin‐10 in urine using liquid chromatography high‐resolution mass spectrometry.
peer_reviewed_research
2024 · study · Temporal status not established
Phenytoin causes behavioral abnormalities and suppresses kisspeptin expression, reducing reproductive performance in Japanese medaka.
peer_reviewed_research
2024 · study · Temporal status not established
Decoding the effect of photoperiodic cues in transducing kisspeptin-melatonin circuit during the pubertal onset in common carp.
peer_reviewed_research
2024 · study · Temporal status not established
Adipose Kiss1 controls aerobic exercise-related adaptive responses in adipose tissue energy homeostasis.
peer_reviewed_research
2024 · study · Temporal status not established
AVPV Kiss1 neuron-specific knockdown of purinergic P2X2 receptor suppresses LH surge and ovulation in Kiss1-Cre rats.
peer_reviewed_research
2024 · study · Temporal status not established
Effects of kisspeptin on the maturation of human ovarian primordial follicles in vitro.
peer_reviewed_research
2024 · study · Temporal status not established
Deletion of Nuclear Progesterone Receptors From Kisspeptin Cells Does Not Impair Negative Feedback in Female Mice.
peer_reviewed_research
2024 · study · Temporal status not established
Predictive efficiency of phoenixin, spexin and kisspeptin neuropeptides concentration levels in diagnosis of bipolar disorder in paediatric population.
peer_reviewed_research
2024 · study · Temporal status not established
Alteration in kisspeptin and reproductive hormones during different superovulation protocols in dromedary camel.
peer_reviewed_research
2024 · study · Temporal status not established
Development of KISS1 knockout pigs is characterized by hypogonadotropic hypogonadism, normal growth, and reduced skatole†.
peer_reviewed_research
2024 · study · Temporal status not established
Reduced voluntary wheel running behaviour in Kiss1r knockout mice.
peer_reviewed_research
2024 · study · Temporal status not established
Participation of kisspeptin, progesterone, and GnRH receptors on lordosis behavior induced by kisspeptin.
peer_reviewed_research
2024 · study · Temporal status not established
Does the miR-105-1-Kisspeptin Axis Promote Ovarian Cell Functions?
peer_reviewed_research
2024 · study · Temporal status not established
The evolutionary conserved miR-137/325 tandem mediates obesity-induced hypogonadism and metabolic comorbidities by repressing hypothalamic kisspeptin.
peer_reviewed_research
2024 · study · Temporal status not established
Interactions between kisspeptin and bone: Cellular mechanisms, clinical evidence, and future potential.
peer_reviewed_research
2024 · study · Temporal status not established
Nitric oxide mediated kisspeptin regulation of steroidogenesis and gametogenesis in the catfish, Clarias batrachus.
peer_reviewed_research
2024 · study · Temporal status not established
The role of placental kisspeptin in trophoblast invasion and migration: an assessment in Kiss1r knockout mice, BeWo cell lines and human term placenta.
peer_reviewed_research
2024 · study · Temporal status not established
Targeted inhibition of kisspeptin neurons reverses hyperandrogenemia and abnormal hyperactive LH secretion in a preclinical mouse model of polycystic ovary syndrome.
peer_reviewed_research
2024 · study · Temporal status not established
Selective depletion of kisspeptin neurons in the hypothalamic arcuate nucleus in early juvenile life reduces pubertal LH secretion and delays puberty onset in mice.
peer_reviewed_research
2024 · study · Temporal status not established
Obesity Alters POMC and Kisspeptin Neuron Cross Talk Leading to Reduced Luteinizing Hormone in Male Mice.
peer_reviewed_research
2024 · study · Temporal status not established
Comprehensive Analysis of Kisspeptin Signaling: Effects on Cellular Dynamics in Cervical Cancer.
peer_reviewed_research
2024 · study · Temporal status not established
Intracerebroventricular injection of kisspeptin in male rats activates hypothalamo-pituitary-gonadal axis, but not hypothalamo-pituitary-adrenal axis.
peer_reviewed_research
2024 · study · Temporal status not established
The antidepressant-like effects of kisspeptin-10 are reversed by kisspeptin antagonist peptide 234 in male rats.
peer_reviewed_research
2024 · study · Temporal status not established
Investigation of effect peripheral kisspeptin treatment on hypothalamo-pituitary-gonadal axis and hypothalamo-pituitary-adrenal axis in male rats.
peer_reviewed_research
2024 · study · Temporal status not established
Spatial local expressions of kisspeptin in the uterus and uterine tubes and its relationship to the reproductive potential in goats.
peer_reviewed_research
2024 · study · Temporal status not established
Intraperitoneal administration of kisspeptin-10 modulates follicle maturation, gonadal steroids, calcium and metabolites in Sterlet sturgeon, Acipenser ruthenus.
peer_reviewed_research
2024 · study · Temporal status not established
Chronic Nasal Administration of Kisspeptin-54 Regulates Mood-Related Disorders Via Amygdaloid GABA in Hemi-Parkinsonian Rats
peer_reviewed_research
2024 · study · Temporal status not established
Chronic inflammation decreases arcuate kisspeptin expression in male sheep.
peer_reviewed_research
2024 · study · Temporal status not established
Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor.
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin stimulates sheep ovarian follicular development in vitro through homologous receptors.
peer_reviewed_research
2024 · study · Temporal status not established
Role of serum kisspeptin as a biomarker to detect miscarriage: a systematic review and meta-analysis.
systematic_review_or_meta_analysis
2024 · study · Temporal status not established
Lunar Age-Dependent Oscillations in Expression of the Genes for Kisspeptin, GnIH, and Their Receptors in the Grass Puffer during the Spawning Season.
peer_reviewed_research
2024 · study · Temporal status not established
Characterizing the relationship between gonadotropin releasing hormone (GnRH), kisspeptin, and RFamide related peptide 3 (RFRP-3) neurons in the equine hypothalamus across the estrous cycle and in the anovulatory seasons.
peer_reviewed_research
2024 · study · Temporal status not established
Dynamics in cortisol levels in Danio rerio fish under the influence of a synthetic analog of kisspeptin 1.
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin and mammalian reproduction.
peer_reviewed_research
2024 · study · Temporal status not established
Kisspeptin and neurokinin B neuroendocrine pathways in the control of human ovulation.
systematic_review_or_meta_analysis
2025 · study · Temporal status not established
Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study.
peer_reviewed_research
2025 · study · Temporal status not established
Recurrent spontaneous ovarian hyperstimulation in a young nonpregnant Chinese woman with Rathke cleft cyst and a KISS1R variant: A rare case report and literature review.
peer_reviewed_research
2025 · study · Temporal status not established
The association between 1st trimester serum kisspeptin level and antenatal complications.
peer_reviewed_research
2025 · study · Temporal status not established
AMH and Kisspeptin Receptor Expression in Rare Hydropic Leiomyoma: A Case Study.
peer_reviewed_research
2025 · study · Temporal status not established
Existence of Coexpressive Role of Kisspeptin and Insulin-2 in the Regulation of Luteinizing Hormone in Chronic Stress-Induced Polycystic Ovarian Syndrome-Like Phenotype in Rattus norvegicus.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin 10 Inhibited the Proliferation, Migration, and Stemness of Esophageal Cancer Cells via Regulating the SIX1/Wnt/β-Catetin Signaling.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin as a marker for male infertility: a comparative study of serum and seminal plasma kisspeptin between fertile and infertile men.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin control of hypothalamus-pituitary-ovarian functions.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin system-physiology and clinical perspectives.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin-54 ameliorates chondrocyte senescence in osteoarthritis via SIRT3-mediated telomere protection and p53 acetylation inhibition.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin-13 induces hyperalgesia and modulates the expression of opioid and glutamate receptors in mice.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin participates in the positive reward state induced by paced mating and modulates sexual receptivity and paced mating behavior in female rats.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin Suppresses the Growth of Primary Pterygial Cells via Inhibiting Chemokine (C-X-C Motif) Ligands in Microenvironment.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin-54 Restores Blood-Brain Barrier Integrity via GATA-4 in Ischemic Stroke.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin fiber and receptor distribution analysis suggests its potential role in central sensorial processing and behavioral state control.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin-dependent puberty onset triggered by increased Kiss1 and Pdyn expression in arcuate Tac3 neurons under reduced estrogen negative feedback and sufficient energy balance in female rats.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin isoforms: versatile players in reproduction and beyond.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin Retards Tumor Growth of Lewis Lung Carcinoma Cells Through p38 MAPK-mediated Senescence.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin Administration and mRNA Expression in Adult Syrian Hamsters.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin Mitigates Hepatic De Novo Lipogenesis in Metabolic Dysfunction-Associated Steatotic Liver Disease.
peer_reviewed_research
2025 · study · Temporal status not established
Quercetin-loaded PEGylated liposomes alleviate testicular dysfunction in alloxan-induced diabetic rats: The role of Kisspeptin/Neurokinin B/Dynorphin pathway.
peer_reviewed_research
2025 · study · Temporal status not established
Maternal high-fat diet programs reproductive function of female offspring rat through IL-6-mediated regulation of Kiss1 gene methylation.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin-10 Protects Against TNF-α-Induced Chondrocyte Senescence via the SIRT1/p53/p21 Signaling.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin-10 Improves Gestational Diabetes Mellitus Symptoms in Rats by Suppressing Insulin Resistance in Placental Trophoblast Cells by Activating the Cyclic AMP/Protein Kinase A Pathway.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin-10 Prevents the Development of Cerebral Aneurysms by Reducing the Expression of Egr-1.
peer_reviewed_research
2025 · study · Temporal status not established
Early Development of Hypothalamic Neurons Expressing Proopiomelanocortin Peptides, Neuropeptide Y, and Kisspeptin in Fetal Rhesus Macaques.
peer_reviewed_research
2025 · study · Temporal status not established
Postnatal undernutrition increases estradiol plasma levels and sexual receptivity and disrupts the kisspeptin-GnRH pathway in adult female rats.
peer_reviewed_research
2025 · study · Temporal status not established
Involvement of nuclear receptor corepressor 2 (NCOR2) in estrogen-induced repression of arcuate Kiss1 expression in female rats.
peer_reviewed_research
2025 · study · Temporal status not established
The effect of COVID-19 on placental functioning in South African pregnancies: investigation of kisspeptin expression and vascular and inflammatory alterations.
peer_reviewed_research
2025 · study · Temporal status not established
Design and implication of a breast cancer-targeted drug delivery system utilizing the Kisspeptin/GPR54 system.
peer_reviewed_research
2025 · study · Temporal status not established
The Neuroendocrine Regulation of Reproductive Behavior and Emotional Control by Kisspeptin.
peer_reviewed_research
2025 · study · Temporal status not established
Perinatal exposure to bisphenol A or S alters differently sexual behavior and kisspeptin system in mice.
peer_reviewed_research
2025 · study · Temporal status not established
Comprehensive chemoanatomical mapping, and the gonadal regulation, of seven kisspeptin neuronal populations in the mouse brain.
peer_reviewed_research
2025 · study · Temporal status not established
SRA deficiency induces follicular dysplasia by disrupting the hypothalamic Kisspeptin-GPR54 system in mice†.
peer_reviewed_research
2025 · study · Temporal status not established
Developmental expression patterns of gonadal hormone receptors in arcuate kisspeptin and GABA neurons of the postnatal female mouse.
peer_reviewed_research
2025 · study · Temporal status not established
Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice.
peer_reviewed_research
2025 · study · Temporal status not established
Lipopolysaccharide-induced inflammation modulates testicular kisspeptin system in mice.
peer_reviewed_research
2025 · study · Temporal status not established
The kisspeptin analog C6 reverses reproductive dysfunction in a mouse model of hyperprolactinemia.
peer_reviewed_research
2025 · study · Temporal status not established
Central kisspeptin injection enhances food consumption in broiler chickens: role of opioidergic and dopaminergic receptors.
peer_reviewed_research
2025 · study · Temporal status not established
Effect of active immunization with recombinant GnRH6-kisspeptin fusion protein on reproductive function in male rats.
peer_reviewed_research
2025 · study · Temporal status not established
Exogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer.
peer_reviewed_research
2025 · study · Temporal status not established
Effect of Kisspeptin Fortification in Freezing Media on Post-Thaw Quality and Fertility of Buffalo Bull Semen.
peer_reviewed_research
2025 · study · Temporal status not established
Effect of kisspeptin, neurokinin, and dynorphin neurons on regulation of reproduction.
peer_reviewed_research
2025 · study · Temporal status not established
Effects of Kisspeptin on rabbit ovulation: a comprehensive study of ovulatory, endocrine and histological response.
peer_reviewed_research
2025 · study · Temporal status not established
Profile of opioid peptide receptors in GnRH and kisspeptin neurons of female mice and rats.
peer_reviewed_research
2025 · study · Temporal status not established
Nociceptin-Opioid-Related Nociceptin Receptor 1 Signaling Partly Mediates Glucoprivic Suppression of Luteinizing Hormone Pulses in Female Rats: Arcuate <italic>Kiss1</italic> Neurons as a Possible Target for Nociceptin.
peer_reviewed_research
2025 · study · Temporal status not established
Effect of galanin-like peptide on hypothalamic kisspeptin expression in female Zucker fatty rats.
peer_reviewed_research
2025 · study · Temporal status not established
Hypothalamic kisspeptin alleviates myasthenia gravis by regulating Th1/Th17/Treg balance through Inhibition of NF-κB signaling pathway.
peer_reviewed_research
2025 · study · Temporal status not established
Association of Kisspeptin and KISS1 Gene Polymorphism (rs35431622) with Circulating Sex Hormones and Male Infertility.
peer_reviewed_research
2025 · study · Temporal status not established
Recombinant GnRH6-kisspeptin-CRM197 vaccine inhibits reproductive function in male rats and dogs.
peer_reviewed_research
2025 · study · Temporal status not established
Potential role of kisspeptin in the estradiol-induced modulation of inhibin subunit gene expression: Insights from in vivo rat models and hypothalamic cell models.
peer_reviewed_research
2025 · study · Temporal status not established
Exploring GABA and Kisspeptin Roles in Reproductive and Metabolic Regulation: Insights from Kiss1-GABAB1KO Female Mice.
peer_reviewed_research
2025 · study · Temporal status not established
Evidence for human kisspeptin receptor homo-oligomerisation and its functional relevance.
peer_reviewed_research
2025 · study · Temporal status not established
Distribution of the kisspeptin system and its relation with gonadotropin-releasing hormone in the hypothalamus.
peer_reviewed_research
2025 · study · Temporal status not established
Multiple effects of kisspeptin on neuroendocrine, reproduction, and metabolism in polycystic ovary syndrome.
peer_reviewed_research
2025 · study · Temporal status not established
Adult Neurogenesis Is Regulated by the Endocannabinoid and Kisspeptin Systems.
peer_reviewed_research
2025 · study · Temporal status not established
Sodium benzoate exposure disrupts HPG-axis in male rats: insights into oxidative stress, hormonal dysregulation, histopathology and kisspeptin/RFRP-3 expression.
peer_reviewed_research
2025 · study · Temporal status not established
Brain-derived neurotrophic factor (BDNF), an autocrine/paracrine regulator of basic ovarian functions and antagonist of kisspeptin.
peer_reviewed_research
2025 · study · Temporal status not established
Manipulating seasonality by using PMSG and Kisspeptin hormones and the impact of the MTNR1A gene on reproduction efficiency in ewes.
peer_reviewed_research
2025 · study · Temporal status not established
Brainstem noradrenergic modulation of the kisspeptin neuron GnRH pulse generator in mice.
peer_reviewed_research
2025 · study · Temporal status not established
A novel mechanism of kisspeptin regulating ovarian granulosa cell function via down-regulating let-7b to activate ERK/PI3K-Akt pathway in Tan sheep.
peer_reviewed_research
2025 · study · Temporal status not established
The role of neonatal kisspeptin in long-term social behavior in mammals.
peer_reviewed_research
2025 · study · Temporal status not established
Synthesis and characterisation of DOTA-kisspeptin-10 as a potential gallium-68/lutetium-177 pan-tumour radiopharmaceutical.
peer_reviewed_research
2025 · study · Temporal status not established
Regulatory Involvement of Kisspeptin in Energy Balance and Reproduction.
peer_reviewed_research
2025 · study · Temporal status not established
Administration of Exogenous Kisspeptin Induces Breeding Competence in Post-pubertal Female Common Carp (Cyprinus carpio).
peer_reviewed_research
2025 · study · Temporal status not established
Hypothyroidism Alters Uterine Kisspeptin System and Activity Modulators in Cyclic Rats.
peer_reviewed_research
2025 · study · Temporal status not established
Central administration of p234, kisspeptin antagonist, but not kisspeptin-10, reduces the power of epileptiform activity and slow EEG waves in male rats.
peer_reviewed_research
2025 · study · Temporal status not established
Critical role of arcuate nucleus kisspeptin and Kiss1R in regulation of the ovine luteinizing hormone surge.
peer_reviewed_research
2025 · study · Temporal status not established
Estrogen-Regulated Lateral Septal Kisspeptin Neurons Abundantly Project to GnRH Neurons and the Hypothalamic Supramammillary Nucleus.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin and neurokinin B: roles in reproductive health.
peer_reviewed_research
2025 · study · Temporal status not established
Serum kisspeptin is higher in hypertensive than non-hypertensive female subjects and positively correlated with systolic blood pressure.
peer_reviewed_research
2025 · study · Temporal status not established
Activity of arcuate kisspeptin/neurokinin B neurons and the melanocortin system during pubertal development in female sheep†.
peer_reviewed_research
2025 · study · Temporal status not established
The Investigation of Kisspeptin, Spexin and Galanin in Euthyroid Women with Hashimoto's Thyroiditis.
peer_reviewed_research
2025 · study · Temporal status not established
Dysregulated serum levels of kisspeptin, NKB, GABA in women with polycystic ovary syndrome and their association with hormonal profiles.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin and its Current Clinical Status-A Systematic Review.
systematic_review_or_meta_analysis
2025 · study · Temporal status not established
Anatomic distribution of kisspeptin neurons in the adult sheep amygdala: Associations with sex, estrogen receptor alpha, androgen receptor, and sexual partner preference.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin Receptor Agonists and Antagonists: Strategies for Discovery and Implications for Human Health and Disease.
peer_reviewed_research
2025 · study · Temporal status not established
Direct effect of kisspeptin on steroidogenesis, proliferation and apoptosis in Tan sheep ovarian granulosa cells.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans.
peer_reviewed_research
2025 · study · Temporal status not established
Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans.
peer_reviewed_research
2025 · study · Temporal status not established
Serum Kisspeptin levels in patients undergoing maintenance hemodialysis: a case-control study protocol.
peer_reviewed_research
2025 · study · Temporal status not established
The Kisspeptin analogue C6 induces more synchronized ovulation than eCG in the transition period to breeding season in Corriedale ewes.
peer_reviewed_research
2025 · study · Temporal status not established
Can kisspeptin be a new treatment for sexual dysfunction?
systematic_review_or_meta_analysis
2025 · study · Temporal status not established
Sex-dependent increases in oxytocin levels in response to intravenous kisspeptin in humans.
peer_reviewed_research
2025 · study · Temporal status not established
Kisspeptin levels in infertile and miscarried women: a cross-sectional study on the relationship with methylenetetrahydrofolate reductase gene polymorphisms and biochemical parameters.
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin as a Precision Biomarker in Personalized Pharmacy: Implications for Individualized Monitoring of Early Pregnancy Viability.
peer_reviewed_research
2026 · study · Temporal status not established
Serological biomarker models composed of luteinizing hormone, kisspeptin, vitamin D and estradiol, and their clinical test value in girls.
peer_reviewed_research
2026 · study · Temporal status not established
Dynamic changes of Kisspeptin during controlled ovarian hyperstimulation (COH) in polycystic ovary syndrome patients and its correlation with COH outcomes.
peer_reviewed_research
2026 · study · Temporal status not established
First clinical use of the kisspeptin analog TAK-683 in the treatment of a follicular cyst in a goat: case report.
peer_reviewed_research
2026 · study · Temporal status not established
Novel KISS1 Gene Mutation Leading to Male Hypogonadotropic Hypogonadism.
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin System: A Modulator of Neuroinflammation and Behaviour in Temporal Lobe Epileptic Rats.
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin-2 stimulates testicular function in adult pejerrey (Odontesthes bonariensis): Does it act directly on the testes?
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin-10 attenuates pulmonary arterial hypertension via restoration of mitochondrial function in pulmonary artery smooth muscle cells.
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin-54 attenuates acute lung injury in septic mice through AMPK-mediated suppression of NLRP3 inflammasome.
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin-54 confers renal protection in diabetic nephropathy by ameliorating endothelial permeability through ZEB1 inhibition.
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders.
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats.
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin and early pregnancy: Insights from animal models into hormonal regulation and miscarriage.
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin exacerbates androgen-induced follicular dysplasia by promoting Drp1 phosphorylation imbalance and mitochondrial excessive fission in granulosa cells of polycystic ovary syndrome.
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females.
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin improves local ovarian insulin resistance in PCOS by modulating the PI3K/AKT/GLUT4 signaling pathway.
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin Signaling Suppresses HRasG12V-induced Tumor Growth and Metastasis by Inhibiting SP1-dependent N-cadherin Expression in NIH3T3 Cells.
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin Neurons as Integrative Hub: Cross-Talk of HPO-HPT-HPA Axes in Perimenopausal Reproductive Health.
peer_reviewed_research
2026 · study · Temporal status not established
Sodium benzoate induces reproductive toxicity via hormonal disruption, ovarian damage and altering kisspeptin/RFRP-3 expression.
peer_reviewed_research
2026 · study · Temporal status not established
[Effect of acupuncture on ovarian function in rats with premature ovarian insufficiency based on kisspeptin/GPR54 pathway].
peer_reviewed_research
2026 · study · Temporal status not established
The p75 neurotrophin receptor is expressed in brain regions mastering reproduction but not in kisspeptin or GnRH neurons.
peer_reviewed_research
2026 · study · Temporal status not established
Dlk1-deficient mice achieve puberty despite low body weight and low levels of leptin and kisspeptin.
peer_reviewed_research
2026 · study · Temporal status not established
High-Fat Diet Promotes Glycolysis in Hepatocellular Carcinoma by Suppressing Hepatic Kisspeptin Signaling in Mice.
peer_reviewed_research
2026 · study · Temporal status not established
Integrated transcriptomics and miRNA-mRNA network analysis reveals Kisspeptin-10 mediated regulation of EMT and apoptosis in glioblastoma.
peer_reviewed_research
2026 · study · Temporal status not established
The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.
peer_reviewed_research
2026 · study · Temporal status not established
The KISS1/KISS1R Axis in Human Placentation: Molecular Mechanisms and Implications for Foetal Growth Restriction and Pre-Eclampsia.
peer_reviewed_research
2026 · study · Temporal status not established
Endocrine-metabolic effects of kisspeptin in mammals.
peer_reviewed_research
2026 · study · Temporal status not established
Evolution of neurohormone function revealed by actions of kisspeptin-type peptides in an echinoderm.
peer_reviewed_research
2026 · study · Temporal status not established
KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone-independent manner.
peer_reviewed_research
2026 · study · Temporal status not established
Photoperiodic modulation of puberty through melatonin-kisspeptin-GnRH signalling in female Wistar rats.
peer_reviewed_research
2026 · study · Temporal status not established
Maternal Kisspeptin-10 Treatment Partially Rescues Fetal and Postnatal Cardiac Programming Disrupted by Maternal Hypothyroidism.
peer_reviewed_research
2026 · study · Temporal status not established
Preoptic kisspeptin-nNOS-GnRH (KiNG) neuronal network regulates LH rhythmicity through activation-inhibition in mice.
peer_reviewed_research
2026 · study · Temporal status not established
Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice.
peer_reviewed_research
2026 · study · Temporal status not established
The role of Kiss1 neurons in regulating metabolism and energy balance.
peer_reviewed_research
2026 · study · Temporal status not established
Deciphering protein-DNA interactions of KISS1 with transcription factors through molecular docking, molecular dynamics simulations, and gene expression analysis.
peer_reviewed_research
2026 · study · Temporal status not established
Molecular and functional characterization of the kisspeptin receptor Kissr3 in the large yellow croaker (Larimichthys crocea).
peer_reviewed_research
2026 · study · Temporal status not established
Progesterone-KISS1 axis impairs amniotic epithelial cell function and promotes premature rupture of membranes.
peer_reviewed_research
2026 · study · Temporal status not established
Gonadotropin secretion and ovarian response of KISS1 knockout gilts treated with hormone analogs activating the hypothalamic-pituitary-gonadal axis†.
peer_reviewed_research
2026 · study · Temporal status not established
Expressions of Kisspeptin System and Ki-67 in the Reproductive Tissues of Cyclic Bitches.
peer_reviewed_research
2026 · study · Temporal status not established
Atrazine alters kisspeptin signaling and downstream neuroendocrine regulation following embryonic exposure in zebrafish.
peer_reviewed_research
2026 · study · Temporal status not established
Targeting the NR5A1-KISS1R-EMT axis with a small-molecule inhibitor suppresses lung adenocarcinoma progression and metastasis.
peer_reviewed_research
2026 · study · Temporal status not established
Associations between kisspeptin hormone level and its genetic polymorphisms with polycystic ovary syndrome.
peer_reviewed_research
2026 · study · Temporal status not established
Progestogen priming is not essential to trigger ovulation in seasonal anoestrus ewes injected twice with a synthetic kisspeptin analogue.
peer_reviewed_research
2026 · study · Temporal status not established
Evaluation of Betatrophin, Chemerin, and Kisspeptin Levels in Acromegaly Patients.
peer_reviewed_research
2026 · study · Temporal status not established
The role of hypothalamic kisspeptin neurons in coordinating reproduction and metabolism.
peer_reviewed_research
2026 · study · Temporal status not established
Vesicular GABA transport expression in kisspeptin cells may contribute to the preovulatory gonadotropin surge.
peer_reviewed_research
2026 · study · Temporal status not established
GABA receptor modulation of arcuate kisspeptin neuron bursting and synchronization activity in female mice.
peer_reviewed_research
2026 · study · Temporal status not established
Prolonged oscillating preoptic area kisspeptin neuron activity underlies the preovulatory luteinizing hormone surge in mice.
peer_reviewed_research
2026 · study · Temporal status not established
Robust serotonin activation of the kisspeptin GnRH pulse generator in male and female mice.
peer_reviewed_research
2026 · study · Temporal status not established
Therapeutic potential of nasal kisspeptin-54 for reducing α-synuclein accumulation and restoring hippocampal synaptic plasticity in a 6-hydroxydopamine-induced rat model of Parkinson's disease.
peer_reviewed_research
2026 · study · Temporal status not established
Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography-High-Resolution Mass Spectrometry for Doping Control Purposes.
peer_reviewed_research
2026 · study · Temporal status not established
Phase-dependent changes in serum kisspeptin and irisin levels across the menstrual cycle in healthy women.
peer_reviewed_research
2026 · study · Temporal status not established
Kisspeptin-10 regulates glycosaminoglycan and decorin content in human cardiac fibroblast cultures.
peer_reviewed_research
2026 · study · Temporal status not established
Daily Rhythmic Changes in Kisspeptin Gene Expression and Testosterone Hormone in Male Syrian Hamsters (Mesocricetus auratus).
peer_reviewed_research
2026 · study · Temporal status not established
Exploring the Role of Kisspeptin in Polycystic Ovary Syndrome and Its Associated Pregnancy Complications.
systematic_review_or_meta_analysis
2026 · study · Temporal status not established
Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men.
peer_reviewed_research
2026 · study · Temporal status not established
The Expression of Kisspeptin Receptor, Catsper 3 and Acrosome Integrity in Oligozoospermic and Normozoospermic Individuals.
peer_reviewed_research
2026 · study · Temporal status not established
Intravenous kisspeptin 112-121 bolus does not acutely impact circulating vasopressin in humans.
peer_reviewed_research
2026 · study · Temporal status not established
Neurotransmitter and neuromodulator imbalance in kisspeptin/GnRH regulation in rodent models of polycystic ovary syndrome and its implications for mental health disorders: A systematic review.
systematic_review_or_meta_analysis
2026 · study · Temporal status not established
Effect of kisspeptin with or without cabergoline on the estrus cycle and reproductive hormones in female dogs.
peer_reviewed_research
2026 · study · Temporal status not established
Serum kisspeptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis.
systematic_review_or_meta_analysis
2026 · regulatory · Temporal status not established
Regulatory review: not_approved
European Union — EMA
2026 · regulatory · Temporal status not established
Regulatory review: not_approved
United States — FDA
2027 · study · Temporal status not established
Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche.
peer_reviewed_research

The represented chronology reflects records currently included in the governed dataset and does not claim to represent the entire scientific literature.

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Kisspeptin research, ranked and separated by purpose

Kisspeptin: what this atlas does and does not establish

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6 conclusions connected to 0 featured studies

Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study.

Kisspeptin expression levels in patients with placenta previa: A randomized trial.

Chemistry and represented biological context

Molecular and structural record

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The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54

A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse

Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat

Central and Peripheral Administration of Kisspeptin‐10 Stimulates the Hypothalamic‐Pituitary‐Gonadal Axis

Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts

Changes in Hypothalamic KiSS-1 System and Restoration of Pubertal Activation of the Reproductive Axis by Kisspeptin in Undernutrition

Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54

Kisspeptin-10-Induced Signaling of GPR54 Negatively Regulates Chemotactic Responses Mediated by CXCR4: a Potential Mechanism for the Metastasis Suppressor Activity of Kisspeptins

Repetitive Activation of Hypothalamic G Protein-Coupled Receptor 54 with Intravenous Pulses of Kisspeptin in the Juvenile Monkey (Macaca mulatta) Elicits a Sustained Train of Gonadotropin-Releasing Hormone Discharges

Minireview: Kisspeptin Neurons as Central Processors in the Regulation of Gonadotropin-Releasing Hormone Secretion

Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty

Kisspeptin-54 Stimulates the Hypothalamic-Pituitary Gonadal Axis in Human Males

Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats

Hypothalamic Expression of KiSS-1 System and Gonadotropin-Releasing Effects of Kisspeptin in Different Reproductive States of the Female Rat

Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat

Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats

Postnatal Development of Kisspeptin Neurons in Mouse Hypothalamus; Sexual Dimorphism and Projections to Gonadotropin-Releasing Hormone Neurons

Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha

A role for kisspeptin in islet function

Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling

Kisspeptin Mediates the Photoperiodic Control of Reproduction in Hamsters

GPR54 and kisspeptin in reproduction

Metastin/Kisspeptin and control of estrous cycle in rats

Kisspeptin Is Present in Ovine Hypophysial Portal Blood But Does Not Increase during the Preovulatory Luteinizing Hormone Surge: Evidence that Gonadotropes Are Not Direct Targets of Kisspeptin in Vivo

Involvement of Anteroventral Periventricular Metastin/Kisspeptin Neurons in Estrogen Positive Feedback Action on Luteinizing Hormone Release in Female Rats

The Kisspeptin Receptor GPR54 Is Required for Sexual Differentiation of the Brain and Behavior

Hypertrophy and Increased Kisspeptin Gene Expression in the Hypothalamic Infundibular Nucleus of Postmenopausal Women and Ovariectomized Monkeys

Emerging ideas about kisspeptin– GPR54 signaling in the neuroendocrine regulation of reproduction

New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function

The Role of Kisspeptin–GPR54 Signaling in the Tonic Regulation and Surge Release of Gonadotropin-Releasing Hormone/Luteinizing Hormone

The Role of Kisspeptins and GPR54 in the Neuroendocrine Regulation of Reproduction

The Kisspeptin/Gonadotropin-Releasing Hormone Pathway and Molecular Signaling of Puberty in Fish1

Kisspeptin-54 Stimulates Gonadotropin Release Most Potently during the Preovulatory Phase of the Menstrual Cycle in Women

Kisspeptin Acts Directly and Indirectly to Increase Gonadotropin-Releasing Hormone Neuron Activity and Its Effects Are Modulated by Estradiol

Kisspeptin Neurons in the Arcuate Nucleus of the Ewe Express Both Dynorphin A and Neurokinin B

Kisspeptin Synchronizes Preovulatory Surges in Cyclical Ewes and Causes Ovulation in Seasonally Acyclic Ewes

Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system

Kisspeptin signalling in the brain: Steroid regulation in the rodent and ewe

Kisspeptin: A key link to seasonal breeding

Kisspeptins and the placenta: Regulation of trophoblast invasion

Kisspeptin expression in the brain: Catalyst for the initiation of puberty

Neuroendocrine factors in the initiation of puberty: The emergent role of kisspeptin

Direct Pituitary Effects of Kisspeptin: Activation of Gonadotrophs and Somatotrophs and Stimulation of Luteinising Hormone and Growth Hormone Secretion

Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals

Molecular Identification and Functional Characterization of the Kisspeptin/Kisspeptin Receptor System in Lower Vertebrates1

An Increase in Kisspeptin-54 Release Occurs with the Pubertal Increase in Luteinizing Hormone-Releasing Hormone-1 Release in the Stalk-Median Eminence of Female Rhesus Monkeys in Vivo

Central and peripheral administration of kisspeptin activates gonadotropin but not somatotropin secretion in prepubertal gilts

Kisspeptin Depolarizes Gonadotropin-Releasing Hormone Neurons through Activation of TRPC-Like Cationic Channels

The neuroanatomy of the kisspeptin system in the mammalian brain

The role of kisspeptin in the control of gonadotrophin secretion

GPR54 and Kisspeptins

Comparison of the effects of peripherally administered kisspeptins

From KISS1 to kisspeptins: An historical perspective and suggested nomenclature

The kisspeptin (KiSS-1)/GPR54 system in cancer biology

Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback

Kisspeptin–GPR54 Signaling Is Essential for Preovulatory Gonadotropin-Releasing Hormone Neuron Activation and the Luteinizing Hormone Surge

Kisspeptins and GnRH neuronal signalling

Kisspeptin Excites Gonadotropin-Releasing Hormone Neurons through a Phospholipase C/Calcium-Dependent Pathway Regulating Multiple Ion Channels

Kisspeptin Can Stimulate Gonadotropin-Releasing Hormone (GnRH) Release by a Direct Action at GnRH Nerve Terminals