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Experience 2.0

Neuropeptide

Kisspeptin

Kisspeptin refers to a family of neuropeptides involved in reproductive neuroendocrine signaling. The parent peptide family, named fragments, and synthetic analogs should not be treated as interchangeable interventions.

Record status

Traceability partial

Last meaningful update: 9/26/2026

Evidence searched through:
Not recorded
Assessment updated:
9/26/2026
Documented human review:
No documented human review recorded
Automated scientific assessment:
None recorded
AI source check:
None recorded

Published source links and profile text pass separate gates. Only a documented human review is labelled as human review; an automated scientific assessment applies deterministic checks, and an AI source check confirms only that a source exists and matches its identifiers. A source count alone does not establish a review.

Evidence coverage has three distinct layers. The corpus count is a transparent screening inventory, the featured set contains study-level tiering and interpretation, and the published-source count contains records promoted through the institutional publication workflow. Source validation, editorial publication, and scientific appraisal are separate decisions; these numbers must not be merged.

Ranked research corpus

500

Categorized publications with provisional ranking; scientific review remains separate.

Featured tiered studies

0

Cornerstone publications with study-level interpretation, limitations, and tier disclosure.

Research domains

6

Clinical and scientific questions synthesized independently across the evidence atlas.

Published source records

453

Database records promoted through the governed publication workflow—not the corpus total.

Corpus generated 2026-09-18. Counts remain separately labeled so screening is not represented as completed review.

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Eligible observations remain below the privacy and reliability threshold. WPF will not convert a handful of reports into a percentage, trend, or clinical claim.

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n ≥ 20 eligible observations

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The state of the record

A compact view of what is represented, what remains unresolved, and how completely the record can be traced.

Ranked research corpus

500

Categorized screening records; proposed rankings remain pending human appraisal.

Featured tiered studies

0

Cornerstone studies with published study-level interpretation and tier disclosure.

Research domains

6

Independent evidence dossiers covering the major research questions.

Published source records

453

Source records published through the governed workflow; this count does not certify scientific conclusions.

Contradictions

0

Conflicting evidence relationships that remain visible.

Research gaps

1

Questions the current record identifies as unresolved.

Connected media

0

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What we know

Evidence, claims, and boundaries

The project separates represented evidence from qualification, contradiction, uncertainty, and what the evidence does not establish.

Reconciled domain conclusions

6 published domain syntheses connected to 0 featured studies

Kisspeptin no longer relies on the legacy “no public claim” state. Each research domain publishes a bounded synthesis, confidence level, evidence context, limitations, geographic applicability, regulatory interpretation, and research gaps. Publication of these syntheses is separate from the scientific review status shown above.

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Inspect the published evidence record453 governed records · titles, provenance, and original-source linksOpen records ↓
2025Phase 1–2 human evidence

Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study.

Content-verified record concerning Kisspeptin: "Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study." Abstract excerpt: Kisspeptin plays a major role in the onset of puberty by stimulating the gonadotropin-releasing hormone (GnRH) neurons. The aim of this study was to investigate whether GnRH inhibits kisspeptin secretion via a negative feedback mechanism and potential associations between kisspeptin levels and other hormones of importance for pubertal onset. Thirteen girls with suspected central precocious puberty

Source
peer_reviewed_research
DOI
10.1515/jpem-2024-0606
PubMed
39847034
Open original source
2023Phase 1–2 human evidence

Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.

Content-verified record concerning Kisspeptin: "Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial." Abstract excerpt: The human physiological sexual response is crucial for reward, satisfaction, and reproduction. Disruption of the associated neurophysiological pathways predisposes to low sexual desire; the most prevalent psychological form is hypoactive sexual desire disorder (HSDD), which affects 8% of men but currently has no effective pharmacological treatment options. The reproductive neuropeptide kisspeptin

Source
peer_reviewed_research
DOI
10.1001/jamanetworkopen.2022.54313
PubMed
36735255
Open original source
2022Phase 1–2 human evidence

Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.

Content-verified record concerning Kisspeptin: "Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial." Abstract excerpt: Despite being the most common female sexual health complaint worldwide, current treatment options for hypoactive sexual desire disorder (HSDD) are limited in their safety and effectiveness. The hormone kisspeptin is a key endogenous activator of the reproductive hormonal axis with additional emerging roles in sexual and emotional behavior; however, its effects in women with HSDD are unknown. To te

Source
peer_reviewed_research
DOI
10.1001/jamanetworkopen.2022.36131
PubMed
36287566
Open original source
2024Phase 1–2 human evidence

Kisspeptin expression levels in patients with placenta previa: A randomized trial.

Content-verified record concerning Kisspeptin: "Kisspeptin expression levels in patients with placenta previa: A randomized trial." Abstract excerpt: This study aimed to explore the potential influence of kisspeptin (KISS1) levels on the etiology of placenta previa for early pregnancy diagnosis. The study included 20 pregnant women diagnosed with placenta previa and 20 pregnant woman with normal pregnancies between 2021 and 2022. Plasma KISS1 levels were determined through biochemical analysis, while genetic analysis assessed KISS1 and KISS1 re

Source
peer_reviewed_research
DOI
10.1097/md.0000000000038866
PubMed
38996103
Open original source
2027Observational human evidence

Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche.

Content-verified record concerning Kisspeptin: "Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche." Abstract excerpt: Distinguishing idiopathic central precocious puberty (ICPP) from premature thelarche (PT) remains a clinical challenge and often necessitates GnRH stimulation testing. Kisspeptin-10 (Kp-10), Neurokinin B (NKB), and Neuropeptide Y (NPY) are key regulators of GnRH secretion and may serve as surrogate biomarkers. We evaluated whether these neuropeptides, alone or in combination with basal gonadotropi

Source
peer_reviewed_research
DOI
10.1016/j.cca.2026.121207
PubMed
42364891
Open original source
2024Observational human evidence

Kisspeptin signalling and its correlation with placental ultrastructure and clinical outcomes in pregnant South African women with obesity and gestational diabetes.

Content-verified record concerning Kisspeptin: "Kisspeptin signalling and its correlation with placental ultrastructure and clinical outcomes in pregnant South African women with obesity and gestational diabetes." Abstract excerpt: Gestational diabetes mellitus (GDM) is a major pregnancy metabolic disorder and is strongly linked with obesity. Kisspeptin is a hormone that increases several thousand-fold in the maternal circulation during human pregnancy, with placenta as its main source. Studies have suggested that kisspeptin regulates trophoblast invasion and promotes pancreatic insulin secretion and peripheral insulin sensi

Source
peer_reviewed_research
DOI
10.1016/j.placenta.2024.05.138
PubMed
38878622
Open original source
2025Observational human evidence

The association between 1st trimester serum kisspeptin level and antenatal complications.

Content-verified record concerning Kisspeptin: "The association between 1st trimester serum kisspeptin level and antenatal complications." Abstract excerpt: We aimed to evaluate the usefulness of serum kisspeptin (KP), measured in the 1st trimester (11-14 weeks), as a new biomarker that can predict antenatal complications. A prospective case-control study of prospectively collected data. Blood samples of all patients (N = 124) were preserved at -70 °C for the assessment of serum KP-10 and KP-54 levels. The KP levels were analyzed for comparison a

Source
peer_reviewed_research
DOI
10.48095/cccg2025212
PubMed
40663448
Open original source
2025Observational human evidence

Recurrent spontaneous ovarian hyperstimulation in a young nonpregnant Chinese woman with Rathke cleft cyst and a KISS1R variant: A rare case report and literature review.

Content-verified record concerning Kisspeptin: "Recurrent spontaneous ovarian hyperstimulation in a young nonpregnant Chinese woman with Rathke cleft cyst and a KISS1R variant: A rare case report and literature review." Abstract excerpt: Unexplained spontaneous ovarian hyperstimulation syndrome (sOHSS) in a nonpregnant young woman is rare, with fewer than five cases documented in the literature. Although four distinct causative types of sOHSS have been identified, some cases remain beyond the scope of our current understanding. A young Chinese woman with sOHSS presented on multiple occasions with sOHSS between the ages of 18.6 and

Source
peer_reviewed_research
DOI
10.1002/ijgo.16072
PubMed
39620881
Open original source
2024Observational human evidence

[Notch1/Akt/Foxo1 Pathway Regulated by Kisspeptin Is Involved in Endometrial Decidualization in Patients With Recurrent Spontaneous Abortion].

Content-verified record concerning Kisspeptin: "[Notch1/Akt/Foxo1 Pathway Regulated by Kisspeptin Is Involved in Endometrial Decidualization in Patients With Recurrent Spontaneous Abortion]." Abstract excerpt: Kisspeptin, a protein encoded by the KISS1 gene, functions as an essential factor in suppressing tumor growth. The intricate orchestration of cellular processes such as proliferation and differentiation is governed by the Notch1/Akt/Foxo1 signaling pathway, which assumes a central role in maintaining cellular homeostasis. In the specific context of this investigation, the focal point lies in a met

Source
peer_reviewed_research
DOI
10.12182/20240560206
PubMed
38948287
Open original source
2024Observational human evidence

Kisspeptin and DLK1 levels for monitoring treatment of girls with central precocious puberty.

Content-verified record concerning Kisspeptin: "Kisspeptin and DLK1 levels for monitoring treatment of girls with central precocious puberty." Abstract excerpt: Kisspeptin and delta-like 1 homolog (DLK1) are neuropeptides that reportedly play an important role in pubertal timing by activating and inhibiting the hypothalamic-pituitary-gonadal axis, respectively. Consequently, serum kisspeptin and DLK1 levels may be novel biomarkers for differentiating between central precocious puberty (CPP) and premature thelarche (PT) in girls and used to monitor CPP tre

Source
peer_reviewed_research
DOI
10.3345/cep.2023.01361
PubMed
38772409
Open original source
2026Observational human evidence

Novel KISS1 Gene Mutation Leading to Male Hypogonadotropic Hypogonadism.

Content-verified record concerning Kisspeptin: "Novel KISS1 Gene Mutation Leading to Male Hypogonadotropic Hypogonadism." Abstract excerpt: The human KISS1 gene encodes the hypothalamic Kisspeptin, which is released in a pulsatile manner and binds the KISS1 receptor, that is located on gonadotropin releasing hormone neurons. This interaction ensures pulsatile gonadotropin releasing hormone secretion leading to induction of the hypothalamic-pituitary-gonadal axis and by this controls puberty onset. Disruption of this process is associa

Source
peer_reviewed_research
DOI
10.1055/a-2787-6622
PubMed
41786302
Open original source
2023Observational human evidence

Kisspeptin: a potential therapeutic target in patients with unexplained infertility?

Content-verified record concerning Kisspeptin: "Kisspeptin: a potential therapeutic target in patients with unexplained infertility?" Abstract excerpt: Kisspeptin has recently emerged as a key regulator of the reproductive axis in women. Kisspeptin, acting centrally via the kisspeptin receptor, stimulates the secretion of the gonadotrophin-releasing hormone (GnRH). To investigate serum kisspeptin levels in infertility patients for its clinical utilisation in management and understanding of the pathophysiology of infertility in a wide array of pat

Source
peer_reviewed_research
DOI
10.1007/s11845-022-03152-1
PubMed
36114933
Open original source
2022Observational human evidence

Gestational exposure to bisphenol analogues and kisspeptin levels in pregnant women and their children: A pregnancy-birth cohort study.

Content-verified record concerning Kisspeptin: "Gestational exposure to bisphenol analogues and kisspeptin levels in pregnant women and their children: A pregnancy-birth cohort study." Abstract excerpt: Gestational exposure to bisphenol analogues (BPs)，especially bisphenol A (BPA), has been associated with adverse pregnancy-related outcomes and altered reproductive development of offspring, but the underlying mechanisms are not well documented. Kisspeptin, a key regulator of reproductive health, could be the potential target for endocrine disrupting compounds like BPs. Among 528 mother-chi

Source
peer_reviewed_research
DOI
10.1016/j.scitotenv.2022.157720
PubMed
35914601
Open original source
2026Observational human evidence

Dynamic changes of Kisspeptin during controlled ovarian hyperstimulation (COH) in polycystic ovary syndrome patients and its correlation with COH outcomes.

Content-verified record concerning Kisspeptin: "Dynamic changes of Kisspeptin during controlled ovarian hyperstimulation (COH) in polycystic ovary syndrome patients and its correlation with COH outcomes." Abstract excerpt: Polycystic ovary syndrome (PCOS) is a common cause of anovulatory infertility in women, and patients often exhibit ovarian hyperresponse during controlled ovarian hyperstimulation (COH) in assisted reproductive technology. Kisspeptin is a key upstream regulator of the hypothalamic-pituitary-ovarian axis (HPOA). This study aims to explore the dynamic changes in serum and follicular fluid (FF) Kissp

Source
peer_reviewed_research
DOI
10.3389/fendo.2026.1835699
PubMed
42244951
Open original source
2026Observational human evidence

Serological biomarker models composed of luteinizing hormone, kisspeptin, vitamin D and estradiol, and their clinical test value in girls.

Content-verified record concerning Kisspeptin: "Serological biomarker models composed of luteinizing hormone, kisspeptin, vitamin D and estradiol, and their clinical test value in girls." Abstract excerpt: Central precocious puberty (CPP) may lead to premature pubertal onset. While the GnRH stimulation test remains the gold standard, its invasive nature and prolonged procedure limit clinical utility, particularly in pediatric populations. Emerging biomarkers, including luteinizing hormone, estradiol, kisspeptin, and vitamin D, have shown promise in distinguishing CPP from normal puberty. This study

Source
peer_reviewed_research
DOI
10.1016/j.jped.2025.101477
PubMed
41253291
Open original source
2024Observational human evidence

A prospective study to evaluate whether serum kisspeptin is a marker predictive of the first-trimester miscarriage of women who conceive in IVF.

Content-verified record concerning Kisspeptin: "A prospective study to evaluate whether serum kisspeptin is a marker predictive of the first-trimester miscarriage of women who conceive in IVF." Abstract excerpt: Kisspeptin is an emerging biomarker for the discrimination of viable pregnancy. The aim of the study is to determine whether serum kisspeptin can predict the first-trimester miscarriage and compare it with serum HCG in the prediction of the first-trimester miscarriage. This study is a prospective case-control design including 178 women who had experienced early miscarriage (n = 21) and viable sing

Source
peer_reviewed_research
DOI
10.1007/s10815-023-02974-x
PubMed
37935913
Open original source
2024Observational human evidence

Associations between maternal urinary kisspeptin in late pregnancy and decreased fetal growth: a pregnancy-birth cohort study.

Content-verified record concerning Kisspeptin: "Associations between maternal urinary kisspeptin in late pregnancy and decreased fetal growth: a pregnancy-birth cohort study." Abstract excerpt: Kisspeptin has been indicated to be a biomarker of fetal growth. Although some evidence suggested that maternal kisspeptin concentrations in early pregnancy were associated with increased fetal growth, studies are still limited and the effect of kisspeptin in late pregnancy remains unknown. This study aimed to investigate the associations between maternal kisspeptin in late pregnancy and fetal gro

Source
peer_reviewed_research
DOI
10.3389/fendo.2024.1257248
PubMed
38318290
Open original source
2025Observational human evidence

AMH and Kisspeptin Receptor Expression in Rare Hydropic Leiomyoma: A Case Study.

Content-verified record concerning Kisspeptin: "AMH and Kisspeptin Receptor Expression in Rare Hydropic Leiomyoma: A Case Study." Abstract excerpt: BACKGROUND Leiomyomas are common benign uterine tumors (BUMTs) with diverse histopathological subtypes and variable clinical presentations. While most are asymptomatic, some cause significant morbidity, including abnormal uterine bleeding, infertility, and pain. Hydropic leiomyomas (HLMs) are rare variants histopathologically characterized by zonal edema and may pose diagnostic challenges, particu

Source
peer_reviewed_research
DOI
10.12659/ajcr.947953
PubMed
40305440
Open original source
2026Observational human evidence

First clinical use of the kisspeptin analog TAK-683 in the treatment of a follicular cyst in a goat: case report.

Content-verified record concerning Kisspeptin: "First clinical use of the kisspeptin analog TAK-683 in the treatment of a follicular cyst in a goat: case report." Abstract excerpt: This case report presents the therapeutic response to TAK‑683, a long-acting kisspeptin analog, in the treatment of a follicular cyst that developed following a conventional estrus synchronization protocol in a goat during the non-breeding season. A two-year-old lactating Aleppo goat showing persistent nymphomaniac behaviour after estrus synchronization was diagnosed with an ovarian follicu

Source
peer_reviewed_research
DOI
10.1007/s11259-026-11141-3
PubMed
41817855
Open original source
2024Observational human evidence

Urinary phthalate/DINCH metabolites associations with kisspeptin and reproductive hormones in teenagers: A cross-sectional study from the HBM4EU aligned studies.

Content-verified record concerning Kisspeptin: "Urinary phthalate/DINCH metabolites associations with kisspeptin and reproductive hormones in teenagers: A cross-sectional study from the HBM4EU aligned studies." Abstract excerpt: Exposure to phthalate/DINCH metabolites can induce human reproductive toxicity, however, their endocrine-disrupting mechanisms are not fully elucidated. To investigate the association between concentrations of phthalate/DINCH metabolites, serum kisspeptin, and reproductive hormones among European teenagers from three of the HBM4EU Aligned Studies. In 733 Belgian (FLEHS IV study), Slovak (PCB cohor

Source
peer_reviewed_research
DOI
10.1016/j.scitotenv.2024.172426
PubMed
38631641
Open original source
2026Observational human evidence

Kisspeptin as a Precision Biomarker in Personalized Pharmacy: Implications for Individualized Monitoring of Early Pregnancy Viability.

Content-verified record concerning Kisspeptin: "Kisspeptin as a Precision Biomarker in Personalized Pharmacy: Implications for Individualized Monitoring of Early Pregnancy Viability." Abstract excerpt: Precision medicine aims to improve early, individualized risk stratification using biologically relevant biomarkers. In early pregnancy, markers reflecting placental function remain limited. Kisspeptin, a placentally derived peptide that rises during normal gestation, has emerged as a potential indicator of pregnancy viability. We aimed to evaluate evidence on maternal serum kisspeptin levels and

Source
peer_reviewed_research
DOI
10.3390/pharmacy14030084
PubMed
42347060
Open original source
2024Observational human evidence

Kisspeptin expression during menstruation in PCOS patients undergoing ovulation induction and the correlation with early pregnancy.

Content-verified record concerning Kisspeptin: "Kisspeptin expression during menstruation in PCOS patients undergoing ovulation induction and the correlation with early pregnancy." Abstract excerpt: To examine the pattern of kisspeptin expression throughout the menstrual cycle in polycystic ovary syndrome (PCOS) patients under the ovulation induction and identify any possible associations with early pregnancy. A prospective cohort of 80 PCOS women who expressed the desire for fertility was enrolled in this study. All of them received the ovulation induction by using letrozole. Levels of kissp

Source
peer_reviewed_research
DOI
10.1007/s10815-024-03144-3
PubMed
38809329
Open original source
2025Animal research

Central administration of p234, kisspeptin antagonist, but not kisspeptin-10, reduces the power of epileptiform activity and slow EEG waves in male rats.

Content-verified record concerning Kisspeptin: "Central administration of p234, kisspeptin antagonist, but not kisspeptin-10, reduces the power of epileptiform activity and slow EEG waves in male rats." Abstract excerpt: We aimed to investigate the effects of central kisspeptin-10 and p234 administration on basal brain activity and epilepsy-like conditions induced by 4-aminopyridine (4-AP), as well as their roles in the electrocorticogram (ECoG) power spectrum and EEG waves. Thirty-five male Wistar rats were divided into five groups: sham,4-AP (2.5 mg/kg i.p.), kisspeptin-10 post-treatment (200 pmoli.c.v.), p234 p

Source
peer_reviewed_research
DOI
10.1080/01616412.2025.2456293
PubMed
39838653
Open original source
2013Animal research

Neurokinin B Activates Arcuate Kisspeptin Neurons Through Multiple Tachykinin Receptors in the Male Mouse

Content-verified record concerning Kisspeptin: "Neurokinin B Activates Arcuate Kisspeptin Neurons Through Multiple Tachykinin Receptors in the Male Mouse" Abstract excerpt: Kisspeptin neurons located in the arcuate nucleus (ARN) coexpress dynorphin and neurokinin B (NKB) and may interact to influence gonadotropin secretion. Using a kisspeptin-green fluorescent protein mouse model, the present study examined whether the neuropeptides kisspeptin, dynorphin, and NKB modulate the electrical activity of ARN kisspeptin neurons in the adult male mouse. Cell-attached recordi

Source
peer_reviewed_research
DOI
10.1210/en.2013-1231
PubMed
23744641
Open original source
2026Animal research

Therapeutic potential of nasal kisspeptin-54 for reducing α-synuclein accumulation and restoring hippocampal synaptic plasticity in a 6-hydroxydopamine-induced rat model of Parkinson's disease.

Content-verified record concerning Kisspeptin: "Therapeutic potential of nasal kisspeptin-54 for reducing α-synuclein accumulation and restoring hippocampal synaptic plasticity in a 6-hydroxydopamine-induced rat model of Parkinson's disease." Abstract excerpt: Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons and pathological aggregation of α-synuclein (α-syn), leading to significant motor and cognitive impairments. Kisspeptin-54 (KP-54), a neuropeptide primarily involved in reproductive regulation, has recently been implicated in neurorestorative processes, with emerging evidence suggesting benefi

Source
peer_reviewed_research
DOI
10.55730/1300-0144.6376
PubMed
42676968
Open original source
2025Animal research

Early Development of Hypothalamic Neurons Expressing Proopiomelanocortin Peptides, Neuropeptide Y, and Kisspeptin in Fetal Rhesus Macaques.

Content-verified record concerning Kisspeptin: "Early Development of Hypothalamic Neurons Expressing Proopiomelanocortin Peptides, Neuropeptide Y, and Kisspeptin in Fetal Rhesus Macaques." Abstract excerpt: We have documented the early embryonic development of hypothalamic neurons expressing β-endorphin, α-melanocyte-stimulating hormone, neuropeptide Y, and kisspeptin in rhesus macaques, an animal model that is very similar to humans. Neurons expressing both β-End and αMSH are the first to develop and are initially located in the lateral basal hypothalamus (LBH) as early as da

Source
peer_reviewed_research
DOI
10.1523/eneuro.0087-25.2025
PubMed
40389300
Open original source
2024Animal research

The evolutionary conserved miR-137/325 tandem mediates obesity-induced hypogonadism and metabolic comorbidities by repressing hypothalamic kisspeptin.

Content-verified record concerning Kisspeptin: "The evolutionary conserved miR-137/325 tandem mediates obesity-induced hypogonadism and metabolic comorbidities by repressing hypothalamic kisspeptin." Abstract excerpt: Obesity-induced hypogonadism (OIH) is a prevalent, but often neglected condition in men, which aggravates the metabolic complications of overweight. While hypothalamic suppression of Kiss1-encoded kisspeptin has been suggested to contribute to OIH, the molecular mechanisms for such repression in obesity, and the therapeutic implications thereof, remain unknown. A combination of bioinformatic, expr

Source
peer_reviewed_research
DOI
10.1016/j.metabol.2024.155932
PubMed
38729600
Open original source
2025Animal research

Postnatal undernutrition increases estradiol plasma levels and sexual receptivity and disrupts the kisspeptin-GnRH pathway in adult female rats.

Content-verified record concerning Kisspeptin: "Postnatal undernutrition increases estradiol plasma levels and sexual receptivity and disrupts the kisspeptin-GnRH pathway in adult female rats." Abstract excerpt: Undernutrition has increased worldwide in recent years and it is known that environmental factors to which individuals are exposed in early life can result in metabolic and reproductive changes that remain in adult life. In this context, the litter size expansion is a classic model used to induce undernutrition early in development. Thus, this study aimed to evaluate the effects of neonatal undern

Source
peer_reviewed_research
DOI
10.1016/j.physbeh.2025.114817
PubMed
39855583
Open original source
2026Animal research

Sodium benzoate induces reproductive toxicity via hormonal disruption, ovarian damage and altering kisspeptin/RFRP-3 expression.

Content-verified record concerning Kisspeptin: "Sodium benzoate induces reproductive toxicity via hormonal disruption, ovarian damage and altering kisspeptin/RFRP-3 expression." Abstract excerpt: Sodium benzoate (SB) is a widely used food preservative; however, it has been shown to exert dose-dependent reproductive toxicity. In this study, we investigated its effects on the female reproductive axis. Sprague-Dawley rats (n = 30) were assigned to six groups (n = 5 each); the control group received distilled water, while treatment groups administered SB at doses of 10, 50,

Source
peer_reviewed_research
DOI
10.1016/j.yrtph.2026.106069
PubMed
41740828
Open original source
2026Animal research

[Effect of acupuncture on ovarian function in rats with premature ovarian insufficiency based on kisspeptin/GPR54 pathway].

Content-verified record concerning Kisspeptin: "[Effect of acupuncture on ovarian function in rats with premature ovarian insufficiency based on kisspeptin/GPR54 pathway]." Abstract excerpt: To explore the effect of acupuncture on ovarian function in rats with premature ovarian insufficiency (POI) based on kisspeptin/G protein-coupled receptor 54 (GPR54) pathway. Thirty female SD rats were randomly divided into a blank group (10 rats) and a modeling group (20 rats). In the modeling group, POI model was established by intraperitoneal injection of cyclophosphamide. The successfully mode

Source
peer_reviewed_research
DOI
10.13703/j.0255-2930.20250110-k0004
PubMed
42343523
Open original source
2026Animal research

Kisspeptin System: A Modulator of Neuroinflammation and Behaviour in Temporal Lobe Epileptic Rats.

Content-verified record concerning Kisspeptin: "Kisspeptin System: A Modulator of Neuroinflammation and Behaviour in Temporal Lobe Epileptic Rats." Abstract excerpt: Temporal lobe epilepsy (TLE) is the most prevalent form of drug-resistant epilepsy and is driven by persistent neuroinflammatory cascades wherein interactions between inflammatory mediators and hormones play a crucial role. Kisspeptin (Kiss1), a neuropeptide known to modulate synaptic transmission in the hippocampus, has an unclear role in pathophysiology of epilepsy. To investigate this, a lithiu

Source
peer_reviewed_research
DOI
10.1007/s12035-026-06171-6
PubMed
42680947
Open original source
2026Animal research

Kisspeptin-2 stimulates testicular function in adult pejerrey (Odontesthes bonariensis): Does it act directly on the testes?

Content-verified record concerning Kisspeptin: "Kisspeptin-2 stimulates testicular function in adult pejerrey (Odontesthes bonariensis): Does it act directly on the testes?" Abstract excerpt: Kisspeptin is a neuropeptide that regulates GnRHergic neurons in mammals; however, its function in teleost fish remains less understood. This study examined the role of kisspeptin2 (Kiss2) in the regulation of testicular function in adult pejerrey (Odontesthes bonariensis), with a particular focus on differentiating between central and direct gonadal effects. Spermiating males were intraperitoneal

Source
peer_reviewed_research
DOI
10.1016/j.cbpa.2026.112043
PubMed
42364900
Open original source
2026Animal research

Kisspeptin-10 attenuates pulmonary arterial hypertension via restoration of mitochondrial function in pulmonary artery smooth muscle cells.

Content-verified record concerning Kisspeptin: "Kisspeptin-10 attenuates pulmonary arterial hypertension via restoration of mitochondrial function in pulmonary artery smooth muscle cells." Abstract excerpt: Mitochondrial dysfunction and dysregulated mitophagy in pulmonary artery smooth muscle cells (PASMCs) critically drive pulmonary arterial hypertension (PAH). Here we show that Kisspeptin-10, acting via its receptor GPR54, markedly attenuates PAH in the SU5416/hypoxia mouse model. The administration of kisspeptin-10 resulted in a considerable reduction in the systolic pressure of the right ventricl

Source
peer_reviewed_research
DOI
10.1016/j.npep.2026.102611
PubMed
41955717
Open original source
2026Animal research

Kisspeptin-54 attenuates acute lung injury in septic mice through AMPK-mediated suppression of NLRP3 inflammasome.

Content-verified record concerning Kisspeptin: "Kisspeptin-54 attenuates acute lung injury in septic mice through AMPK-mediated suppression of NLRP3 inflammasome." Abstract excerpt: Sepsis-induced acute lung injury (ALI) remains a leading cause of death in intensive care, yet targeted therapies are lacking. Kisspeptin-54 is a neuropeptide primarily known for reproductive regulation, though its role in sepsis is unexplored. This study investigated whether exogenous kisspeptin-54 protects against septic lung injury and examined the underlying mechanism. In a cecal ligation and

Source
peer_reviewed_research
DOI
10.1016/j.npep.2026.102639
PubMed
42418889
Open original source
2026Animal research

Kisspeptin-54 confers renal protection in diabetic nephropathy by ameliorating endothelial permeability through ZEB1 inhibition.

Content-verified record concerning Kisspeptin: "Kisspeptin-54 confers renal protection in diabetic nephropathy by ameliorating endothelial permeability through ZEB1 inhibition." Abstract excerpt: Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD). A central pathological feature is the breakdown of the glomerular endothelial barrier. Although the Kisspeptin-54/GPR54 pathway is known to regulate vascular function, its specific role and mechanism in DN-related renal endothelial damage are unclear. This study used db/db mice (type 2 DN model) and human renal glomeru

Source
peer_reviewed_research
DOI
10.1016/j.tice.2026.103503
PubMed
41950743
Open original source
2026Animal research

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders.

Content-verified record concerning Kisspeptin: "Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders." Abstract excerpt: The hypothalamic-pituitary-gonadal axis is regulated by the gonadotropin-releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and gametogenesis from the gonads. Many reproductive disorders in bo

Source
peer_reviewed_research
DOI
10.1111/andr.13843
PubMed
39834030
Open original source
2026Animal research

Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats.

Content-verified record concerning Kisspeptin: "Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats." Abstract excerpt: Reduced placental mTOR signaling is associated with intrauterine growth restriction and impaired maternal and placental metabolism. Since maternal hypothyroidism induces intrauterine growth restriction, and maternal treatment with kisspeptin-10 (Kp10) has been shown to improve feto-placental development in hypothyroid rats, this study aimed to evaluate the effects of maternal hypothyroidism, with

Source
peer_reviewed_research
DOI
10.1111/apha.70188
PubMed
41782211
Open original source
2026Animal research

Kisspeptin and early pregnancy: Insights from animal models into hormonal regulation and miscarriage.

Content-verified record concerning Kisspeptin: "Kisspeptin and early pregnancy: Insights from animal models into hormonal regulation and miscarriage." Abstract excerpt: Miscarriage, defined as spontaneous pregnancy loss before 20 weeks of gestation, affects 10-15% of pregnancies in women under 30, rising to over 50% in women over 45. Implantation failure and early placental dysfunction are major contributors, yet the precise mechanisms remain incompletely understood. Kisspeptin, encoded by KISS1, is a critical regulator of the reproductive axis and is highly expr

Source
peer_reviewed_research
DOI
10.1111/jne.70120
PubMed
41310413
Open original source
2026Animal research

Kisspeptin exacerbates androgen-induced follicular dysplasia by promoting Drp1 phosphorylation imbalance and mitochondrial excessive fission in granulosa cells of polycystic ovary syndrome.

Content-verified record concerning Kisspeptin: "Kisspeptin exacerbates androgen-induced follicular dysplasia by promoting Drp1 phosphorylation imbalance and mitochondrial excessive fission in granulosa cells of polycystic ovary syndrome." Abstract excerpt: BACKGROUND: An excess of androgens induces follicular dysplasia. Kisspeptin is a polypeptide hormone that is expressed in both the central nervous system and ovary, and it is correlated with follicle development. However, the mechanism underlying its role in androgen-induced follicular dysplasia of polycystic ovary syndrome (PCOS) is unclear. This study aimed to explore whether Kisspeptin can exac

Source
peer_reviewed_research
DOI
10.1186/s13048-026-02055-4
PubMed
42057167
Open original source
2026Animal research

Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females.

Content-verified record concerning Kisspeptin: "Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females." Abstract excerpt: Ovulation is triggered by a surge in luteinizing hormone (LH) secretion from the pituitary. The LH surge is itself driven by a surge in gonadotropin-releasing hormone release induced by estrogen positive feedback action in the hypothalamus. While ERα-expressing kisspeptin (Kiss1) neurons in the preoptic area (in mice, the rostral periventricular region of the third ventricle [RP3V]) are prop

Source
peer_reviewed_research
DOI
10.1210/endocr/bqag049
PubMed
42057695
Open original source
2026Animal research

Kisspeptin improves local ovarian insulin resistance in PCOS by modulating the PI3K/AKT/GLUT4 signaling pathway.

Content-verified record concerning Kisspeptin: "Kisspeptin improves local ovarian insulin resistance in PCOS by modulating the PI3K/AKT/GLUT4 signaling pathway." Abstract excerpt: Insulin resistance (IR) is commonly observed in patients with polycystic ovary syndrome (PCOS), affecting 44% to 70% of these individuals. Kisspeptin is a key regulatory factor in energy balance and reproduction, and it may alleviate PCOS-related symptoms by improving insulin resistance. In this study, a PCOS-IR mouse model was established using dehydroepiandrosterone (DHEA) and a high-fat diet. T

Source
peer_reviewed_research
DOI
10.1371/journal.pone.0342158
PubMed
41628190
Open original source
2026Animal research

Kisspeptin Signaling Suppresses HRas<sup>G12V</sup>-induced Tumor Growth and Metastasis by Inhibiting SP1-dependent N-cadherin Expression in NIH3T3 Cells.

Content-verified record concerning Kisspeptin: "Kisspeptin Signaling Suppresses HRas<sup>G12V</sup>-induced Tumor Growth and Metastasis by Inhibiting SP1-dependent N-cadherin Expression in NIH3T3 Cells." Abstract excerpt: Kisspeptin signaling is recognized as a metastasis-suppressive pathway, but its role in oncogenic HRAS-driven tumor progression remains incompletely understood. This study investigated whether kisspeptin signaling suppresses HRAS G12V -induced tumorigenic and metastatic phenotypes in NIH3T3 cells and examined the involvement of SP1-dependent transcription of N-cadherin. NIH3T3 cells expressing HRA

Source
peer_reviewed_research
DOI
10.21873/anticanres.18291
PubMed
42527090
Open original source
2025Animal research

Kisspeptin 10 Inhibited the Proliferation, Migration, and Stemness of Esophageal Cancer Cells via Regulating the SIX1/Wnt/β-Catetin Signaling.

Content-verified record concerning Kisspeptin: "Kisspeptin 10 Inhibited the Proliferation, Migration, and Stemness of Esophageal Cancer Cells via Regulating the SIX1/Wnt/β-Catetin Signaling." Abstract excerpt: Esophageal cancer (EC) treatment remains challenging due to the disease's aggressive nature, frequent late-stage diagnosis, and the need for effective multimodal therapies with minimal side effects. Kisspeptin-10, a naturally occurring neuropeptide and known GPR54 agonist, has been shown to significantly influence tumor growth and progression. However, its specific role in EC remains poorly unders

Source
peer_reviewed_research
DOI
10.1002/jbt.70244
PubMed
40192612
Open original source
2025Animal research

Kisspeptin as a marker for male infertility: a comparative study of serum and seminal plasma kisspeptin between fertile and infertile men.

Content-verified record concerning Kisspeptin: "Kisspeptin as a marker for male infertility: a comparative study of serum and seminal plasma kisspeptin between fertile and infertile men." Abstract excerpt: This study aimed to identify kisspeptin as a new marker for infertility in men with abnormal semen parameters by comparing serum and seminal plasma kisspeptin levels between fertile men and infertile men with normal and abnormal semen parameters. Fertile men (group A), infertile men with normal semen parameters (group B), and infertile men with abnormal semen parameters (group C) were recruited. F

Source
peer_reviewed_research
DOI
10.1007/s10815-025-03644-w
PubMed
40936057
Open original source
2025Animal research

Kisspeptin control of hypothalamus-pituitary-ovarian functions.

Content-verified record concerning Kisspeptin: "Kisspeptin control of hypothalamus-pituitary-ovarian functions." Abstract excerpt: The discovery of Kisspeptin (Kiss) has opened a new direction in research on neuroendocrine control of reproduction in vertebrates. Belonging to the RF amide family of peptides, Kiss and its cognate receptor Gpr54 (Kissr) have a long and complex evolutionary history. Multiple forms of Kiss and Kissr are identified in non-mammalian vertebrates, with the exception of birds, and monotreme mammals. Ho

Source
peer_reviewed_research
DOI
10.1016/bs.vh.2024.06.005
PubMed
39864941
Open original source
2025Animal research

Kisspeptin system-physiology and clinical perspectives.

Content-verified record concerning Kisspeptin: "Kisspeptin system-physiology and clinical perspectives." Abstract excerpt: To summarize the state of knowledge on kisspeptin, a factor that alters the migration properties of some types of cancer cell and also plays an important role in the control of the reproductive axis. PubMed search, identifying the most recent relevant information. This review describes the physiological aspects about the regulation of kisspeptin release and its place in the regulation of reproduct

Source
peer_reviewed_research
DOI
10.1016/j.ando.2025.101793
PubMed
40446957
Open original source
2025Animal research

Kisspeptin-54 ameliorates chondrocyte senescence in osteoarthritis via SIRT3-mediated telomere protection and p53 acetylation inhibition.

Content-verified record concerning Kisspeptin: "Kisspeptin-54 ameliorates chondrocyte senescence in osteoarthritis via SIRT3-mediated telomere protection and p53 acetylation inhibition." Abstract excerpt: Osteoarthritis (OA), characterized by chondrocyte senescence and oxidative stress, affects over 300 million people globally. Kisspeptin-54, a neuropeptide with pleiotropic protective effects, was investigated for its role in chondrocyte senescence and its underlying mechanisms. Oxidative stress and senescence were induced in primary mouse chondrocytes by treating them with TBHP. Kisspeptin-54 was

Source
peer_reviewed_research
DOI
10.1016/j.npep.2025.102562
PubMed
41022004
Open original source
2025Animal research

Kisspeptin-13 induces hyperalgesia and modulates the expression of opioid and glutamate receptors in mice.

Content-verified record concerning Kisspeptin: "Kisspeptin-13 induces hyperalgesia and modulates the expression of opioid and glutamate receptors in mice." Abstract excerpt: Kisspeptins are hypothalamic neuropeptides well known for their role in reproductive biology. Our previous results have demonstrated that kisspeptin-13 (KP-13) has pronociceptive and anti-opioid effects. In our present experiments, we investigated the effects of KP-13 on nociception under both physiological and inflammatory conditions, as well as on the gene expression of regions involved in media

Source
peer_reviewed_research
DOI
10.1016/j.pbb.2025.174098
PubMed
40939812
Open original source
2025Animal research

Kisspeptin participates in the positive reward state induced by paced mating and modulates sexual receptivity and paced mating behavior in female rats.

Content-verified record concerning Kisspeptin: "Kisspeptin participates in the positive reward state induced by paced mating and modulates sexual receptivity and paced mating behavior in female rats." Abstract excerpt: Kisspeptin (Kp), a potent regulator of the hypothalamic-pituitary-gonad axis, was recently shown to be involved in partner preference and sexual receptivity in females. Interestingly, Kp and its receptor (Kiss1r) are expressed in brain regions involved in the reward and motivation of reinforcing behaviors. Therefore, in the present study, we designed 3 experiments to determine the participation of

Source
peer_reviewed_research
DOI
10.1016/j.yhbeh.2024.105671
PubMed
39637765
Open original source
2025Animal research

Kisspeptin Suppresses the Growth of Primary Pterygial Cells via Inhibiting Chemokine (C-X-C Motif) Ligands in Microenvironment.

Content-verified record concerning Kisspeptin: "Kisspeptin Suppresses the Growth of Primary Pterygial Cells via Inhibiting Chemokine (C-X-C Motif) Ligands in Microenvironment." Abstract excerpt: Pterygium is a prevalent ocular surface condition characterized by its extension toward the cornea at the corneoscleral junction. The etiology and development of pterygium are not fully understood. The discovery of new biomarkers may facilitate early intervention and the prevention of postoperative recurrence. Kisspeptin and GPR54 expression in pterygium were investigated in vivo by qPCR, Western

Source
peer_reviewed_research
DOI
10.1080/02713683.2025.2511866
PubMed
40555256
Open original source
2025Animal research

Kisspeptin-54 Restores Blood-Brain Barrier Integrity via GATA-4 in Ischemic Stroke.

Content-verified record concerning Kisspeptin: "Kisspeptin-54 Restores Blood-Brain Barrier Integrity via GATA-4 in Ischemic Stroke." Abstract excerpt: Ischemic stroke damages the blood-brain barrier (BBB), worsening neuronal injury. Treatments to protect the BBB are limited. We evaluated the neurovascular protective capacity of Kisspeptin-54 in ischemic stroke using in vivo and in vitro models. In vivo, mice underwent middle cerebral artery occlusion (MCAO), and cerebral infarct volume, neurological function, and blood-brain barri

Source
peer_reviewed_research
DOI
10.1111/cbdd.70134
PubMed
40454669
Open original source
2025Animal research

Kisspeptin fiber and receptor distribution analysis suggests its potential role in central sensorial processing and behavioral state control.

Content-verified record concerning Kisspeptin: "Kisspeptin fiber and receptor distribution analysis suggests its potential role in central sensorial processing and behavioral state control." Abstract excerpt: Kisspeptin (KP) signaling in the brain is defined by the anatomical distribution of KP-producing neurons, their fibers, receptors, and connectivity. Technological advances have prompted a re-evaluation of these chemoanatomical aspects, originally studied in the early years after the discovery of KP and its receptor Kiss1r. Previously, we characterized (Hernández et al. bioRxiv 2024) seven KP

Source
peer_reviewed_research
DOI
10.1111/jne.70007
PubMed
40065551
Open original source
2025Animal research

Kisspeptin-dependent puberty onset triggered by increased Kiss1 and Pdyn expression in arcuate Tac3 neurons under reduced estrogen negative feedback and sufficient energy balance in female rats.

Content-verified record concerning Kisspeptin: "Kisspeptin-dependent puberty onset triggered by increased Kiss1 and Pdyn expression in arcuate Tac3 neurons under reduced estrogen negative feedback and sufficient energy balance in female rats." Abstract excerpt: The pre-pubertal quiescence of pulsatile gonadotropin-releasing hormone secretion in mammals is considered due to repressed Kiss1 (encoding kisspeptin) expression in kisspeptin/neurokinin B/dynorphin A (KNDy) neurons. In this study, we aimed to investigate the effects of negative feedback levels of estradiol-17β (low E2) and energy balance on Kiss1, Tac3 (encoding neurokinin B), and Pdyn (en

Source
peer_reviewed_research
DOI
10.1159/000548403
PubMed
40947842
Open original source
2025Animal research

Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models.

Content-verified record concerning Kisspeptin: "Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models." Abstract excerpt: Polycystic ovary syndrome (PCOS) and mental health disorders have high rates of co-occurrence. Although the precise pathophysiological mechanisms remain unknown, the observed changes in those conditions may be modulated by kisspeptin (Kiss1), a protein that regulates energy metabolism. AIM: The aim of this study was to investigate whether Kiss1 plays an important role in linking dysfunctional repr

Source
peer_reviewed_research
DOI
10.1186/s13048-025-01918-6
PubMed
41430614
Open original source
2025Animal research

Kisspeptin isoforms: versatile players in reproduction and beyond.

Content-verified record concerning Kisspeptin: "Kisspeptin isoforms: versatile players in reproduction and beyond." Abstract excerpt: Kisspeptin and its cognate G-protein-coupled receptor (GPCR), the kisspeptin-1 receptor (KISS-1R), are central to mammalian reproduction, regulating the hypothalamic-pituitary-gonadal axis. They are upstream regulators of gonadotropin-releasing hormone (GnRH) secretion, a hallmark of the onset of puberty, subsequently tuning luteinizing hormone and follicle-stimulating hormone levels and bringing

Source
peer_reviewed_research
DOI
10.1530/jme-25-0001
PubMed
40271959
Open original source
2025Animal research

Kisspeptin Retards Tumor Growth of Lewis Lung Carcinoma Cells Through p38 MAPK-mediated Senescence.

Content-verified record concerning Kisspeptin: "Kisspeptin Retards Tumor Growth of Lewis Lung Carcinoma Cells Through p38 MAPK-mediated Senescence." Abstract excerpt: Kisspeptin has multifaceted roles in both normal and pathological conditions. Although lung cancer is a leading cause of cancer worldwide, the role of kisspeptin in lung cancer remains poorly understood. Thus, this study aimed to investigate the effects of kisspeptin on lung cancer. Mouse LLC cells were used to examine kisspeptin's effect on cell growth and death. Analyses for apoptosis, cell cycl

Source
peer_reviewed_research
DOI
10.21873/anticanres.17398
PubMed
39740824
Open original source
2025Animal research

Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice.

Content-verified record concerning Kisspeptin: "Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice." Abstract excerpt: Kisspeptin is a neuropeptide recognised for a pivotal role within the reproductive system, but potentially important endocrine metabolic effects are less well understood. We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of en

Source
peer_reviewed_research
DOI
10.3390/biom15111591
PubMed
41301510
Open original source
2025Animal research

Kisspeptin Administration and mRNA Expression in Adult Syrian Hamsters.

Content-verified record concerning Kisspeptin: "Kisspeptin Administration and mRNA Expression in Adult Syrian Hamsters." Abstract excerpt: Kisspeptin ( Kiss1 ) and kisspeptin 1 receptor ( Kiss1R ) are vital in regulating various functions across many species, primarily those relating to reproduction. The kisspeptin system has recently attracted clinical interest as a potential therapeutic treatment for patients with hypoactive sexual desire disorder. This study maps the distribution of Kiss1 and Kiss1R mRNA in the Syrian hamster fore

Source
peer_reviewed_research
DOI
10.3390/cells14130992
PubMed
40643513
Open original source
2025Animal research

Kisspeptin Mitigates Hepatic De Novo Lipogenesis in Metabolic Dysfunction-Associated Steatotic Liver Disease.

Content-verified record concerning Kisspeptin: "Kisspeptin Mitigates Hepatic De Novo Lipogenesis in Metabolic Dysfunction-Associated Steatotic Liver Disease." Abstract excerpt: The peptide hormone kisspeptin, signaling via its receptor, KISS1R, decreases hepatic steatosis and protects against metabolic dysfunction-associated steatotic liver disease (MASLD). Enhanced de novo lipogenesis (DNL) contributes to MASLD. Here, we investigated whether kisspeptin treatment in obese, diabetic mice directly attenuates DNL. DNL was assessed in kisspeptin-treated mouse livers, using a

Source
peer_reviewed_research
DOI
10.3390/cells14161289
PubMed
40862768
Open original source
2024Animal research

Elevated temperature impairs gonadal development by suppressing the expression of the genes for kisspeptin, GnRH1 and GTH subunits in Nile tilapia Oreochromis niloticus.

Content-verified record concerning Kisspeptin: "Elevated temperature impairs gonadal development by suppressing the expression of the genes for kisspeptin, GnRH1 and GTH subunits in Nile tilapia Oreochromis niloticus." Abstract excerpt: Temperature is a preeminent factor in the regulation of fish reproduction and hinders gonadal development beyond a specific threshold. To comprehend the molecular mechanism responsible for reproductive suppression at different temperature, expression of the genes encoding kisspeptin (kiss2), gonadotropin-releasing hormone (gnrh1) and their receptors (gpr54, gnrh1r) in the brain, and the gonadotrop

Source
peer_reviewed_research
DOI
10.1016/j.cbpa.2024.111714
PubMed
39089445
Open original source
2024Animal research

Kisspeptin administration may promote precopulatory behavior in male rats independently or supplementally to testosterone and contribute to proceptive behavior in female partners, reducing mating failure.

Content-verified record concerning Kisspeptin: "Kisspeptin administration may promote precopulatory behavior in male rats independently or supplementally to testosterone and contribute to proceptive behavior in female partners, reducing mating failure." Abstract excerpt: Kisspeptin is a peptide that plays an important role through its effects on the hypothalamus-pituitary-gonadal (HPG) axis. It has also been implicated in sexual behavior. The present study investigated whether the relationship between kisspeptin and sexual behavior is independent of the HPG axis, i.e., testosterone. Sexual behavior was examined after the administration of kisspeptin to gonadally i

Source
peer_reviewed_research
DOI
10.1016/j.ygcen.2024.114528
PubMed
38643848
Open original source
2024Animal research

Kisspeptin prevents pregnancy loss by modulating the immune microenvironment at the maternal-fetal interface in recurrent spontaneous abortion.

Content-verified record concerning Kisspeptin: "Kisspeptin prevents pregnancy loss by modulating the immune microenvironment at the maternal-fetal interface in recurrent spontaneous abortion." Abstract excerpt: Immune factors are crucial in the development of recurrent spontaneous abortion (RSA). This study aimed to investigate whether kisspeptin regulates immune cells at the maternal-fetal interface and whether G protein-coupled receptor 54 (GPR54) is involved in this process, through which it contributes to the pathogenesis of RSA. Normal pregnancy (NP) (CBA/J × BALB/c) and RSA (CBA/J × DBA/2

Source
peer_reviewed_research
DOI
10.1111/aji.13818
PubMed
38414308
Open original source
2024Animal research

Kisspeptin/KISS1R Signaling Modulates Human Airway Smooth Muscle Cell Migration.

Content-verified record concerning Kisspeptin: "Kisspeptin/KISS1R Signaling Modulates Human Airway Smooth Muscle Cell Migration." Abstract excerpt: Airway remodeling is a cardinal feature of asthma, associated with increased airway smooth muscle (ASM) cell mass and upregulation of extracellular matrix deposition. Exaggerated ASM cell migration contributes to excessive ASM mass. Previously, we demonstrated the alleviating role of Kp (kisspeptin) receptor (KISS1R) activation by Kp-10 in mitogen (PDGF [platelet-derived growth factor])-induced hu

Source
peer_reviewed_research
DOI
10.1165/rcmb.2023-0469oc
PubMed
38512807
Open original source
2024Animal research

Kisspeptin signaling in astrocytes modulates the reproductive axis.

Content-verified record concerning Kisspeptin: "Kisspeptin signaling in astrocytes modulates the reproductive axis." Abstract excerpt: Reproduction is safeguarded by multiple, often cooperative, regulatory networks. Kisspeptin signaling, via KISS1R, plays a fundamental role in reproductive control, primarily by regulation of hypothalamic GnRH neurons. We disclose herein a pathway for direct kisspeptin actions in astrocytes that contributes to central reproductive modulation. Protein-protein interaction and ontology analyses of hy

Source
peer_reviewed_research
DOI
10.1172/jci172908
PubMed
38861336
Open original source
2024Animal research

Kisspeptin Regulates Cell Invasion and Migration in Endometrial Cancer.

Content-verified record concerning Kisspeptin: "Kisspeptin Regulates Cell Invasion and Migration in Endometrial Cancer." Abstract excerpt: Kisspeptin (a product of the KISS1 gene and its receptor) plays an important role in obstetrics, gynecology, and cancer cell metastasis and behavior. In hypothalamic-pituitary-gonadal axis and placentation, Kisspeptin/Kisspeptin receptor affects hormone release and represses trophoblast invasion into maternal deciduae. Endometrial cancer is one of the common gynecological cancers and is usually ac

Source
peer_reviewed_research
DOI
10.1210/jendso/bvae001
PubMed
38264268
Open original source
2024Animal research

Kisspeptin Alleviates Human Hepatic Fibrogenesis by Inhibiting TGFβ Signaling in Hepatic Stellate Cells.

Content-verified record concerning Kisspeptin: "Kisspeptin Alleviates Human Hepatic Fibrogenesis by Inhibiting TGFβ Signaling in Hepatic Stellate Cells." Abstract excerpt: The peptide hormone kisspeptin attenuates liver steatosis, metabolic dysfunction-associated steatohepatitis (MASH), and fibrosis in mouse models by signaling via the kisspeptin 1 receptor (KISS1R). However, whether kisspeptin impacts fibrogenesis in the human liver is not known. We investigated the impact of a potent kisspeptin analog (KPA) on fibrogenesis using human precision-cut liver slices (h

Source
peer_reviewed_research
DOI
10.3390/cells13191651
PubMed
39404414
Open original source
2024Animal research

Kisspeptin and Endometriosis-Is There a Link?

Content-verified record concerning Kisspeptin: "Kisspeptin and Endometriosis-Is There a Link?" Abstract excerpt: This article presents a narrative review that explores the potential link between kisspeptin-a key regulator of the hypothalamic-pituitary-gonadal axis-and the pathogenesis of endometriosis. Kisspeptin plays a significant role in regulating reproductive functions by modulating the release of gonadotropin-releasing hormone (GnRH), which in turn stimulates the secretion of luteinizing hormone (LH) a

Source
peer_reviewed_research
DOI
10.3390/jcm13247683
PubMed
39768606
Open original source
2023Animal research

Kisspeptin neuron projections to oxytocin neurons are not necessary for parturition in the mouse.

Content-verified record concerning Kisspeptin: "Kisspeptin neuron projections to oxytocin neurons are not necessary for parturition in the mouse." Abstract excerpt: Oxytocin is synthesized by hypothalamic supraoptic nucleus (SON) and paraventricular nucleus (PVN) neurons and is released from the posterior pituitary gland to trigger uterine contractions during parturition. In rats, oxytocin neuron innervation by periventricular nucleus (PeN) kisspeptin neurons increases over pregnancy and intra-SON kisspeptin administration excites oxytocin neurons only in lat

Source
peer_reviewed_research
DOI
10.1007/s00429-023-02670-7
PubMed
37389617
Open original source
2023Animal research

Kisspeptin and lactational anestrus: Current understanding and future prospects.

Content-verified record concerning Kisspeptin: "Kisspeptin and lactational anestrus: Current understanding and future prospects." Abstract excerpt: Lactational anestrus, characterized by the suppression of pulsatile gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) release, would be a strategic adaptation to ensure survival by avoiding pregnancy during lactation in mammals. In the present article, we first provide a current understanding of the central regulation of reproduction in mammals, i.e., a fundamental role of arcuate kis

Source
peer_reviewed_research
DOI
10.1016/j.peptides.2023.171026
PubMed
37230188
Open original source
2023Animal research

Kisspeptin induces Kiss-1 and GnRH gene expression in mHypoA-55 hypothalamic cell models: Involvement of the ERK and PKA signaling pathways.

Content-verified record concerning Kisspeptin: "Kisspeptin induces Kiss-1 and GnRH gene expression in mHypoA-55 hypothalamic cell models: Involvement of the ERK and PKA signaling pathways." Abstract excerpt: mHypoA-55 cells are kisspeptin-expressing neuronal cells originating from the arcuate nucleus of the mouse hypothalamus. These cells are called KNDy neurons because they co-express kisspeptin, neurokinin B, and dynorphin A. In addition, they express gonadotropin-releasing hormone (GnRH). Here, we found that kisspeptin 10 (KP10) increased Kiss-1 (encoding kisspeptin) and GnRH gene expression in kis

Source
peer_reviewed_research
DOI
10.1016/j.ygcen.2023.114260
PubMed
36933747
Open original source
2023Animal research

Kisspeptin decreases the adverse effects of human ovarian vitrification by regulating ROS-related apoptotic occurrences.

Content-verified record concerning Kisspeptin: "Kisspeptin decreases the adverse effects of human ovarian vitrification by regulating ROS-related apoptotic occurrences." Abstract excerpt: Kisspeptin is characterized as a neuropeptide with a pivotal function in female and male infertility, and its antioxidant properties have been demonstrated. In this study, the effects of kisspeptin on the improvement of the vitrification and thawing results of human ovarian tissues were investigated. In this work, 12 ovaries from patients who underwent hysterectomy were collected laparoscopically,

Source
peer_reviewed_research
DOI
10.1017/s0967199423000412
PubMed
37655529
Open original source
2023Animal research

Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity.

Content-verified record concerning Kisspeptin: "Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity." Abstract excerpt: The aim of the study was to evaluate the role of kisspeptin-10 (KiSS-10) in the regulation of collagen content in cardiac fibroblasts. An attempt was also made to describe the mechanism of the effect of KiSS-10 on collagen metabolism. The studies indicate that kisspeptin-10 significantly increases the content of intracellular collagen in the myocardium. KiSS-10 also elevates the level of phosphory

Source
peer_reviewed_research
DOI
10.1038/s41598-023-47224-3
PubMed
37968564
Open original source
2023Animal research

Kisspeptin regulates the proliferation and apoptosis of ovary granulosa cells in polycystic ovary syndrome by modulating the PI3K/AKT/ERK signalling pathway.

Content-verified record concerning Kisspeptin: "Kisspeptin regulates the proliferation and apoptosis of ovary granulosa cells in polycystic ovary syndrome by modulating the PI3K/AKT/ERK signalling pathway." Abstract excerpt: The development of polycystic ovary syndrome (PCOS) is closely correlated with apoptosis and oxidative stress in ovarian granulosa cells. Kisspeptin plays an important role in reproductive organ function. This study aimed to explore the role of kisspeptin in PCOS and oxidative stress-triggered apoptosis of ovarian granular cells. A PCOS rat model was established by injecting dehydroepiandrosterone

Source
peer_reviewed_research
DOI
10.1186/s12905-022-02154-6
PubMed
36627631
Open original source
2023Animal research

Kisspeptin Suppresses Inflammasome-NLRP3 Activation and Pyroptosis Caused by Hypothyroidism at the Maternal-Fetal Interface of Rats.

Content-verified record concerning Kisspeptin: "Kisspeptin Suppresses Inflammasome-NLRP3 Activation and Pyroptosis Caused by Hypothyroidism at the Maternal-Fetal Interface of Rats." Abstract excerpt: Gestational diseases such as preeclampsia and gestational diabetes cause inflammasome activation and pyroptosis in the placenta and changes in placental kisspeptin levels. Although maternal hypothyroidism also reduces the kisspeptin/Kiss1R system at the maternal-fetal interface, there is still no information on whether this dysfunction causes inflammasome activation and pyroptosis in the placenta

Source
peer_reviewed_research
DOI
10.3390/ijms24076820
PubMed
37047793
Open original source
2022Animal research

Kisspeptin-10 in cryodiluent improves the post-thaw quality of Nili-Ravi buffalo (Bubalus bubalis) bull spermatozoa.

Content-verified record concerning Kisspeptin: "Kisspeptin-10 in cryodiluent improves the post-thaw quality of Nili-Ravi buffalo (Bubalus bubalis) bull spermatozoa." Abstract excerpt: Effects of kisspeptin-10 as antioxidant in cryodiluent were evaluated on post-thaw quality of buffalo spermatozoa. Qualified semen samples from five bulls were pooled, divided into five aliquots and extended in Tris-citric acid cryodiluent containing differential doses of kisspeptin-10 (5, 10, 15, and 20 μmol L -1 and negative control. Extended sperm suspension was cooled to 4°C, packag

Source
peer_reviewed_research
DOI
10.1111/and.14564
PubMed
36054451
Open original source
2025Animal research

Sodium benzoate exposure disrupts HPG-axis in male rats: insights into oxidative stress, hormonal dysregulation, histopathology and kisspeptin/RFRP-3 expression.

Content-verified record concerning Kisspeptin: "Sodium benzoate exposure disrupts HPG-axis in male rats: insights into oxidative stress, hormonal dysregulation, histopathology and kisspeptin/RFRP-3 expression." Abstract excerpt: The reproductive effects related to sodium benzoate (SB) are increasingly recognized as concerns for public health. To elucidate the underlying mechanistic pathway in SB-induced reproductive impairment, we evaluated its dose-dependent effects by assessing the key elements of HPG- axis, encompassing wide range of doses from dietary to presumably harmful levels. Thirty-five adult male rats (Sprague-

Source
peer_reviewed_research
DOI
10.1007/s10735-025-10611-3
PubMed
40965716
Open original source
2025Animal research

Brain-derived neurotrophic factor (BDNF), an autocrine/paracrine regulator of basic ovarian functions and antagonist of kisspeptin.

Content-verified record concerning Kisspeptin: "Brain-derived neurotrophic factor (BDNF), an autocrine/paracrine regulator of basic ovarian functions and antagonist of kisspeptin." Abstract excerpt: The aim of the present study was to examine whether brain-derived neurotrophic factor (BDNF) and BDNF-related molecules, such as the neuronal membrane glycoprotein M6a (GPM6A) and myocyte enhancer factor 2C (MEF2C), can be produced by ovarian cells and regulate ovarian cell functions as well as elucidate its functional interrelationships with the known regulator of ovarian cell functions kisspepti

Source
peer_reviewed_research
DOI
10.1016/j.theriogenology.2025.117520
PubMed
40513411
Open original source
2023Animal research

Hindbrain Adenosine 5-Triphosphate (ATP)-Purinergic Signaling Triggers LH Surge and Ovulation via Activation of AVPV Kisspeptin Neurons in Rats.

Content-verified record concerning Kisspeptin: "Hindbrain Adenosine 5-Triphosphate (ATP)-Purinergic Signaling Triggers LH Surge and Ovulation via Activation of AVPV Kisspeptin Neurons in Rats." Abstract excerpt: Ovulation disorders are a serious problem for humans and livestock. In female rodents, kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) are responsible for generating a luteinizing hormone (LH) surge and consequent ovulation. Here, we report that adenosine 5-triphosphate (ATP), a purinergic receptor ligand, is a possible neurotransmitter that stimulates AVPV kisspeptin neuron

Source
peer_reviewed_research
DOI
10.1523/jneurosci.1496-22.2023
PubMed
36813577
Open original source
2026Animal research

Progestogen priming is not essential to trigger ovulation in seasonal anoestrus ewes injected twice with a synthetic kisspeptin analogue.

Content-verified record concerning Kisspeptin: "Progestogen priming is not essential to trigger ovulation in seasonal anoestrus ewes injected twice with a synthetic kisspeptin analogue." Abstract excerpt: A key aspect of husbandry is reproduction management, and current methods often rely on the use of hormonal treatments. In the ewe, which is a seasonal breeder, a combination of progestogen and equine Chorionic Gonadotropin is the benchmark method for reproduction control. However, for different reasons, these hormones are leading to an increase in societal aversion. In order to find an alternativ

Source
peer_reviewed_research
DOI
10.1016/j.animal.2026.101779
PubMed
41785553
Open original source
2025Animal research

Quercetin-loaded PEGylated liposomes alleviate testicular dysfunction in alloxan-induced diabetic rats: The role of Kisspeptin/Neurokinin B/Dynorphin pathway.

Content-verified record concerning Kisspeptin: "Quercetin-loaded PEGylated liposomes alleviate testicular dysfunction in alloxan-induced diabetic rats: The role of Kisspeptin/Neurokinin B/Dynorphin pathway." Abstract excerpt: Diabetes mellitus (DM) is a chronic metabolic disorder that can lead to serious complications, including testicular dysfunction. This dysfunction is considered a significant cause of male infertility. Quercetin (Que), a naturally existing flavonoid with versatile biological functions, has limited water solubility and low bioavailability. The current study was designed to develop a bioavailable for

Source
peer_reviewed_research
DOI
10.1016/j.taap.2025.117337
PubMed
40239742
Open original source
2025Animal research

Involvement of nuclear receptor corepressor 2 (NCOR2) in estrogen-induced repression of arcuate Kiss1 expression in female rats.

Content-verified record concerning Kisspeptin: "Involvement of nuclear receptor corepressor 2 (NCOR2) in estrogen-induced repression of arcuate Kiss1 expression in female rats." Abstract excerpt: Hypothalamic arcuate (ARC) kisspeptin neurons are considered the gonadotropin-releasing hormone pulse generator in rats. In virgin rats, the expression of the ARC kisspeptin gene (Kiss1) is repressed by proestrous levels of estradiol-17β (high E2) but not by diestrous levels of E2 (low E2). In lactating rats, ARC Kiss1 expression is repressed by low E2 during late lactation. This study aimed

Source
peer_reviewed_research
DOI
10.1262/jrd.2024-100
PubMed
39864859
Open original source
2024Animal research

Kisspeptin is elevated in the brain after intracerebral haemorrhagic stroke.

Content-verified record concerning Kisspeptin: "Kisspeptin is elevated in the brain after intracerebral haemorrhagic stroke." Abstract excerpt: Intracerebral haemorrhage (ICH) is the most severe subtype of stroke, with a 2-year mortality of nearly 50% and the greatest rate of disability amongst stroke survivors. Whilst treatment options for ICH remain limited, the condition requires prompt identification and rapid intervention to reduce permanent brain damage, with diagnosis traditionally confirmed by CT imaging. Although imaging is excel

Source
peer_reviewed_research
DOI
10.1038/s41598-024-83514-0
PubMed
39738446
Open original source
2025Animal research

The effect of COVID-19 on placental functioning in South African pregnancies: investigation of kisspeptin expression and vascular and inflammatory alterations.

Content-verified record concerning Kisspeptin: "The effect of COVID-19 on placental functioning in South African pregnancies: investigation of kisspeptin expression and vascular and inflammatory alterations." Abstract excerpt: The coronavirus disease 2019 (COVID-19) pandemic has passed; however, its long-term effects are yet to be determined. Pregnant women and their neonates faced a higher risk for complications during this pandemic as COVID-19 was reported to result in oxidative and inflammatory stress and the cytokine storm, which would impact pregnancy, namely the trophoblast invasion and placental development and f

Source
peer_reviewed_research
DOI
10.1007/s00418-025-02381-6
PubMed
40323370
Open original source
2026Animal research

Kisspeptin Neurons as Integrative Hub: Cross-Talk of HPO-HPT-HPA Axes in Perimenopausal Reproductive Health.

Content-verified record concerning Kisspeptin: "Kisspeptin Neurons as Integrative Hub: Cross-Talk of HPO-HPT-HPA Axes in Perimenopausal Reproductive Health." Abstract excerpt: This study methodically examines the mechanisms of interaction of these neuroendocrine axes in perimenopausal women and their overall effects on their reproductive health. The results show that the dysfunction of the HPT axis is closely related to depression and anxiety, whereas HPA axis hyperactivity inhibits HPO axis functioning and results in reproductive dysfunction. Thyroid hormones indirectl

Source
peer_reviewed_research
DOI
10.1002/cph4.70115
PubMed
41721211
Open original source
2025Animal research

Kisspeptin-10 Protects Against TNF-α-Induced Chondrocyte Senescence via the SIRT1/p53/p21 Signaling.

Content-verified record concerning Kisspeptin: "Kisspeptin-10 Protects Against TNF-α-Induced Chondrocyte Senescence via the SIRT1/p53/p21 Signaling." Abstract excerpt: In Osteoarthritis (OA), the senescence of chondrocytes plays a pivotal role, contributing to cartilage degradation and impairing tissue repair mechanisms. (Kp-10), a peptide hormone, exerts diverse biological functions across multiple cell types and tissues via its receptor Gpr54. However, its role in chondrocytes and OA has been understudied. This study investigates the role of Kp-10 in mitigatin

Source
peer_reviewed_research
DOI
10.1002/jbt.70298
PubMed
40400312
Open original source
2007Animal research

Metastin/Kisspeptin and control of estrous cycle in rats

Content-verified record concerning Kisspeptin: "Metastin/Kisspeptin and control of estrous cycle in rats" Abstract excerpt: Estrous cyclicity is controlled by a cascade of neuroendocrine events, involving the activation of the hypothalamo-pituitary-gonadal axis. Two modes of gonadotropin-releasing hormone (GnRH) are well established to regulate the estrous cycle: one is a tonic or pulse mode of secretion which is responsible for the stimulation of follicular development and steroidogenesis; the other is a surge mode, w

Source
peer_reviewed_research
DOI
10.1007/s11154-007-9032-6
PubMed
17377846
Open original source
2025Animal research

Kisspeptin-10 Improves Gestational Diabetes Mellitus Symptoms in Rats by Suppressing Insulin Resistance in Placental Trophoblast Cells by Activating the Cyclic AMP/Protein Kinase A Pathway.

Content-verified record concerning Kisspeptin: "Kisspeptin-10 Improves Gestational Diabetes Mellitus Symptoms in Rats by Suppressing Insulin Resistance in Placental Trophoblast Cells by Activating the Cyclic AMP/Protein Kinase A Pathway." Abstract excerpt: Gestational diabetes mellitus (GDM) is a common pregnancy complication that leads to insulin resistance (IR) and adversely affects both maternal and fetal health. Kisspeptin-10 (Kp-10), a peptide acting via G Protein-Coupled Receptor 54 (Gpr54), has shown potential in modulating insulin secretion, but its role in GDM remains unclear. This study explores Kp-10's therapeutic effects on GDM by target

Source
peer_reviewed_research
DOI
10.1111/cbdd.70169
PubMed
40944385
Open original source
2025Animal research

Kisspeptin-10 Prevents the Development of Cerebral Aneurysms by Reducing the Expression of Egr-1.

Content-verified record concerning Kisspeptin: "Kisspeptin-10 Prevents the Development of Cerebral Aneurysms by Reducing the Expression of Egr-1." Abstract excerpt: Cerebral aneurysms (CAs) are a prevalent brain condition with poorly understood pathological features. The Kisspeptin-10 (KP-10)/G protein-coupled receptor 54 (GPR54) system is a vital neuroendocrine pathway primarily implicated in the regulation of reproductive functions and energy metabolism. This research explores the role of the KP-10/GPR54 system in CAs. Serum levels of KP-10 in CA patients a

Source
peer_reviewed_research
DOI
10.1111/cns.70413
PubMed
40384564
Open original source
2024Animal research

Kisspeptin in functional hypothalamic amenorrhea: Pathophysiology and therapeutic potential.

Content-verified record concerning Kisspeptin: "Kisspeptin in functional hypothalamic amenorrhea: Pathophysiology and therapeutic potential." Abstract excerpt: Functional hypothalamic amenorrhea (FHA) is one of the most common causes of secondary amenorrhea, resulting in anovulation and infertility, and is a low estrogen state that increases the risk of cardiovascular disease and impairs bone health. FHA is characterized by acquired suppression of physiological pulsatile gonadotropin-releasing hormone (GnRH) release by the hypothalamus in the absence of

Source
peer_reviewed_research
DOI
10.1111/nyas.15220
PubMed
39287750
Open original source
2024Animal research

Kisspeptin upregulates β-cell serotonin production during pregnancy.

Content-verified record concerning Kisspeptin: "Kisspeptin upregulates β-cell serotonin production during pregnancy." Abstract excerpt: During pregnancy the maternal pancreatic islets of Langerhans undergo adaptive changes to compensate for gestational insulin resistance. The lactogenic hormones are well established to play a key role in regulating the islet adaptation to pregnancy, and one of the mechanisms through which they act is through upregulating β-cell serotonin production. During pregnancy islet serotonin levels ar

Source
peer_reviewed_research
DOI
10.1530/joe-23-0218
PubMed
37997938
Open original source
2013Animal research

Kisspeptin and GnRH Pulse Generation

Content-verified record concerning Kisspeptin: "Kisspeptin and GnRH Pulse Generation" Abstract excerpt: The reproductive neuropeptide gonadotropin-releasing hormone (GnRH) has two modes of secretion. Besides the surge mode, which induces ovulation in females, the pulse mode of GnRH release is essential to cause various reproductive events in both sexes, such as spermatogenesis, follicular development, and sex steroid synthesis. Some environmental cues control gonadal activities through modulating Gn

Source
peer_reviewed_research
DOI
10.1007/978-1-4614-6199-9_14
PubMed
23550012
Open original source
2025Animal research

Maternal high-fat diet programs reproductive function of female offspring rat through IL-6-mediated regulation of Kiss1 gene methylation.

Content-verified record concerning Kisspeptin: "Maternal high-fat diet programs reproductive function of female offspring rat through IL-6-mediated regulation of Kiss1 gene methylation." Abstract excerpt: Maternal high-fat diet (HFD) is known to impair the reproductive function of female offspring, but the underlying epigenetic mechanisms of this developmental programming remain unclear. In this study, female rats were fed either a control diet (CD; 10 % kcal from fat) or an HFD (60 % kcal from fat) prior to and during gestation and lactation. After weaning, female offspring were rand

Source
peer_reviewed_research
DOI
10.1016/j.reprotox.2025.108975
PubMed
40541745
Open original source
2014Animal research

Positive, But Not Negative Feedback Actions of Estradiol in Adult Female Mice Require Estrogen Receptor α in Kisspeptin Neurons

Content-verified record concerning Kisspeptin: "Positive, But Not Negative Feedback Actions of Estradiol in Adult Female Mice Require Estrogen Receptor α in Kisspeptin Neurons" Abstract excerpt: Hypothalamic kisspeptin (Kiss1) neurons express estrogen receptor α (ERα) and exert control over GnRH/LH secretion in female rodents. It has been proposed that estradiol (E2) activation of ERα in kisspeptin neurons in the arcuate nucleus (ARC) suppresses GnRH/LH secretion (negative feedback), whereas E2 activation of ERα in kisspeptin neurons in the anteroventral periventri

Source
peer_reviewed_research
DOI
10.1210/en.2014-1851
PubMed
25545386
Open original source
2026Animal research

The p75 neurotrophin receptor is expressed in brain regions mastering reproduction but not in kisspeptin or GnRH neurons.

Content-verified record concerning Kisspeptin: "The p75 neurotrophin receptor is expressed in brain regions mastering reproduction but not in kisspeptin or GnRH neurons." Abstract excerpt: Neurotrophins (BDNF, NGF, NT3, and NT4/5) acting through different receptors are able to impact numerous functions, including cell fate and morphological plasticity, an asset for the maturation and differentiation of cells from neurogenic niches. They bind to the neurotrophin receptor p75 (p75), which could either heterodimerize with Trk receptors or act on its own to relay the varied physiologica

Source
peer_reviewed_research
DOI
10.1111/jne.70102
PubMed
41137779
Open original source
2006Animal research

Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats

Content-verified record concerning Kisspeptin: "Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats" Abstract excerpt: Hypogonadotropism is a common feature of uncontrolled diabetes, for which the ultimate mechanism remains to be elucidated. Kisspeptins, ligands of G protein-coupled receptor 54 (GPR54) encoded by the KiSS-1 gene, have recently emerged as major gatekeepers of the gonadotropic axis. Alteration in the hypothalamic KiSS-1 system has been reported in adverse metabolic conditions linked to suppressed go

Source
peer_reviewed_research
DOI
10.2337/db05-1584
PubMed
16936210
Open original source
2010Animal research

Timing and completion of puberty in female mice depend on estrogen receptor α-signaling in kisspeptin neurons

Content-verified record concerning Kisspeptin: "Timing and completion of puberty in female mice depend on estrogen receptor α-signaling in kisspeptin neurons" Abstract excerpt: Puberty onset is initiated by activation of neurons that secrete gonadotropin-releasing hormone (GnRH). The timing and progression of puberty may depend upon temporal coordination of two opposing central mechanisms--a restraint of GnRH secretion before puberty onset, followed by enhanced stimulation of GnRH release to complete reproductive maturation during puberty. Neuronal estrogen receptor &#x3

Source
peer_reviewed_research
DOI
10.1073/pnas.1012406108
PubMed
21149719
Open original source
2023Animal research

Treadmill exercise has healing effects on obesity-induced sexual behavior disorder through kisspeptin and kiss1R expression in male rats.

Content-verified record concerning Kisspeptin: "Treadmill exercise has healing effects on obesity-induced sexual behavior disorder through kisspeptin and kiss1R expression in male rats." Abstract excerpt: The basic objective of this study was to examine the possible effects of treadmill exercise on obesity-related sexual behavior disorder in obese male rats and the role of kisspeptin in this effect. The rats were separated from their mothers at the age of 3 weeks, and classified into four groups as Control (C): normal diet-sedentary group, Exercise (E): normal diet-exercise group, Obese (O): high-f

Source
peer_reviewed_research
DOI
10.14715/cmb/2023.69.3.2
PubMed
37300694
Open original source
2026Animal research

Dlk1-deficient mice achieve puberty despite low body weight and low levels of leptin and kisspeptin.

Content-verified record concerning Kisspeptin: "Dlk1-deficient mice achieve puberty despite low body weight and low levels of leptin and kisspeptin." Abstract excerpt: Loss-of-function mutations in DLK1, encoding Delta Like Non-Canonical Notch Ligand 1, have been linked to central precocious puberty (CPP) and increased body fat in girls, suggesting a role in the connection between metabolism and reproduction. DLK1 is located in the imprinted region of human chromosome 14, and mice lacking Dlk1 exhibit growth retardation and metabolic changes, phenotypes that ove

Source
peer_reviewed_research
DOI
10.1111/jne.70248
PubMed
42677749
Open original source
2024Animal research

Jiawei Buzhong Yiqi Decoction attenuates polycystic ovary syndrome through regulating kisspeptin-GPR54-AKT-SHBG system.

Content-verified record concerning Kisspeptin: "Jiawei Buzhong Yiqi Decoction attenuates polycystic ovary syndrome through regulating kisspeptin-GPR54-AKT-SHBG system." Abstract excerpt: Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disorders. Accumulated evidence has suggested the indispensable role of kisspeptin-G protein-coupled receptor (GPR54) system and SHBG in development of PCOS. However, potential mechanisms and their relationship are unclear. Jiawei Buzhong Yiqi Decoction (JWBZYQ) has been reported to ameliorate obese PCOS. Whereas, po

Source
peer_reviewed_research
DOI
10.1016/j.phymed.2024.155931
PubMed
39116604
Open original source
2025Animal research

Design and implication of a breast cancer-targeted drug delivery system utilizing the Kisspeptin/GPR54 system.

Content-verified record concerning Kisspeptin: "Design and implication of a breast cancer-targeted drug delivery system utilizing the Kisspeptin/GPR54 system." Abstract excerpt: Kisspeptins function as endogenous ligands for the G protein-coupled receptor GPR54. While the primary role of the Kisspeptin/GPR54 signaling pathway pertains to reproduction, several studies have shown that GPR54 is highly expressed in breast cancer, and we further confirmed this result that GPR54 expression is significantly upregulated in breast cancer cells. Based on this finding, we developed

Source
peer_reviewed_research
DOI
10.1016/j.ijpharm.2024.125154
PubMed
39755342
Open original source
2026Animal research

High-Fat Diet Promotes Glycolysis in Hepatocellular Carcinoma by Suppressing Hepatic Kisspeptin Signaling in Mice.

Content-verified record concerning Kisspeptin: "High-Fat Diet Promotes Glycolysis in Hepatocellular Carcinoma by Suppressing Hepatic Kisspeptin Signaling in Mice." Abstract excerpt: Hepatocellular carcinoma is a leading cause of cancer-related mortality worldwide, with metabolic syndrome emerging as a major risk factor. However, the molecular mechanisms underlying the association between metabolic syndrome and hepatocellular carcinoma progression are not fully understood. Here, we investigated the role of kisspeptin signaling in hepatocellular carcinoma progression under meta

Source
peer_reviewed_research
DOI
10.1002/mc.70068
PubMed
41328591
Open original source
2024Animal research

Chronic estradiol exposure suppresses luteinizing hormone surge without affecting kisspeptin neurons and estrogen receptor alpha in anteroventral periventricular nucleus†.

Content-verified record concerning Kisspeptin: "Chronic estradiol exposure suppresses luteinizing hormone surge without affecting kisspeptin neurons and estrogen receptor alpha in anteroventral periventricular nucleus†." Abstract excerpt: Mammalian ovulation is induced by a luteinizing hormone surge, which is triggered by elevated plasma estrogen levels; however, chronic exposure to high levels of estradiol is known to inhibit luteinizing hormone secretion. In the present study, we hypothesized that the inhibition of the luteinizing hormone surge by chronic estradiol exposure is due to the downregulation of the estrogen receptor al

Source
peer_reviewed_research
DOI
10.1093/biolre/ioad129
PubMed
37774351
Open original source
2024Animal research

Structural basis for the ligand recognition and G protein subtype selectivity of kisspeptin receptor.

Content-verified record concerning Kisspeptin: "Structural basis for the ligand recognition and G protein subtype selectivity of kisspeptin receptor." Abstract excerpt: Kisspeptin receptor (KISS1R), belonging to the class A peptide-GPCR family, plays a key role in the regulation of reproductive physiology after stimulation by kisspeptin and is regarded as an attractive drug target for reproductive diseases. Here, we demonstrated that KISS1R can couple to the G i/o pathway besides the well-known G q/11 pathway. We further resolved the cryo-electron microscopy (cry

Source
peer_reviewed_research
DOI
10.1126/sciadv.adn7771
PubMed
39151001
Open original source
2025Animal research

The Neuroendocrine Regulation of Reproductive Behavior and Emotional Control by Kisspeptin.

Content-verified record concerning Kisspeptin: "The Neuroendocrine Regulation of Reproductive Behavior and Emotional Control by Kisspeptin." Abstract excerpt: Reproductive success and ultimately species survival at a population level is contingent on a plethora of neuroendocrine signals working in concert to regulate gonadal function and reproductive behavior. Among these, the neuropeptide kisspeptin (encoded by the KISS1/Kiss1 gene) has emerged as the master regulator of the hypothalamic-pituitary-gonadal axis. Besides the hypothalamus, both kisspeptin

Source
peer_reviewed_research
DOI
10.1210/clinem/dgaf055
PubMed
39880372
Open original source
2006Animal research

Hypothalamic Expression of KiSS-1 System and Gonadotropin-Releasing Effects of Kisspeptin in Different Reproductive States of the Female Rat

Content-verified record concerning Kisspeptin: "Hypothalamic Expression of KiSS-1 System and Gonadotropin-Releasing Effects of Kisspeptin in Different Reproductive States of the Female Rat" Abstract excerpt: Kisspeptins, products of the KiSS-1 gene with ability to bind G protein-coupled receptor 54 (GPR54), have been recently identified as major gatekeepers of reproductive function with ability to potently activate the GnRH/LH axis. Yet, despite the diversity of functional states of the female gonadotropic axis, pharmacological characterization of this effect has been mostly conducted in pubertal anim

Source
peer_reviewed_research
DOI
10.1210/en.2005-1463
PubMed
16527840
Open original source
2008Animal research

Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals

Content-verified record concerning Kisspeptin: "Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals" Abstract excerpt: Kisspeptins, the products of KiSS-1 gene, have recently emerged as fundamental regulators of reproductive function in different mammalian and, presumably, non-mammalian species. To date, a single form of KiSS-1 has been described in mammals, and recently, in several fish species and Xenopus. We report herein the cloning and characterization of two distinct KiSS-like genes, namely, KiSS-1 and KiSS-

Source
peer_reviewed_research
DOI
10.1016/j.mce.2008.11.017
PubMed
19084576
Open original source
2023Animal research

[Effects of electroacupuncture on the secretion function of ovarian cells and kisspeptin/kiss1r system in rats with polycystic ovarian syndrome].

Content-verified record concerning Kisspeptin: "[Effects of electroacupuncture on the secretion function of ovarian cells and kisspeptin/kiss1r system in rats with polycystic ovarian syndrome]." Abstract excerpt: To observe the effects of electroacupuncture （EA） on hormone secretion function of ovarian granulosa cells and theca cells, as well as the expression changes of kisspeptin and kiss1r in rats with polycystic ovarian syndrome （PCOS）, so as to explore the mechanism of EA for relieving ovarian dysfunction in PCOS rats. Forty-eight SD female rats were randomly divided into c

Source
peer_reviewed_research
DOI
10.13702/j.1000-0607.20220481
PubMed
37614139
Open original source
2025Animal research

Perinatal exposure to bisphenol A or S alters differently sexual behavior and kisspeptin system in mice.

Content-verified record concerning Kisspeptin: "Perinatal exposure to bisphenol A or S alters differently sexual behavior and kisspeptin system in mice." Abstract excerpt: The effects of bisphenol A (BPA), a highly diffused endocrine-disrupting chemical found mainly in plastics, on neural circuits and behaviors are well-known. However, the effects of its substitutes have not been fully investigated. Thus, in the present study, we compare the effects of perinatal exposure to bisphenol A or S (BPS) on reproductive behaviors and related hypothalamic kisspeptin system i

Source
peer_reviewed_research
DOI
10.1016/j.envres.2025.120888
PubMed
39828186
Open original source
2022Animal research

Morphometric and Myelin Basic Protein Expression Changes in Arcuate Nucleus Kisspeptin Neurons Underlie Activation of Hypothalamic Pituitary Gonadal-axis in Monkeys (<i>Macaca Mulatta</i>) during the Breeding Season.

Content-verified record concerning Kisspeptin: "Morphometric and Myelin Basic Protein Expression Changes in Arcuate Nucleus Kisspeptin Neurons Underlie Activation of Hypothalamic Pituitary Gonadal-axis in Monkeys (<i>Macaca Mulatta</i>) during the Breeding Season." Abstract excerpt: Kisspeptin is involved in the hypothalamic pituitary gonadal-axis' seasonal regulation in rodents and sheep. Studies of kisspeptin signaling in regulating the transition between breeding and nonbreeding seasons have focused on kisspeptin expression, myelin basic protein (MBP) expression around kisspeptin-ir cells, and quantifying the synaptic connections between kisspeptin and gonadotropin-releasi

Source
peer_reviewed_research
DOI
10.1080/07435800.2022.2102649
PubMed
35866239
Open original source
2025Animal research

Comprehensive chemoanatomical mapping, and the gonadal regulation, of seven kisspeptin neuronal populations in the mouse brain.

Content-verified record concerning Kisspeptin: "Comprehensive chemoanatomical mapping, and the gonadal regulation, of seven kisspeptin neuronal populations in the mouse brain." Abstract excerpt: Kisspeptinergic signaling is well-established as crucial for the regulation of reproduction, but its potential broader role in brain function is less understood. This study investigates the distribution and chemotyping of kisspeptin-expressing neurons within the mouse brain. RNAscope single, dual, and multiplex in situ hybridization methods were used to assess kisspeptin mRNA (Kiss1) expression an

Source
peer_reviewed_research
DOI
10.1111/jne.70019
PubMed
40102056
Open original source
2025Animal research

SRA deficiency induces follicular dysplasia by disrupting the hypothalamic Kisspeptin-GPR54 system in mice†.

Content-verified record concerning Kisspeptin: "SRA deficiency induces follicular dysplasia by disrupting the hypothalamic Kisspeptin-GPR54 system in mice†." Abstract excerpt: To investigate how steroid receptor RNA activator (SRA) regulates follicular development in mice. Systemic SRA knockout mice were introduced. SRA expression was reinstated in the anteroventral periventricular nucleus (AVPV) of the hypothalamus using lentiviral vectors. Subsequently, the estrous cycle, serum hormone levels, follicle development, and hypothalamic kisspeptin expression in mice were a

Source
peer_reviewed_research
DOI
10.1093/biolre/ioaf049
PubMed
40057968
Open original source
2025Animal research

Developmental expression patterns of gonadal hormone receptors in arcuate kisspeptin and GABA neurons of the postnatal female mouse.

Content-verified record concerning Kisspeptin: "Developmental expression patterns of gonadal hormone receptors in arcuate kisspeptin and GABA neurons of the postnatal female mouse." Abstract excerpt: The arcuate nucleus of the hypothalamus (ARC) is central in the neuronal regulation of fertility and reproduction through translating gonadal steroid hormone cues into the GnRH signaling pathway in the brain. Evidence suggests that circulating gonadal steroids play an important role in modulating female reproduction via kisspeptin and &#x3b3;-aminobutyric acid (GABA) neurons in the ARC in both dev

Source
peer_reviewed_research
DOI
10.1111/jne.13477
PubMed
39605295
Open original source
2013Animal research

Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes

Content-verified record concerning Kisspeptin: "Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes" Abstract excerpt: Despite affecting millions of individuals, the etiology of hot flushes remains unknown. Here we review the physiology of hot flushes, CNS pathways regulating heat-dissipation effectors, and effects of estrogen on thermoregulation in animal models. Based on the marked changes in hypothalamic kisspeptin, neurokinin B and dynorphin (KNDy) neurons in postmenopausal women, we hypothesize that KNDy neur

Source
peer_reviewed_research
DOI
10.1016/j.yfrne.2013.07.003
PubMed
23872331
Open original source
2022Animal research

Effects of intracerebroventricular and intravenous administration of Kisspeptin-54 and Gonadotropin-releasing hormone agonist in rats with ovarian hyperstimulation.

Content-verified record concerning Kisspeptin: "Effects of intracerebroventricular and intravenous administration of Kisspeptin-54 and Gonadotropin-releasing hormone agonist in rats with ovarian hyperstimulation." Abstract excerpt: We aim to determine the effect of local and systemic administration of kisspeptin-54 on ovarian hyperstimulation. Immature female rats were used. In order to generate the ovarian hyperstimulation model, 50&#xa0;IU PMSG was administered for 4 consecutive days and a single dose of 25&#xa0;IU hCG was administered to all groups except for the sham group. To synchronize the sham group, a single dose of

Source
peer_reviewed_research
DOI
10.1016/j.npep.2022.102298
PubMed
36367482
Open original source
2026Animal research

Integrated transcriptomics and miRNA-mRNA network analysis reveals Kisspeptin-10 mediated regulation of EMT and apoptosis in glioblastoma.

Content-verified record concerning Kisspeptin: "Integrated transcriptomics and miRNA-mRNA network analysis reveals Kisspeptin-10 mediated regulation of EMT and apoptosis in glioblastoma." Abstract excerpt: Glioblastoma multiforme (GB) is the most aggressive and lethal primary brain tumor, with limited biomarkers for diagnosis and therapeutic targeting. This study aimed to investigate the regulatory effects of Kisspeptin-10 on epithelial-mesenchymal transition (EMT) and apoptosis in GB by integrating transcriptomic profiling, network analysis, and in-vitro validation. Kisspeptin-10, a metastasis-supp

Source
peer_reviewed_research
DOI
10.1016/j.compbiolchem.2025.108826
PubMed
41389577
Open original source
2024Animal research

The effect of coadministration of vitamin D and tramadol on serum kisspeptin, testosterone, oxidative stress levels and testicular histology in Wistar rats: a preliminary report.

Content-verified record concerning Kisspeptin: "The effect of coadministration of vitamin D and tramadol on serum kisspeptin, testosterone, oxidative stress levels and testicular histology in Wistar rats: a preliminary report." Abstract excerpt: Tramadol, an opioid analgesic, is known to induce testicular damage and impair reproductive parameters. Vitamin D3, recognized for its antioxidant and protective properties, might offer a potential protective effect against tramadol-induced testicular damage. This study observed the effects of co-administration of vitamin D3 and tramadol on serum kisspeptin levels, testicular histology, semen para

Source
peer_reviewed_research
DOI
10.22514/j.androl.2024.031
PubMed
39748771
Open original source
2024Animal research

Investigating the detection of the novel doping‐relevant peptide kisspeptin‐10 in urine using liquid chromatography high‐resolution mass spectrometry.

Content-verified record concerning Kisspeptin: "Investigating the detection of the novel doping‐relevant peptide kisspeptin‐10 in urine using liquid chromatography high‐resolution mass spectrometry." Abstract excerpt: Kisspeptin-10 is a peptide hormone capable of increasing circulating follicle-stimulating hormone, luteinizing hormone and testosterone levels in humans. Clinically, these effects suggest its use as a treatment for infertility. However, its testosterone-increasing effect indicates potential misuse in sports. As such, it is included in the 2024 World Anti-Doping Agency Prohibited List. This work de

Source
peer_reviewed_research
DOI
10.1002/bmc.5946
PubMed
38978171
Open original source
2006Animal research

Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat

Content-verified record concerning Kisspeptin: "Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat" Abstract excerpt: Kisspeptins have recently emerged as essential regulators of gonadotropin secretion and puberty onset. These functions are primarily conducted by stimulation of hypothalamic gonadotropin-releasing hormone (GnRH) secretion. However, relevant aspects of KiSS-1 physiology, including the ontogeny and major signaling systems of its stimulatory action, remain to be fully elucidated. To cover these issue

Source
peer_reviewed_research
DOI
10.1016/j.mce.2006.07.002
PubMed
16930819
Open original source
2008Animal research

Molecular Identification and Functional Characterization of the Kisspeptin/Kisspeptin Receptor System in Lower Vertebrates1

Content-verified record concerning Kisspeptin: "Molecular Identification and Functional Characterization of the Kisspeptin/Kisspeptin Receptor System in Lower Vertebrates1" Abstract excerpt: The KISS1 gene encodes the kisspeptin neuropeptide, which activates the KISS1 receptor (KISS1R; G protein-coupled receptor 54; GPR54) and participates in neuroendocrine regulation of GnRH secretion. To study the physiological function(s) and evolutionary conservation of KISS1, we cloned opossum, Xenopus, and zebrafish kiss1 cDNAs. Processing zebrafish, Xenopus, or opossum KISS proteins would liber

Source
peer_reviewed_research
DOI
10.1095/biolreprod.107.066266
PubMed
18509165
Open original source
2023Animal research

Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse model.

Content-verified record concerning Kisspeptin: "Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse model." Abstract excerpt: Airway-associated adipose tissue increases with body mass index and is a local source of pro-inflammatory adipokines that may contribute to airway pathology in asthma co-existing with obesity. Genetic susceptibility to airway adiposity was considered in the present study through kisspeptin/kisspeptin receptor signalling, known to modulate systemic adiposity and potentially drive airway remodelling

Source
peer_reviewed_research
DOI
10.1042/cs20230792
PubMed
37732890
Open original source
2011Animal research

Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice

Content-verified record concerning Kisspeptin: "Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice" Abstract excerpt: The hormone leptin modulates a diverse range of biological functions, including energy homeostasis and reproduction. Leptin promotes GnRH function via an indirect action on forebrain neurons. We tested whether leptin deficiency or leptin resistance due to a high-fat diet (HFD) can regulate the potent reproductive neuropeptide kisspeptin. In mice with normalized levels of estradiol, leptin deficien

Source
peer_reviewed_research
DOI
10.1210/en.2010-1100
PubMed
21325051
Open original source
2025Animal research

Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice.

Content-verified record concerning Kisspeptin: "Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice." Abstract excerpt: The specific role that prolactin plays in lactational infertility, as distinct from other suckling or metabolic cues, remains unresolved. Here, deletion of the prolactin receptor (Prlr) from forebrain neurons or arcuate kisspeptin neurons resulted in failure to maintain normal lactation-induced suppression of estrous cycles. Kisspeptin immunoreactivity and pulsatile LH secretion were increased in

Source
peer_reviewed_research
DOI
10.7554/elife.94570
PubMed
39819370
Open original source
2012Animal research

Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration

Content-verified record concerning Kisspeptin: "Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration" Abstract excerpt: Hyperprolactinemia is the most common cause of hypogonadotropic anovulation and is one of the leading causes of infertility in women aged 25-34. Hyperprolactinemia has been proposed to block ovulation through inhibition of GnRH release. Kisspeptin neurons, which express prolactin receptors, were recently identified as major regulators of GnRH neurons. To mimic the human pathology of anovulation, w

Source
peer_reviewed_research
DOI
10.1172/jci63937
PubMed
23006326
Open original source
2023Animal research

Fasting Modulates GABAergic Synaptic Transmission to Arcuate Kisspeptin Neurons in Female Mice.

Content-verified record concerning Kisspeptin: "Fasting Modulates GABAergic Synaptic Transmission to Arcuate Kisspeptin Neurons in Female Mice." Abstract excerpt: It is well-established that the hypothalamic-pituitary-gonadal (HPG) axis is suppressed due to negative energy balance. However, less information is available on whether kisspeptin neuronal activity contributes to fasting-induced responses. In the present study, female and male mice were fasted for 24 hours or provided food ad libitum (fed group) to determine whether acute fasting is sufficient to

Source
peer_reviewed_research
DOI
10.1210/endocr/bqad150
PubMed
37793082
Open original source
2025Animal research

Lipopolysaccharide-induced inflammation modulates testicular kisspeptin system in mice.

Content-verified record concerning Kisspeptin: "Lipopolysaccharide-induced inflammation modulates testicular kisspeptin system in mice." Abstract excerpt: Kisspeptin, a neuropeptide hormone, plays an indispensable role in regulating reproduction. Acting upstream of gonadotropin-releasing hormone, it controls gonadotropin release, and concomitant gonadal functions, and in turn, is regulated by gonadal steroid hormones. Nevertheless, expression of kisspeptin (Kiss1) and its receptor (Kiss1r) is reported in tissues other than hypothalamus, including te

Source
peer_reviewed_research
DOI
10.1016/j.reprotox.2025.109005
PubMed
40706774
Open original source
2011Animal research

Projections of Arcuate Nucleus and Rostral Periventricular Kisspeptin Neurons in the Adult Female Mouse Brain

Content-verified record concerning Kisspeptin: "Projections of Arcuate Nucleus and Rostral Periventricular Kisspeptin Neurons in the Adult Female Mouse Brain" Abstract excerpt: The important role of kisspeptin neurons in the regulation of GnRH neuron activity is now well accepted. However, the ways in which kisspeptin neurons located in the arcuate nucleus (ARN) and rostral periventricular area of the third ventricle (RP3V) control GnRH neurons are poorly understood. The present study used anterograde and retrograde tracing techniques to establish the neuronal projection

Source
peer_reviewed_research
DOI
10.1210/en.2011-0164
PubMed
21486932
Open original source
2022Animal research

Mechanism of LH release after peripheral administration of kisspeptin in cattle.

Content-verified record concerning Kisspeptin: "Mechanism of LH release after peripheral administration of kisspeptin in cattle." Abstract excerpt: Kisspeptin modulates GnRH secretion in mammals and peripheral administration of 10-amino acid fragment of kisspeptin (Kp10) induces LH release and ovulation in cattle. Experiments were done to determine if iv administration of kisspeptin will activate GnRH neurons (i.e., after crossing the blood-brain barrier) and if pre-treatment with a GnRH receptor blocker will alter kisspeptin-induced LH relea

Source
peer_reviewed_research
DOI
10.1371/journal.pone.0278564
PubMed
36459509
Open original source
2009Animal research

Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse

Content-verified record concerning Kisspeptin: "Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse" Abstract excerpt: Kisspeptin is encoded by the Kiss1 gene, and kisspeptin signaling plays a critical role in reproduction. In rodents, kisspeptin neurons in the arcuate nucleus (Arc) provide tonic drive to gonadotropin-releasing hormone (GnRH) neurons, which in turn supports basal luteinizing hormone (LH) secretion. Our objectives were to determine whether preprodynorphin (Dyn) and neurokinin B (NKB) are coexpresse

Source
peer_reviewed_research
DOI
10.1523/jneurosci.1569-09.2009
PubMed
19776272
Open original source
2023Animal research

Physiological and pathological roles of locally expressed kisspeptin and KISS1R in the endometrium.

Content-verified record concerning Kisspeptin: "Physiological and pathological roles of locally expressed kisspeptin and KISS1R in the endometrium." Abstract excerpt: Kisspeptins, encoded by the KISS1 gene, are a family of polypeptides that bind the kisspeptin receptor (KISS1R) to perform biological functions. Produced mainly in the hypothalamus, these neuropeptides regulate the pulsatile secretion of GnRH and trigger the hypothalamus-pituitary-gonadal axis. Other peripheral organs also express kisspeptin, which inhibits metastasis. Kisspeptin and KISS1R are re

Source
peer_reviewed_research
DOI
10.1093/humrep/dead080
PubMed
37105233
Open original source
2026Animal research

Evolution of neurohormone function revealed by actions of kisspeptin-type peptides in an echinoderm.

Content-verified record concerning Kisspeptin: "Evolution of neurohormone function revealed by actions of kisspeptin-type peptides in an echinoderm." Abstract excerpt: The neurohormone kisspeptin regulates reproductive maturation and function in mammals by stimulating hypothalamic production and release of gonadotropin-releasing hormone. However, little is known about kisspeptin-type neuropeptide function in invertebrates and the evolution of kisspeptin signalling as a regulator of physiological processes. Here, we address these issues in a deuterostome inverteb

Source
peer_reviewed_research
DOI
10.1186/s12915-026-02555-1
PubMed
41709256
Open original source
2024Animal research

Phenytoin causes behavioral abnormalities and suppresses kisspeptin expression, reducing reproductive performance in Japanese medaka.

Content-verified record concerning Kisspeptin: "Phenytoin causes behavioral abnormalities and suppresses kisspeptin expression, reducing reproductive performance in Japanese medaka." Abstract excerpt: Phenytoin, an antiepileptic drug, induces neurotoxicity and abnormal embryonic development and reduces spontaneous locomotor activity in fish. However, its effects on other endpoints remain unclear. Therefore, we investigated the effects of phenytoin on the swimming behavior and reproductive ability of Japanese medaka. Abnormalities in swimming behavior, such as imbalance, rotation, rollover, and

Source
peer_reviewed_research
DOI
10.1016/j.aquatox.2024.107007
PubMed
38943866
Open original source
2024Animal research

Decoding the effect of photoperiodic cues in transducing kisspeptin-melatonin circuit during the pubertal onset in common carp.

Content-verified record concerning Kisspeptin: "Decoding the effect of photoperiodic cues in transducing kisspeptin-melatonin circuit during the pubertal onset in common carp." Abstract excerpt: This study unravels the intricate interplay between photoperiod, melatonin, and kisspeptin to orchestrate the pubertal onset of Common carp. Female fingerlings exposed to long days (LD) exhibited a hormonal crescendo, with upregulated hypothalamic-pituitary-ovarian (HPO) axis genes (kiss1, kiss1r, kiss2, gnrh2, gnrh3) and their downstream targets (lhr, fshr, ar1, esr1). However, the expression of

Source
peer_reviewed_research
DOI
10.1002/mrd.23744
PubMed
38800960
Open original source
2026Animal research

Photoperiodic modulation of puberty through melatonin-kisspeptin-GnRH signalling in female Wistar rats.

Content-verified record concerning Kisspeptin: "Photoperiodic modulation of puberty through melatonin-kisspeptin-GnRH signalling in female Wistar rats." Abstract excerpt: Pubertal onset results from a complex interaction between neuroendocrine signalling and environmental factors such as photoperiod. This study examined how variations in melatonin and estradiol levels, individually and in combination, affect hypothalamic gene expression to identify neuroendocrine regulators of the hypothalamic-pituitary-gonadal (HPG) axis. Juvenile female Wistar rats were exposed t

Source
peer_reviewed_research
DOI
10.1007/s43630-026-00895-z
PubMed
42018125
Open original source
2009Animal research

A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10

Content-verified record concerning Kisspeptin: "A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10" Abstract excerpt: The kisspeptins are neuropeptides that stimulate the hypothalamo-pituitary-gonadal (HPG) axis. The smallest endogenous kisspeptin, kisspeptin-10 (KP-10), binds to the receptor KISS1R with a similar affinity to the full-length peptide, kisspeptin-54 (KP-54), but is less effective in vivo, possibly because of increased enzymatic breakdown or clearance. The kisspeptin system may have therapeutic pote

Source
peer_reviewed_research
DOI
10.1152/ajpendo.00426.2009
PubMed
19934405
Open original source
2026Animal research

The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.

Content-verified record concerning Kisspeptin: "The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54." Abstract excerpt: The discovery of the neuropeptide kisspeptin (Kp) and its receptor has attracted considerable attention as a potential therapeutic target for the treatment of various medical disorders and for the management of reproduction in livestock. To this end, endogenous agonists (hKp10 and hKp54) as well as synthetic agonists (TAK-448 and C6) have been evaluated in vivo with promising results. However, dir

Source
peer_reviewed_research
DOI
10.1016/j.mce.2026.112854
PubMed
42379494
Open original source
2026Animal research

The KISS1/KISS1R Axis in Human Placentation: Molecular Mechanisms and Implications for Foetal Growth Restriction and Pre-Eclampsia.

Content-verified record concerning Kisspeptin: "The KISS1/KISS1R Axis in Human Placentation: Molecular Mechanisms and Implications for Foetal Growth Restriction and Pre-Eclampsia." Abstract excerpt: Pre-eclampsia and foetal growth restriction (FGR) are major pregnancy complications primarily driven by placental dysfunction, and remain leading causes of maternal and perinatal morbidity. Ultrasound imaging, Doppler studies, and angiogenic biomarkers like placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) constitute the main diagnostic modalities; however, these predo

Source
peer_reviewed_research
DOI
10.3390/ijms27093748
PubMed
42123334
Open original source
2025Animal research

The kisspeptin analog C6 reverses reproductive dysfunction in a mouse model of hyperprolactinemia.

Content-verified record concerning Kisspeptin: "The kisspeptin analog C6 reverses reproductive dysfunction in a mouse model of hyperprolactinemia." Abstract excerpt: Kisspeptin has been shown to be tightly associated with hyperprolactinemia. This study shows that similar to kisspeptin, its analog C6 produces a reversal of HPRL estrus cycle and ovulation disruption. HPRL, characterized by elevated prolactin levels, disrupts the hypothalamic-pituitary-gonadal axis, leading to reproductive dysfunctions such as menstrual irregularities, anovulation and infertility

Source
peer_reviewed_research
DOI
10.1530/rep-25-0036
PubMed
40062901
Open original source
2023Animal research

The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin.

Content-verified record concerning Kisspeptin: "The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin." Abstract excerpt: Azoxystrobin, a strobilurin widely used to control rice diseases, has raised concerns about possible adverse effects on aquatic ecosystems. At present, very little is known about the effects of azoxystrobin on courtship and aggressive behavior and the potential underlying mechanisms. In the present study, after exposing adult male and female zebrafish to worst-case scenario concentrations of azoxy

Source
peer_reviewed_research
DOI
10.1016/j.envpol.2023.121461
PubMed
36934963
Open original source
2005Animal research

Changes in Hypothalamic KiSS-1 System and Restoration of Pubertal Activation of the Reproductive Axis by Kisspeptin in Undernutrition

Content-verified record concerning Kisspeptin: "Changes in Hypothalamic KiSS-1 System and Restoration of Pubertal Activation of the Reproductive Axis by Kisspeptin in Undernutrition" Abstract excerpt: Activation of the gonadotropic axis critically depends on sufficient body energy stores, and conditions of negative energy balance result in lack of puberty onset and reproductive failure. Recently, KiSS-1 gene-derived kisspeptin, signaling through the G protein-coupled receptor 54 (GPR54), has been proven as a pivotal regulator in the control of gonadotropin secretion and puberty. However, the im

Source
peer_reviewed_research
DOI
10.1210/en.2005-0337
PubMed
15932928
Open original source
2022Animal research

Kisspeptin in the Prediction of Pregnancy Complications.

Content-verified record concerning Kisspeptin: "Kisspeptin in the Prediction of Pregnancy Complications." Abstract excerpt: Kisspeptin and its receptor are central to reproductive health acting as key regulators of the reproductive endocrine axis in humans. Kisspeptin is most widely recognised as a regulator of gonadotrophin releasing hormone (GnRH) neuronal function. However, recent evidence has demonstrated that kisspeptin and its receptor also play a fundamental role during pregnancy in the regulation of placentatio

Source
peer_reviewed_research
DOI
10.3389/fendo.2022.942664
PubMed
35928889
Open original source
2025Animal research

Effect of active immunization with recombinant GnRH6-kisspeptin fusion protein on reproductive function in male rats.

Content-verified record concerning Kisspeptin: "Effect of active immunization with recombinant GnRH6-kisspeptin fusion protein on reproductive function in male rats." Abstract excerpt: Immunological castration can be an alternative to traditional surgical castration. The active immunization against GnRH or kisspeptin has a castrating effect. To date, the fusion protein vaccine of combination with GnRH and kisspeptin have not been studied. Thus, the present study will develop a GnRH6-kisspeptin vaccine by genetic engineering method and investigate its immunocastration effect in m

Source
peer_reviewed_research
DOI
10.1017/s0967199425000036
PubMed
40078105
Open original source
2026Animal research

Endocrine-metabolic effects of kisspeptin in mammals.

Content-verified record concerning Kisspeptin: "Endocrine-metabolic effects of kisspeptin in mammals." Abstract excerpt: Kisspeptins (Kp) play crucial roles in regulating reproductive functions. In recent decades, new effects of Kp on other systems, such as the cardiovascular, respiratory, and musculoskeletal systems, and its possible therapeutic effects on gestational hypothyroidism, diabetes mellitus, and neoplasms have been identified. Additionally, Kp signaling has been investigated in endocrine-metabolic regula

Source
peer_reviewed_research
DOI
10.1016/j.ygcen.2026.114888
PubMed
41581529
Open original source
2026Animal research

Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice.

Content-verified record concerning Kisspeptin: "Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice." Abstract excerpt: Pulsatile gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1 ARH neurons via neurokinin B (NKB) signaling through TacR3. However, discrepancies between ex vivo and in vivo pharmacology limit mechanistic understanding of how TacR3 activation regulates pulsatile hormon

Source
peer_reviewed_research
DOI
10.1111/jne.70255
PubMed
42711067
Open original source
2022Animal research

Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides.

Content-verified record concerning Kisspeptin: "Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides." Abstract excerpt: Kisspeptins are neuropeptides that regulate reproductive maturation in mammals via G-protein-coupled receptor-mediated stimulation of gonadotropin-releasing hormone secretion from the hypothalamus. Phylogenetic analysis of kisspeptin-type receptors indicates that this neuropeptide signaling system originated in a common ancestor of the Bilateria, but little is known about kisspeptin signaling in i

Source
peer_reviewed_research
DOI
10.1186/s12915-022-01387-z
PubMed
36002813
Open original source
2023Animal research

The impact of inflammatory stress on hypothalamic kisspeptin neurons: Mechanisms underlying inflammation-associated infertility in humans and domestic animals.

Content-verified record concerning Kisspeptin: "The impact of inflammatory stress on hypothalamic kisspeptin neurons: Mechanisms underlying inflammation-associated infertility in humans and domestic animals." Abstract excerpt: Inflammatory diseases attenuate reproductive functions in humans and domestic animals. Lipopolysaccharide (LPS), an endotoxin released by bacteria, is known to disrupt female reproductive functions in various inflammatory diseases. LPS administration has been used to elucidate the impact of pathophysiological activation of the immune system on reproduction. Hypothalamic kisspeptin neurons are the

Source
peer_reviewed_research
DOI
10.1016/j.peptides.2023.170958
PubMed
36682622
Open original source
2011Animal research

Female reproductive maturation in the absence of kisspeptin/GPR54 signaling

Content-verified record concerning Kisspeptin: "Female reproductive maturation in the absence of kisspeptin/GPR54 signaling" Abstract excerpt: Puberty onset is initiated in the brain by activation of gonadotropin-releasing hormone (GnRH) neurosecretion. Different permissive signals must be integrated for the initiation of reproductive maturation; however, the neural circuits controlling timely awakening of the reproductive axis are not understood. The identification of the neuropeptide kisspeptin as a potent activator of GnRH neuronal ac

Source
peer_reviewed_research
DOI
10.1038/nn.2818
PubMed
21516099
Open original source
2022Animal research

Stereology of gonadotropin-releasing hormone and kisspeptin neurons in PACAP gene-deficient female mice.

Content-verified record concerning Kisspeptin: "Stereology of gonadotropin-releasing hormone and kisspeptin neurons in PACAP gene-deficient female mice." Abstract excerpt: The hypothalamic gonadotropin-releasing hormone (GnRH)-kisspeptin neuronal network regulates fertility in all mammals. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide isolated from the hypothalamus that is involved in the regulation of several releasing hormones and trop hormones. It is well-known that PACAP influences fertility at central and peripheral levels. Howeve

Source
peer_reviewed_research
DOI
10.3389/fendo.2022.993228
PubMed
36387875
Open original source
2026Animal research

KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone-independent manner.

Content-verified record concerning Kisspeptin: "KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone-independent manner." Abstract excerpt: Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity. Polycystic ovary syndrome (PCOS) is characterized by accelerated gon

Source
peer_reviewed_research
DOI
10.1111/jne.70208
PubMed
42219677
Open original source
2026Animal research

Deciphering protein-DNA interactions of &lt;i&gt;KISS1&lt;/i&gt; with transcription factors through molecular docking, molecular dynamics simulations, and gene expression analysis.

Content-verified record concerning Kisspeptin: "Deciphering protein-DNA interactions of &lt;i&gt;KISS1&lt;/i&gt; with transcription factors through molecular docking, molecular dynamics simulations, and gene expression analysis." Abstract excerpt: Metastasis is a key hallmark of cancer aggressiveness, particularly in triple-negative breast cancer (TNBC), which lacks effective targeted therapies. Kisspeptin-1 (KISS1), a known metastasis suppressor is emerging as a potential therapeutic modulator. This study investigates the structural and regulatory interactions between KISS1 and key transcription factors (TFs) involved in metastasis: SP1, C

Source
peer_reviewed_research
DOI
10.1080/07391102.2025.2553344
PubMed
40910466
Open original source
2026Animal research

Molecular and functional characterization of the kisspeptin receptor Kissr3 in the large yellow croaker (Larimichthys crocea).

Content-verified record concerning Kisspeptin: "Molecular and functional characterization of the kisspeptin receptor Kissr3 in the large yellow croaker (Larimichthys crocea)." Abstract excerpt: Kisspeptin is a conserved neuropeptide that regulates reproductive function and other physiological processes across vertebrates via its cognate G protein-coupled receptors (GPCRs), commonly referred to as kisspeptin receptors (KissRs). In teleosts, extensive gene duplication and lineage-specific diversification have generated multiple kisspeptin ligands and receptors, yet the molecular properties

Source
peer_reviewed_research
DOI
10.1016/j.cbpb.2026.111225
PubMed
41912081
Open original source
2023Animal research

Serum kisspeptin, neurokinin B and inhibin B levels can be used as alternative parameters to distinguish idiopathic CPP from premature thelarche in the early stages of puberty.

Content-verified record concerning Kisspeptin: "Serum kisspeptin, neurokinin B and inhibin B levels can be used as alternative parameters to distinguish idiopathic CPP from premature thelarche in the early stages of puberty." Abstract excerpt: There is controversial results about serum kisspeptin, neurokinin-B (NKB), anti-M&#xfc;llerian hormone (AMH)&#xa0;and inhibin B (INHB) levels in girls with central precocious puberty (CPP). Aim of this study is to evaluate serum levels of these four peptides in patients presented with early pubertal signs, and to evaluate their diagnostic validity in the diagnosis of CPP. Cross-sectional study. St

Source
peer_reviewed_research
DOI
10.1111/cen.14906
PubMed
36879296
Open original source
2019Animal research

Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism

Content-verified record concerning Kisspeptin: "Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism" Abstract excerpt: Successful reproduction in female mammals is precisely timed and must be able to withstand the metabolic demand of pregnancy and lactation. We show that kisspeptin-expressing neurons in the arcuate hypothalamus (Kiss1 ARH ) of female mice control the&#xa0;daily timing of food intake, along with the circadian regulation of locomotor activity, sleep, and core body temperature. Toxin-induced silencin

Source
peer_reviewed_research
DOI
10.1016/j.cub.2019.01.022
PubMed
30744968
Open original source
2018Animal research

Female sexual behavior in mice is controlled by kisspeptin neurons

Content-verified record concerning Kisspeptin: "Female sexual behavior in mice is controlled by kisspeptin neurons" Abstract excerpt: Sexual behavior is essential for the survival of many species. In female rodents, mate preference and copulatory behavior depend on pheromones and are synchronized with ovulation to ensure reproductive success. The neural circuits driving this orchestration in the brain have, however, remained elusive. Here, we demonstrate that neurons controlling ovulation in the mammalian brain are at the core o

Source
peer_reviewed_research
DOI
10.1038/s41467-017-02797-2
PubMed
29374161
Open original source
2025Animal research

Central kisspeptin injection enhances food consumption in broiler chickens: role of opioidergic and dopaminergic receptors.

Content-verified record concerning Kisspeptin: "Central kisspeptin injection enhances food consumption in broiler chickens: role of opioidergic and dopaminergic receptors." Abstract excerpt: Kisspeptin, acting as both a neuropeptide and a hormone, known for its pivotal role in reproductive function and energy homeostasis, exerts multifaceted effects on central nervous system pathways involved in appetite regulation. Therefore, this study aimed to examine the impact of intracerebroventricular (ICV) infusion of kisspeptin on feeding behavior in neonatal broilers and to elucidate its int

Source
peer_reviewed_research
DOI
10.1016/j.psj.2025.106007
PubMed
41151445
Open original source
2024Animal research

Adipose Kiss1 controls aerobic exercise-related adaptive responses in adipose tissue energy homeostasis.

Content-verified record concerning Kisspeptin: "Adipose Kiss1 controls aerobic exercise-related adaptive responses in adipose tissue energy homeostasis." Abstract excerpt: Kisspeptin signaling regulates energy homeostasis. Adiposity is the principal source and receiver of peripheral Kisspeptin, and adipose Kiss1 metastasis suppressor (Kiss1) gene expression is stimulated by exercise. However, whether the adipose Kiss1 gene regulates energy homeostasis and plays a role in adaptive alterations during prolonged exercise remains unknown. Here, we investigated the role o

Source
peer_reviewed_research
DOI
10.1096/fj.202302598rr
PubMed
38877852
Open original source
2024Animal research

AVPV <i>Kiss1</i> neuron-specific knockdown of purinergic P2X2 receptor suppresses LH surge and ovulation in <i>Kiss1-Cre</i> rats.

Content-verified record concerning Kisspeptin: "AVPV <i>Kiss1</i> neuron-specific knockdown of purinergic P2X2 receptor suppresses LH surge and ovulation in <i>Kiss1-Cre</i> rats." Abstract excerpt: Ovulation disorders are a major cause of low pregnancy rates and infertility in humans and livestock. Kisspeptin neurons located in the anteroventral periventricular nucleus (AVPV) are responsible for the generation of the gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) surge and the consequent ovulation in female rodents. The present study aimed to examine whether purinergic neuron

Source
peer_reviewed_research
DOI
10.1262/jrd.2024-046
PubMed
39428487
Open original source
2023Animal research

Role of kisspeptin in decidualization and unexplained recurrent spontaneous abortion via the ERK1/2 signalling pathway.

Content-verified record concerning Kisspeptin: "Role of kisspeptin in decidualization and unexplained recurrent spontaneous abortion via the ERK1/2 signalling pathway." Abstract excerpt: This study aimed to study the expression and function of kisspeptin during human uterine decidualization in recurrent spontaneous abortion (RSA) and the underlying mechanism. All patients were recruited from the Clinical Reproductive Center of the Second Affiliated Hospital of Soochow University. Mice models of RSA (CBA/J&#xa0;&#xd7;&#xa0;DBA/2) and normal pregnancy (CBA/J&#xa0;&#xd7;&#xa0;BALB/c)

Source
peer_reviewed_research
DOI
10.1016/j.placenta.2023.01.006
PubMed
36680818
Open original source
2023Animal research

Role of kisspeptin in polycystic ovarian syndrome: A metabolomics study.

Content-verified record concerning Kisspeptin: "Role of kisspeptin in polycystic ovarian syndrome: A metabolomics study." Abstract excerpt: Polycystic ovary syndrome (PCOS) is a pathophysiological disease affecting reproductive and metabolic indicators. Research has shown that kisspeptin might be involved in the regulation of pituitary hormone secretion and energy metabolism. The aim of this study was to investigate the relationship between serum kisspeptin levels and abnormal metabolism in PCOS. Fifty patients with PCOS and 50 contro

Source
peer_reviewed_research
DOI
10.1111/cen.14899
PubMed
36843187
Open original source
2024Animal research

Deletion of Nuclear Progesterone Receptors From Kisspeptin Cells Does Not Impair Negative Feedback in Female Mice.

Content-verified record concerning Kisspeptin: "Deletion of Nuclear Progesterone Receptors From Kisspeptin Cells Does Not Impair Negative Feedback in Female Mice." Abstract excerpt: Reproductive function in mammals depends on the ability of progesterone (P4) to suppress pulsatile gonadotrophin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion in a homeostatic-negative feedback loop. Previous research identified that cells upstream from GnRH neurons expressing the nuclear progesterone receptor (PGR) are required for P4-negative feedback. However, the identity of

Source
peer_reviewed_research
DOI
10.1210/endocr/bqae121
PubMed
39253941
Open original source
2026Animal research

Maternal Kisspeptin-10 Treatment Partially Rescues Fetal and Postnatal Cardiac Programming Disrupted by Maternal Hypothyroidism.

Content-verified record concerning Kisspeptin: "Maternal Kisspeptin-10 Treatment Partially Rescues Fetal and Postnatal Cardiac Programming Disrupted by Maternal Hypothyroidism." Abstract excerpt: Cardiovascular diseases are the leading cause of global mortality and have been associated with alterations in fetal programming. Maternal hypothyroidism (MH) impairs placental function and induces intrauterine growth restriction (IUGR), both of which are risk factors for cardiovascular disease. Kisspeptin-10 (Kp10) has been shown to improve feto-placental development in hypothyroid rats, but its

Source
peer_reviewed_research
DOI
10.1007/s12012-026-10185-w
PubMed
42726152
Open original source
2026Animal research

Preoptic kisspeptin-nNOS-GnRH (KiNG) neuronal network regulates LH rhythmicity through activation-inhibition in mice.

Content-verified record concerning Kisspeptin: "Preoptic kisspeptin-nNOS-GnRH (KiNG) neuronal network regulates LH rhythmicity through activation-inhibition in mice." Abstract excerpt: Gonadotropin-releasing hormone (GnRH) neurons are the final target of a complex network regulating reproduction. The balance between excitatory and inhibitory inputs is essential for rhythmic GnRH secretion, including pulses and surges, yet the underlying mechanisms remain unresolved. Here, using adult animals of both sexes, we test the hypothesis that excitatory kisspeptin and inhibitory neuronal

Source
peer_reviewed_research
DOI
10.1038/s41467-026-69316-0
PubMed
41667486
Open original source
2012Animal research

Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature

Content-verified record concerning Kisspeptin: "Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature" Abstract excerpt: Estrogen withdrawal in menopausal women leads to hot flushes, a syndrome characterized by the episodic activation of heat dissipation effectors. Despite the extraordinary number of individuals affected, the etiology of flushes remains an enigma. Because menopause is accompanied by marked alterations in hypothalamic kisspeptin/neurokinin B/dynorphin (KNDy) neurons, we hypothesized that these neuron

Source
peer_reviewed_research
DOI
10.1073/pnas.1211517109
PubMed
23150555
Open original source
2025Animal research

Profile of opioid peptide receptors in GnRH and kisspeptin neurons of female mice and rats.

Content-verified record concerning Kisspeptin: "Profile of opioid peptide receptors in GnRH and kisspeptin neurons of female mice and rats." Abstract excerpt: Kisspeptin neurons play a critical role in the estradiol feedback effects on gonadotropin-releasing hormone (GnRH) neurons and luteinizing hormone (LH) secretion. Endogenous opioid peptides regulate LH secretion, but the neuroendocrine mechanisms involved remain elusive. We used RNAscope to characterize the expression of kappa (Oprk1)-, mu (Oprm1)-, and delta (Oprd1)-opioid receptors in GnRH (Gnrh

Source
peer_reviewed_research
DOI
10.1111/jne.70075
PubMed
40765036
Open original source
2010Animal research

Identification of Prolactin-Sensitive GABA and Kisspeptin Neurons in Regions of the Rat Hypothalamus Involved in the Control of Fertility

Content-verified record concerning Kisspeptin: "Identification of Prolactin-Sensitive GABA and Kisspeptin Neurons in Regions of the Rat Hypothalamus Involved in the Control of Fertility" Abstract excerpt: High levels of circulating prolactin are known to cause infertility, but the precise mechanisms by which prolactin influences the neuroendocrine axis are yet to be determined. We used dual-label in situ hybridization to investigate whether prolactin-receptor (PRLR) mRNA is expressed in GnRH neurons. In addition, because &#x3b3;-aminobutyric acidergic and kisspeptin neurons in the rostral hypothala

Source
peer_reviewed_research
DOI
10.1210/en.2010-0668
PubMed
21177834
Open original source
2026Animal research

The role of Kiss1 neurons in regulating metabolism and energy balance.

Content-verified record concerning Kisspeptin: "The role of Kiss1 neurons in regulating metabolism and energy balance." Abstract excerpt: Hypothalamic kisspeptin, encoded by the Kiss1 gene, serves as an important regulator of the reproductive axis and sexual maturation. Since reproductive physiology is tightly coupled to metabolic cues, metabolic status exerts significant influence on puberty and fertility. Emerging evidence identifies kisspeptin signaling as a key determinant of central energy homeostasis. This review focuses on di

Source
peer_reviewed_research
DOI
10.1016/j.peptides.2026.171497
PubMed
42269723
Open original source
2025Animal research

Exogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer.

Content-verified record concerning Kisspeptin: "Exogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer." Abstract excerpt: Triple-negative breast cancer (TNBC) is an aggressive subtype lacking ER, PR, and HER2 receptors making it highly clinically challenging subtype pf breast cancer. In this study, we investigated the effect of exogenous Kisspeptin-10 (Kp-10), on MDA-MB-231 and MDA-MB-468 cells. TNBC cells using both in vitro and in silico approaches. Kp-10 treatment significantly reduced cell viability and migration

Source
peer_reviewed_research
DOI
10.1038/s41598-025-19140-1
PubMed
41062590
Open original source
2025Animal research

Effect of Kisspeptin Fortification in Freezing Media on Post-Thaw Quality and Fertility of Buffalo Bull Semen.

Content-verified record concerning Kisspeptin: "Effect of Kisspeptin Fortification in Freezing Media on Post-Thaw Quality and Fertility of Buffalo Bull Semen." Abstract excerpt: The present study was undertaken to assess the effect of kisspeptin supplementation (0.0, 5.0, 10.0, 15.0, 20.0 and 40.0 &#x3bc;M) in cryodiluent on freezability and in&#xa0;vivo fertility of buffalo bull spermatozoa. Twenty-four semen ejaculates were collected using an artificial vagina from four Murrah buffalo bulls. Ejaculates having &gt; 70% sperm motility, &lt; 25% morphological abnormalities

Source
peer_reviewed_research
DOI
10.1111/rda.70124
PubMed
40923151
Open original source
2025Animal research

Effect of kisspeptin, neurokinin, and dynorphin neurons on regulation of reproduction.

Content-verified record concerning Kisspeptin: "Effect of kisspeptin, neurokinin, and dynorphin neurons on regulation of reproduction." Abstract excerpt: Gonadotropin-releasing hormone pulsatility is under the influence of hypothalamic neuropeptides, especially neurons expressing kisspeptin, neurokinin B, and dynorphin. These hypothalamic cells are called KNDy neurons. By integrating hormonal and environmental stimuli in the brain, they modulate the effects on neuropeptide release and control the frequency and amplitude of pulses. The relationship

Source
peer_reviewed_research
DOI
10.48095/cccg2025413
PubMed
41170798
Open original source
2022Animal research

GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice.

Content-verified record concerning Kisspeptin: "GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice." Abstract excerpt: Kisspeptin neurons in the arcuate nucleus of the hypothalamus generate gonadotrophin-releasing hormone (GnRH) pulses, and act as critical initiators of functional gonadotrophin secretion and reproductive competency. However, kisspeptin in other brain regions, most notably the posterodorsal subnucleus of the medial amygdala (MePD), plays a significant modulatory role over the hypothalamic kisspepti

Source
peer_reviewed_research
DOI
10.1111/jne.13207
PubMed
36305576
Open original source
2023Animal research

CRISPR-Cas9 knockdown of ESR1 in preoptic GABA-kisspeptin neurons suppresses the preovulatory surge and estrous cycles in female mice.

Content-verified record concerning Kisspeptin: "CRISPR-Cas9 knockdown of ESR1 in preoptic GABA-kisspeptin neurons suppresses the preovulatory surge and estrous cycles in female mice." Abstract excerpt: Evidence suggests that estradiol-sensing preoptic area GABA neurons are involved in the preovulatory surge mechanism necessary for ovulation. In vivo CRISPR-Cas9 editing was used to achieve a 60-70% knockdown in estrogen receptor alpha (ESR1) expression by GABA neurons located within the regions of the rostral periventricular area of the third ventricle (RP3V) and medial preoptic nuclei (MPN) in a

Source
peer_reviewed_research
DOI
10.7554/elife.90959
PubMed
38126277
Open original source
2024Animal research

Predictive efficiency of phoenixin, spexin and kisspeptin neuropeptides concentration levels in diagnosis of bipolar disorder in paediatric population.

Content-verified record concerning Kisspeptin: "Predictive efficiency of phoenixin, spexin and kisspeptin neuropeptides concentration levels in diagnosis of bipolar disorder in paediatric population." Abstract excerpt: The aim of the study was to assess concentrations of the following neuropeptides: phoenixin, spexin and kisspeptin in venous blood serum of children and adolescents suffering from bipolar disorder, and by this their predictive efficiency in this disorder. The study covered 75 individuals with a mean age of 15.26 years (95% CI: 14.86-15.67), of which the study group comprised of 57 individuals diag

Source
peer_reviewed_research
DOI
10.12740/pp/onlinefirst/155178
PubMed
36989336
Open original source
2025Animal research

Effect of galanin-like peptide on hypothalamic kisspeptin expression in female Zucker fatty rats.

Content-verified record concerning Kisspeptin: "Effect of galanin-like peptide on hypothalamic kisspeptin expression in female Zucker fatty rats." Abstract excerpt: Kisspeptin and galanin-like peptide (GALP) neurons in the hypothalamic arcuate nucleus (ARC) are involved in gonadotropin-releasing hormone (GnRH) neuron-mediated pulsatile luteinizing hormone (LH) secretion. Zucker fatty (ZF) rats display a leptin receptor gene abnormality and suppressed pulsatile LH secretion. ZF rats reportedly exhibit low hypothalamic GALP and kisspeptin expression, and GALP a

Source
peer_reviewed_research
DOI
10.1016/j.neulet.2024.138081
PubMed
39672293
Open original source
2025Animal research

Effects of Kisspeptin on rabbit ovulation: a comprehensive study of ovulatory, endocrine and histological response.

Content-verified record concerning Kisspeptin: "Effects of Kisspeptin on rabbit ovulation: a comprehensive study of ovulatory, endocrine and histological response." Abstract excerpt: Mammalian reproductive function is regulated by hypothalamic neurons that secrete Kisspeptin (Kp), a neuropeptide that stimulates gonadotropin-releasing hormone (GnRH) secretion, triggering pituitary gonadotrophins (LH and FSH) and gonadal steroids. This study evaluated the effect of Kisspeptin-10 (Kp10) on ovulation induction in rabbits, comparing its efficacy with that of the GnRH analogue gonad

Source
peer_reviewed_research
DOI
10.1016/j.theriogenology.2025.117524
PubMed
40505597
Open original source
2024Animal research

Effects of kisspeptin on the maturation of human ovarian primordial follicles <i>in vitro</i>.

Content-verified record concerning Kisspeptin: "Effects of kisspeptin on the maturation of human ovarian primordial follicles <i>in vitro</i>." Abstract excerpt: At this time, with advances in medical science, many cancers and chronic diseases are treatable, but one of their side effects is infertility. Some women also want to delay pregnancy for personal reasons. There has been some evidence that kisspeptin activates broad signals by binding to its receptor, suggesting that the role of kisspeptin in direct control of ovarian function includes follicle gro

Source
peer_reviewed_research
DOI
10.1017/s0967199423000527
PubMed
38099429
Open original source
2023Animal research

Effects of Kisspeptin on the reproductive function in the Dabry's sturgeon (Acipenser dabrynus).

Content-verified record concerning Kisspeptin: "Effects of Kisspeptin on the reproductive function in the Dabry's sturgeon (Acipenser dabrynus)." Abstract excerpt: Kisspeptin, a kind of neuropeptide, is involved in various physiological processes such as tumor metastasis inhibition and reproductive regulation due to its ability to interact with Kisspeptin receptor-Kissr. In teleost, Kisspeptin/Kissr system stimulates the hypothalamus-pituitary-gonadal axis (HPG axis), which is crucial for the reproductive regulation. Compared to one Kisspeptin protein Kiss1

Source
peer_reviewed_research
DOI
10.1016/j.ygcen.2023.114244
PubMed
36841441
Open original source
2010Animal research

Mapping of Kisspeptin Fibres in the Brain of the Pro‐Oestrous Rat

Content-verified record concerning Kisspeptin: "Mapping of Kisspeptin Fibres in the Brain of the Pro‐Oestrous Rat" Abstract excerpt: Kisspeptins are a family of small peptides that play a key role in the neuroendocrine regulation of the reproductive function through neural pathways that have not yet been completely identified. The present study aimed to investigate the distribution of kisspeptin neurone fibres in the female rat brain by comparing precisely the immunoreactive pattern obtained with two antibodies: one specificall

Source
peer_reviewed_research
DOI
10.1111/j.1365-2826.2010.02053.x
PubMed
20673302
Open original source
2004Animal research

A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse

Content-verified record concerning Kisspeptin: "A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse" Abstract excerpt: Kisspeptins are products of the KiSS-1 gene, which bind to a G protein-coupled receptor known as GPR54. Mutations or targeted disruptions in the GPR54 gene cause hypogonadotropic hypogonadism in humans and mice, suggesting that kisspeptin signaling may be important for the regulation of gonadotropin secretion. To examine the effects of kisspeptin-54 (metastin) and kisspeptin-10 (the biologically a

Source
peer_reviewed_research
DOI
10.1210/en.2004-0431
PubMed
15217982
Open original source
2026Animal research

Gonadotropin secretion and ovarian response of KISS1 knockout gilts treated with hormone analogs activating the hypothalamic-pituitary-gonadal axis†.

Content-verified record concerning Kisspeptin: "Gonadotropin secretion and ovarian response of KISS1 knockout gilts treated with hormone analogs activating the hypothalamic-pituitary-gonadal axis†." Abstract excerpt: Kisspeptin knockout (KISS1-/-) pigs exhibit hypogonadotropic hypogonadism. Hormone analogs targeting different levels of the hypothalamic-pituitary-gonad axis were used to characterize the secretion of reproductive hormones (LH, luteinizing hormone; and follicle-stimulating hormone, FSH) and ovarian responses (estradiol and progesterone) in KISS1-/- gilts. Uteri and ovaries were collected from KIS

Source
peer_reviewed_research
DOI
10.1093/biolre/ioaf174
PubMed
40751666
Open original source
2022Animal research

Effects of empagliflozin on the expression of kisspeptin gene and reproductive system function in streptozotocin-induced diabetic male rats.

Content-verified record concerning Kisspeptin: "Effects of empagliflozin on the expression of kisspeptin gene and reproductive system function in streptozotocin-induced diabetic male rats." Abstract excerpt: One of the main health concerns of diabetes is testicular dysfunction and impairment of reproductive function and sperm quality which can cause male infertility. kisspeptin is a hypothalamic neuropeptide hormone that is involved in the regulation of energy metabolism, gonadotrophin-releasing hormone (GnRH), and reproductive function. In the present study, the therapeutic effects of empagliflozin (

Source
peer_reviewed_research
DOI
10.3389/fendo.2022.1059942
PubMed
36479221
Open original source
2023Animal research

The role of kisspeptin in the pathogenesis of a polycystic ovary syndrome.

Content-verified record concerning Kisspeptin: "The role of kisspeptin in the pathogenesis of a polycystic ovary syndrome." Abstract excerpt: Hypothalamic-pituitary gonadal (HPG) axis is responsible for the development and regulation of the female reproductive system. In polycystic ovary syndrome (PCOS), there is a disturbance in the HPG axis. Kisspeptin, a neuropeptide produced by the KISS1 gene, plays a vital role in the regulation of HPG axis by binding with its receptors KISS1R/GPR54, and stimulates gonadotropin secretion from the h

Source
peer_reviewed_research
DOI
10.2478/enr-2023-0032
PubMed
38127687
Open original source
2014Animal research

Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization

Content-verified record concerning Kisspeptin: "Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization" Abstract excerpt: Patients with mutations that inactivate kisspeptin signaling are infertile. Kisspeptin-54, the major circulating isoform of kisspeptin in humans, potently stimulates reproductive hormone secretion in humans. Animal studies suggest that kisspeptin is involved in generation of the luteinizing hormone surge, which is required for ovulation; therefore, we hypothesized that kisspeptin-54 could be used

Source
peer_reviewed_research
DOI
10.1172/jci75730
PubMed
25036713
Open original source
2009Animal research

Distribution of Kisspeptin Neurones in the Adult Female Mouse Brain

Content-verified record concerning Kisspeptin: "Distribution of Kisspeptin Neurones in the Adult Female Mouse Brain" Abstract excerpt: Kisspeptin-GPR54 signalling is essential for normal reproductive functioning. However, the distribution of kisspeptin neuronal cell bodies and their projections is not well established. The present study aimed to provide a detailed account of kisspeptin neuroanatomy in the mouse brain. Using a polyclonal rabbit antibody AC566, directed towards the final ten C-terminal amino acids of murine kisspep

Source
peer_reviewed_research
DOI
10.1111/j.1365-2826.2009.01892.x
PubMed
19515163
Open original source
2014Animal research

Kisspeptin modulates fertilization capacity of mouse spermatozoa

Content-verified record concerning Kisspeptin: "Kisspeptin modulates fertilization capacity of mouse spermatozoa" Abstract excerpt: Kisspeptin acts as an upstream regulator of the hypothalamus-pituitary-gonad axis, which is one of the main regulatory systems for mammalian reproduction. Kiss1 and its receptor Kiss1r (also known as G protein-coupled receptor 54 (Gpr54)) are expressed in various organs, but their functions are not well understood. The purpose of this study was to investigate the expression profiles and functions

Source
peer_reviewed_research
DOI
10.1530/rep-13-0368
PubMed
24567427
Open original source
2007Animal research

Involvement of Anteroventral Periventricular Metastin/Kisspeptin Neurons in Estrogen Positive Feedback Action on Luteinizing Hormone Release in Female Rats

Content-verified record concerning Kisspeptin: "Involvement of Anteroventral Periventricular Metastin/Kisspeptin Neurons in Estrogen Positive Feedback Action on Luteinizing Hormone Release in Female Rats" Abstract excerpt: Metastin/kisspeptin, the KiSS-1 gene product, has been identified as an endogenous ligand of GPR54 that reportedly regulates GnRH/LH surges and estrous cyclicity in female rats. The aim of the present study was to determine if metastin/kisspeptin neurons are a target of estrogen positive feedback to induce GnRH/LH surges. We demonstrated that preoptic area (POA) infusion of the anti-rat metastin/k

Source
peer_reviewed_research
DOI
10.1262/jrd.18146
PubMed
17213691
Open original source
2022Animal research

What is the protective effect of preischemic kisspeptin-10 administration against ischemia/reperfusion injury of striatum on mice?

Content-verified record concerning Kisspeptin: "What is the protective effect of preischemic kisspeptin-10 administration against ischemia/reperfusion injury of striatum on mice?" Abstract excerpt: Kisspeptin is a neuropeptide with a primary role on the onset of puberty and has beneficial effects on ischemia/ reperfusion (I/R) injury. In this study, we aimed to investigate the effect of kisspeptin administration on striatal I/R injury in mice. Forty adult C57/BL6 mice were randomly divided into four groups: Sham, Kisspeptin, I/R, and I/R + Kisspeptin groups. The groups were administered with

Source
peer_reviewed_research
DOI
10.55730/1300-0144.5493
PubMed
36422497
Open original source
2024Animal research

Reduced voluntary wheel running behaviour in Kiss1r knockout mice.

Content-verified record concerning Kisspeptin: "Reduced voluntary wheel running behaviour in Kiss1r knockout mice." Abstract excerpt: Kisspeptin and its receptor, Kiss1r, are novel players in the central balance of energy intake and expenditure. Recent evidence also indicates that kisspeptin signalling is important in thermoregulation and generation of the circadian rhythm. We used global Kiss1r knockout mice (Kiss1r KO), which are hypogonadal and develop obesity, to determine the impact of kisspeptin on circadian related behavi

Source
peer_reviewed_research
DOI
10.1016/j.physbeh.2024.114701
PubMed
39317294
Open original source
2015Animal research

Selective optogenetic activation of arcuate kisspeptin neurons generates pulsatile luteinizing hormone secretion

Content-verified record concerning Kisspeptin: "Selective optogenetic activation of arcuate kisspeptin neurons generates pulsatile luteinizing hormone secretion" Abstract excerpt: Normal reproductive functioning in mammals depends upon gonadotropin-releasing hormone (GnRH) neurons generating a pulsatile pattern of gonadotropin secretion. The neural mechanism underlying the episodic release of GnRH is not known, although recent studies have suggested that the kisspeptin neurons located in the arcuate nucleus (ARN) may be involved. In the present experiments we expressed chan

Source
peer_reviewed_research
DOI
10.1073/pnas.1512243112
PubMed
26443858
Open original source
2010Animal research

Developmental Changes in the Expression of Kisspeptin mRNA in Rat Hypothalamus

Content-verified record concerning Kisspeptin: "Developmental Changes in the Expression of Kisspeptin mRNA in Rat Hypothalamus" Abstract excerpt: Kisspeptin is a family of neuropeptides and the natural ligands of G protein-coupled receptor (GPR)-54. Kisspeptin/GPR-54 system is known to play a pivotal role in puberty onset and in the regulation of reproductive functions. To clarify the postnatal ontogeny of kisspeptin neurons in rat hypothalamus, we analyzed the expression patterns of kisspeptin mRNA from neonate to adult by in situ hybridiz

Source
peer_reviewed_research
DOI
10.1007/s12031-010-9430-1
PubMed
20665248
Open original source
2026Animal research

Progesterone-KISS1 axis impairs amniotic epithelial cell function and promotes premature rupture of membranes.

Content-verified record concerning Kisspeptin: "Progesterone-KISS1 axis impairs amniotic epithelial cell function and promotes premature rupture of membranes." Abstract excerpt: Premature rupture of membranes (PROM) is a major cause of preterm birth and perinatal morbidity. Disruption of fetal membrane integrity is central to PROM pathogenesis; however, the molecular mechanisms underlying membrane weakening remain incompletely understood. Proteomic analysis was performed on fetal membrane tissues from patients with early PPROM, late PPROM, full-term PROM, and full-term no

Source
peer_reviewed_research
DOI
10.1016/j.placenta.2026.06.016
PubMed
42385385
Open original source
2025Animal research

Hypothalamic kisspeptin alleviates myasthenia gravis by regulating Th1/Th17/Treg balance through Inhibition of NF-κB signaling pathway.

Content-verified record concerning Kisspeptin: "Hypothalamic kisspeptin alleviates myasthenia gravis by regulating Th1/Th17/Treg balance through Inhibition of NF-κB signaling pathway." Abstract excerpt: Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular junctions. While neuroendocrine-immune system dysfunction plays a crucial role in the development of autoimmune diseases, its involvement in MG remains largely unexplored. Kisspeptin, a neuropeptide hormone and endogenous ligand for GPR54 receptor, has been demonstrated to regulate antitumor immunity, antiviral immunity, and

Source
peer_reviewed_research
DOI
10.1186/s12974-025-03486-4
PubMed
40524201
Open original source
2023Animal research

Hypothalamic Kisspeptin Neurons as a Target for Whole-Cell Patch-Clamp Recordings.

Content-verified record concerning Kisspeptin: "Hypothalamic Kisspeptin Neurons as a Target for Whole-Cell Patch-Clamp Recordings." Abstract excerpt: Kisspeptins are essential for the maturation of the hypothalamic-pituitary-gonadal (HPG) axis and fertility. Hypothalamic kisspeptin neurons located in the anteroventral periventricular nucleus and rostral periventricular nucleus, as well as the arcuate nucleus of the hypothalamus, project to gonadotrophin-releasing hormone (GnRH) neurons, among other cells. Previous studies have demonstrated that

Source
peer_reviewed_research
DOI
10.3791/64989
PubMed
37010276
Open original source
2024Animal research

Alteration in kisspeptin and reproductive hormones during different superovulation protocols in dromedary camel.

Content-verified record concerning Kisspeptin: "Alteration in kisspeptin and reproductive hormones during different superovulation protocols in dromedary camel." Abstract excerpt: This study explored the alteration in kisspeptin and reproductive hormones during different superovulation protocols (SOP) in dromedary camel. The kisspeptin and reproductive hormonal profile, ovarian response, and the quality and quantity of embryos in dromedary camel donors were evaluated. A total of thirty donor camels were divided into two groups: the 5dSOP group, which received diluent contai

Source
peer_reviewed_research
DOI
10.1016/j.theriogenology.2024.06.011
PubMed
38909433
Open original source
2023Animal research

Effects of <i>KISS1</i> structural polymorphism on the risk of polycystic ovary syndrome and reproductive hormones in Iraqi women who take metformin.

Content-verified record concerning Kisspeptin: "Effects of <i>KISS1</i> structural polymorphism on the risk of polycystic ovary syndrome and reproductive hormones in Iraqi women who take metformin." Abstract excerpt: To identify the effects of metformin and kisspeptin structural polymorphism on the risk of polycystic ovary syndrome (PCOS) in Iraqi women. Samples were collected at the family planning center of Al-Hassan Teaching Hospital (infertility clinic), Iraq. Hormonal and hematological parameters were measured. Kisspeptin structural polymorphisms were analyzed by polymerase chain reaction using a conventi

Source
peer_reviewed_research
DOI
10.1177/03000605231196837
PubMed
37702549
Open original source
2013Animal research

Kisspeptin Neurones do not Directly Signal to RFRP ‐3 Neurones but RFRP ‐3 may Directly Modulate a Subset of Hypothalamic Kisspeptin Cells in Mice

Content-verified record concerning Kisspeptin: "Kisspeptin Neurones do not Directly Signal to RFRP ‐3 Neurones but RFRP ‐3 may Directly Modulate a Subset of Hypothalamic Kisspeptin Cells in Mice" Abstract excerpt: The neuropeptides kisspeptin (encoded by Kiss1) and RFamide-related peptide-3 (also known as GnIH; encoded by Rfrp) are potent stimulators and inhibitors, respectively, of reproduction. Whether kisspeptin or RFRP-3 might act directly on each other's neuronal populations to indirectly modulate reproductive status is unknown. To examine possible interconnectivity of the kisspeptin and RFRP-3 systems

Source
peer_reviewed_research
DOI
10.1111/jne.12084
PubMed
23927071
Open original source
2025Animal research

Manipulating seasonality by using PMSG and Kisspeptin hormones and the impact of the MTNR1A gene on reproduction efficiency in ewes.

Content-verified record concerning Kisspeptin: "Manipulating seasonality by using PMSG and Kisspeptin hormones and the impact of the MTNR1A gene on reproduction efficiency in ewes." Abstract excerpt: One of the most important problems in sheep is seasonal anestrus, which limits the reproductive efficiency of the sheep. Estrous synchronization is considered the first plan for reproductive performance in sheep due to the pregnancy time is limited, and parturition as well as an increase in twining and reached good genetic characteristics. This study aimed to manipulate seasonality that limits fer

Source
peer_reviewed_research
DOI
10.5455/ovj.2025.v15.i8.19
PubMed
41035969
Open original source
2026Animal research

Expressions of Kisspeptin System and Ki-67 in the Reproductive Tissues of Cyclic Bitches.

Content-verified record concerning Kisspeptin: "Expressions of Kisspeptin System and Ki-67 in the Reproductive Tissues of Cyclic Bitches." Abstract excerpt: Kisspeptin is a peptide that plays a pivotal role in the central regulation of gonadotropins. It is regarded as a key regulator of reproductive processes, including follicular and luteal development and endometrial remodelling. The objective of this study was to investigate the expression of KISS1, its receptor KISS1R and the proliferation marker Ki-67 in the uterus, oviduct and ovary of bitches a

Source
peer_reviewed_research
DOI
10.1111/rda.70205
PubMed
41983751
Open original source
2025Animal research

Association of Kisspeptin and KISS&lt;sub&gt;1&lt;/sub&gt; Gene Polymorphism (rs35431622) with Circulating Sex Hormones and Male Infertility.

Content-verified record concerning Kisspeptin: "Association of Kisspeptin and KISS&lt;sub&gt;1&lt;/sub&gt; Gene Polymorphism (rs35431622) with Circulating Sex Hormones and Male Infertility." Abstract excerpt: This research delves into the association of Kisspeptin and the KISS 1 gene (rs35431622) single nucleotide polymorphism with circulating sex hormones and semen parameters in males diagnosed with infertility. Eighty male participants were recruited from fertility clinic, were divided into two groups: Group A, characterized by normal sperm count and Group B, exhibiting low count. The analysis involv

Source
peer_reviewed_research
DOI
10.1007/s43032-025-01803-z
PubMed
39909971
Open original source
2024Animal research

Development of KISS1 knockout pigs is characterized by hypogonadotropic hypogonadism, normal growth, and reduced skatole†.

Content-verified record concerning Kisspeptin: "Development of KISS1 knockout pigs is characterized by hypogonadotropic hypogonadism, normal growth, and reduced skatole†." Abstract excerpt: Kisspeptin is a major regulator of gonadotropin secretion in pigs. Previously, CRISPR/Cas9 knockout of KISS1 was used to develop a mosaic parental line of pigs to generate offspring that would not need castration due to loss of kisspeptin. The current goal was to characterize growth and reproductive development of F1 pigs from this parental line. Body weights, gonadotropin concentrations and gonad

Source
peer_reviewed_research
DOI
10.1093/biolre/ioae140
PubMed
39375014
Open original source
2008Animal research

An Increase in Kisspeptin-54 Release Occurs with the Pubertal Increase in Luteinizing Hormone-Releasing Hormone-1 Release in the Stalk-Median Eminence of Female Rhesus Monkeys in Vivo

Content-verified record concerning Kisspeptin: "An Increase in Kisspeptin-54 Release Occurs with the Pubertal Increase in Luteinizing Hormone-Releasing Hormone-1 Release in the Stalk-Median Eminence of Female Rhesus Monkeys in Vivo" Abstract excerpt: The G-protein coupled receptor GPR54 and its ligand, KiSS-1-derived peptide kisspeptin-54, appear to play an important role in the mechanism of puberty. This study measures the release of kisspeptin-54 in the stalk-median eminence (S-ME) during puberty and examines its potential role in the pubertal increase in LHRH-1 release in female rhesus monkeys. First, developmental changes in release of kis

Source
peer_reviewed_research
DOI
10.1210/en.2008-0231
PubMed
18450954
Open original source
2025Animal research

Brainstem noradrenergic modulation of the kisspeptin neuron GnRH pulse generator in mice.

Content-verified record concerning Kisspeptin: "Brainstem noradrenergic modulation of the kisspeptin neuron GnRH pulse generator in mice." Abstract excerpt: Brainstem noradrenaline (NA) neurons modulate the activity of many neural networks including those responsible for the control of fertility. Using brain slice electrophysiology, we demonstrate that the arcuate nucleus kisspeptin (ARN KISS ) neurons, recently identified to be the gonadotropin-releasing hormone (GnRH) pulse generator, are directly hyperpolarized by NA through both alpha 2- and beta-

Source
peer_reviewed_research
DOI
10.1038/s41467-025-60837-8
PubMed
40593679
Open original source
2004Animal research

Central and Peripheral Administration of Kisspeptin‐10 Stimulates the Hypothalamic‐Pituitary‐Gonadal Axis

Content-verified record concerning Kisspeptin: "Central and Peripheral Administration of Kisspeptin‐10 Stimulates the Hypothalamic‐Pituitary‐Gonadal Axis" Abstract excerpt: Kisspeptin is the peptide product of the KiSS-1 gene and the endogenous agonist for the GPR54 receptor. Recent evidence suggests the kisspeptin/GPR54 system is a key regulator of the reproductive system. We examined the effect of intracerebroventricular (i.c.v.) and peripheral administration of the active kisspeptin fragment, kisspeptin-10, on circulating gonadotrophins and total testosterone leve

Source
peer_reviewed_research
DOI
10.1111/j.1365-2826.2004.01240.x
PubMed
15500545
Open original source
2008Animal research

Central and peripheral administration of kisspeptin activates gonadotropin but not somatotropin secretion in prepubertal gilts

Content-verified record concerning Kisspeptin: "Central and peripheral administration of kisspeptin activates gonadotropin but not somatotropin secretion in prepubertal gilts" Abstract excerpt: It is well established that kisspeptin signaling is necessary for the onset of puberty in laboratory animals. However, the role that kisspeptin may have in regulating puberty in large domestic animals is unknown. We tested the hypothesis that either central or peripheral infusion of kisspeptin would stimulate gonadotropin and GH secretion in prepubertal gilts. In experiment 1, prepubertal gilts we

Source
peer_reviewed_research
DOI
10.1530/rep-07-0502
PubMed
18339687
Open original source
2026Animal research

Atrazine alters kisspeptin signaling and downstream neuroendocrine regulation following embryonic exposure in zebrafish.

Content-verified record concerning Kisspeptin: "Atrazine alters kisspeptin signaling and downstream neuroendocrine regulation following embryonic exposure in zebrafish." Abstract excerpt: Atrazine is an herbicide used to control broadleaf and grassy weeds but is also a known endocrine disrupting chemical classified by the US EPA for its effect on the luteinizing hormone (LH) surge. The US EPA's maximum contaminant level (MCL) for atrazine in drinking water is 3 parts per billion (ppb; &#xb5;g/L), though concentrations may exceed this during peak crop seasons. Because drinking water

Source
peer_reviewed_research
DOI
10.1016/j.tox.2026.154503
PubMed
42142733
Open original source
2026Animal research

Evaluation of Betatrophin, Chemerin, and Kisspeptin Levels in Acromegaly Patients.

Content-verified record concerning Kisspeptin: "Evaluation of Betatrophin, Chemerin, and Kisspeptin Levels in Acromegaly Patients." Abstract excerpt: Acromegaly is a chronic disorder characterized by excessive growth hormone (GH) secretion from pituitary somatotroph cells, resulting in metabolic complications and increased morbidity. Elevated levels of GH and insulin-like growth factor 1 (IGF-1) contribute to various metabolic and morphological abnormalities. Betatrophin, produced in the liver and adipose tissue, plays a significant role in reg

Source
peer_reviewed_research
DOI
10.2174/0118715303375180250312035323
PubMed
40264311
Open original source
2022Animal research

Sex-specific hypothalamic expression of kisspeptin, gonadotropin releasing hormone, and kisspeptin receptor in progressive demyelination model.

Content-verified record concerning Kisspeptin: "Sex-specific hypothalamic expression of kisspeptin, gonadotropin releasing hormone, and kisspeptin receptor in progressive demyelination model." Abstract excerpt: Demyelinating diseases, such as multiple sclerosis, decrease the quality of life of patients and can affect reproduction. Assisted reproductive therapies are available, which although effective, aggravate motor symptoms. For this reason, it is important to determine how the control of the hypothalamus-pituitary-gonadal axis is affected in order to develop better strategies for these patients. One

Source
peer_reviewed_research
DOI
10.1016/j.jchemneu.2022.102120
PubMed
35718292
Open original source
2024Animal research

Participation of kisspeptin, progesterone, and GnRH receptors on lordosis behavior induced by kisspeptin.

Content-verified record concerning Kisspeptin: "Participation of kisspeptin, progesterone, and GnRH receptors on lordosis behavior induced by kisspeptin." Abstract excerpt: The neuropeptide kisspeptin (Kiss) is crucial in regulating the hypothalamic-pituitary-gonadal axis. It is produced by two main groups of neurons in the hypothalamus: the rostral periventricular region around the third ventricle and the arcuate nucleus. Kiss is the peptide product of the KiSS-1 gene and serves as the endogenous agonist for the GPR54 receptor. The Kiss/GPR54 system functions as a c

Source
peer_reviewed_research
DOI
10.1016/j.physbeh.2024.114609
PubMed
38851441
Open original source
2006Animal research

Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats

Content-verified record concerning Kisspeptin: "Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats" Abstract excerpt: The kisspeptins are KiSS-1 gene-derived peptides that signal through the G protein-coupled receptor-54 (GPR54) and have recently been shown to be critical regulators of reproduction. Acute intracerebroventricular or peripheral administration of kisspeptin stimulates the hypothalamic-pituitary-gonadal (HPG) axis. This effect is thought to be mediated via the hypothalamic gonadotropin-releasing horm

Source
peer_reviewed_research
DOI
10.1152/ajpendo.00040.2006
PubMed
16787965
Open original source
2025Animal research

Recombinant GnRH6-kisspeptin-CRM197 vaccine inhibits reproductive function in male rats and dogs.

Content-verified record concerning Kisspeptin: "Recombinant GnRH6-kisspeptin-CRM197 vaccine inhibits reproductive function in male rats and dogs." Abstract excerpt: Immunocastration vaccines, as an alternative to surgical castration, have gained prominence for improving meat quality in livestock by suppressing reproductive functions. Central to this process is gonadotropin-releasing hormone (GnRH), a pivotal regulator of the hypothalamic-pituitary-gonadal axis whose secretion is modulated by the upstream neuropeptide kisspeptin. Building upon this regulatory

Source
peer_reviewed_research
DOI
10.1016/j.tvjl.2025.106501
PubMed
41271083
Open original source
2025Animal research

Potential role of kisspeptin in the estradiol-induced modulation of inhibin subunit gene expression: Insights from in vivo rat models and hypothalamic cell models.

Content-verified record concerning Kisspeptin: "Potential role of kisspeptin in the estradiol-induced modulation of inhibin subunit gene expression: Insights from in vivo rat models and hypothalamic cell models." Abstract excerpt: The hypothalamic-pituitary-gonadal (HPG) axis is primarily regulated by kisspeptin neurons. In addition, activin and inhibin within the central nervous system might contribute to the regulation of the HPG axis because they are expressed near kisspeptin and gonadotropin-releasing hormone (GnRH) neurons. We investigated the effects of inhibin and activin within the hypothalamus in the estradiol (E2)

Source
peer_reviewed_research
DOI
10.1507/endocrj.ej25-0044
PubMed
40414719
Open original source
2022Animal research

Socs3 ablation in kisspeptin cells partially prevents lipopolysaccharide-induced body weight loss.

Content-verified record concerning Kisspeptin: "Socs3 ablation in kisspeptin cells partially prevents lipopolysaccharide-induced body weight loss." Abstract excerpt: Many cytokines have been proposed to regulate reproduction due to their actions on hypothalamic kisspeptin cells, the main modulators of gonadotropin-releasing hormone (GnRH) neurons. Hormones such as leptin, prolactin and growth hormone are good examples of cytokines that lead to Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway activation, consequently exerting eff

Source
peer_reviewed_research
DOI
10.1016/j.cyto.2022.155999
PubMed
35985175
Open original source
2014Animal research

The Integrated Hypothalamic Tachykinin-Kisspeptin System as a Central Coordinator for Reproduction

Content-verified record concerning Kisspeptin: "The Integrated Hypothalamic Tachykinin-Kisspeptin System as a Central Coordinator for Reproduction" Abstract excerpt: Tachykinins are comprised of the family of related peptides, substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). NKB has emerged as regulator of kisspeptin release in the arcuate nucleus (ARC), whereas the roles of SP and NKA in reproduction remain unknown. This work explores the roles of SP and NKA in the central regulation of GnRH release. First, central infusion of specific agonists f

Source
peer_reviewed_research
DOI
10.1210/en.2014-1651
PubMed
25422875
Open original source
2025Animal research

Synthesis and characterisation of DOTA-kisspeptin-10 as a potential gallium-68/lutetium-177 pan-tumour radiopharmaceutical.

Content-verified record concerning Kisspeptin: "Synthesis and characterisation of DOTA-kisspeptin-10 as a potential gallium-68/lutetium-177 pan-tumour radiopharmaceutical." Abstract excerpt: Kisspeptin (KISS1) and its cognate receptor (KISS1R) are implicated in the progression of various cancers. A gallium-68 labelled kisspeptin-10 (KP10), the minimal biologically active structure, has potential as a pan-tumour radiopharmaceutical for the detection of cancers. Furthermore, a lutetium-177 labelled KP10 could find therapeutic application in treating oncological diseases. DOTA (1,4,7,10-

Source
peer_reviewed_research
DOI
10.1111/jne.13487
PubMed
39775975
Open original source
2025Animal research

Exploring GABA and Kisspeptin Roles in Reproductive and Metabolic Regulation: Insights from Kiss1-GABAB1KO Female Mice.

Content-verified record concerning Kisspeptin: "Exploring GABA and Kisspeptin Roles in Reproductive and Metabolic Regulation: Insights from Kiss1-GABAB1KO Female Mice." Abstract excerpt: &#x3b3;-Aminobutyric acid (GABA) and kisspeptin play essential roles in reproduction and metabolism, being expressed in the central nervous system and peripheral organs (ovaries, testes, pancreas, liver, and white adipose tissue [WAT]). While previous research has shed light on their functions, the interaction between GABA and kisspeptin in regulating these processes remains poorly explored. In a

Source
peer_reviewed_research
DOI
10.1210/endocr/bqaf165
PubMed
41206596
Open original source
2025Animal research

Evidence for human kisspeptin receptor homo-oligomerisation and its functional relevance.

Content-verified record concerning Kisspeptin: "Evidence for human kisspeptin receptor homo-oligomerisation and its functional relevance." Abstract excerpt: The signalling of kisspeptin-1 through the kisspeptin-1 receptor (KISS1R) is central to mammalian reproduction. Naturally occurring heterozygous KISS1R mutations and Kiss1r +/- knockout mice are less affected than their homozygous counterparts, suggesting that the mutant receptors possibly form oligomers with the wild-type (WT) KISS1R, rescuing the receptor function to some extent. To test this hy

Source
peer_reviewed_research
DOI
10.1530/jme-25-0043
PubMed
40680729
Open original source
2024Animal research

Does the miR-105-1-Kisspeptin Axis Promote Ovarian Cell Functions?

Content-verified record concerning Kisspeptin: "Does the miR-105-1-Kisspeptin Axis Promote Ovarian Cell Functions?" Abstract excerpt: The objective of this study was to elucidate the intricate interplay among miR-105-1, kisspeptin, and their synergistic influence on basic ovarian granulosa cell functions. The effects of miR-105-1 mimics or miR-105-1 inhibitor, kisspeptin (0, 1, and 10&#xa0;ng/ml), and its combinations with miR-105-1 mimics on porcine granulosa cells were assessed. The expression levels of miR-105-1, viability, p

Source
peer_reviewed_research
DOI
10.1007/s43032-024-01554-3
PubMed
38632222
Open original source
2026Animal research

Targeting the NR5A1-KISS1R-EMT axis with a small-molecule inhibitor suppresses lung adenocarcinoma progression and metastasis.

Content-verified record concerning Kisspeptin: "Targeting the NR5A1-KISS1R-EMT axis with a small-molecule inhibitor suppresses lung adenocarcinoma progression and metastasis." Abstract excerpt: Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death worldwide, with an urgent need for novel therapeutic targets beyond the established driver mutations. Here, we identify the orphan nuclear receptor NR5A1 (Steroidogenic Factor-1) as an oncogenic factor in LUAD. Through integrated bioinformatic analyses, we discovered that NR5A1 is significantly overexpressed in LUAD tumors and

Source
peer_reviewed_research
DOI
10.1016/j.cellsig.2026.112453
PubMed
41765312
Open original source
2025Animal research

Distribution of the kisspeptin system and its relation with gonadotropin-releasing hormone in the hypothalamus.

Content-verified record concerning Kisspeptin: "Distribution of the kisspeptin system and its relation with gonadotropin-releasing hormone in the hypothalamus." Abstract excerpt: Kisspeptin (KISS1), originally catalogued as metastin because of its capacity as a metastasis suppressor in human melanoma and breast cancer, is now recognized as the major puberty gatekeeper and gonadotropin-releasing hormone (GnRH) neuroendocrine system modulator. It is a member of the family of RFamide-related peptides&#xa0;that also includes the neuropeptide FF group, the gonadotropin-inhibito

Source
peer_reviewed_research
DOI
10.1016/bs.vh.2024.06.004
PubMed
39864946
Open original source
2025Animal research

Multiple effects of kisspeptin on neuroendocrine, reproduction, and metabolism in polycystic ovary syndrome.

Content-verified record concerning Kisspeptin: "Multiple effects of kisspeptin on neuroendocrine, reproduction, and metabolism in polycystic ovary syndrome." Abstract excerpt: Polycystic ovary syndrome (PCOS) is a highly prevalent and heterogeneous disease characterized by a combination of reproductive and endocrine abnormalities, often associated with metabolic and mental health disorders. The etiology and pathogenesis of PCOS remain unclear, but recent research has increasingly focused on the upstream mechanisms underlying its development. Among these, kisspeptin (KIS

Source
peer_reviewed_research
DOI
10.1111/jne.13482
PubMed
39694850
Open original source
2013Animal research

Neuroanatomy of the Kisspeptin Signaling System in Mammals: Comparative and Developmental Aspects

Content-verified record concerning Kisspeptin: "Neuroanatomy of the Kisspeptin Signaling System in Mammals: Comparative and Developmental Aspects" Abstract excerpt: Our understanding of kisspeptin and its actions depends, in part, on a detailed knowledge of the neuroanatomy of the kisspeptin signaling system in the brain. In this chapter, we will review our current knowledge of the distribution of kisspeptin cells, fibers, and receptors in the mammalian brain, including the development, phenotype, and projections of different kisspeptin subpopulations. A fair

Source
peer_reviewed_research
DOI
10.1007/978-1-4614-6199-9_3
PubMed
23550001
Open original source
2025Animal research

Adult Neurogenesis Is Regulated by the Endocannabinoid and Kisspeptin Systems.

Content-verified record concerning Kisspeptin: "Adult Neurogenesis Is Regulated by the Endocannabinoid and Kisspeptin Systems." Abstract excerpt: Neurogenesis is considered the most robust form of plasticity in the adult brain. To better decipher this process, we evaluated the potential crosstalk of Kisspeptin and Endocannabinoid Systems (KPS and ECS, respectively) on hippocampal neurogenesis. Male adolescent rats were exposed to kisspeptin-10 (KP10) and the endocannabinoid anandamide (AEA) administered alone or in combination with the type

Source
peer_reviewed_research
DOI
10.3390/ijms26093977
PubMed
40362219
Open original source
2013Animal research

Kisspeptin, Neurokinin B, and Dynorphin Act in the Arcuate Nucleus to Control Activity of the GnRH Pulse Generator in Ewes

Content-verified record concerning Kisspeptin: "Kisspeptin, Neurokinin B, and Dynorphin Act in the Arcuate Nucleus to Control Activity of the GnRH Pulse Generator in Ewes" Abstract excerpt: Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin driving GnRH release and neurokinin B (NKB) and dynorphin acting as start and stop signals, respectively. In this study, we tested this hypothesis by determining the actions, if any, of four neurotransmitters found in KNDy neur

Source
peer_reviewed_research
DOI
10.1210/en.2013-1331
PubMed
23959940
Open original source
2012Animal research

Kisspeptin Neurons from Mice to Men: Similarities and Differences

Content-verified record concerning Kisspeptin: "Kisspeptin Neurons from Mice to Men: Similarities and Differences" Abstract excerpt: The discovery that kisspeptin was critical for normal fertility in humans ushered in a new chapter in our understanding of the control of GnRH secretion. In this paper, we will review recent data on the similarities and differences across several mammalian species in the role of kisspeptin in reproductive neuroendocrinology. In all mammals examined to date, there is strong evidence that kisspeptin

Source
peer_reviewed_research
DOI
10.1210/en.2012-1550
PubMed
22989628
Open original source
2012Animal research

Kisspeptin Administration to Women: A Window into Endogenous Kisspeptin Secretion and GnRH Responsiveness across the Menstrual Cycle

Content-verified record concerning Kisspeptin: "Kisspeptin Administration to Women: A Window into Endogenous Kisspeptin Secretion and GnRH Responsiveness across the Menstrual Cycle" Abstract excerpt: Kisspeptin is the most powerful known stimulus of GnRH-induced LH secretion across mammalian species. However, the effects of kisspeptin are just being explored, and the dynamics of kisspeptin responsiveness across the menstrual cycle are incompletely understood. The objective of the study was to characterize the effects of kisspeptin on GnRH secretion in healthy women in different phases of the m

Source
peer_reviewed_research
DOI
10.1210/jc.2012-1282
PubMed
22577171
Open original source
2025Animal research

Regulatory Involvement of Kisspeptin in Energy Balance and Reproduction.

Content-verified record concerning Kisspeptin: "Regulatory Involvement of Kisspeptin in Energy Balance and Reproduction." Abstract excerpt: The hypothalamic-pituitary-gonadal axis, which regulates steroidogenesis and germ cell formation, closely regulates the reproduction process. Nonetheless, other chemical mediators, such as kisspeptin, influence this axis. Kisspeptin is a hypothalamic neuropeptide that modulates the function of this axis and also plays a central role in energy balance. The present study reviews the impact and assoc

Source
peer_reviewed_research
DOI
10.1007/s12013-024-01537-w
PubMed
39327386
Open original source
2026Animal research

Vesicular GABA transport expression in kisspeptin cells may contribute to the preovulatory gonadotropin surge.

Content-verified record concerning Kisspeptin: "Vesicular GABA transport expression in kisspeptin cells may contribute to the preovulatory gonadotropin surge." Abstract excerpt: The neurotransmitter gamma-aminobutyric acid (GABA) plays a vital role in the modulation of reproductive function by controlling gonadotropin-releasing hormone (GnRH) secretion. Most kisspeptin neurons, which are key regulators of GnRH neurons, coexpress GABA and other neuropeptides. However, whether the expression of the vesicular GABA transporter (Vgat) in kisspeptin cells contributes to the rep

Source
peer_reviewed_research
DOI
10.3389/fendo.2026.1807596
PubMed
42100207
Open original source
2026Animal research

Associations between kisspeptin hormone level and its genetic polymorphisms with polycystic ovary syndrome.

Content-verified record concerning Kisspeptin: "Associations between kisspeptin hormone level and its genetic polymorphisms with polycystic ovary syndrome." Abstract excerpt: Polycystic ovary syndrome (PCOS) is among the most common endocrine and metabolic disorders. Kisspeptin, a neuropeptide, which has been implicated in enhancing hypothalamic-pituitary-ovarian (HPO) axis activity, might play a role in the pathogenesis of PCOS. However, previous studies have had inconsistent results. In this study, we conducted meta-analyses to assess the possible association between

Source
peer_reviewed_research
DOI
10.1002/ijgo.70411
PubMed
40704698
Open original source
2025Animal research

A novel mechanism of kisspeptin regulating ovarian granulosa cell function via down-regulating let-7b to activate ERK/PI3K-Akt pathway in Tan sheep.

Content-verified record concerning Kisspeptin: "A novel mechanism of kisspeptin regulating ovarian granulosa cell function via down-regulating let-7b to activate ERK/PI3K-Akt pathway in Tan sheep." Abstract excerpt: The aim of this study was to verify the hypothesis that kisspeptin, a peptide encoded by the kiss1 gene, regulates steroidogenesis and cell proliferation in ovarian granulosa cells (GCs) from Tan sheep through modulation of let-7b and ITGB7 (integrin subunit beta 7). First, primary ovarian GCs were transfected with let-7b mimics and inhibitors. Next, HEK293T cells were cultured to validate the tar

Source
peer_reviewed_research
DOI
10.1016/j.domaniend.2025.106947
PubMed
40354677
Open original source
2025Animal research

The role of neonatal kisspeptin in long-term social behavior in mammals.

Content-verified record concerning Kisspeptin: "The role of neonatal kisspeptin in long-term social behavior in mammals." Abstract excerpt: Kisspeptins (Kiss) are key regulators of the hypothalamic-pituitary-gonadal axis, influencing testosterone surges essential for brain masculinization and behavioral development in mammals. This study explored the effects of transient neonatal Kiss blockade on long-term social behaviors in Wistar rats. Newborn rats of both sexes were injected with either a Kiss antagonist or vehicle during the post

Source
peer_reviewed_research
DOI
10.1038/s42003-025-08478-x
PubMed
40696196
Open original source
2024Animal research

Interactions between kisspeptin and bone: Cellular mechanisms, clinical evidence, and future potential.

Content-verified record concerning Kisspeptin: "Interactions between kisspeptin and bone: Cellular mechanisms, clinical evidence, and future potential." Abstract excerpt: The neuropeptide kisspeptin and its cognate receptor have been extensively studied in reproductive physiology, with diverse and well-established functions, including as an upstream regulator of pubertal onset, reproductive hormone secretion, and sexual behavior. Besides classical reproduction, both kisspeptin and its receptor are extensively expressed in bone-resorbing osteoclasts and bone-forming

Source
peer_reviewed_research
DOI
10.1111/nyas.15213
PubMed
39269749
Open original source
2023Animal research

Mechanism of Arcuate Kisspeptin Neuron Synchronization in Acute Brain Slices From Female Mice.

Content-verified record concerning Kisspeptin: "Mechanism of Arcuate Kisspeptin Neuron Synchronization in Acute Brain Slices From Female Mice." Abstract excerpt: The mechanism by which arcuate kisspeptin (ARNKISS) neurons co-expressing glutamate, neurokinin B, and dynorphin intermittently synchronize their activity to drive pulsatile hormone secretion remains unclear in females. In order to study spontaneous synchronization within the ARNKISS neuron network, acute brain slices were prepared from adult female Kiss1-GCaMP6 mice. Analysis of both spontaneous

Source
peer_reviewed_research
DOI
10.1210/endocr/bqad167
PubMed
37936337
Open original source
2023Animal research

Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovary syndrome.

Content-verified record concerning Kisspeptin: "Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovary syndrome." Abstract excerpt: Kisspeptin is a neuropeptide that has an important role in the female reproductive cycle which is indicated by its role in regulating the hypothalamic-pituitary-gonadal axis. To analyze the correlation between serum kisspeptin levels, ovarian kisspeptin expression, and ovarian Bone Morphogenic Protein-15 (BMP15) expression in polycystic ovary syndrome (PCOS) model rats. The research was accurate e

Source
peer_reviewed_research
DOI
10.5455/ovj.2023.v13.i3.4
PubMed
37026063
Open original source
2010Animal research

Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat

Content-verified record concerning Kisspeptin: "Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat" Abstract excerpt: Neurokinin B (NKB) and its cognate receptor neurokinin 3 (NK3R) play a critical role in reproduction. NKB and NK3R are coexpressed with dynorphin (Dyn) and kisspeptin (Kiss1) genes in neurons of the arcuate nucleus (Arc). However, the mechanisms of action of NKB as a cotransmitter with kisspeptin and dynorphin remain poorly understood. We explored the role of NKB in the control of LH secretion in

Source
peer_reviewed_research
DOI
10.1152/ajpendo.00517.2010
PubMed
21045176
Open original source
2011Animal research

Kisspeptin Signaling Is Indispensable for Neurokinin B, but not Glutamate, Stimulation of Gonadotropin Secretion in Mice

Content-verified record concerning Kisspeptin: "Kisspeptin Signaling Is Indispensable for Neurokinin B, but not Glutamate, Stimulation of Gonadotropin Secretion in Mice" Abstract excerpt: Kisspeptins (Kp), products of the Kiss1 gene that act via Gpr54 to potently stimulate GnRH secretion, operate as mediators of other regulatory signals of the gonadotropic axis. Mouse models of Gpr54 and/or Kiss1 inactivation have been used to address the contribution of Kp in the central control of gonadotropin secretion; yet, phenotypic and hormonal differences have been detected among the transg

Source
peer_reviewed_research
DOI
10.1210/en.2011-1260
PubMed
22067321
Open original source
2023Animal research

Effects of electroacupuncture on the kisspeptin-gonadotropin-releasing hormone (GnRH) /luteinizing hormone (LH) neural circuit abnormalities and androgen receptor expression of kisspeptin/neurokinin B/dynorphin neurons in PCOS rats.

Content-verified record concerning Kisspeptin: "Effects of electroacupuncture on the kisspeptin-gonadotropin-releasing hormone (GnRH) /luteinizing hormone (LH) neural circuit abnormalities and androgen receptor expression of kisspeptin/neurokinin B/dynorphin neurons in PCOS rats." Abstract excerpt: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, anovulation, and polycystic ovaries. Electroacupuncture (EA) can effectively improve hyperandrogenism and increase ovulation frequency in patients with PCOS. Pieces of suggest that androgen activity in the brain is associated with impaired steroid negative feedback in such patients. Studies have shown that EA regulated androgen

Source
peer_reviewed_research
DOI
10.1186/s13048-022-01078-x
PubMed
36650561
Open original source
2024Animal research

Nitric oxide mediated kisspeptin regulation of steroidogenesis and gametogenesis in the catfish, Clarias batrachus.

Content-verified record concerning Kisspeptin: "Nitric oxide mediated kisspeptin regulation of steroidogenesis and gametogenesis in the catfish, Clarias batrachus." Abstract excerpt: Nitric oxide (NO) is a gaseous molecule that regulates various reproductive functions. It is a well-recognized regulator of GnRH-FSH/LH-sex steroid secretion in vertebrates including fish. Kisspeptin is a recently discovered neuropeptide which also regulates GnRH secretion. Nitrergic and kisspeptin neurons are reported in close physical contact in the mammalian brain suggesting their interactive r

Source
peer_reviewed_research
DOI
10.1007/s00441-024-03899-2
PubMed
38829397
Open original source
2024Animal research

The role of placental kisspeptin in trophoblast invasion and migration: an assessment in <i>Kiss1r</i> knockout mice, BeWo cell lines and human term placenta.

Content-verified record concerning Kisspeptin: "The role of placental kisspeptin in trophoblast invasion and migration: an assessment in <i>Kiss1r</i> knockout mice, BeWo cell lines and human term placenta." Abstract excerpt: Context There is mounting evidence implicating kisspeptin signalling in placental development and function. Aims This study aimed to elucidate kisspeptin's role in trophoblast invasion and migration using three experimental models. Methods First, we examined the mouse fetus and placenta in a kisspeptin receptor (Kiss1r) knockout (KO) model. Fetal/placental weights and gene expression (quantitative

Source
peer_reviewed_research
DOI
10.1071/rd23230
PubMed
38976640
Open original source
2023Animal research

The interplay between kisspeptin and endocannabinoid systems modulates male hypothalamic and gonadic control of reproduction <i>in vivo</i>.

Content-verified record concerning Kisspeptin: "The interplay between kisspeptin and endocannabinoid systems modulates male hypothalamic and gonadic control of reproduction <i>in vivo</i>." Abstract excerpt: Male reproduction is under the control of the hypothalamus-pituitary-gonadal (HPG) axis. The endocannabinoid system (ECS) and the kisspeptin system (KS) are two major signaling systems in the central and peripheral control of reproduction, but their possible interaction has been poorly investigated in mammals. This manuscript analyzes their possible reciprocal modulation in the control of the HPG

Source
peer_reviewed_research
DOI
10.3389/fendo.2023.1269334
PubMed
37900144
Open original source
2024Animal research

Intracerebroventricular injection of kisspeptin in male rats activates hypothalamo-pituitary-gonadal axis, but not hypothalamo-pituitary-adrenal axis.

Content-verified record concerning Kisspeptin: "Intracerebroventricular injection of kisspeptin in male rats activates hypothalamo-pituitary-gonadal axis, but not hypothalamo-pituitary-adrenal axis." Abstract excerpt: Kisspeptin is an important hormone involved in the stimulation of the hypothalamo-pituitary gonadal (HPG) axis. The HPG axis can be suppressed in certain conditions such as stress, which gives rise to the activation of the hypothalamo-pituitary-adrenal (HPA) axis. However, the physiological role of kisspeptin in the interaction of HPG and HPA axis is not fully understood yet. This study was conduc

Source
peer_reviewed_research
DOI
10.1080/10799893.2024.2333470
PubMed
38647103
Open original source
2024Animal research

Targeted inhibition of kisspeptin neurons reverses hyperandrogenemia and abnormal hyperactive LH secretion in a preclinical mouse model of polycystic ovary syndrome.

Content-verified record concerning Kisspeptin: "Targeted inhibition of kisspeptin neurons reverses hyperandrogenemia and abnormal hyperactive LH secretion in a preclinical mouse model of polycystic ovary syndrome." Abstract excerpt: Do hyperactive kisspeptin neurons contribute to abnormally high LH secretion and downstream hyperandrogenemia in polycystic ovary syndrome (PCOS)-like conditions and can inhibition of kisspeptin neurons rescue such endocrine impairments? Targeted inhibition of endogenous kisspeptin neuron activity in a mouse model of PCOS reduced the abnormally hyperactive LH pulse secretion and hyperandrogenemia

Source
peer_reviewed_research
DOI
10.1093/humrep/deae153
PubMed
38978296
Open original source
2024Animal research

Selective depletion of kisspeptin neurons in the hypothalamic arcuate nucleus in early juvenile life reduces pubertal LH secretion and delays puberty onset in mice.

Content-verified record concerning Kisspeptin: "Selective depletion of kisspeptin neurons in the hypothalamic arcuate nucleus in early juvenile life reduces pubertal LH secretion and delays puberty onset in mice." Abstract excerpt: Puberty is the critical developmental transition to reproductive capability driven by the activation of gonadotropin-releasing hormone (GnRH) neurons. The complex neural mechanisms underlying pubertal activation of GnRH secretion still remain unknown, yet likely include kisspeptin neurons. However, kisspeptin neurons reside in several hypothalamic areas and the specific kisspeptin population timin

Source
peer_reviewed_research
DOI
10.1096/fj.202401696r
PubMed
39377760
Open original source
2010Animal research

Characterisation of Arcuate Nucleus Kisspeptin/Neurokinin B Neuronal Projections and Regulation during Lactation in the Rat

Content-verified record concerning Kisspeptin: "Characterisation of Arcuate Nucleus Kisspeptin/Neurokinin B Neuronal Projections and Regulation during Lactation in the Rat" Abstract excerpt: Lactation results in negative energy balance in the rat leading to decreased gonadotrophin-releasing hormone (GnRH) release and anoestrus. Inhibited GnRH release may be a result of decreased stimulatory tone from neuropeptides critical for GnRH neuronal activity, such as kisspeptin (Kiss1) and neurokinin B (NKB). The present study aimed to identify neuronal projections from the colocalised populat

Source
peer_reviewed_research
DOI
10.1111/j.1365-2826.2010.02076.x
PubMed
21029216
Open original source
2024Animal research

Obesity Alters POMC and Kisspeptin Neuron Cross Talk Leading to Reduced Luteinizing Hormone in Male Mice.

Content-verified record concerning Kisspeptin: "Obesity Alters POMC and Kisspeptin Neuron Cross Talk Leading to Reduced Luteinizing Hormone in Male Mice." Abstract excerpt: Obesity is associated with hypogonadism in males, characterized by low testosterone and sperm number. Previous studies determined that these stem from dysregulation of hypothalamic circuitry that regulates reproduction, by unknown mechanisms. Herein, we used mice fed chronic high-fat diet, which mimics human obesity, to determine mechanisms of impairment at the level of the hypothalamus, in partic

Source
peer_reviewed_research
DOI
10.1523/jneurosci.0222-24.2024
PubMed
38744532
Open original source
2023Animal research

Optogenetics studies of kisspeptin neurons.

Content-verified record concerning Kisspeptin: "Optogenetics studies of kisspeptin neurons." Abstract excerpt: Optical systems and genetic engineering technologies have made it possible to control neurons and unravel neuronal circuit behavior with high temporal and spatial resolution. The application of optogenetic strategies to understand the physiology of kisspeptin neuronal circuits has evolved in recent years among the neuroendocrine community. Kisspeptin neurons are fundamentally involved in controlli

Source
peer_reviewed_research
DOI
10.1016/j.peptides.2023.170961
PubMed
36731655
Open original source
2022Animal research

Current Perspectives on Kisspeptins Role in Behaviour.

Content-verified record concerning Kisspeptin: "Current Perspectives on Kisspeptins Role in Behaviour." Abstract excerpt: The neuropeptide kisspeptin is now well-established as the master regulator of the mammalian reproductive axis. Beyond the hypothalamus, kisspeptin and its cognate receptor are also extensively distributed in extra-hypothalamic brain regions. An expanding pool of animal and human data demonstrates that kisspeptin sits within an extensive neuroanatomical and functional framework through which it ca

Source
peer_reviewed_research
DOI
10.3389/fendo.2022.928143
PubMed
35757400
Open original source
2014Animal research

Prolactin Regulation of Kisspeptin Neurones in the Mouse Brain and its Role in the Lactation‐Induced Suppression of Kisspeptin Expression

Content-verified record concerning Kisspeptin: "Prolactin Regulation of Kisspeptin Neurones in the Mouse Brain and its Role in the Lactation‐Induced Suppression of Kisspeptin Expression" Abstract excerpt: Hyperprolactinaemia is a major cause of infertility in both males and females, although the mechanism by which prolactin inhibits the reproductive axis is not clear. The aim of the present study was to test the hypothesis that elevated prolactin causes suppression of kisspeptin expression in the hypothalamus, resulting in reduced release of gonadotrophin-releasing hormone (GnRH) and consequent inf

Source
peer_reviewed_research
DOI
10.1111/jne.12223
PubMed
25207795
Open original source
2009Animal research

Kisspeptin Signalling in the Hypothalamic Arcuate Nucleus Regulates GnRH Pulse Generator Frequency in the Rat

Content-verified record concerning Kisspeptin: "Kisspeptin Signalling in the Hypothalamic Arcuate Nucleus Regulates GnRH Pulse Generator Frequency in the Rat" Abstract excerpt: Kisspeptin and its G protein-coupled receptor (GPR) 54 are essential for activation of the hypothalamo-pituitary-gonadal axis. In the rat, the kisspeptin neurons critical for gonadotropin secretion are located in the hypothalamic arcuate (ARC) and anteroventral periventricular (AVPV) nuclei. As the ARC is known to be the site of the gonadotropin-releasing hormone (GnRH) pulse generator we explored

Source
peer_reviewed_research
DOI
10.1371/journal.pone.0008334
PubMed
20016824
Open original source
2023Animal research

Deletion of Androgen Receptors From Kisspeptin Neurons Prevents PCOS Features in a Letrozole Mouse Model.

Content-verified record concerning Kisspeptin: "Deletion of Androgen Receptors From Kisspeptin Neurons Prevents PCOS Features in a Letrozole Mouse Model." Abstract excerpt: Polycystic ovarian syndrome (PCOS) is the leading cause of anovulatory infertility and is a heterogenous condition associated with a range of reproductive and metabolic impairments. While its etiology remains unclear, hyperandrogenism and impaired steroid negative feedback have been identified as key factors underpinning the development of PCOS-like features both clinically and in animal models. W

Source
peer_reviewed_research
DOI
10.1210/endocr/bqad077
PubMed
37191144
Open original source
2023Animal research

Deletion of GABAB receptors from <i>Kiss1</i> cells affects glucose homeostasis without altering reproduction in male mice.

Content-verified record concerning Kisspeptin: "Deletion of GABAB receptors from <i>Kiss1</i> cells affects glucose homeostasis without altering reproduction in male mice." Abstract excerpt: Kisspeptin and &#x3b3;-amino butyric acid (GABA), synthesized in the central nervous system, are critical for reproduction. Both are also expressed in peripheral organs/tissues critical to metabolic control (liver/pancreas/adipose). Many kisspeptin neurons coexpress GABAB receptors (GABABR) and GABA controls kisspeptin expression and secretion. We developed a unique mouse lacking GABABR exclusivel

Source
peer_reviewed_research
DOI
10.1152/ajpendo.00129.2022
PubMed
36652400
Open original source
2026Animal research

Prolonged oscillating preoptic area kisspeptin neuron activity underlies the preovulatory luteinizing hormone surge in mice.

Content-verified record concerning Kisspeptin: "Prolonged oscillating preoptic area kisspeptin neuron activity underlies the preovulatory luteinizing hormone surge in mice." Abstract excerpt: The population of kisspeptin neurons located in the rostral periventricular area of the third ventricle (RP3V) is thought to have a key role in generating the GnRH surge that triggers ovulation. Using a modified GCaMP fibre photometry procedure, we have been able to record the in vivo population activity of RP3V KISS neurons across the estrous cycle of female mice. A marked increase in GCaMP activ

Source
peer_reviewed_research
DOI
10.7554/elife.109215
PubMed
42095546
Open original source
2026Animal research

The role of hypothalamic kisspeptin neurons in coordinating reproduction and metabolism.

Content-verified record concerning Kisspeptin: "The role of hypothalamic kisspeptin neurons in coordinating reproduction and metabolism." Abstract excerpt: The hypothalamic control of fertility is a quintessential homeostatic function. Given that reproduction is metabolically demanding, coordination between energy status and reproductive function is essential. Since GnRH neurons lack receptors for key metabolic hormones, nutrient sensing must occur via presynaptic neurons. Among the candidates are anorexigenic POMC and orexigenic NPY/AgRP neurons, bo

Source
peer_reviewed_research
DOI
10.1111/jne.70128
PubMed
41407546
Open original source
2006Animal research

Postnatal Development of Kisspeptin Neurons in Mouse Hypothalamus; Sexual Dimorphism and Projections to Gonadotropin-Releasing Hormone Neurons

Content-verified record concerning Kisspeptin: "Postnatal Development of Kisspeptin Neurons in Mouse Hypothalamus; Sexual Dimorphism and Projections to Gonadotropin-Releasing Hormone Neurons" Abstract excerpt: The neuropeptide kisspeptin has recently been implicated as having a critical role in the activation of the GnRH neurons to bring about puberty. We examined here the postnatal development of kisspeptin neuronal populations and their projections to GnRH neurons in the mouse. Three populations of kisspeptin neurons located in the 1) anteroventral periventricular nucleus (AVPV) and the preoptic periv

Source
peer_reviewed_research
DOI
10.1210/en.2006-0787
PubMed
16959837
Open original source
2025Animal research

Nociceptin-Opioid-Related Nociceptin Receptor 1 Signaling Partly Mediates Glucoprivic Suppression of Luteinizing Hormone Pulses in Female Rats: Arcuate &lt;italic&gt;Kiss1&lt;/italic&gt; Neurons as a Possible Target for Nociceptin.

Content-verified record concerning Kisspeptin: "Nociceptin-Opioid-Related Nociceptin Receptor 1 Signaling Partly Mediates Glucoprivic Suppression of Luteinizing Hormone Pulses in Female Rats: Arcuate &lt;italic&gt;Kiss1&lt;/italic&gt; Neurons as a Possible Target for Nociceptin." Abstract excerpt: During malnutrition, mammalian reproductive functions are suppressed by inhibition of the pulsatile release of gonadotropin-releasing hormone (GnRH)/gonadotropins. This study aimed to investigate whether nociceptin-opioid-related nociceptin receptor 1 (OPRL1) signaling mediates glucoprivic suppression of luteinizing hormone (LH) pulses in female rats. RNA sequencing analysis of tdTomato-positive a

Source
peer_reviewed_research
DOI
10.1159/000546766
PubMed
40518913
Open original source
2026Animal research

GABA receptor modulation of arcuate kisspeptin neuron bursting and synchronization activity in female mice.

Content-verified record concerning Kisspeptin: "GABA receptor modulation of arcuate kisspeptin neuron bursting and synchronization activity in female mice." Abstract excerpt: The arcuate nucleus kisspeptin (ARN KISS ) neurons intermittently synchronize their activity to operate as the GnRH pulse generator and drive pulsatile reproductive hormone secretion in mammals. Although ARN KISS neurons are known to receive various GABAergic inputs, the effects of GABA A and GABA B receptor modulation on their ability to synchronize remain unknown. We have used GCaMP6s to monitor

Source
peer_reviewed_research
DOI
10.1111/jne.70170
PubMed
41912143
Open original source
2024Animal research

The antidepressant-like effects of kisspeptin-10 are reversed by kisspeptin antagonist peptide 234 in male rats.

Content-verified record concerning Kisspeptin: "The antidepressant-like effects of kisspeptin-10 are reversed by kisspeptin antagonist peptide 234 in male rats." Abstract excerpt: Kisspeptins are reported to be the most potent activators of the hypothalamus-pituitary-gonadal (HPG) axis known to date. Kisspeptin potently elicits gonadotropin-releasing hormone (GnRH) release and luteinizing hormone (LH) secretion, even in the pre-pubertal period. Beyond the hypothalamus, kisspeptin is also expressed in limbic and paralimbic brain regions, which are areas of the neurobiologica

Source
peer_reviewed_research
DOI
10.14715/cmb/2024.70.10.13
PubMed
39605118
Open original source
2024Animal research

Investigation of effect peripheral kisspeptin treatment on hypothalamo-pituitary-gonadal axis and hypothalamo-pituitary-adrenal axis in male rats.

Content-verified record concerning Kisspeptin: "Investigation of effect peripheral kisspeptin treatment on hypothalamo-pituitary-gonadal axis and hypothalamo-pituitary-adrenal axis in male rats." Abstract excerpt: Kisspeptin is an endogenous peptide hormone that is the most potent stimulator of the hypothalamo-pituitary-gonadal (HPG) axis. The HPG axis can be suppressed by the activation of the hypothalamo-pituitary-adrenal (HPA) axis. The physiological role of kisspeptin in the interaction of the HPG axis and the HPA axis is not fully understood yet. The purpose of the current study was to investigate the

Source
peer_reviewed_research
DOI
10.1007/s42977-024-00241-3
PubMed
39249652
Open original source
2012Animal research

Kisspeptin-GPR54 Signaling in Mouse NO-Synthesizing Neurons Participates in the Hypothalamic Control of Ovulation

Content-verified record concerning Kisspeptin: "Kisspeptin-GPR54 Signaling in Mouse NO-Synthesizing Neurons Participates in the Hypothalamic Control of Ovulation" Abstract excerpt: Reproduction is controlled in the brain by a neural network that drives the secretion of gonadotropin-releasing hormone (GnRH). Various permissive homeostatic signals must be integrated to achieve ovulation in mammals. However, the neural events controlling the timely activation of GnRH neurons are not completely understood. Here we show that kisspeptin, a potent activator of GnRH neuronal activit

Source
peer_reviewed_research
DOI
10.1523/jneurosci.4765-11.2012
PubMed
22262891
Open original source
2024Animal research

Comprehensive Analysis of Kisspeptin Signaling: Effects on Cellular Dynamics in Cervical Cancer.

Content-verified record concerning Kisspeptin: "Comprehensive Analysis of Kisspeptin Signaling: Effects on Cellular Dynamics in Cervical Cancer." Abstract excerpt: Kisspeptin, a key neuropeptide derived from the KISS1R gene, is renowned for its critical role in regulating the hypothalamic-pituitary-gonadal axis and reproductive hormone secretion. Beyond its primary function in reproductive biology, emerging research has illuminated its influence in various cancers, mediating significant effects through its interaction with the G protein-coupled receptor, kis

Source
peer_reviewed_research
DOI
10.3390/biom14080923
PubMed
39199311
Open original source
2009Animal research

Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women with Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis

Content-verified record concerning Kisspeptin: "Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women with Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis" Abstract excerpt: Kisspeptin is a critical regulator of normal reproductive function. A single injection of kisspeptin in healthy human volunteers potently stimulates gonadotropin release. However, the effects of kisspeptin on gonadotropin release in women with hypothalamic amenorrhea (HA) and the effects of repeated administration of kisspeptin to humans are unknown. The aim of this study was to determine the effe

Source
peer_reviewed_research
DOI
10.1210/jc.2009-0406
PubMed
19820030
Open original source
2026Animal research

Robust serotonin activation of the kisspeptin GnRH pulse generator in male and female mice.

Content-verified record concerning Kisspeptin: "Robust serotonin activation of the kisspeptin GnRH pulse generator in male and female mice." Abstract excerpt: Serotonin neurons are thought to exert a modulatory influence on the secretion of the gonadotropin hormones in mammals, but their mechanism of action remains unclear. We examined here the potential role of serotonin neurons in modulating the activity of the gonadotropin-releasing hormone (GnRH) pulse generator formed by the arcuate nucleus kisspeptin (ARNKISS) neurons. Acute brain slice electrophy

Source
peer_reviewed_research
DOI
10.1210/endocr/bqag034
PubMed
41906629
Open original source
2024Animal research

Intraperitoneal administration of kisspeptin-10 modulates follicle maturation, gonadal steroids, calcium and metabolites in Sterlet sturgeon, Acipenser ruthenus.

Content-verified record concerning Kisspeptin: "Intraperitoneal administration of kisspeptin-10 modulates follicle maturation, gonadal steroids, calcium and metabolites in Sterlet sturgeon, Acipenser ruthenus." Abstract excerpt: Kisspeptin is a multifunctional neurohormone, primarily involved in the regulation of reproduction. We tested whether peripheral administration of kisspeptin10 (KP-10) via intraperitoneal injection or slow release affects reproductive hormones and metabolites in Sterlet sturgeon (Acipenser ruthenus). Plasma and mucus 17&#x3b2;-estradiol (E 2 ), and testosterone (T), plasma and follicular vitelloge

Source
peer_reviewed_research
DOI
10.1016/j.cbpa.2024.111609
PubMed
38401763
Open original source
2025Animal research

Estrogen-Regulated Lateral Septal Kisspeptin Neurons Abundantly Project to GnRH Neurons and the Hypothalamic Supramammillary Nucleus.

Content-verified record concerning Kisspeptin: "Estrogen-Regulated Lateral Septal Kisspeptin Neurons Abundantly Project to GnRH Neurons and the Hypothalamic Supramammillary Nucleus." Abstract excerpt: While hypothalamic kisspeptin (KP) neurons play well-established roles in the estrogen-dependent regulation of reproduction, little is known about extrahypothalamic KP-producing (KP LS ) neurons of the lateral septum. As established previously, Kiss1 expression in this region is low and regulated by estrogen receptor- and GABA B receptor-dependent mechanisms. Our present experiments on Kiss1-Cre/Z

Source
peer_reviewed_research
DOI
10.1523/jneurosci.1307-24.2024
PubMed
39746822
Open original source
2025Animal research

Existence of Coexpressive Role of Kisspeptin and Insulin-2 in the Regulation of Luteinizing Hormone in Chronic Stress-Induced Polycystic Ovarian Syndrome-Like Phenotype in Rattus norvegicus.

Content-verified record concerning Kisspeptin: "Existence of Coexpressive Role of Kisspeptin and Insulin-2 in the Regulation of Luteinizing Hormone in Chronic Stress-Induced Polycystic Ovarian Syndrome-Like Phenotype in Rattus norvegicus." Abstract excerpt: Polycystic ovary syndrome (PCOS) is an ill manifestation of the normal ovarian function that obstructs folliculogenesis. Clinically, patients diagnosed with PCOS possess chronic psychological distress with the downregulated hypothalamus-pituitary-gonadal (HPG) axis under the influence of cortisol, but, in contrast, studies done elsewhere have demonstrated an increased hypothalamus-pituitary activi

Source
peer_reviewed_research
DOI
10.1159/000546126
PubMed
40288358
Open original source
2025Animal research

Critical role of arcuate nucleus kisspeptin and Kiss1R in regulation of the ovine luteinizing hormone surge.

Content-verified record concerning Kisspeptin: "Critical role of arcuate nucleus kisspeptin and Kiss1R in regulation of the ovine luteinizing hormone surge." Abstract excerpt: Hypothalamic kisspeptin (Kiss), neurokinin B (NKB), and dynorphin-containing (KNDy) neurons in the arcuate nucleus (ARC) have consistently been shown to be the central generator of gonadotropin-releasing hormone (GnRH) and corresponding luteinizing hormone (LH) pulses in mammals and possibly contribute to surge secretion as well. Additionally, recent evidence from experiments in sheep suggests tha

Source
peer_reviewed_research
DOI
10.1111/jne.70010
PubMed
40033679
Open original source
2026Animal research

Phase-dependent changes in serum kisspeptin and irisin levels across the menstrual cycle in healthy women.

Content-verified record concerning Kisspeptin: "Phase-dependent changes in serum kisspeptin and irisin levels across the menstrual cycle in healthy women." Abstract excerpt: The menstrual cycle is a complex biological process regulated by the hypothalamic-pituitary-ovarian axis, resulting in cyclical hormonal changes that affect various physiological systems. Irisin, a myokine linked to energy metabolism, and kisspeptin, a key regulator of gonadotropin-releasing hormone (GnRH) secretion, are emerging as essential modulators of reproductive function. This study evaluat

Source
peer_reviewed_research
DOI
10.1007/s40618-025-02716-z
PubMed
41042501
Open original source
2026Animal research

Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography-High-Resolution Mass Spectrometry for Doping Control Purposes.

Content-verified record concerning Kisspeptin: "Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography-High-Resolution Mass Spectrometry for Doping Control Purposes." Abstract excerpt: The use of testosterone-stimulating peptides for doping purposes is prohibited for male athletes by the World Anti-Doping Agency (WADA). Among these substances is kisspeptin (KP-54), its isoforms (KP-14, KP-13, and KP-10), and synthetic receptor agonists such as TAK-448. Thus, they have been included in the WADA Prohibited List in 2024. To enable effective detection of kisspeptin misuse, reliable

Source
peer_reviewed_research
DOI
10.1002/dta.70081
PubMed
42057309
Open original source
2010Animal research

Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat

Content-verified record concerning Kisspeptin: "Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat" Abstract excerpt: Gonadotropin-releasing hormone (GnRH) neurons in the basal forebrain are the final common pathway through which the brain regulates reproduction. GnRH secretion occurs in a pulsatile manner, and indirect evidence suggests the kisspeptin neurons in the arcuate nucleus (ARC) serve as the central pacemaker that drives pulsatile GnRH secretion. The purpose of this study was to investigate the possible

Source
peer_reviewed_research
DOI
10.1523/jneurosci.5848-09.2010
PubMed
20181609
Open original source
2025Animal research

Administration of Exogenous Kisspeptin Induces Breeding Competence in Post-pubertal Female Common Carp (Cyprinus carpio).

Content-verified record concerning Kisspeptin: "Administration of Exogenous Kisspeptin Induces Breeding Competence in Post-pubertal Female Common Carp (Cyprinus carpio)." Abstract excerpt: Puberty is a crucial stage in vertebrates, controlled by complex neuroendocrine mechanisms, yet its precise pathways remain unclear. Kisspeptin and melatonin are central to this regulation, acting as opposing forces: kisspeptin activates the hypothalamic-pituitary-gonadal (HPG) axis, while melatonin suppresses it. Serotonin also influences GnRH secretion. Despite advancements, identifying novel ho

Source
peer_reviewed_research
DOI
10.1002/mrd.70037
PubMed
40552678
Open original source
2009Animal research

Molecular Evolution of Multiple Forms of Kisspeptins and GPR54 Receptors in Vertebrates

Content-verified record concerning Kisspeptin: "Molecular Evolution of Multiple Forms of Kisspeptins and GPR54 Receptors in Vertebrates" Abstract excerpt: Kisspeptin and its receptor GPR54 play important roles in mammalian reproduction and cancer metastasis. Because the KiSS and GPR54 genes have been identified in a limited number of vertebrate species, mainly in mammals, the evolutionary history of these genes is poorly understood. In the present study, we have cloned multiple forms of kisspeptin and GPR54 cDNAs from a variety of vertebrate species

Source
peer_reviewed_research
DOI
10.1210/en.2008-1679
PubMed
19164475
Open original source
2023Animal research

Conditional Oprk1-dependent Kiss1 deletion in kisspeptin neurons caused estrogen-dependent LH pulse disruption and LH surge attenuation in female rats.

Content-verified record concerning Kisspeptin: "Conditional Oprk1-dependent Kiss1 deletion in kisspeptin neurons caused estrogen-dependent LH pulse disruption and LH surge attenuation in female rats." Abstract excerpt: The gonadotropin-releasing hormone (GnRH) pulse and surge are considered to be generated by arcuate kisspeptin/neurokinin B/dynorphin A (KNDy) neurons and anteroventral periventricular nucleus (AVPV) kisspeptin neurons, respectively, in female rodents. The majority of KNDy and AVPV kisspeptin neurons express &#x3ba;-opioid receptors (KORs, encoded by Oprk1) in female rodents. Thus, this study aime

Source
peer_reviewed_research
DOI
10.1038/s41598-023-47222-5
PubMed
37993510
Open original source
2022Animal research

Invited review: Translating kisspeptin and neurokinin B biology into new therapies for reproductive health.

Content-verified record concerning Kisspeptin: "Invited review: Translating kisspeptin and neurokinin B biology into new therapies for reproductive health." Abstract excerpt: The reproductive neuropeptide kisspeptin has emerged as the master regulator of mammalian reproduction due to its key roles in the initiation of puberty and the control of fertility. Alongside the tachykinin neurokinin B and the endogenous opioid dynorphin, these peptides are central to the hormonal control of reproduction. Building on the expanding body of experimental animal models, interest has

Source
peer_reviewed_research
DOI
10.1111/jne.13201
PubMed
36262016
Open original source
2011Animal research

Comparative insights of the kisspeptin/kisspeptin receptor system: Lessons from non-mammalian vertebrates

Content-verified record concerning Kisspeptin: "Comparative insights of the kisspeptin/kisspeptin receptor system: Lessons from non-mammalian vertebrates" Abstract excerpt: Kisspeptins, the peptide products of the Kiss1 gene, were initially identified in mammals as ligands of the G protein-coupled receptor 54 (GPR54; also termed Kiss1R) with ability to suppress tumor metastasis. In late 2003, the indispensable role of kisspeptins in the control of reproductive function was disclosed by the seminal observations that humans and mice carrying inactivating mutations of G

Source
peer_reviewed_research
DOI
10.1016/j.ygcen.2011.11.015
PubMed
22137912
Open original source
2024Animal research

Chronic Nasal Administration of Kisspeptin-54 Regulates Mood-Related Disorders Via Amygdaloid GABA in Hemi-Parkinsonian Rats

Content-verified record concerning Kisspeptin: "Chronic Nasal Administration of Kisspeptin-54 Regulates Mood-Related Disorders Via Amygdaloid GABA in Hemi-Parkinsonian Rats" Abstract excerpt: Depression and anxiety, the most prevalent neuropsychiatric manifestations in Parkinson&#x2019;s disease (PD), negatively impact their quality of life. To determine whether the chronic nasal administration of kisspeptin-54 (KP-54) could. Alleviate symptoms of anxiety and depression in hemi-Parkinsonian rats. Experimental study. This study included adult Sprague Dawley male rats who were administer

Source
peer_reviewed_research
DOI
10.4274/balkanmedj.galenos.2024.2024-7-46
PubMed
39319821
Open original source
2024Animal research

Spatial local expressions of kisspeptin in the uterus and uterine tubes and its relationship to the reproductive potential in goats.

Content-verified record concerning Kisspeptin: "Spatial local expressions of kisspeptin in the uterus and uterine tubes and its relationship to the reproductive potential in goats." Abstract excerpt: Kisspeptins are neuropeptides encoded by the Kiss1 gene that was discovered as a metastasis suppressor gene in melanoma and breast cancer. Kisspeptin has pivotal functions for gonadotropin-releasing hormone secretion and plays integrated roles in the hypothalamic-pituitary-gonadal axis. However, little is known about the peripheral expression of kisspeptin in ruminants, especially in the female re

Source
peer_reviewed_research
DOI
10.1016/j.domaniend.2024.106850
PubMed
38640803
Open original source
2007Animal research

Kisspeptin Is Present in Ovine Hypophysial Portal Blood But Does Not Increase during the Preovulatory Luteinizing Hormone Surge: Evidence that Gonadotropes Are Not Direct Targets of Kisspeptin in Vivo

Content-verified record concerning Kisspeptin: "Kisspeptin Is Present in Ovine Hypophysial Portal Blood But Does Not Increase during the Preovulatory Luteinizing Hormone Surge: Evidence that Gonadotropes Are Not Direct Targets of Kisspeptin in Vivo" Abstract excerpt: There is strong evidence that kisspeptin acts to regulate GnRH secretion, but whether there is also a component of action on the gonadotropes is not clear. Using quantitative RT-PCR, we found that G protein-coupled receptor-54 mRNA is expressed in ovine pituitary cell fractions enriched for gonadotropes as well as in somatotropes and lactotropes. To test whether kisspeptin acts directly on the pit

Source
peer_reviewed_research
DOI
10.1210/en.2007-1425
PubMed
18162520
Open original source
2025Animal research

Hypothyroidism Alters Uterine Kisspeptin System and Activity Modulators in Cyclic Rats.

Content-verified record concerning Kisspeptin: "Hypothyroidism Alters Uterine Kisspeptin System and Activity Modulators in Cyclic Rats." Abstract excerpt: Hypothyroidism causes ovarian dysfunction and infertility in women and animals and impairs the hypothalamic expression of kisspeptin (Kp). However, kisspeptin is also expressed in the genital system, and the lack of the Kp receptor (Kiss1r) in the uterus is linked to reduced implantation rates. This study investigated the impact of hypothyroidism on the uterine expression of Kp and Kiss1r in femal

Source
peer_reviewed_research
DOI
10.3390/ijms26020543
PubMed
39859259
Open original source
2022Animal research

Novel therapeutic avenues for kisspeptin.

Content-verified record concerning Kisspeptin: "Novel therapeutic avenues for kisspeptin." Abstract excerpt: Kisspeptin is a hypothalamic neuropeptide that acts via the hypothalamus to stimulate hypothalamic gonadotrophin-releasing hormone secretion and downstream gonadotrophin release. In health, kisspeptin induces normal puberty and modulates ovulation in healthy women. Hypothalamic kisspeptin expression is reduced in several functional reproductive disorders; thus, treating such conditions with kisspe

Source
peer_reviewed_research
DOI
10.1016/j.coph.2022.102319
PubMed
36413854
Open original source
2004Animal research

Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat

Content-verified record concerning Kisspeptin: "Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat" Abstract excerpt: The KiSS-1 gene codes for a family of neuropeptides called kisspeptins which bind to the G-protein-coupled receptor GPR54. To assess the possible effects of kisspeptins on gonadotropin secretion, we injected kisspeptin-52 into the lateral cerebral ventricles of adult male rats and found that kisspeptin-52 increased the serum levels of luteinizing hormone (p &lt; 0.05). To determine whether the kis

Source
peer_reviewed_research
DOI
10.1159/000083140
PubMed
15665556
Open original source
2025Laboratory research

Kisspeptin and neurokinin B: roles in reproductive health.

Content-verified record concerning Kisspeptin: "Kisspeptin and neurokinin B: roles in reproductive health." Abstract excerpt: Kisspeptin and neurokinin B (NKB) play a key role in several physiological processes including in puberty, adult reproductive function including the menstrual cycle, as well as mediating the symptoms of menopause. Infundibular kisspeptin neurons, which coexpress NKB, regulate the activity of gonadotropin-releasing hormone (GnRH) neurons and thus the physiological pulsatile secretion of GnRH from t

Source
peer_reviewed_research
DOI
10.1152/physrev.00015.2024
PubMed
39813600
Open original source
2010Laboratory research

Kisspeptin Cells in the Ewe Brain Respond to Leptin and Communicate with Neuropeptide Y and Proopiomelanocortin Cells

Content-verified record concerning Kisspeptin: "Kisspeptin Cells in the Ewe Brain Respond to Leptin and Communicate with Neuropeptide Y and Proopiomelanocortin Cells" Abstract excerpt: Kisspeptin stimulates reproduction, and kisspeptin cells in the arcuate nucleus (ARC) express Ob-Rb in the mouse. Herein we report studies in ewes to determine whether kisspeptin cells express Ob-Rb and respond to leptin and whether reciprocal connections exist between kisspeptin cells and proopiomelanocortin (POMC) or neuropeptide Y (NPY) cells to modulate reproduction and metabolic function. Kis

Source
peer_reviewed_research
DOI
10.1210/en.2009-1190
PubMed
20207832
Open original source
2018Laboratory research

Kisspeptin/Kisspeptin Receptor System in the Ovary

Content-verified record concerning Kisspeptin: "Kisspeptin/Kisspeptin Receptor System in the Ovary" Abstract excerpt: Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating ovulation in sexually mature females via the central control of the hypothalamic-pituitary-gonadal axis. Recent studies have shown that kisspeptin and its receptor kisspeptin receptor (KISS1R) are expressed in the mammalian ovary. Convincing evidence indicates that kisspeptins can activate a wide vari

Source
peer_reviewed_research
DOI
10.3389/fendo.2017.00365
PubMed
29354093
Open original source
2010Laboratory research

Kisspeptin Directly Excites Anorexigenic Proopiomelanocortin Neurons but Inhibits Orexigenic Neuropeptide Y Cells by an Indirect Synaptic Mechanism

Content-verified record concerning Kisspeptin: "Kisspeptin Directly Excites Anorexigenic Proopiomelanocortin Neurons but Inhibits Orexigenic Neuropeptide Y Cells by an Indirect Synaptic Mechanism" Abstract excerpt: The neuropeptide kisspeptin is necessary for reproduction, fertility, and puberty. Here, we show strong kisspeptin innervation of hypothalamic anorexigenic proopiomelanocortin (POMC) cells, coupled with a robust direct excitatory response by POMC neurons (n &gt; 200) to kisspeptin, mediated by mechanisms based on activation of a sodium/calcium exchanger and possibly opening of nonselective cation

Source
peer_reviewed_research
DOI
10.1523/jneurosci.2098-10.2010
PubMed
20668204
Open original source
2009Laboratory research

Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines

Content-verified record concerning Kisspeptin: "Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines" Abstract excerpt: Kisspeptins, and their G-protein coupled receptor 54 (GPR54), are key components in the regulation of gonadotropin-releasing hormone (GnRH) secretion in humans and other mammals. Several studies demonstrate that the central or systemic administration of kisspeptin increases GnRH and gonadotropin secretion in both prepubertal and adult animals; however, the cellular targets and intracellular mechan

Source
peer_reviewed_research
DOI
10.1016/j.mce.2009.06.011
PubMed
19576263
Open original source
2008Laboratory research

Kisspeptin Depolarizes Gonadotropin-Releasing Hormone Neurons through Activation of TRPC-Like Cationic Channels

Content-verified record concerning Kisspeptin: "Kisspeptin Depolarizes Gonadotropin-Releasing Hormone Neurons through Activation of TRPC-Like Cationic Channels" Abstract excerpt: Kisspeptin and its cognate receptor, GPR54, are critical for reproductive development and for the regulation of gonadotropin-releasing hormone (GnRH) secretion. Although kisspeptin has been found to depolarize GnRH neurons, the underlying ionic mechanism has not been elucidated. Presently, we found that kisspeptin depolarized GnRH neurons in a concentration-dependent manner with a maximum depolari

Source
peer_reviewed_research
DOI
10.1523/jneurosci.5352-07.2008
PubMed
18434521
Open original source
2006Laboratory research

Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha

Content-verified record concerning Kisspeptin: "Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha" Abstract excerpt: Kisspeptins are peptide ligands of the G protein-coupled receptor GPR54, recently shown to be essential to reproductive function. We have raised specific rabbit antisera against a highly conserved 10 amino acid-amidated peptide (kp10) common to all kisspeptin isoforms isolated so far and mapped the distribution of kp10-immunoreactive (ir) cells in the ovine hypothalamus. Kp10-ir cells were predomi

Source
peer_reviewed_research
DOI
10.1016/j.neulet.2006.03.039
PubMed
16621281
Open original source
2005Laboratory research

Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54

Content-verified record concerning Kisspeptin: "Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54" Abstract excerpt: We have recently described a molecular gatekeeper of the hypothalamic-pituitary-gonadal axis with the observation that G protein-coupled receptor 54 (GPR54) is required in mice and men for the pubertal onset of pulsatile luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion to occur. In the present study, we investigate the possible central mode of action of GPR54 and kisspepti

Source
peer_reviewed_research
DOI
10.1073/pnas.0409330102
PubMed
15665093
Open original source
2026Laboratory research

Kisspeptin-10 regulates glycosaminoglycan and decorin content in human cardiac fibroblast cultures.

Content-verified record concerning Kisspeptin: "Kisspeptin-10 regulates glycosaminoglycan and decorin content in human cardiac fibroblast cultures." Abstract excerpt: Cardiac fibroblasts play a key role in extracellular matrix (ECM) remodelling through the synthesis of glycosaminoglycans and proteoglycans (PGs), such as decorin; however, the effects of kisspeptin-10 (KiSS-10) on these components in the heart remain unknown. The aim of this study was to determine the influence of KiSS-10 on glycosaminoglycan and decorin content in human cardiac fibroblast cultur

Source
peer_reviewed_research
DOI
10.1007/s43440-026-00870-6
PubMed
42159865
Open original source
2012Laboratory research

Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms

Content-verified record concerning Kisspeptin: "Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms" Abstract excerpt: Procreation is essential for survival of species. Not surprisingly, complex neuronal networks have evolved to mediate the diverse internal and external environmental inputs that regulate reproduction in vertebrates. Ultimately, these regulatory factors impinge, directly or indirectly, on a final common pathway, the neurons producing the gonadotropin-releasing hormone (GnRH), which stimulates pitui

Source
peer_reviewed_research
DOI
10.1152/physrev.00037.2010
PubMed
22811428
Open original source
2005Laboratory research

Kisspeptin-10-Induced Signaling of GPR54 Negatively Regulates Chemotactic Responses Mediated by CXCR4: a Potential Mechanism for the Metastasis Suppressor Activity of Kisspeptins

Content-verified record concerning Kisspeptin: "Kisspeptin-10-Induced Signaling of GPR54 Negatively Regulates Chemotactic Responses Mediated by CXCR4: a Potential Mechanism for the Metastasis Suppressor Activity of Kisspeptins" Abstract excerpt: The product of the KiSS-1 gene is absent or expressed at low level in metastatic melanoma and breast cancer compared with their nonmetastatic counterparts. A polypeptide derived from the KiSS-1 product, designated kisspeptin-10 (Kp-10), activates a receptor coupled to Galphaq subunits (GPR54 or KiSS-1R). To study the mechanism by which Kp-10 antagonizes metastatic spread, the effect on CXCR4-media

Source
peer_reviewed_research
DOI
10.1158/0008-5472.can-05-1757
PubMed
16288036
Open original source
2009Laboratory research

The Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cell Population of the Arcuate Nucleus: Sex Differences and Effects of Prenatal Testosterone in Sheep

Content-verified record concerning Kisspeptin: "The Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cell Population of the Arcuate Nucleus: Sex Differences and Effects of Prenatal Testosterone in Sheep" Abstract excerpt: Recent work in sheep has identified a neuronal subpopulation in the arcuate nucleus that coexpresses kisspeptin, neurokinin B, and dynorphin (referred to here as KNDy cells) and that mediate the negative feedback influence of progesterone on GnRH secretion. We hypothesized that sex differences in progesterone negative feedback are due to sexual dimorphism of KNDy cells and compared neuropeptide an

Source
peer_reviewed_research
DOI
10.1210/en.2009-0541
PubMed
19880810
Open original source
2007Laboratory research

The Kisspeptin Receptor GPR54 Is Required for Sexual Differentiation of the Brain and Behavior

Content-verified record concerning Kisspeptin: "The Kisspeptin Receptor GPR54 Is Required for Sexual Differentiation of the Brain and Behavior" Abstract excerpt: GPR54 is a G-protein-coupled receptor, which binds kisspeptins and is widely expressed throughout the brain. Kisspeptin-GPR54 signaling has been implicated in the regulation of pubertal and adulthood gonadotropin-releasing hormone (GnRH) secretion, and mutations or deletions of GPR54 cause hypogonadotropic hypogonadism in humans and mice. Other reproductive roles for kisspeptin-GPR54 signaling, in

Source
peer_reviewed_research
DOI
10.1523/jneurosci.2099-07.2007
PubMed
17699664
Open original source
2025Laboratory research

Serum kisspeptin is higher in hypertensive than non-hypertensive female subjects and positively correlated with systolic blood pressure.

Content-verified record concerning Kisspeptin: "Serum kisspeptin is higher in hypertensive than non-hypertensive female subjects and positively correlated with systolic blood pressure." Abstract excerpt: Kisspeptin has a major role in reproductive regulation. Furthermore, it is also involved in metabolic and cardiovascular regulation as well as is a potent vasoconstrictor. This study aimed to: 1) determine correlations between serum kisspeptin levels with obesity/metabolic parameters; 2) compare parameters between non-hypertensive ([non-HT] N.=15) and hypertensive ([HT] N.=15) female subjects; and

Source
peer_reviewed_research
DOI
10.23736/s2724-6507.22.03766-6
PubMed
37733292
Open original source
2022Laboratory research

The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction.

Content-verified record concerning Kisspeptin: "The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction." Abstract excerpt: The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given people a novel understanding of the neuroendocrine regulation in human reproduction. Kisspeptin activates the signaling pathway by binding to its receptor kisspeptin receptor (KISS1R) to promote GnRH secretion, thereby regulating the hypothalamic-pituitary-gonadal axis (HPG) axis. Recent studies have show

Source
peer_reviewed_research
DOI
10.3389/fendo.2022.925206
PubMed
35837314
Open original source
2010Laboratory research

Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion

Content-verified record concerning Kisspeptin: "Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion" Abstract excerpt: Recently, a subset of neurons was identified in the arcuate nucleus of the hypothalamus that colocalize three neuropeptides, kisspeptin, neurokinin B, and dynorphin, each of which has been shown to play a critical role in the central control of reproduction. Growing evidence suggests that these neurons, abbreviated as the KNDy subpopulation, are strongly conserved across a range of species from ro

Source
peer_reviewed_research
DOI
10.1210/en.2010-0022
PubMed
20501670
Open original source
2013Laboratory research

Expression of Kisspeptins and Kiss Receptors Suggests a Large Range of Functions for Kisspeptin Systems in the Brain of the European Sea Bass

Content-verified record concerning Kisspeptin: "Expression of Kisspeptins and Kiss Receptors Suggests a Large Range of Functions for Kisspeptin Systems in the Brain of the European Sea Bass" Abstract excerpt: This study, conducted in the brain of a perciform fish, the European sea bass, aimed at raising antibodies against the precursor of the kisspeptins in order to map the kiss systems and to correlate the expression of kisspeptins, kiss1 and kiss2, with that of kisspeptin receptors (kiss-R1 and kiss-R2). Specific antibodies could be raised against the preprokiss2, but not the preoprokiss1. The data i

Source
peer_reviewed_research
DOI
10.1371/journal.pone.0070177
PubMed
23894610
Open original source
2025Laboratory research

Activity of arcuate kisspeptin/neurokinin B neurons and the melanocortin system during pubertal development in female sheep†.

Content-verified record concerning Kisspeptin: "Activity of arcuate kisspeptin/neurokinin B neurons and the melanocortin system during pubertal development in female sheep†." Abstract excerpt: The increase in luteinizing hormone (LH) that elicits puberty in many species results from a decrease in sensitivity to estradiol (E2) negative feedback. The neural mechanisms underlying this change are unknown, but do not occur at the gonadotropin-releasing hormone neurons as they lack estrogen receptor alpha (ERalpha). A potentially important area is the arcuate nucleus of the hypothalamus, wher

Source
peer_reviewed_research
DOI
10.1093/biolre/ioaf074
PubMed
40156104
Open original source
2023Laboratory research

Correlation between kisspeptin and biochemical markers in obese and non-obese women with polycystic ovary syndrome.

Content-verified record concerning Kisspeptin: "Correlation between kisspeptin and biochemical markers in obese and non-obese women with polycystic ovary syndrome." Abstract excerpt: Introduction The purpose of this study was to determine the association between kisspeptin levels and obesity in patients with polycystic ovary syndrome (PCOS) or in healthy controls and to explore the correlation between levels of kisspeptin and various endocrine and metabolic indices in each group. Methods From August 2020 to December 2021, the clinical data of 78 patients with polycystic ovary

Source
peer_reviewed_research
DOI
10.1080/09513590.2023.2215869
PubMed
37236245
Open original source
2016Laboratory research

The localization of kisspeptin and kisspeptin receptor in the canine ovary during different stages of the reproductive cycle

Content-verified record concerning Kisspeptin: "The localization of kisspeptin and kisspeptin receptor in the canine ovary during different stages of the reproductive cycle" Abstract excerpt: Kisspeptin is a neuropeptide involved in the hypothalamic regulation of reproduction in many species. Recent studies have revealed kisspeptin within the ovaries of rats, Siberian hamsters and humans, indicating a local role in reproduction. However, the role of kisspeptin in the ovary is poorly understood in the bitch. This study investigated the presence and location of kisspeptin protein (KISS1)

Source
peer_reviewed_research
DOI
10.1111/rda.12841
PubMed
27774658
Open original source
2009Laboratory research

Discovery of Potent Kisspeptin Antagonists Delineate Physiological Mechanisms of Gonadotropin Regulation

Content-verified record concerning Kisspeptin: "Discovery of Potent Kisspeptin Antagonists Delineate Physiological Mechanisms of Gonadotropin Regulation" Abstract excerpt: Neurons that produce gonadotropin-releasing hormone (GnRH) are the final common pathway by which the brain regulates reproduction. GnRH neurons are regulated by an afferent network of kisspeptin-producing neurons. Kisspeptin binds to its cognate receptor on GnRH neurons and stimulates their activity, which in turn provides an obligatory signal for GnRH secretion, thus gating down-stream events sup

Source
peer_reviewed_research
DOI
10.1523/jneurosci.5740-08.2009
PubMed
19321788
Open original source
2025Laboratory research

The Investigation of Kisspeptin, Spexin and Galanin in Euthyroid Women with Hashimoto's Thyroiditis.

Content-verified record concerning Kisspeptin: "The Investigation of Kisspeptin, Spexin and Galanin in Euthyroid Women with Hashimoto's Thyroiditis." Abstract excerpt: The hallmarks of Hashimoto's thyroiditis (HT) include the destruction of thyroid cells by leading to insulin resistance (IR), hypothyroidism, and metabolic abnormalities. Kisspeptin, spexin, and galanin control appetite and body weight (BW) to regulate metabolisms. Here, we sought to determine if galanin, kisspeptin, and spexin are linked to the pathophysiology of HT in euthyroid female individual

Source
peer_reviewed_research
DOI
10.1080/07435800.2024.2384576
PubMed
39056111
Open original source
2018Laboratory research

Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation

Content-verified record concerning Kisspeptin: "Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation" Abstract excerpt: Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regulators of the mammalian reproductive axis. Accumulating evidence has shown that kisspeptin is able to control both the pulsatile and surge GnRH release, playing fundamental roles in female reproduction, which include the secretion of gonadotropins, puberty onset,

Source
peer_reviewed_research
DOI
10.1093/humupd/dmy046
PubMed
30649364
Open original source
2010Laboratory research

Molecular coevolution of kisspeptins and their receptors from fish to mammals

Content-verified record concerning Kisspeptin: "Molecular coevolution of kisspeptins and their receptors from fish to mammals" Abstract excerpt: Kisspeptin and its receptor, GPR54, play a pivotal role in vertebrate reproduction. Recent advances in bioinformatic tools combined with comparative genomics have led to the identification of a large number of kisspeptin and GPR54 genes in a variety of vertebrate species. Genome duplications may have produced at least two isoforms of both ligand (KiSS1 and KiSS2) and receptor (GPR54-1 and GPR54-2)

Source
peer_reviewed_research
DOI
10.1111/j.1749-6632.2010.05508.x
PubMed
20633134
Open original source
2025Laboratory research

Dysregulated serum levels of kisspeptin, NKB, GABA in women with polycystic ovary syndrome and their association with hormonal profiles.

Content-verified record concerning Kisspeptin: "Dysregulated serum levels of kisspeptin, NKB, GABA in women with polycystic ovary syndrome and their association with hormonal profiles." Abstract excerpt: The clinical study aimed to evaluate the levels of serum kisspeptin, NKB, and GABA in Chinese patients with polycystic ovary syndrome (PCOS) and explore their association with hormonal profiles, as well as the relationship between these levels in PCOS patients and controls. From December 2022 to December 2023, medical records of 60 individuals diagnosed with PCOS and 32 healthy subjects were obtai

Source
peer_reviewed_research
DOI
10.1080/09513590.2025.2463533
PubMed
39932739
Open original source
2014Laboratory research

MOLECULAR EVOLUTION OF GPCRS: Kisspeptin/kisspeptin receptors

Content-verified record concerning Kisspeptin: "MOLECULAR EVOLUTION OF GPCRS: Kisspeptin/kisspeptin receptors" Abstract excerpt: Following the discovery of kisspeptin (Kiss) and its receptor (GPR54 or KissR) in mammals, phylogenetic studies revealed up to three Kiss and four KissR paralogous genes in other vertebrates. The multiplicity of Kiss and KissR types in vertebrates probably originated from the two rounds of whole-genome duplication (1R and 2R) that occurred in early vertebrates. This review examines compelling rece

Source
peer_reviewed_research
DOI
10.1530/jme-13-0224
PubMed
24577719
Open original source
2014Laboratory research

Coevolution of the Spexin/Galanin/Kisspeptin Family: Spexin Activates Galanin Receptor Type II and III

Content-verified record concerning Kisspeptin: "Coevolution of the Spexin/Galanin/Kisspeptin Family: Spexin Activates Galanin Receptor Type II and III" Abstract excerpt: The novel neuropeptide spexin (SPX) was discovered using bioinformatics. The function of this peptide is currently under investigation. Here, we identified SPX along with a second SPX gene (SPX2) in vertebrate genomes. Syntenic analysis and relocating SPXs and their neighbor genes on reconstructed vertebrate ancestral chromosomes revealed that SPXs reside in the near vicinity of the kisspeptin (KI

Source
peer_reviewed_research
DOI
10.1210/en.2013-2106
PubMed
24517231
Open original source
2009Laboratory research

Postnatal Development of an Estradiol-Kisspeptin Positive Feedback Mechanism Implicated in Puberty Onset

Content-verified record concerning Kisspeptin: "Postnatal Development of an Estradiol-Kisspeptin Positive Feedback Mechanism Implicated in Puberty Onset" Abstract excerpt: The regulation of GnRH neurons by kisspeptin is critical for normal puberty onset in mammals. In the rodent the kisspeptin neurons innervating GnRH neurons are thought to reside in the rostral periventricular area of the third ventricle (RP3V). Using kisspeptin immunocytochemistry we show that kisspeptin peptide expression in the RP3V of female mice begins around postnatal d 15 (P15) and rapidly i

Source
peer_reviewed_research
DOI
10.1210/en.2008-1733
PubMed
19299459
Open original source
2024Laboratory research

Chronic inflammation decreases arcuate kisspeptin expression in male sheep.

Content-verified record concerning Kisspeptin: "Chronic inflammation decreases arcuate kisspeptin expression in male sheep." Abstract excerpt: Lipopolysaccharide (LPS) from Gram-negative bacteria induces an immune response and impairs reproduction through suppression of gonadotropin releasing hormone (GnRH), subsequently luteinizing hormone (LH) secretion. While there is evidence that acute inflammation inhibits kisspeptin, little is known about the impact of chronic inflammation on this key reproductive neuropeptide in livestock species

Source
peer_reviewed_research
DOI
10.1016/j.domaniend.2024.106868
PubMed
38901139
Open original source
2016Laboratory research

Phoenixin Activates Immortalized GnRH and Kisspeptin Neurons Through the Novel Receptor GPR173

Content-verified record concerning Kisspeptin: "Phoenixin Activates Immortalized GnRH and Kisspeptin Neurons Through the Novel Receptor GPR173" Abstract excerpt: Reproductive function is coordinated by kisspeptin (Kiss) and GnRH neurons. Phoenixin-20 amide (PNX) is a recently described peptide found to increase GnRH-stimulated LH secretion in the pituitary. However, the effects of PNX in the hypothalamus, the putative signaling pathways, and PNX receptor have yet to be identified. The mHypoA-GnRH/GFP and mHypoA-Kiss/GFP-3 cell lines represent populations o

Source
peer_reviewed_research
DOI
10.1210/me.2016-1039
PubMed
27268078
Open original source
2001Laboratory research

The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54

Content-verified record concerning Kisspeptin: "The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54" Abstract excerpt: Natural peptides displaying agonist activity on the orphan G protein-coupled receptor GPR54 were isolated from human placenta. These 54-, 14,- and 13-amino acid peptides, with a common RF-amide C terminus, derive from the product of KiSS-1, a metastasis suppressor gene for melanoma cells, and were therefore designated kisspeptins. They bound with low nanomolar affinities to rat and human GPR54 exp

Source
peer_reviewed_research
DOI
10.1074/jbc.m104847200
PubMed
11457843
Open original source
2012Laboratory research

RFamide-Related Peptide-3 Receptor Gene Expression in GnRH and Kisspeptin Neurons and GnRH-Dependent Mechanism of Action

Content-verified record concerning Kisspeptin: "RFamide-Related Peptide-3 Receptor Gene Expression in GnRH and Kisspeptin Neurons and GnRH-Dependent Mechanism of Action" Abstract excerpt: RFamide-related peptide-3 (RFRP-3) is known to inhibit the activity of GnRH neurons. It is not yet clear whether its G protein-coupled receptors, GPR147 and GPR74, are present on GnRH neurons or on afferent inputs of the GnRH neuronal network or whether RFRP-3 can inhibit gonadotropin secretion independently of GnRH. We tested the following: 1) whether GnRH is essential for the effects of RFRP-3 o

Source
peer_reviewed_research
DOI
10.1210/en.2012-1133
PubMed
22691552
Open original source
2012Laboratory research

Seasonal Variation in the Gonadotropin-Releasing Hormone Response to Kisspeptin in Sheep: Possible Kisspeptin Regulation of the Kisspeptin Receptor

Content-verified record concerning Kisspeptin: "Seasonal Variation in the Gonadotropin-Releasing Hormone Response to Kisspeptin in Sheep: Possible Kisspeptin Regulation of the Kisspeptin Receptor" Abstract excerpt: Kisspeptin signaling in the hypothalamus appears critical for the onset of puberty and driving the reproductive axis. In sheep, reproduction is seasonal, being activated by short days and inhibited by long days. During the non-breeding (anestrous) season, gonadotropin-releasing hormone (GnRH) and gonadotropin secretion is reduced, as is the expression of Kiss1 mRNA in the brain. Conversely, the lu

Source
peer_reviewed_research
DOI
10.1159/000335998
PubMed
22343304
Open original source
2024Laboratory research

Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor.

Content-verified record concerning Kisspeptin: "Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor." Abstract excerpt: Kisspeptin signaling through its G protein-coupled receptor, KISS1R, plays an indispensable role in regulating reproduction via the hypothalamic-pituitary-gonadal axis. Dysregulation of this pathway underlies severe disorders like infertility and precocious puberty. Here, we present cryo-EM structures of KISS1R bound to the endogenous agonist kisspeptin-10 and a synthetic analog TAK-448. These str

Source
peer_reviewed_research
DOI
10.1016/j.celrep.2024.114389
PubMed
38935498
Open original source
2005Laboratory research

Repetitive Activation of Hypothalamic G Protein-Coupled Receptor 54 with Intravenous Pulses of Kisspeptin in the Juvenile Monkey (Macaca mulatta) Elicits a Sustained Train of Gonadotropin-Releasing Hormone Discharges

Content-verified record concerning Kisspeptin: "Repetitive Activation of Hypothalamic G Protein-Coupled Receptor 54 with Intravenous Pulses of Kisspeptin in the Juvenile Monkey (Macaca mulatta) Elicits a Sustained Train of Gonadotropin-Releasing Hormone Discharges" Abstract excerpt: The purpose of the present study was to further examine the hypothesis that activation of G protein-coupled receptor 54 (GPR54) signaling at the end of the juvenile phase of primate development is responsible for initiation of gonadarche and the onset of puberty. Accordingly, we determined whether repetitive iv administration of the GPR54 receptor agonist kisspeptin-10 (2 microg as a brief 1-min i

Source
peer_reviewed_research
DOI
10.1210/en.2005-1261
PubMed
16282350
Open original source
2011Insufficient evidence

Organization of Two Independent Kisspeptin Systems Derived from Evolutionary-Ancient Kiss Genes in the Brain of Zebrafish

Content-verified record concerning Kisspeptin: "Organization of Two Independent Kisspeptin Systems Derived from Evolutionary-Ancient Kiss Genes in the Brain of Zebrafish" Abstract excerpt: Kisspeptins are new actors in the neuroendocrine regulation of reproduction. In vertebrates, the number of kiss genes varies from none to three. Zebrafish have two kiss genes, kiss1 and kiss2, and two kiss receptors (GPR54), kiss1r and kiss2r. To provide detailed information on the organization of the kiss systems in zebrafish, antibodies were raised against the C terminus of zebrafish preproKiss1

Source
peer_reviewed_research
DOI
10.1210/en.2010-0948
PubMed
21325050
Open original source
2013Insufficient evidence

Sex Steroid Regulation of Kisspeptin Circuits

Content-verified record concerning Kisspeptin: "Sex Steroid Regulation of Kisspeptin Circuits" Abstract excerpt: Kisspeptin cells appear to be the "missing link," bridging the divide between levels of gonadal steroids and feedback control of gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin neurons are important in the generation of both sex steroid negative and estrogen positive feedback signals to GnRH neurons, the former being involved in the tonic regulation of GnRH secretion in males and femal

Source
peer_reviewed_research
DOI
10.1007/978-1-4614-6199-9_13
PubMed
23550011
Open original source
2019Insufficient evidence

Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery

Content-verified record concerning Kisspeptin: "Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery" Abstract excerpt: Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role of extra-hypothalamic kisspeptin in reproductive function. Here, we summarize recent advances in our understanding of the physiological significa

Source
peer_reviewed_research
DOI
10.1186/s12958-019-0511-x
PubMed
31399145
Open original source
Insufficient evidence

Effects of chrysin on Kisspeptin, neurokinin B, and dynorphin neurons and &lt;i&gt;gonadotropin-releasing hormone&lt;/i&gt; gene expression in stress-induced rats: An experimental study.

Source reference associated with Kisspeptin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.18502/ijrm.v24i4.21174
PubMed
42312111
Open original source
2011Insufficient evidence

Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility

Content-verified record concerning Kisspeptin: "Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility" Abstract excerpt: The neurohormonal control of reproduction involves a hierarchical network of central and peripheral signals in the hypothalamic-pituitary-gonadal (HPG) axis. Development and function of this neuroendocrine system is the result of a lifelong delicate balance between endogenous regulators and environmental cues, including nutritional and metabolic factors. Kisspeptins are the peptide products of KIS

Source
systematic_review_or_meta_analysis
DOI
10.1038/nrendo.2011.147
PubMed
21912400
Open original source
2026Insufficient evidence

Daily Rhythmic Changes in Kisspeptin Gene Expression and Testosterone Hormone in Male Syrian Hamsters (&lt;i&gt;Mesocricetus auratus&lt;/i&gt;).

Content-verified record concerning Kisspeptin: "Daily Rhythmic Changes in Kisspeptin Gene Expression and Testosterone Hormone in Male Syrian Hamsters (&lt;i&gt;Mesocricetus auratus&lt;/i&gt;)." Abstract excerpt: This study examines how testosterone levels and kisspeptin gene expression are affected in male Syrian hamsters following pinealectomy and photoperiod modification. By examining the rhythmic changes in these parameters under long (16L: 8D) and short (8L: 16D) photoperiods, we aim to elucidate the role of melatonin and photoperiod in regulating seasonal reproductive physiology. One hundred and nine

Source
peer_reviewed_research
DOI
10.2108/zs250118
PubMed
42555223
Open original source
2023Insufficient evidence

Editorial: The versatile kisspeptin: advances in cancer, metabolism, and reproduction.

Content-verified record concerning Kisspeptin: "Editorial: The versatile kisspeptin: advances in cancer, metabolism, and reproduction." (identity confirmed; no abstract text available to excerpt.)

Source
peer_reviewed_research
DOI
10.3389/fendo.2023.1239694
PubMed
37522118
Open original source
2025Insufficient evidence

Anatomic distribution of kisspeptin neurons in the adult sheep amygdala: Associations with sex, estrogen receptor alpha, androgen receptor, and sexual partner preference.

Content-verified record concerning Kisspeptin: "Anatomic distribution of kisspeptin neurons in the adult sheep amygdala: Associations with sex, estrogen receptor alpha, androgen receptor, and sexual partner preference." Abstract excerpt: Kisspeptin neurons are primarily known for regulating reproductive function by stimulating hormone release that controls puberty and fertility. While typically associated with the hypothalamus, recent research suggests their presence in other brain regions, including the amygdala. The amygdala, crucial for emotional processing and social behaviors, consists of various nuclei. However, the specific

Source
peer_reviewed_research
DOI
10.1111/jne.70011
PubMed
40033683
Open original source
2008Insufficient evidence

The neuroanatomy of the kisspeptin system in the mammalian brain

Content-verified record concerning Kisspeptin: "The neuroanatomy of the kisspeptin system in the mammalian brain" Abstract excerpt: The kisspeptin precursor is the protein transcribed from the Kiss-1 gene and the kisspeptins are the peptides that are posttranslationally processed from the precursor. The kisspeptins activate the G-protein coupled receptor GPR54 and are strongly implicated in puberty onset and in regulation of the hypothalamo-pituitary gonadal axis in mammals. Physiological studies have indicated that these effe

Source
peer_reviewed_research
DOI
10.1016/j.peptides.2008.09.004
PubMed
18840491
Open original source
2011Insufficient evidence

Characterization of the kisspeptin system in human spermatozoa

Content-verified record concerning Kisspeptin: "Characterization of the kisspeptin system in human spermatozoa" Abstract excerpt: Kisspeptin, the product of the KISS1 gene, plays an essential role in the regulation of spermatogenesis acting primarily at the hypothalamic level of the gonadotropic axis. However, the presence of kisspeptin and its canonical receptor, KISS1R, in spermatozoa has not been explored nor the direct effects of kisspeptin on sperm function have been studied so far. In the present study, we analysed the

Source
peer_reviewed_research
DOI
10.1111/j.1365-2605.2011.01177.x
PubMed
21651574
Open original source
2020Insufficient evidence

Metabolic regulation of kisspeptin - the link between energy balance and reproduction.

Content-verified record concerning Kisspeptin: "Metabolic regulation of kisspeptin - the link between energy balance and reproduction." Abstract excerpt: Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive function. These neurons are subjected to a plethora of regulatory factors that ultimately affect the release of kisspeptin, which modulates gonadotropin-releasing hormone (GnRH) release from GnRH neurons to control the reproductive axis. The presence of sufficient energy reserves is critical to achieve successful

Source
peer_reviewed_research
DOI
10.1038/s41574-020-0363-7
PubMed
32427949
Open original source
2012Insufficient evidence

Evidence of a Role for Kisspeptin and Neurokinin B in Puberty of Female Sheep

Content-verified record concerning Kisspeptin: "Evidence of a Role for Kisspeptin and Neurokinin B in Puberty of Female Sheep" Abstract excerpt: Puberty onset in female sheep is marked by a decrease in estradiol-negative feedback, allowing for the increase in GnRH and LH pulses that heralds the first ovulation. Based on recent genetic studies in humans, two possible neuropeptides that could promote puberty onset are kisspeptin and neurokinin B (NKB). Our first experiment determined whether the NKB agonist, senktide, could stimulate LH secr

Source
peer_reviewed_research
DOI
10.1210/en.2011-2009
PubMed
22434087
Open original source
2022Insufficient evidence

Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction.

Content-verified record concerning Kisspeptin: "Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction." Abstract excerpt: Kisspeptin is the leading upstream regulator of pulsatile and surge Gonadotrophin-Releasing Hormone secretion (GnRH) in the hypothalamus, which acts as the key governor of the hypothalamic-pituitary-ovary axis. Exogenous kisspeptin or its receptor agonist can stimulate GnRH release and subsequent physiological gonadotropin secretion in humans. Based on the role of kisspeptin in the hypothalamus, a

Source
peer_reviewed_research
DOI
10.1186/s12958-022-00953-y
PubMed
35606759
Open original source
2026Insufficient evidence

Exploring the Role of Kisspeptin in Polycystic Ovary Syndrome and Its Associated Pregnancy Complications.

Content-verified record concerning Kisspeptin: "Exploring the Role of Kisspeptin in Polycystic Ovary Syndrome and Its Associated Pregnancy Complications." Abstract excerpt: Polycystic ovary syndrome (PCOS) is a common endocrine disorder with a complex pathogenesis that includes disordered follicle development, hypothalamic-pituitary-ovarian (HPO) axis dysfunction, hyperandrogenemia, and insulin resistance. The risk of complications during pregnancy, such as gestational diabetes mellitus (GDM) and preeclampsia (PE), among PCOS patients is higher than that in the gener

Source
systematic_review_or_meta_analysis
DOI
10.1111/obr.70008
PubMed
40776390
Open original source
2013Insufficient evidence

Interactions Between Kisspeptins and Neurokinin B

Content-verified record concerning Kisspeptin: "Interactions Between Kisspeptins and Neurokinin B" Abstract excerpt: Reproductive function is tightly regulated by an intricate network of central and peripheral factors; however, the precise mechanism triggering critical reproductive events, such as puberty onset, remains largely unknown. Recently, the neuropeptides kisspeptin (encoded by Kiss1) and neurokinin B (NKB, encoded by TAC3 in humans and Tac2 in rodents) have been placed as essential gatekeepers of puber

Source
peer_reviewed_research
DOI
10.1007/978-1-4614-6199-9_15
PubMed
23550013
Open original source
2007Insufficient evidence

Emerging ideas about kisspeptin– GPR54 signaling in the neuroendocrine regulation of reproduction

Content-verified record concerning Kisspeptin: "Emerging ideas about kisspeptin– GPR54 signaling in the neuroendocrine regulation of reproduction" Abstract excerpt: Neurons that produce gonadotropin-releasing hormone (GnRH) drive the reproductive axis, but the molecular and cellular mechanisms by which hormonal and environmental signals regulate GnRH secretion remain poorly understood. Kisspeptins are products of the Kiss1 gene, and the interaction of kisspeptin and its receptor GPR54 plays a crucial role in governing the onset of puberty and adult reproducti

Source
systematic_review_or_meta_analysis
DOI
10.1016/j.tins.2007.08.001
PubMed
17904653
Open original source
Insufficient evidence

Relationship between kisspeptin-10, neurokinin B and dynorphin A in the course of normal and delayed puberty in ewes.

Source reference associated with Kisspeptin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.2478/jvetres-2026-0010
PubMed
41953732
Open original source
2026Insufficient evidence

Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men.

Content-verified record concerning Kisspeptin: "Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men." Abstract excerpt: To develop a protocol for chronic kisspeptin administration that persistently stimulates gonadotropin secretion. We evaluated the effects of acute and chronic subcutaneous kisspeptin-10 administration on reproductive hormones in healthy men to (1) characterize the acute dose--response relationship to subcutaneous kisspeptin-10 infusion, (2) assess the effects of continuous kisspeptin-10 infusion o

Source
peer_reviewed_research
DOI
10.1093/ejendo/lvag134
PubMed
42549827
Open original source
2017Insufficient evidence

Is there a role for kisspeptin in pathogenesis of polycystic ovary syndrome?

Content-verified record concerning Kisspeptin: "Is there a role for kisspeptin in pathogenesis of polycystic ovary syndrome?" Abstract excerpt: To investigate association of kisspeptin levels in infertile women with different ovarian reserve patterns. In this prospective cross-sectional study, 157 participants were recruited. The women were divided into three groups: (i) adequate ovarian reserve (AOR) (n = 57), (ii) high ovarian reserve (PCOS) (n = 60), (iii) diminished ovarian reserve (DOR) (n = 40). Weight, height, waist circumference (

Source
peer_reviewed_research
DOI
10.1080/09513590.2017.1379499
PubMed
28933574
Open original source
2009Insufficient evidence

Critical Roles of Kisspeptins in Female Puberty and Preovulatory Gonadotropin Surges as Revealed by a Novel Antagonist

Content-verified record concerning Kisspeptin: "Critical Roles of Kisspeptins in Female Puberty and Preovulatory Gonadotropin Surges as Revealed by a Novel Antagonist" Abstract excerpt: Kisspeptins (Kp) have recently emerged as master regulators of the reproductive axis and among the most potent elicitors of GnRH-gonadotropin secretion. Despite their paramount importance in reproductive physiology and their potential therapeutic implications, development of Kp antagonists has remained elusive, and only recently has the first compound with the ability to block Kp actions in vitro

Source
peer_reviewed_research
DOI
10.1210/en.2009-0803
PubMed
19952274
Open original source
2026Insufficient evidence

The Expression of Kisspeptin Receptor, Catsper 3 and Acrosome Integrity in Oligozoospermic and Normozoospermic Individuals.

Content-verified record concerning Kisspeptin: "The Expression of Kisspeptin Receptor, Catsper 3 and Acrosome Integrity in Oligozoospermic and Normozoospermic Individuals." Abstract excerpt: Background : Male infertility remains a significant clinical challenge. The KISS1R-CATSPER3 signaling axis and acrosomal integrity are vital for fertilization, yet their regional expression patterns in subfertile men are not fully characterized. Objectives : This study investigated regional expression patterns of KISS1R and CATSPER3 and evaluated acrosomal integrity in oligozoospermic and normozoo

Source
peer_reviewed_research
DOI
10.3390/genes17030266
PubMed
41898800
Open original source
2007Insufficient evidence

New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function

Content-verified record concerning Kisspeptin: "New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function" Abstract excerpt: Identification, in late 2003, of inactivating mutations of the G protein-coupled receptor GPR54 as causative factor for absence of puberty and hypogonadotropic hypogonadism in humans and mice was a major breakthrough in modern Neuroendocrinology, and drew considerable interest on the characterization of the roles of this receptor and its ligands (kisspeptins, encoded by the KiSS-1 gene) in the phy

Source
peer_reviewed_research
DOI
10.1016/j.yfrne.2007.07.002
PubMed
17870152
Open original source
Insufficient evidence

IGF-1 supplementation improves &lt;i&gt;in vitro&lt;/i&gt; maturation quality of &lt;i&gt;Capra hircus&lt;/i&gt; oocytes via PDE3A activation, gap junction remodeling, apoptosis suppression, and kisspeptin signaling.

Source reference associated with Kisspeptin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.3389/fvets.2026.1821251
PubMed
42290791
Open original source
2013Insufficient evidence

Neuroanatomy of the Human Hypothalamic Kisspeptin System

Content-verified record concerning Kisspeptin: "Neuroanatomy of the Human Hypothalamic Kisspeptin System" Abstract excerpt: Hypothalamic kisspeptin (KP) neurons are key players in the neuronal network that regulates the onset of puberty and the pulsatile secretion of gonadotropin-releasing hormone (GnRH). In various mammalian species, the majority of KP-synthesizing neurons are concentrated in two distinct cell populations in the preoptic region and the arcuate nucleus (ARC). While studies of female rodents have provid

Source
peer_reviewed_research
DOI
10.1159/000356903
PubMed
24401651
Open original source
2022Insufficient evidence

Acute Effects of Kisspeptin Administration on Bone Metabolism in Healthy Men.

Content-verified record concerning Kisspeptin: "Acute Effects of Kisspeptin Administration on Bone Metabolism in Healthy Men." Abstract excerpt: Osteoporosis results from disturbances in bone formation and resorption. Recent nonhuman data suggest that the reproductive hormone kisspeptin directly stimulates osteoblast differentiation in vitro and thus could have clinical therapeutic potential. However, the effects of kisspeptin on human bone metabolism are currently unknown. To assess the effects of kisspeptin on human bone metabolism in vi

Source
peer_reviewed_research
DOI
10.1210/clinem/dgac117
PubMed
35244717
Open original source
2025Insufficient evidence

Direct effect of kisspeptin on steroidogenesis, proliferation and apoptosis in Tan sheep ovarian granulosa cells.

Content-verified record concerning Kisspeptin: "Direct effect of kisspeptin on steroidogenesis, proliferation and apoptosis in Tan sheep ovarian granulosa cells." Abstract excerpt: Kisspeptin, encoded by Kiss1 gene, regulates reproduction via the hypothalamic-pituitary-gonadal axis. While kisspeptin treatment promotes follicular development in Tan sheep, its direct action on ovarian granulosa cells remains unclear. For this, we first detected the expression of Kiss1 and its receptor Kiss1r in primary ovarian granulosa cells of Tan sheep. Second, the effect of kisspeptin on s

Source
peer_reviewed_research
DOI
10.1017/s0967199425100191
PubMed
41362283
Open original source
2010Insufficient evidence

Anatomy of the kisspeptin neural network in mammals

Content-verified record concerning Kisspeptin: "Anatomy of the kisspeptin neural network in mammals" Abstract excerpt: Kisspeptin has been recognized as a key regulator of GnRH secretion during puberty and adulthood, conveying the feedback influence of endogenous gonadal steroids onto the GnRH system. Understanding the functional roles of this peptide depends on knowledge of the anatomical framework in which it acts, including the location of kisspeptin-expressing cells in the brain and their connections. In this

Source
peer_reviewed_research
DOI
10.1016/j.brainres.2010.09.020
PubMed
20858464
Open original source
2011Insufficient evidence

The Effects of Kisspeptin-10 on Reproductive Hormone Release Show Sexual Dimorphism in Humans

Content-verified record concerning Kisspeptin: "The Effects of Kisspeptin-10 on Reproductive Hormone Release Show Sexual Dimorphism in Humans" Abstract excerpt: Kisspeptin peptides are critical in human reproductive physiology and are potential therapies for infertility. Kisspeptin-10 stimulates gonadotropin release in both male and female rodents. However, few studies have investigated the effects of kisspeptin-10 on gonadotropin release in humans, and none have investigated the effect in women. If kisspeptin is to be useful for treating reproductive dis

Source
peer_reviewed_research
DOI
10.1210/jc.2011-1408
PubMed
21976724
Open original source
2013Insufficient evidence

Current and future applications of GnRH, kisspeptin and neurokinin B analogues

Content-verified record concerning Kisspeptin: "Current and future applications of GnRH, kisspeptin and neurokinin B analogues" Abstract excerpt: Reproductive hormones affect all stages of life from gamete production, fertilization, fetal development and parturition, neonatal development and puberty through to adulthood and senescence. The reproductive hormone cascade has, therefore, been the target for the development of numerous drugs that modulate its activity at many levels. As the central regulator of the cascade, gonadotropin-releasin

Source
systematic_review_or_meta_analysis
DOI
10.1038/nrendo.2013.120
PubMed
23817290
Open original source
2023Insufficient evidence

Oral sodium oxybate does not alter plasma kisspeptin levels in healthy male volunteers.

Content-verified record concerning Kisspeptin: "Oral sodium oxybate does not alter plasma kisspeptin levels in healthy male volunteers." Abstract excerpt: Gamma-hydroxybutyrate (GHB, clinically administrated as sodium oxybate) is a GABA-B/GHB receptor agonist inducing prosexual effects and progesterone secretion in humans. As the neuropeptide kisspeptin has well-established roles in regulating sexual behavior and as it was also associated with GABA-B receptor and progesterone function, we investigated the effect of two GHB doses (20 and 35 mg/kg p.o

Source
peer_reviewed_research
DOI
10.1177/02698811231185097
PubMed
37401623
Open original source
2023Insufficient evidence

The effects of kisspeptin on food intake in women with overweight or obesity.

Content-verified record concerning Kisspeptin: "The effects of kisspeptin on food intake in women with overweight or obesity." (identity confirmed; no abstract text available to excerpt.)

Source
peer_reviewed_research
DOI
10.1111/dom.15086
PubMed
37039248
Open original source
Insufficient evidence

Serum kisspeptin levels in pregnant and non-pregnant diestrus bitches: a pilot study.

Source reference associated with Kisspeptin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.3389/fvets.2026.1826654
PubMed
42003949
Open original source
2024Insufficient evidence

Role of serum kisspeptin as a biomarker to detect miscarriage: a systematic review and meta-analysis.

Content-verified record concerning Kisspeptin: "Role of serum kisspeptin as a biomarker to detect miscarriage: a systematic review and meta-analysis." Abstract excerpt: Miscarriage is a common adverse pregnancy outcome with physical and emotional effects. Identifying predictive miscarriage biomarkers should improve early detection and management. Serum kisspeptin, known for its critical role in reproductive biology, has emerged as a potential biomarker for miscarriage. With this systematic review and meta-analysis, we aimed to assess the association between serum

Source
systematic_review_or_meta_analysis
DOI
10.1080/14647273.2024.2417934
PubMed
39468787
Open original source
2007Insufficient evidence

The Role of Kisspeptin–GPR54 Signaling in the Tonic Regulation and Surge Release of Gonadotropin-Releasing Hormone/Luteinizing Hormone

Content-verified record concerning Kisspeptin: "The Role of Kisspeptin–GPR54 Signaling in the Tonic Regulation and Surge Release of Gonadotropin-Releasing Hormone/Luteinizing Hormone" Abstract excerpt: The Kiss1 gene codes for kisspeptin, which binds to GPR54, a G-protein-coupled receptor. Kisspeptin and GPR54 are expressed in discrete regions of the forebrain, and they have been implicated in the neuroendocrine regulation of reproduction. Kiss1-expressing neurons are thought to regulate the secretion of gonadotropin-releasing hormone (GnRH) and thus coordinate the estrous cycle in rodents; howe

Source
peer_reviewed_research
DOI
10.1523/jneurosci.2748-07.2007
PubMed
17978050
Open original source
2023Insufficient evidence

A fresh look at kisspeptin neuron synchronization.

Content-verified record concerning Kisspeptin: "A fresh look at kisspeptin neuron synchronization." (identity confirmed; no abstract text available to excerpt.)

Source
peer_reviewed_research
DOI
10.1038/s41574-023-00802-x
PubMed
36646873
Open original source
2008Insufficient evidence

The role of kisspeptin in the control of gonadotrophin secretion

Content-verified record concerning Kisspeptin: "The role of kisspeptin in the control of gonadotrophin secretion" Abstract excerpt: Kisspeptins, and their cognate receptor gpr-54, were first found to regulate the hypothalamic-pituitary-gonadal (HPG) axis in 2003, when two groups demonstrated that mutations in gpr-54 cause idiopathic hypogonadotropic hypogonadism characterized by delayed or absent puberty. This review aims to highlight discoveries in the KiSS-1/gpr-54 system, focusing on their regulation of the HPG axis in male

Source
peer_reviewed_research
DOI
10.1093/humupd/dmn058
PubMed
19109311
Open original source
2023Insufficient evidence

Is There an Association Between Circulating Kisspeptin Levels and Ovarian Reserve in Women of Reproductive Age?

Content-verified record concerning Kisspeptin: "Is There an Association Between Circulating Kisspeptin Levels and Ovarian Reserve in Women of Reproductive Age?" Abstract excerpt: To investigate the possible association of kisspeptin levels with the ovarian reserves of women of reproductive age. Eighty women aged 19-40 participated after signing an informed consent. Of these, 74 were finally included as in 6 women the blood samples were considered inappropriate due to hemolysis. They were divided into three main groups according to their ovarian reserve patterns: women with

Source
peer_reviewed_research
DOI
10.21873/invivo.13322
PubMed
37652519
Open original source
2010Insufficient evidence

Hypothesis: Kisspeptin Mediates Male Hypogonadism in Obesity and Type 2 Diabetes

Content-verified record concerning Kisspeptin: "Hypothesis: Kisspeptin Mediates Male Hypogonadism in Obesity and Type 2 Diabetes" Abstract excerpt: Hypogonadism occurs commonly in men with type 2 diabetes (T2DM) and severe obesity. Current evidence points to a decreased secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus and thereby decreased secretion of gonadotropins from the pituitary gland as a central feature of the pathophysiology in these men. Hyperglycaemia, inflammation, leptin and oestrogen-related feedback have

Source
peer_reviewed_research
DOI
10.1159/000299767
PubMed
20628262
Open original source
2005Insufficient evidence

Minireview: Kisspeptin Neurons as Central Processors in the Regulation of Gonadotropin-Releasing Hormone Secretion

Content-verified record concerning Kisspeptin: "Minireview: Kisspeptin Neurons as Central Processors in the Regulation of Gonadotropin-Releasing Hormone Secretion" Abstract excerpt: The Kiss1 gene encodes a family of peptides called kisspeptins, which bind to the G protein-coupled receptor GPR54. Kisspeptin(s) and its receptor are expressed in the forebrain, and the discovery that mice and humans lacking a functional GPR54 fail to undergo puberty and exhibit hypogonadotropic hypogonadism implies that kisspeptin signaling plays an essential role in reproduction. Studies in sev

Source
systematic_review_or_meta_analysis
DOI
10.1210/en.2005-1282
PubMed
16373418
Open original source
2007Insufficient evidence

The Role of Kisspeptins and GPR54 in the Neuroendocrine Regulation of Reproduction

Content-verified record concerning Kisspeptin: "The Role of Kisspeptins and GPR54 in the Neuroendocrine Regulation of Reproduction" Abstract excerpt: Neurons that produce gonadotropin-releasing hormone (GnRH) reside in the basal forebrain and drive reproductive function in mammals. Understanding the circuitry that regulates GnRH neurons is fundamental to comprehending the neuroendocrine control of puberty and reproduction in the adult. This review focuses on a family of neuropeptides encoded by the Kiss1 gene, the kisspeptins, and their cognate

Source
systematic_review_or_meta_analysis
DOI
10.1146/annurev.physiol.70.113006.100540
PubMed
17988212
Open original source
2026Insufficient evidence

Intravenous kisspeptin 112-121 bolus does not acutely impact circulating vasopressin in humans.

Content-verified record concerning Kisspeptin: "Intravenous kisspeptin 112-121 bolus does not acutely impact circulating vasopressin in humans." Abstract excerpt: Arginine-vasopressin (AVP) deficiency (AVP-D) is caused by hypothalamic-pituitary damage of vasopressinergic neurons leading to polyuria and polydipsia. Diagnostic tests for AVP-D are limited by low accuracy and/or tolerability. Kisspeptin (KP) stimulates AVP release in animals, but no study has investigated KP as a provocative test for AVP-D in humans. We investigated circulating AVP levels in re

Source
peer_reviewed_research
DOI
10.1111/jne.70114
PubMed
41273106
Open original source
2006Insufficient evidence

A role for kisspeptin in islet function

Content-verified record concerning Kisspeptin: "A role for kisspeptin in islet function" Abstract excerpt: We investigated the production of kisspeptin (KISS1) and the KISS1 receptor, GPR54, in pancreatic islets and determined the effects of exogenous kisspeptin on insulin secretion. RT-PCR and immunohistochemistry were used to detect expression of KISS1 and GPR54 mRNAs and the production of KISS1 and GPR54 in human and mouse islets and in beta (MIN6) and alpha- (alphaTC1) cell lines. The effects of KI

Source
peer_reviewed_research
DOI
10.1007/s00125-006-0343-z
PubMed
16826407
Open original source
Insufficient evidence

Correction: IGF-1 supplementation improves &lt;i&gt;in vitro&lt;/i&gt; maturation quality of &lt;i&gt;Capra hircus&lt;/i&gt; oocytes via PDE3A activation, gap junction remodeling, apoptosis suppression, and kisspeptin signaling.

Source reference associated with Kisspeptin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.3389/fvets.2026.1897588
PubMed
42445326
Open original source
2009Insufficient evidence

Oestrogen, Kisspeptin, GPR54 and the Pre‐Ovulatory Luteinising Hormone Surge

Content-verified record concerning Kisspeptin: "Oestrogen, Kisspeptin, GPR54 and the Pre‐Ovulatory Luteinising Hormone Surge" Abstract excerpt: Ovulation is central to mammalian fertility, yet the precise mechanism through which oestrogen triggers the gonadotrophin-releasing hormone (GnRH) surge that generates the pre-ovulatory luteinising hormone (LH) surge has remained elusive. The recent discovery that kisspeptin-GPR54 signalling is an essential regulator of the neuroendocrine axis at puberty has led investigators to evaluate the role

Source
peer_reviewed_research
DOI
10.1111/j.1365-2826.2009.01835.x
PubMed
19207812
Open original source
2025Insufficient evidence

Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans.

Content-verified record concerning Kisspeptin: "Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans." Abstract excerpt: Kisspeptin administration by intravenous or subcutaneous routes activates hypothalamic gonadotropin-releasing hormone (GnRH) neurons and is being developed to treat reproductive disorders. However, these invasive routes markedly limit patient acceptability and clinical use. Recent rodent data has identified a large GnRH population within the olfactory system communicating directly with hypothalami

Source
peer_reviewed_research
DOI
10.1016/j.ebiom.2025.105689
PubMed
40215751
Open original source
2008Insufficient evidence

GPR54 and Kisspeptins

Content-verified record concerning Kisspeptin: "GPR54 and Kisspeptins" Abstract excerpt: The G-protein coupled receptor GPR54 has an essential role in the initiation and maintenance of mammalian fertility. Humans and mice with mutations in GPR54 have hypogonadotropic hypogonadism characterized by absence of sexual maturation and low levels of gonadotropic hormones (LH and FSH). The ligand for GPR54 is encoded by the KISS1 gene, which produces a 54-amino-acid peptide (metastin or kissp

Source
peer_reviewed_research
DOI
10.1007/400_2007_050
PubMed
18193176
Open original source
2014Insufficient evidence

Disrupted Kisspeptin Signaling in GnRH Neurons Leads to Hypogonadotrophic Hypogonadism

Content-verified record concerning Kisspeptin: "Disrupted Kisspeptin Signaling in GnRH Neurons Leads to Hypogonadotrophic Hypogonadism" Abstract excerpt: Landmark studies have shown that mutations in kisspeptin and the kisspeptin receptor (Kiss1r) result in reproductive dysfunction in humans and genetically altered mouse models. However, because kisspeptin and its receptor are present in target cells of the central and peripheral reproductive axis, the precise location(s) for the pathogenic signal is unknown. The study described herein shows that t

Source
peer_reviewed_research
DOI
10.1210/me.2013-1319
PubMed
24422632
Open original source
2014Insufficient evidence

Habenular kisspeptin modulates fear in the zebrafish

Content-verified record concerning Kisspeptin: "Habenular kisspeptin modulates fear in the zebrafish" Abstract excerpt: Kisspeptin, a neuropeptide encoded by the KISS1/Kiss1, and its cognate G protein-coupled receptor, GPR54 (kisspeptin receptor, Kiss-R), are critical for the control of reproduction in vertebrates. We have previously identified two kisspeptin genes (kiss1 and kiss2) in the zebrafish, of which kiss1 neurons are located in the habenula, which project to the median raphe. kiss2 neurons are located in

Source
peer_reviewed_research
DOI
10.1073/pnas.1314184111
PubMed
24567386
Open original source
2026Insufficient evidence

Effect of kisspeptin with or without cabergoline on the estrus cycle and reproductive hormones in female dogs.

Content-verified record concerning Kisspeptin: "Effect of kisspeptin with or without cabergoline on the estrus cycle and reproductive hormones in female dogs." Abstract excerpt: This study aimed to evaluate the effects of Kisspeptin (KP-10) and Cabergoline (CB) on hormonal regulation in anestrus female dogs. Twenty-three clinically healthy anestrus female dogs were randomly allocated into five treatment groups. Group 1 (G1, n&#xa0;=&#xa0;4) received CB with saline; Group 2 (G2, n&#xa0;=&#xa0;4) received 0.5&#xa0;&#x3bc;g/kg KP-10&#xa0;+&#xa0;CB; Group 3 (G3, n&#xa0;=&#xa0

Source
peer_reviewed_research
DOI
10.1016/j.theriogenology.2025.117633
PubMed
40816115
Open original source
2014Insufficient evidence

Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity

Content-verified record concerning Kisspeptin: "Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity" Abstract excerpt: The neuropeptide kisspeptin regulates reproduction by stimulating gonadotropin-releasing hormone (GnRH) neurons via the kisspeptin receptor KISS1R. In addition to GnRH neurons, KISS1R is expressed in other brain areas and peripheral tissues, which suggests that kisspeptin has additional functions beyond reproduction. Here, we studied the energetic and metabolic phenotype in mice lacking kisspeptin

Source
peer_reviewed_research
DOI
10.1172/jci71075
PubMed
24937427
Open original source
2015Insufficient evidence

There is Kisspeptin – And Then There is Kisspeptin

Content-verified record concerning Kisspeptin: "There is Kisspeptin – And Then There is Kisspeptin" Abstract excerpt: While kisspeptin was initially found to function as a metastasis suppressor, after identification of its receptor KISS1R and their expression profiles in tissues such as the hypothalamus and adrenals, kisspeptin and KISS1R were predominantly assigned endocrine functions, including regulating puberty and fertility through their actions on hypothalamic gonadotropin releasing hormone production. More

Source
systematic_review_or_meta_analysis
DOI
10.1016/j.tem.2015.07.008
PubMed
26412157
Open original source
2012Insufficient evidence

Arcuate Kisspeptin/Neurokinin B/Dynorphin (KNDy) Neurons Mediate the Estrogen Suppression of Gonadotropin Secretion and Body Weight

Content-verified record concerning Kisspeptin: "Arcuate Kisspeptin/Neurokinin B/Dynorphin (KNDy) Neurons Mediate the Estrogen Suppression of Gonadotropin Secretion and Body Weight" Abstract excerpt: Estrogen withdrawal increases gonadotropin secretion and body weight, but the critical cell populations mediating these effects are not well understood. Recent studies have focused on a subpopulation of hypothalamic arcuate neurons that coexpress estrogen receptor &#x3b1;, neurokinin 3 receptor (NK(3)R), kisspeptin, neurokinin B, and dynorphin for the regulation of reproduction. To investigate the

Source
peer_reviewed_research
DOI
10.1210/en.2012-1045
PubMed
22508514
Open original source
2026Insufficient evidence

Serum kisspeptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis.

Content-verified record concerning Kisspeptin: "Serum kisspeptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis." Abstract excerpt: Kisspeptin is a key regulator of the hypothalamic-pituitary-gonadal axis and has been implicated in the pathophysiology of polycystic ovary syndrome (PCOS). However, reported associations between kisspeptin levels and PCOS have been inconsistent. A systematic search of PubMed, Scopus, and Web of Science was performed from inception to August 2025 for studies comparing serum kisspeptin concentratio

Source
systematic_review_or_meta_analysis
PubMed
41914593
Open original source
2025Insufficient evidence

Serum Kisspeptin levels in patients undergoing maintenance hemodialysis: a case-control study protocol.

Content-verified record concerning Kisspeptin: "Serum Kisspeptin levels in patients undergoing maintenance hemodialysis: a case-control study protocol." Abstract excerpt: BACKGROUND: Hypogonadism is a highly prevalent complication in patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis (MHD), leading to a significant reduction in quality of life. The underlying pathophysiology involving the Hypothalamic-Pituitary-Gonadal (HPG) axis is complex and not fully understood. Kisspeptin is the master upstream regulator of the HPG axis, but its s

Source
peer_reviewed_research
DOI
10.1186/s12882-025-04512-6
PubMed
41152775
Open original source
2008Insufficient evidence

From KISS1 to kisspeptins: An historical perspective and suggested nomenclature

Content-verified record concerning Kisspeptin: "From KISS1 to kisspeptins: An historical perspective and suggested nomenclature" Abstract excerpt: The cancer suppressor gene, KISS1, was initially described as having an important role in inhibiting cancer metastasis. Since then, KISS1 and its receptor, KISS1R, have been shown to play a key role in controlling the onset of puberty of reproductive physiology in the human and other species. Recent studies have also linked KISS1/kisspeptin/KISS1R to other processes, such as vasoconstriction, agin

Source
peer_reviewed_research
DOI
10.1016/j.peptides.2008.06.016
PubMed
18644415
Open original source
2007Insufficient evidence

The Kisspeptin/Gonadotropin-Releasing Hormone Pathway and Molecular Signaling of Puberty in Fish1

Content-verified record concerning Kisspeptin: "The Kisspeptin/Gonadotropin-Releasing Hormone Pathway and Molecular Signaling of Puberty in Fish1" Abstract excerpt: The mechanisms underlying the initiation of puberty in fish are poorly understood, and whether the Kiss1 receptor (Kiss1r; previously designated G protein-coupled receptor 54; GPR54) and its ligands, kisspeptins, play a significant role, as has been established in mammals, is not yet known. We determined (via real-time PCR) temporal patterns of expression in the brain of kiss1r, gnrh2, and gnrh3 a

Source
peer_reviewed_research
DOI
10.1095/biolreprod.107.063420
PubMed
17978278
Open original source
2008Insufficient evidence

The kisspeptin (KiSS-1)/GPR54 system in cancer biology

Content-verified record concerning Kisspeptin: "The kisspeptin (KiSS-1)/GPR54 system in cancer biology" Abstract excerpt: Kisspeptin (KiSS-1) gene, initially described as a melanoma metastasis suppressor gene, encodes a number of peptides (kp-54, kp-14, kp-13, kp-10), which are endogenous ligands to a G protein-coupled receptor, referred as hOT7T175 or AXOR12 or GPR54. So far intensive investigation has provided substantiate evidence supporting the role of KiSS-1/GPR54 system in cancer biology as well as in the regul

Source
peer_reviewed_research
DOI
10.1016/j.ctrv.2008.05.007
PubMed
18583061
Open original source
2026Insufficient evidence

Neurotransmitter and neuromodulator imbalance in kisspeptin/GnRH regulation in rodent models of polycystic ovary syndrome and its implications for mental health disorders: A systematic review.

Content-verified record concerning Kisspeptin: "Neurotransmitter and neuromodulator imbalance in kisspeptin/GnRH regulation in rodent models of polycystic ovary syndrome and its implications for mental health disorders: A systematic review." Abstract excerpt: Polycystic ovary syndrome (PCOS) is an endocrine disease associated with hyperandrogenism, which causes infertility and often leads to mental health disorders. Although gonadotropin-releasing hormone (GnRH) neuronal dysfunction may contribute to PCOS, the pathophysiology of mood disorders associated with the syndrome remains unclear. We raise the question of whether imbalanced neurotransmitters co

Source
systematic_review_or_meta_analysis
DOI
10.1016/j.bbr.2026.116262
PubMed
42140496
Open original source
2010Insufficient evidence

The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin‐releasing hormone and neurokinin B neurons

Content-verified record concerning Kisspeptin: "The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin‐releasing hormone and neurokinin B neurons" Abstract excerpt: Kisspeptin signaling via the kisspeptin receptor G-protein-coupled receptor-54 plays a fundamental role in the onset of puberty and the regulation of mammalian reproduction. In this immunocytochemical study we addressed the (i) topography, (ii) sexual dimorphism, (iii) relationship to gonadotropin-releasing hormone (GnRH) neurons and (iv) neurokinin B content of kisspeptin-immunoreactive hypothala

Source
peer_reviewed_research
DOI
10.1111/j.1460-9568.2010.07239.x
PubMed
20529119
Open original source
2014Insufficient evidence

The kisspeptin-GnRH pathway in human reproductive health and disease

Content-verified record concerning Kisspeptin: "The kisspeptin-GnRH pathway in human reproductive health and disease" Abstract excerpt: The discovery of kisspeptin as key central regulator of GnRH secretion has led to a new level of understanding of the neuroendocrine regulation of human reproduction. The related discovery of the kisspeptin-neurokinin B-dynorphin (KNDy) pathway in the last decade has further strengthened our understanding of the modulation of GnRH secretion by endocrine, metabolic and environmental inputs. In this

Source
peer_reviewed_research
DOI
10.1093/humupd/dmu009
PubMed
24615662
Open original source
2025Insufficient evidence

The Kisspeptin analogue C6 induces more synchronized ovulation than eCG in the transition period to breeding season in Corriedale ewes.

Content-verified record concerning Kisspeptin: "The Kisspeptin analogue C6 induces more synchronized ovulation than eCG in the transition period to breeding season in Corriedale ewes." Abstract excerpt: This study assessed preovulatory follicular development in ewes and, consequently, the synchronization of ovulations induced by C6 (Compound C6), a synthetic kisspeptin (Kp) analogue with an extended half-life. The estrus of 30 anestrous Corriedale ewes was synchronized using intravaginal sponges (IVS) containing medroxyprogesterone acetate for 14 days. The experimental groups were: (1) GeCG recei

Source
peer_reviewed_research
DOI
10.1007/s11250-025-04800-1
PubMed
41385063
Open original source
2025Insufficient evidence

Can kisspeptin be a new treatment for sexual dysfunction?

Content-verified record concerning Kisspeptin: "Can kisspeptin be a new treatment for sexual dysfunction?" Abstract excerpt: The neuropeptide kisspeptin activates the hypothalamic-pituitary-gonadal (HPG) axis and influences neural circuits controlling sexual behavior. Animal studies have determined its sex-specific roles in reproductive behaviors, whereas human research has linked kisspeptin to increased brain activity in regions associated with sexual and emotional processing, making it a potential treatment for disord

Source
systematic_review_or_meta_analysis
DOI
10.1016/j.tem.2025.03.002
PubMed
40189467
Open original source
2004Insufficient evidence

Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts

Content-verified record concerning Kisspeptin: "Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts" Abstract excerpt: Trophoblast invasion of the uterine extracellular matrix, a critical process of human implantation and essential for fetal development, is a striking example of controlled invasiveness. To identify molecules that regulate trophoblast invasion, mRNA signatures of trophoblast cells isolated from first trimester (high invasiveness) and term placentae (no/low invasiveness) were compared using U95A Gen

Source
peer_reviewed_research
DOI
10.1242/jcs.00971
PubMed
15020672
Open original source
2005Insufficient evidence

Kisspeptin-54 Stimulates the Hypothalamic-Pituitary Gonadal Axis in Human Males

Content-verified record concerning Kisspeptin: "Kisspeptin-54 Stimulates the Hypothalamic-Pituitary Gonadal Axis in Human Males" Abstract excerpt: Mutation of the G protein-coupled receptor 54 is associated with a failure of reproductive function. The endogenous neuropeptide agonist for G protein-coupled receptor 54, kisspeptin, potently stimulates the hypothalamic-pituitary-gonadal axis in rodents and primates. The present study was designed to determine the effects of elevating circulating kisspeptin levels on LH, FSH, and testosterone in

Source
peer_reviewed_research
DOI
10.1210/jc.2005-1468
PubMed
16174713
Open original source
2006Insufficient evidence

Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling

Content-verified record concerning Kisspeptin: "Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling" Abstract excerpt: The Kiss1 gene codes for a family of peptides that act as endogenous ligands for the G protein-coupled receptor GPR54. Spontaneous mutations or targeted deletions of GPR54 in man and mice produce hypogonadotropic hypogonadism and infertility. Centrally administered kisspeptins stimulate gonadotropin secretion by acting directly on GnRH neurons. Sex steroids regulate the expression of KiSS-1 mRNA i

Source
peer_reviewed_research
DOI
10.1530/rep.1.00368
PubMed
16595713
Open original source
2008Insufficient evidence

Comparison of the effects of peripherally administered kisspeptins

Content-verified record concerning Kisspeptin: "Comparison of the effects of peripherally administered kisspeptins" Abstract excerpt: Kisspeptins are structurally closely related peptides derived from the Kiss1 gene that have been demonstrated to stimulate the hypothalamo-pituitary gonadal axis. The natural peptide products derived from post-translational processing of the kisspeptin precursor have not been elucidated. We examined the acute effect on serum levels of free testosterone in the adult male mouse after systemic admini

Source
peer_reviewed_research
DOI
10.1016/j.regpep.2008.10.001
PubMed
18940206
Open original source
2005Insufficient evidence

Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty

Content-verified record concerning Kisspeptin: "Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty" Abstract excerpt: We examined the role of kisspeptin and its receptor, the G-protein-coupled receptor GPR54, in governing the onset of puberty in the mouse. In the adult male and female mouse, kisspeptin (10-100 nM) evoked a remarkably potent, long-lasting depolarization of &gt;90% of gonadotropin-releasing hormone (GnRH)-green fluorescent protein neurons in situ. In contrast, in juvenile [postnatal day 8 (P8) to P

Source
peer_reviewed_research
DOI
10.1523/jneurosci.3328-05.2005
PubMed
16339030
Open original source
2006Insufficient evidence

Kisspeptin Mediates the Photoperiodic Control of Reproduction in Hamsters

Content-verified record concerning Kisspeptin: "Kisspeptin Mediates the Photoperiodic Control of Reproduction in Hamsters" Abstract excerpt: The KiSS-1 gene encodes kisspeptin, the endogenous ligand of the G-protein-coupled receptor GPR54. Recent data indicate that the KiSS-1/GPR54 system is critical for the regulation of reproduction and is required for puberty onset. In seasonal breeders, reproduction is tightly controlled by photoperiod (i.e., day length). The Syrian hamster is a seasonal model in which reproductive activity is prom

Source
peer_reviewed_research
DOI
10.1016/j.cub.2006.07.025
PubMed
16950111
Open original source
2007Insufficient evidence

Kisspeptin-54 Stimulates Gonadotropin Release Most Potently during the Preovulatory Phase of the Menstrual Cycle in Women

Content-verified record concerning Kisspeptin: "Kisspeptin-54 Stimulates Gonadotropin Release Most Potently during the Preovulatory Phase of the Menstrual Cycle in Women" Abstract excerpt: Kisspeptin, the endogenous ligand of the G protein-coupled receptor 54, is a key regulator of the hypothalamo-pituitary-gonadal (HPG) axis. GPR54-null mice exhibit reproductive dysfunction, and exogenous kisspeptin potently stimulates the HPG axis in rodents, primates, and human males. The effects of kisspeptin administration to human females are unknown. Our objective was to investigate the effec

Source
peer_reviewed_research
DOI
10.1210/jc.2007-1116
PubMed
17635940
Open original source
2007Insufficient evidence

Kisspeptin Acts Directly and Indirectly to Increase Gonadotropin-Releasing Hormone Neuron Activity and Its Effects Are Modulated by Estradiol

Content-verified record concerning Kisspeptin: "Kisspeptin Acts Directly and Indirectly to Increase Gonadotropin-Releasing Hormone Neuron Activity and Its Effects Are Modulated by Estradiol" Abstract excerpt: GnRH neurons play a pivotal role in the central regulation of fertility. Kisspeptin greatly increases GnRH/LH release and GnRH neuron firing activity and may be involved in estradiol feedback, but the neurobiological mechanisms for these actions are unknown. G protein-coupled receptor 54, the receptor for kisspeptin, is expressed by GnRH neurons as well as other hypothalamic neurons, suggesting bo

Source
peer_reviewed_research
DOI
10.1210/en.2007-1365
PubMed
18162521
Open original source
2007Insufficient evidence

Kisspeptin Neurons in the Arcuate Nucleus of the Ewe Express Both Dynorphin A and Neurokinin B

Content-verified record concerning Kisspeptin: "Kisspeptin Neurons in the Arcuate Nucleus of the Ewe Express Both Dynorphin A and Neurokinin B" Abstract excerpt: Kisspeptin is a potent stimulator of GnRH secretion that has been implicated in the feedback actions of ovarian steroids. In ewes, the majority of hypothalamic kisspeptin neurons are found in the arcuate nucleus (ARC), with a smaller population located in the preoptic area. Most arcuate kisspeptin neurons express estrogen receptor-alpha, as do a set of arcuate neurons that contain both dynorphin a

Source
peer_reviewed_research
DOI
10.1210/en.2007-0961
PubMed
17823266
Open original source
2007Insufficient evidence

Kisspeptin Synchronizes Preovulatory Surges in Cyclical Ewes and Causes Ovulation in Seasonally Acyclic Ewes

Content-verified record concerning Kisspeptin: "Kisspeptin Synchronizes Preovulatory Surges in Cyclical Ewes and Causes Ovulation in Seasonally Acyclic Ewes" Abstract excerpt: We determined whether kisspeptin could be used to manipulate the gonadotropin axis and ovulation in sheep. First, a series of experiments was performed to determine the gonadotropic responses to different modes and doses of kisspeptin administration during the anestrous season using estradiol-treated ovariectomized ewes. We found that: 1) injections (iv) of doses as low as 6 nmol human C-terminal

Source
peer_reviewed_research
DOI
10.1210/en.2007-0554
PubMed
17702853
Open original source
2007Insufficient evidence

Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system

Content-verified record concerning Kisspeptin: "Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system" Abstract excerpt: Orphan G-protein-coupled receptors that have recently been paired with their cognate ligand are an often untapped resource for novel drug development. The KISS1 receptor (previously designated GPR54) has been paired with biologically active cleavage peptides of the KiSS-1 gene product, the kisspeptins (KP). The focus of this review is the emerging pharmacology and physiology of the KP. Genetic lin

Source
peer_reviewed_research
DOI
10.1038/sj.bjp.0707295
PubMed
17519946
Open original source
2007Insufficient evidence

Kisspeptin signalling in the brain: Steroid regulation in the rodent and ewe

Content-verified record concerning Kisspeptin: "Kisspeptin signalling in the brain: Steroid regulation in the rodent and ewe" Abstract excerpt: The Kiss1 gene encodes a family of peptides called kisspeptins, which are the natural ligands for the receptor GPR54. In humans and mice, inactivating mutations of GPR54 results in hypogonadotropic hypogonadism, indicating that kisspeptins play a vital role in the regulation of GnRH secretion. In many species, centrally administered kisspeptins stimulate gonadotrophin secretion in a GnRH-dependant

Source
peer_reviewed_research
DOI
10.1016/j.brainresrev.2007.04.002
PubMed
17509691
Open original source
2009Insufficient evidence

Characteristics of stimulation of gonadotropin secretion by kisspeptin-10 in female goats

Content-verified record concerning Kisspeptin: "Characteristics of stimulation of gonadotropin secretion by kisspeptin-10 in female goats" Abstract excerpt: The aims of the present study were to clarify the effect of kisspeptin-10 (Kp10) on the secretion of luteinizing hormone (LH), follicle stimulating hormone (FSH), growth hormone (GH) and prolactin (PRL) in goats, and compare the characteristics of any response with those of the response to gonadotropin-releasing hormone (GnRH). The experiments were performed using four female goats (4-5 years old)

Source
peer_reviewed_research
DOI
10.1016/j.anireprosci.2009.05.017
PubMed
19574004
Open original source
2007Insufficient evidence

Kisspeptin: A key link to seasonal breeding

Content-verified record concerning Kisspeptin: "Kisspeptin: A key link to seasonal breeding" Abstract excerpt: In seasonal species, photoperiod (i.e. daylength) tightly regulates reproduction to ensure that birth occurs at the most favorable time of year. In mammals, a distinct photoneuroendocrine circuit controls this process via the pineal hormone melatonin. This hormone is responsible for the seasonal regulation of reproduction, but the anatomical substrate and the cellular mechanism through which melat

Source
peer_reviewed_research
DOI
10.1007/s11154-007-9031-7
PubMed
17380397
Open original source
2007Insufficient evidence

Kisspeptins and the placenta: Regulation of trophoblast invasion

Content-verified record concerning Kisspeptin: "Kisspeptins and the placenta: Regulation of trophoblast invasion" Abstract excerpt: The invasion of extravillous trophoblasts into the uterine wall is of crucial importance for placental and fetal development, and its dysregulation has been implicated in a wide spectrum of abnormal pregnancies. Mechanistically, trophoblast invasion strongly resembles the invasion of tumour cells, but differs from it by tight regulation in time and space. This regulation is accomplished by differe

Source
peer_reviewed_research
DOI
10.1007/s11154-007-9030-8
PubMed
17351756
Open original source
2007Insufficient evidence

Kisspeptin expression in the brain: Catalyst for the initiation of puberty

Content-verified record concerning Kisspeptin: "Kisspeptin expression in the brain: Catalyst for the initiation of puberty" Abstract excerpt: In 2003, two independent groups of researchers discovered almost simultaneously that inactivating mutations of the G protein coupled receptor, GPR54, cause hypogonadotropic hypogonadism in mice and men. Since this discovery, kisspeptins, the natural ligands for GPR54, have been thrust into the reproductive neuroendocrine spotlight, as major regulators of GnRH function. Kisspeptins are the peptide

Source
peer_reviewed_research
DOI
10.1007/s11154-007-9026-4
PubMed
17334929
Open original source
2008Insufficient evidence

Kisspeptin–GPR54 Signaling Is Essential for Preovulatory Gonadotropin-Releasing Hormone Neuron Activation and the Luteinizing Hormone Surge

Content-verified record concerning Kisspeptin: "Kisspeptin–GPR54 Signaling Is Essential for Preovulatory Gonadotropin-Releasing Hormone Neuron Activation and the Luteinizing Hormone Surge" Abstract excerpt: Kisspeptin and its receptor GPR54 have recently been identified as key signaling partners in the neural control of fertility in animal models and humans. The gonadotropin-releasing hormone (GnRH) neurons represent the final output neurons of the neural network controlling fertility and are suspected to be the primary locus of kisspeptin-GPR54 signaling. Using mouse models, the present study addres

Source
peer_reviewed_research
DOI
10.1523/jneurosci.1775-08.2008
PubMed
18753370
Open original source
2008Insufficient evidence

Kisspeptin Excites Gonadotropin-Releasing Hormone Neurons through a Phospholipase C/Calcium-Dependent Pathway Regulating Multiple Ion Channels

Content-verified record concerning Kisspeptin: "Kisspeptin Excites Gonadotropin-Releasing Hormone Neurons through a Phospholipase C/Calcium-Dependent Pathway Regulating Multiple Ion Channels" Abstract excerpt: The present study used perforated-patch electrophysiology and calcium imaging in GnRH transgenic mouse lines to determine the mechanisms underlying the potent excitatory effects of kisspeptin upon GnRH neurons in the acute brain slice preparation. Kisspeptin (100 nm) depolarized (6 +/- 1 mV) and/or evoked an 87 +/- 4% increase in firing rate of 75% of adult GnRH neurons (n = 51). No sex difference

Source
peer_reviewed_research
DOI
10.1210/en.2008-0321
PubMed
18483150
Open original source
2008Insufficient evidence

Kisspeptin Can Stimulate Gonadotropin-Releasing Hormone (GnRH) Release by a Direct Action at GnRH Nerve Terminals

Content-verified record concerning Kisspeptin: "Kisspeptin Can Stimulate Gonadotropin-Releasing Hormone (GnRH) Release by a Direct Action at GnRH Nerve Terminals" Abstract excerpt: The G protein-coupled receptor GPR54, and its peptide ligand kisspeptin (Kp), are crucial for the induction and maintenance of mammalian reproductive function. GPR54 is expressed by GnRH neurons and is directly activated by Kp to stimulate GnRH release. We hypothesized that Kp may be able to act at the GnRH nerve terminals located in the mediobasal hypothalamus (MBH) region. To test this hypothesi

Source
peer_reviewed_research
DOI
10.1210/en.2007-1487
PubMed
18450966
Open original source
Insufficient evidence

Kisspeptin.

Source reference associated with Kisspeptin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1016/j.tem.2026.06.010
PubMed
42457610
Open original source
2008Insufficient evidence

Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback

Content-verified record concerning Kisspeptin: "Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback" Abstract excerpt: Menopause is characterized by depletion of ovarian follicles, a reduction of ovarian hormones to castrate levels and elevated levels of serum gonadotropins. Rather than degenerating, the reproductive neuroendocrine axis in postmenopausal women is intact and responds robustly to the removal of ovarian hormones. Studies in both human and non-human primates provide evidence that the gonadotropin hype

Source
peer_reviewed_research
DOI
10.1016/j.peptides.2008.05.016
PubMed
18614256
Open original source
2008Insufficient evidence

Kisspeptin and GPR54: Discovery of a Novel Pathway in Reproduction

Content-verified record concerning Kisspeptin: "Kisspeptin and GPR54: Discovery of a Novel Pathway in Reproduction" Abstract excerpt: In order to find novel modulators of gonadotrophin-releasing hormone (GnRH) secretion, genetic tools were employed in patients with idiopathic hypogonadotrophic hypogonadism (IHH). Mutations in a G-protein coupled receptor, GPR54, were identified, making this receptor a genetic determinant and indisputable gatekeeper of normal reproductive function. This article places these investigations into hi

Source
peer_reviewed_research
DOI
10.1111/j.1365-2826.2008.01731.x
PubMed
18601695
Open original source
2008Insufficient evidence

Kisspeptins and the control of gonadotropin secretion in male and female rodents

Content-verified record concerning Kisspeptin: "Kisspeptins and the control of gonadotropin secretion in male and female rodents" Abstract excerpt: Kisspeptins, the products of KiSS-1 gene acting via G protein-coupled receptor 54 (GPR54), have recently emerged as fundamental gatekeepers of gonadal function by virtue of their ability to stimulate gonadotropin secretion. Indeed, since the original disclosure of the reproductive facet of the KiSS-1/GPR54 system, an ever-growing number of studies have substantiated the extraordinary potency of ki

Source
peer_reviewed_research
DOI
10.1016/j.peptides.2008.08.009
PubMed
18793689
Open original source
2009Insufficient evidence

Kisspeptin Signaling in the Brain

Content-verified record concerning Kisspeptin: "Kisspeptin Signaling in the Brain" Abstract excerpt: Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged as key players in the regulation of reproduction. Mutations in humans or genetically targeted deletions in mice of either Kiss1 or Kiss1r cause profound hypogonadotropic hypogonadism. Neurons that express Kiss1/kisspeptin are found in discrete nuclei in the hypothalamus, as well as other brain regions in many

Source
peer_reviewed_research
DOI
10.1210/er.2009-0005
PubMed
19770291
Open original source
2024Insufficient evidence

Lunar Age-Dependent Oscillations in Expression of the Genes for Kisspeptin, GnIH, and Their Receptors in the Grass Puffer during the Spawning Season.

Content-verified record concerning Kisspeptin: "Lunar Age-Dependent Oscillations in Expression of the Genes for Kisspeptin, GnIH, and Their Receptors in the Grass Puffer during the Spawning Season." Abstract excerpt: Grass puffer is a semilunar-synchronized spawner: spawning occurs on beaches only for several days of spring tide around new moon (lunar age 0) and full moon (lunar age 15) every 2 weeks from spring to early summer. To investigate the role of kisspeptin and gonadotropin-inhibitory hormone (GnIH) in the semilunar-synchronized spawning, lunar age-dependent expression of the genes encoding kisspeptin

Source
peer_reviewed_research
DOI
10.2108/zs230061
PubMed
38587522
Open original source
2010Insufficient evidence

Kisspeptin and fertility

Content-verified record concerning Kisspeptin: "Kisspeptin and fertility" Abstract excerpt: The kisspeptins are a family of peptide hormones, which in recent years have been shown to play a critical role in the regulation of the hypothalamic-pituitary-gonadal axis, thus in turn influencing fertility and reproduction. This review examines the physiological role of kisspeptin and the kisspeptin receptor in the control of gonadotrophin and gonadal steroid hormone secretion and the implicati

Source
peer_reviewed_research
DOI
10.1677/joe-10-0265
PubMed
21084385
Open original source
2012Insufficient evidence

Cloning and expression of tachykinins and their association with kisspeptins in the brains of zebrafish

Content-verified record concerning Kisspeptin: "Cloning and expression of tachykinins and their association with kisspeptins in the brains of zebrafish" Abstract excerpt: The tachykinins are a family of neuropeptides, including substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), that are encoded by the tac1 (SP and NKA) or tac2/3 (NKB) genes. Tachykinins are widely distributed in the central nervous system and have roles as neurotransmitters and/or neuromodulators. Recent studies in mammals have demonstrated the coexpression of NKB and kisspeptin and thei

Source
peer_reviewed_research
DOI
10.1002/cne.23103
PubMed
22430310
Open original source
2010Insufficient evidence

Kisspeptin Regulates Prolactin Release through Hypothalamic Dopaminergic Neurons

Content-verified record concerning Kisspeptin: "Kisspeptin Regulates Prolactin Release through Hypothalamic Dopaminergic Neurons" Abstract excerpt: Prolactin (PRL) is tonically inhibited by dopamine (DA) released from neurons in the arcuate and periventricular nuclei. Kisspeptin plays a pivotal role in LH regulation. In rodents, kisspeptin neurons are found mostly in the anteroventral periventricular and arcuate nuclei, but the physiology of arcuate kisspeptin neurons is not completely understood. We investigated the role of kisspeptin in the

Source
peer_reviewed_research
DOI
10.1210/en.2009-1414
PubMed
20410200
Open original source
2010Insufficient evidence

Kisspeptin antagonists: Unraveling the role of kisspeptin in reproductive physiology

Content-verified record concerning Kisspeptin: "Kisspeptin antagonists: Unraveling the role of kisspeptin in reproductive physiology" Abstract excerpt: Kisspeptin has recently been identified as a key neuroendocrine gatekeeper of reproduction and is essential for the initiation of human puberty and maintenance of adult reproduction. Kisspeptin neurons appear to be integrative sensors, as they respond to changes in numerous internal and external factors including nutrient and fat status, stress and sex steroids, thus providing a link between these

Source
peer_reviewed_research
DOI
10.1016/j.brainres.2010.09.044
PubMed
20858467
Open original source
2010Insufficient evidence

Kisspeptins: Bridging energy homeostasis and reproduction

Content-verified record concerning Kisspeptin: "Kisspeptins: Bridging energy homeostasis and reproduction" Abstract excerpt: Body energy reserves and metabolic state are relevant modifiers of puberty onset and fertility; forms of metabolic stress ranging from persistent energy insufficiency to morbid obesity are frequently linked to reproductive disorders. The mechanisms for such a close connection between energy balance and reproduction have been the subject of considerable attention; however, our understanding of the

Source
peer_reviewed_research
DOI
10.1016/j.brainres.2010.08.057
PubMed
20800054
Open original source
2008Insufficient evidence

Kisspeptins and GnRH neuronal signalling

Content-verified record concerning Kisspeptin: "Kisspeptins and GnRH neuronal signalling" Abstract excerpt: Kisspeptin binding to its G-protein-coupled receptor KISS1R (also known as GPR54), which is expressed by gonadotropin-releasing hormone (GnRH) neurons, stimulates GnRH release and activation of the mammalian reproductive axis. Kisspeptin neurons make close contact with GnRH neurons acting at both the cell body and the nerve terminals. Kisspeptin can act directly on GnRH neurons and/or indirectly v

Source
systematic_review_or_meta_analysis
DOI
10.1016/j.tem.2008.10.005
PubMed
19097915
Open original source
2025Insufficient evidence

Sex-dependent increases in oxytocin levels in response to intravenous kisspeptin in humans.

Content-verified record concerning Kisspeptin: "Sex-dependent increases in oxytocin levels in response to intravenous kisspeptin in humans." Abstract excerpt: A clinically significant oxytocin-deficient state (OXT-D) has been established in adults with arginine vasopressin deficiency, and there is a need to develop diagnostic testing. Kisspeptin (KP) is a candidate for such a test, as KP receptors are found on oxytocinergic neurons, and KP administration increases plasma OXT in animals. We hypothesized that intravenous KP administration would increase p

Source
peer_reviewed_research
DOI
10.1093/ejendo/lvaf001
PubMed
39965102
Open original source
2011Insufficient evidence

Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men

Content-verified record concerning Kisspeptin: "Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men" Abstract excerpt: Kisspeptins stimulate GnRH and thus gonadotropin secretion. Kisspeptin-10 is the minimal kisspeptin sequence with full intrinsic bioactivity, but it has not been studied in man. We investigated our hypothesis that kisspeptin-10 increases GnRH and thus LH pulse frequency. The dose response of kisspeptin-10 was investigated by administering iv bolus doses (0.01-3.0 &#x3bc;g/kg) and vehicle to health

Source
peer_reviewed_research
DOI
10.1210/jc.2011-0089
PubMed
21632807
Open original source
2016Insufficient evidence

High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons

Content-verified record concerning Kisspeptin: "High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons" Abstract excerpt: Kisspeptin (Kiss1) and neurokinin B (NKB) neurocircuits are essential for pubertal development and fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus (Kiss1(ARH)) co-express Kiss1, NKB, dynorphin and glutamate and are postulated to provide an episodic, excitatory drive to gonadotropin-releasing hormone 1 (GnRH) neurons, the synaptic mechanisms of which are unknown. We characterized

Source
peer_reviewed_research
DOI
10.7554/elife.16246
PubMed
27549338
Open original source
2011Insufficient evidence

Kisspeptin Resets the Hypothalamic GnRH Clock in Men

Content-verified record concerning Kisspeptin: "Kisspeptin Resets the Hypothalamic GnRH Clock in Men" Abstract excerpt: Reproduction in all mammals is controlled by a hypothalamic clock that produces periodic secretory pulses of GnRH, but how the timing of these pulses is determined is poorly understood. The neuropeptide kisspeptin potently and selectively stimulates the secretion of GnRH. Although this property of kisspeptin is well described, the effects of kisspeptin on endogenous GnRH pulse generation remain la

Source
peer_reviewed_research
DOI
10.1210/jc.2010-3046
PubMed
21470997
Open original source
2007Insufficient evidence

Neuroendocrine factors in the initiation of puberty: The emergent role of kisspeptin

Content-verified record concerning Kisspeptin: "Neuroendocrine factors in the initiation of puberty: The emergent role of kisspeptin" Abstract excerpt: Puberty is the end-point of a complex series of developmental events, defined by the dynamic interaction between genetic factors and environmental cues, ultimately leading to the attainment of reproductive capacity. The neuroendocrine basis of puberty has been the subject of extensive investigation in the last decades, and identification of the trigger(s) of puberty onset has drawn considerable at

Source
peer_reviewed_research
DOI
10.1007/s11154-007-9028-2
PubMed
17340172
Open original source
2011Insufficient evidence

Kisspeptin Is Essential for the Full Preovulatory LH Surge and Stimulates GnRH Release from the Isolated Ovine Median Eminence

Content-verified record concerning Kisspeptin: "Kisspeptin Is Essential for the Full Preovulatory LH Surge and Stimulates GnRH Release from the Isolated Ovine Median Eminence" Abstract excerpt: Kisspeptins are the product of the Kiss1 gene and potently stimulate GnRH secretion. In sheep, Kiss1 mRNA-expressing cells are found in the arcuate nucleus (ARC) and dorsal-lateral preoptic area and both appear to mediate the positive feedback effect of estradiol to generate the preovulatory GnRH/LH surge. To determine the role of kisspeptin in transmitting estrogen-positive feedback in the hypoth

Source
peer_reviewed_research
DOI
10.1210/en.2010-1225
PubMed
21239443
Open original source
2011Insufficient evidence

Kisspeptins in Reproductive Biology: Consensus Knowledge and Recent Developments1

Content-verified record concerning Kisspeptin: "Kisspeptins in Reproductive Biology: Consensus Knowledge and Recent Developments1" Abstract excerpt: Kisspeptins, a family of neuropeptides encoded by the Kiss1 gene that are mainly expressed in discrete neuronal populations of the hypothalamus, have recently emerged as essential upstream regulatory elements of GnRH (gonadotropin-releasing hormone) neurons and, thereby, potent elicitors of gonadotropin secretion. Indeed, kisspeptins are now recognized as important regulators of key aspects of the

Source
peer_reviewed_research
DOI
10.1095/biolreprod.111.091538
PubMed
21677307
Open original source
2013Insufficient evidence

Kisspeptin and energy balance in reproduction

Content-verified record concerning Kisspeptin: "Kisspeptin and energy balance in reproduction" Abstract excerpt: Kisspeptin is vital for the neuroendocrine regulation of GNRH secretion. Kisspeptin neurons are now recognized as a central pathway responsible for conveying key homeostatic information to GNRH neurons. This pathway is likely to mediate the well-established link between energy balance and reproductive function. Thus, in states of severely altered energy balance (either negative or positive), ferti

Source
peer_reviewed_research
DOI
10.1530/rep-13-0509
PubMed
24327738
Open original source
2013Insufficient evidence

Kisspeptin and Puberty in Mammals

Content-verified record concerning Kisspeptin: "Kisspeptin and Puberty in Mammals" Abstract excerpt: Since the discovery of the G-protein coupled receptor 54 (kisspeptin receptor) and its ligand, kisspeptin, our understanding of the neurobiological mechanisms that govern the pituitary-gonadal axis has evolved dramatically. In this chapter, we have reviewed progress regarding the relationship between kisspeptin and puberty, and have proposed a novel hypothesis for the role of kisspeptin signaling

Source
peer_reviewed_research
DOI
10.1007/978-1-4614-6199-9_12
PubMed
23550010
Open original source
2015Insufficient evidence

Kisspeptin: Beyond the Brain

Content-verified record concerning Kisspeptin: "Kisspeptin: Beyond the Brain" Abstract excerpt: The hypothalamic-based kisspeptin-signaling system is a major positive regulator of the neuroendocrine-reproductive axis in mammals. During the last decade, major advances have been made in understanding how this signaling system is regulated and how it can be manipulated clinically to achieve beneficial outcomes in treating sex steroid-dependent disorders. Interestingly, kisspeptin was not first

Source
peer_reviewed_research
DOI
10.1210/en.2014-1915
PubMed
25590245
Open original source
2015Insufficient evidence

Kisspeptin signalling and its roles in humans

Content-verified record concerning Kisspeptin: "Kisspeptin signalling and its roles in humans" Abstract excerpt: Kisspeptins are a group of peptide fragments encoded by the KISS1 gene in humans. They bind to kisspeptin receptors with equal efficacy. Kisspeptins and their receptors are expressed by neurons in the arcuate and anteroventral periventricular nuclei of the hypothalamus. Oestrogen mediates negative feedback of gonadotrophin-releasing hormone secretion via the arcuate nucleus. Conversely, it exerts

Source
peer_reviewed_research
DOI
10.11622/smedj.2015183
PubMed
26702158
Open original source
2015Insufficient evidence

Kisspeptin Antagonists Reveal Kisspeptin 1 and Kisspeptin 2 Differential Regulation of Reproduction in the Teleost, Morone saxatilis1

Content-verified record concerning Kisspeptin: "Kisspeptin Antagonists Reveal Kisspeptin 1 and Kisspeptin 2 Differential Regulation of Reproduction in the Teleost, Morone saxatilis1" Abstract excerpt: The importance of kisspeptin in regulating vertebrate reproduction has been well established, but the exact mechanism continues to unfold. Unlike mammals, many lower vertebrates possess a dual kisspeptin system, Kiss1 and Kiss2. To decipher the roles of the kisspeptins in fish, we identified two potential kisspeptin antagonists, pep 234 and pep 359, by screening analogs for their ability to inacti

Source
peer_reviewed_research
DOI
10.1095/biolreprod.115.131870
PubMed
26246220
Open original source
2024Insufficient evidence

Characterizing the relationship between gonadotropin releasing hormone (GnRH), kisspeptin, and RFamide related peptide 3 (RFRP-3) neurons in the equine hypothalamus across the estrous cycle and in the anovulatory seasons.

Content-verified record concerning Kisspeptin: "Characterizing the relationship between gonadotropin releasing hormone (GnRH), kisspeptin, and RFamide related peptide 3 (RFRP-3) neurons in the equine hypothalamus across the estrous cycle and in the anovulatory seasons." Abstract excerpt: To understand better the role that kisspeptin plays in regulating seasonal and estrous cycle changes in the mare, this study investigated the number, location and interactions between GnRH, kisspeptin and RFRP-3 neurons in the equine hypothalamus. Hypothalami were collected from mares during the non-breeding season, vernal transition and various stages of the breeding season. Fluorescent immunohis

Source
peer_reviewed_research
DOI
10.1016/j.theriogenology.2024.02.027
PubMed
38432143
Open original source
2015Insufficient evidence

Kisspeptin signaling in the amygdala modulates reproductive hormone secretion

Content-verified record concerning Kisspeptin: "Kisspeptin signaling in the amygdala modulates reproductive hormone secretion" Abstract excerpt: Kisspeptin (encoded by KISS1) is a crucial activator of reproductive function. The role of kisspeptin has been studied extensively within the hypothalamus but little is known about its significance in other areas of the brain. KISS1 and its cognate receptor are expressed in the amygdala, a key limbic brain structure with inhibitory projections to hypothalamic centers involved in gonadotropin secre

Source
peer_reviewed_research
DOI
10.1007/s00429-015-1024-9
PubMed
25758403
Open original source
2016Insufficient evidence

Kisspeptins, Estrogens and Male Fertility

Content-verified record concerning Kisspeptin: "Kisspeptins, Estrogens and Male Fertility" Abstract excerpt: The control of male fertility requires accurate endocrine, paracrine and autocrine communications along the hypothalamus-pituitary-gonad (HPG) axis. In this respect, the possible interplay between upcoming/classical modulators of reproductive functions deserves attention in that may be a successful tool for the future exploitation of new potential therapeutic targets in the treatment of fertility

Source
peer_reviewed_research
DOI
10.2174/0929867323666160902155434
PubMed
27593959
Open original source
2017Insufficient evidence

Kisspeptin modulates sexual and emotional brain processing in humans

Content-verified record concerning Kisspeptin: "Kisspeptin modulates sexual and emotional brain processing in humans" Abstract excerpt: Sex, emotion, and reproduction are fundamental and tightly entwined aspects of human behavior. At a population level in humans, both the desire for sexual stimulation and the desire to bond with a partner are important precursors to reproduction. However, the relationships between these processes are incompletely understood. The limbic brain system has key roles in sexual and emotional behaviors,

Source
peer_reviewed_research
DOI
10.1172/jci89519
PubMed
28112678
Open original source
2010Insufficient evidence

The Role of Kisspeptin Signaling in Reproduction

Content-verified record concerning Kisspeptin: "The Role of Kisspeptin Signaling in Reproduction" Abstract excerpt: Kisspeptins are a group of peptides that stimulate GnRH release and are required for puberty and maintenance of normal reproductive function. This review focuses on our understanding of the way in which kisspeptin signaling regulates mammalian fertility and how they act as central integrators of different hormonal and physiological signals.

Source
peer_reviewed_research
DOI
10.1152/physiol.00009.2010
PubMed
20699467
Open original source
2018Insufficient evidence

Kisspeptin and LH pulsatile temporal coupling in PCOS patients

Content-verified record concerning Kisspeptin: "Kisspeptin and LH pulsatile temporal coupling in PCOS patients" Abstract excerpt: To evaluate the temporal coupling between spontaneous kisspeptin and luteinizing hormone (LH) pulsatile releases in polycystic ovary syndrome (PCOS) patients. We examined 71 patients diagnosed with PCOS. A 2 h pulsatility study was performed to evaluate serum kisspeptin and LH pulse frequency and concentration, sampled every 10 min; baseline follicle-stimulating hormone (FSH), estradiol (E2), prol

Source
peer_reviewed_research
DOI
10.1007/s12020-018-1609-1
PubMed
29728876
Open original source
2020Insufficient evidence

Kisspeptin and Testicular Function—Is It Necessary?

Content-verified record concerning Kisspeptin: "Kisspeptin and Testicular Function—Is It Necessary?" Abstract excerpt: The role of kisspeptin in stimulating hypothalamic GnRH is undisputed. However, the role of kisspeptin signaling in testicular function is less clear. The testes are essential for male reproduction through their functions of spermatogenesis and steroidogenesis. Our review focused on the current literature investigating the distribution, regulation and effects of kisspeptin and its receptor (KISS1/

Source
peer_reviewed_research
DOI
10.3390/ijms21082958
PubMed
32331420
Open original source
2020Insufficient evidence

Kisspeptin and GnRH interactions in the reproductive brain of teleosts

Content-verified record concerning Kisspeptin: "Kisspeptin and GnRH interactions in the reproductive brain of teleosts" Abstract excerpt: It is well known that gonadotropin-releasing hormone (Gnrh) has a key role in reproduction by regulating the synthesis and release of gonadotropins from the anterior pituitary gland of all vertebrates. About 25&#xa0;years ago, another neuropeptide, kisspeptin (Kiss1) was discovered as a metastasis suppressor of melanoma cell lines and then found to be essential for mammalian reproduction as a stim

Source
peer_reviewed_research
DOI
10.1016/j.ygcen.2020.113568
PubMed
32710898
Open original source
2022Insufficient evidence

Kisspeptins and the neuroendocrine control of reproduction: Recent progress and new frontiers in kisspeptin research

Content-verified record concerning Kisspeptin: "Kisspeptins and the neuroendocrine control of reproduction: Recent progress and new frontiers in kisspeptin research" Abstract excerpt: In late 2003, a major breakthrough in our understanding of the mechanisms that govern reproduction occurred with the identification of the reproductive roles of kisspeptins, encoded by the Kiss1 gene, and their receptor, Gpr54 (aka, Kiss1R). The discovery of this unsuspected reproductive facet attracted an extraordinary interest and boosted an intense research activity, in human and model species,

Source
peer_reviewed_research
DOI
10.1016/j.yfrne.2021.100977
PubMed
34999056
Open original source
2024Insufficient evidence

Kisspeptin and mammalian reproduction.

Content-verified record concerning Kisspeptin: "Kisspeptin and mammalian reproduction." (identity confirmed; no abstract text available to excerpt.)

Source
peer_reviewed_research
DOI
10.1016/j.peptides.2024.171297
PubMed
39306000
Open original source
2025Insufficient evidence

Kisspeptin levels in infertile and miscarried women: a cross-sectional study on the relationship with methylenetetrahydrofolate reductase gene polymorphisms and biochemical parameters.

Content-verified record concerning Kisspeptin: "Kisspeptin levels in infertile and miscarried women: a cross-sectional study on the relationship with methylenetetrahydrofolate reductase gene polymorphisms and biochemical parameters." Abstract excerpt: Low kisspeptin levels are observed in those with reproductive difficulties. This study was designed to examine and compare kisspeptin levels in women with infertility and miscarriages. Moreover, the aim of this study was to evaluate the possible relationship between kisspeptin levels and the C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene, as well as certain biochemi

Source
peer_reviewed_research
DOI
10.1590/1806-9282.20250716
PubMed
41124561
Open original source
2023Insufficient evidence

Kisspeptin as a predictor of miscarriage: a systematic review.

Content-verified record concerning Kisspeptin: "Kisspeptin as a predictor of miscarriage: a systematic review." Abstract excerpt: A highly accurate serum marker for predicting viable pregnancy needs to be developed. Recent studies have demonstrated that kisspeptin is a potential biomarker for this purpose. This systematic review evaluated the available data in the literature on the role of kisspeptin as a miscarriage biomarker. A literature search was conducted in the PubMed/Medline, Embase, Web of Science, and Scopus databa

Source
systematic_review_or_meta_analysis
DOI
10.1080/14767058.2023.2197097
PubMed
37015836
Open original source
2024Insufficient evidence

Dynamics in cortisol levels in Danio rerio fish under the influence of a synthetic analog of kisspeptin 1.

Content-verified record concerning Kisspeptin: "Dynamics in cortisol levels in Danio rerio fish under the influence of a synthetic analog of kisspeptin 1." Abstract excerpt: The effect of a synthetic analog of kisspeptin 1, a peptide involved in the regulation of the hypothalamicpituitary- gonadal (HPG) stress axis, on the cortisol level of Danio rerio fish was investigated. Kisspeptin 1 was administered at doses of 2 &#x3bc;g/kg and 8 &#x3bc;g/kg followed by resting for 1 h and 4 h. We found that kisspeptin at doses of 2 &#x3bc;g/kg and 8 &#x3bc;g/kg increased cortis

Source
peer_reviewed_research
DOI
10.18097/pbmc20247003176
PubMed
38940207
Open original source
2024Insufficient evidence

Kisspeptin and neurokinin B neuroendocrine pathways in the control of human ovulation.

Content-verified record concerning Kisspeptin: "Kisspeptin and neurokinin B neuroendocrine pathways in the control of human ovulation." Abstract excerpt: The roles of initially kisspeptin and subsequently neurokinin B pathways in the regulation of human reproduction through the control of GnRH secretion were first identified 20 years ago, as essential for the onset of puberty in both boys and girls. Within that short time we already now have the first licence for clinical use for a neurokinin antagonist in a related indication, for menopausal vasom

Source
systematic_review_or_meta_analysis
DOI
10.1111/jne.13371
PubMed
38404024
Open original source
2006Insufficient evidence

GPR54 and kisspeptin in reproduction

Content-verified record concerning Kisspeptin: "GPR54 and kisspeptin in reproduction" Abstract excerpt: Kisspeptins, the peptide products of the KiSS-1 gene, were identified in 2001 as natural ligands of the previously orphan G protein-coupled receptor, GPR54. They include, among others, metastin and kisspeptin-10. The known biological functions of kisspeptins were initially restricted to their ability to suppress tumour metastasis, hence the name of metastin. However, in late 2003, two groups indep

Source
peer_reviewed_research
DOI
10.1093/humupd/dml023
PubMed
16731583
Open original source
2011Insufficient evidence

Early Metabolic Programming of Puberty Onset: Impact of Changes in Postnatal Feeding and Rearing Conditions on the Timing of Puberty and Development of the Hypothalamic Kisspeptin System

Content-verified record concerning Kisspeptin: "Early Metabolic Programming of Puberty Onset: Impact of Changes in Postnatal Feeding and Rearing Conditions on the Timing of Puberty and Development of the Hypothalamic Kisspeptin System" Abstract excerpt: Kiss1 neurons have recently emerged as a putative conduit for the metabolic gating of reproduction, with leptin being a regulator of hypothalamic Kiss1 expression. Early perturbations of the nutritional status are known to predispose to different metabolic disorders later in life and to alter the timing of puberty; however, the potential underlying mechanisms remain poorly defined. Here we report

Source
peer_reviewed_research
DOI
10.1210/en.2010-1415
PubMed
21712362
Open original source
2014Insufficient evidence

Increasing LH Pulsatility in Women With Hypothalamic Amenorrhoea Using Intravenous Infusion of Kisspeptin-54

Content-verified record concerning Kisspeptin: "Increasing LH Pulsatility in Women With Hypothalamic Amenorrhoea Using Intravenous Infusion of Kisspeptin-54" Abstract excerpt: Hypothalamic amenorrhea (HA) is the one of the most common causes of period loss in women of reproductive age and is associated with deficient LH pulsatility. High-dose kisspeptin-54 acutely stimulates LH secretion in women with HA, but chronic administration causes desensitization. GnRH has paradoxical effects on reproductive activity; we therefore hypothesized that a dose-dependent therapeutic w

Source
peer_reviewed_research
DOI
10.1210/jc.2013-1569
PubMed
24517142
Open original source
2018Insufficient evidence

The role of kisspeptin neurons in reproduction and metabolism

Content-verified record concerning Kisspeptin: "The role of kisspeptin neurons in reproduction and metabolism" Abstract excerpt: Kisspeptin is a neuropeptide with a critical role in the function of the hypothalamic-pituitary-gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in the hypothalamus, the rostral periventricular region of the third ventricle (RP3V) and arcuate nucleus (ARC). These neurons project to and activate gonadotrophin-releasing hormone (GnRH) neurons (acting via the kis

Source
peer_reviewed_research
DOI
10.1530/joe-18-0108
PubMed
30042117
Open original source
2025Insufficient evidence

Kisspeptin and its Current Clinical Status-A Systematic Review.

Content-verified record concerning Kisspeptin: "Kisspeptin and its Current Clinical Status-A Systematic Review." Abstract excerpt: Kisspeptin was initially known as metastin for its role in suppressing metastasis in melanoma and breast cancer. Later, based on its ability to stimulate GPR54, its importance in maintaining an intact hypothalamic-pituitary-ovarian axis was recognised, which is the basis for the widespread application of the drug in several conditions such as secondary amenorrhea, regulation of puberty onset, ovar

Source
systematic_review_or_meta_analysis
DOI
10.2174/0109298673251224230919093656
PubMed
38265397
Open original source
2024Insufficient evidence

Kisspeptin stimulates sheep ovarian follicular development <i>in vitro</i> through homologous receptors.

Content-verified record concerning Kisspeptin: "Kisspeptin stimulates sheep ovarian follicular development <i>in vitro</i> through homologous receptors." Abstract excerpt: The present study was conducted to elucidate (1) the influence of kisspeptin (KP) on the in vitro development of preantral follicles (PFs) and (2) evolution of KP receptor gene ( KISS1R ) expression during ovarian follicular development in sheep. Kisspeptin was supplemented (0-100 &#xb5;g/ml) in the culture medium of PFs for 6 days. The cumulus-oocyte complexes (COCs) from cultured PFs were subseq

Source
peer_reviewed_research
DOI
10.1017/s096719942300059x
PubMed
38059309
Open original source
2010Insufficient evidence

Neurokinin B Stimulates GnRH Release in the Male Monkey (Macaca mulatta) and Is Colocalized with Kisspeptin in the Arcuate Nucleus

Content-verified record concerning Kisspeptin: "Neurokinin B Stimulates GnRH Release in the Male Monkey (Macaca mulatta) and Is Colocalized with Kisspeptin in the Arcuate Nucleus" Abstract excerpt: Human genetics indicate that kisspeptin and neurokinin B (NKB) signaling are necessary for generating pulsatile LH release and therefore for initiation of puberty and maintaining gonadal function. In the present study, male monkeys were employed to examine 1) whether activation of the NKB receptor (NK3R) is associated with GnRH release, and 2) hypothalamic localization of these peptides using immu

Source
peer_reviewed_research
DOI
10.1210/en.2010-0223
PubMed
20573725
Open original source
2025Insufficient evidence

Kisspeptin Receptor Agonists and Antagonists: Strategies for Discovery and Implications for Human Health and Disease.

Content-verified record concerning Kisspeptin: "Kisspeptin Receptor Agonists and Antagonists: Strategies for Discovery and Implications for Human Health and Disease." Abstract excerpt: The kisspeptin/kisspeptin receptor ( KISS1 / KISS1R ) system has emerged as a vital regulator of various physiological processes, including cancer progression, metabolic function, and reproduction. KISS1R , a member of the G protein-coupled receptor family, is crucial for regulating the hypothalamic/pituitary/gonadal axis. A growing number of KISS1R agonists are currently being investigated in cli

Source
peer_reviewed_research
DOI
10.3390/ijms26104890
PubMed
40430029
Open original source
2025Insufficient evidence

Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans.

Content-verified record concerning Kisspeptin: "Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans." Abstract excerpt: Kisspeptin is a critical endogenous activator of the reproductive system, with escalating clinical interest as a novel therapeutic for common reproductive and psychosexual disorders. However, conflicting animal data suggest that kisspeptin can have anxiolytic, neutral, or anxiogenic effects. Given the rapid development of kisspeptin-based therapeutics, it is important to comprehensively investigat

Source
peer_reviewed_research
DOI
10.1210/clinem/dgaf128
PubMed
40036336
Open original source
2022Insufficient evidence

Stress, kisspeptin, and functional hypothalamic amenorrhea.

Context on reproductive neuroendocrine signaling and a defined clinical question; not a direct efficacy trial.

Source
peer_reviewed_research
DOI
10.1016/j.coph.2022.102288
PubMed
36103784
Open original source
Insufficient evidence

Dynamic modulation of LH secretion by continuous kisspeptin infusion in healthy men.

Source reference associated with Kisspeptin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1007/s42000-026-00795-y
PubMed
42230485
Open original source
Insufficient evidence

Naringenin protects against renal ischemia-reperfusion injury following unilateral nephrectomy via modulation of oxidative stress and kisspeptin expression.

Source reference associated with Kisspeptin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1007/s11255-026-05293-z
PubMed
42490039
Open original source
Insufficient evidence

Stress as a Neuroendocrine Modulator of the Reproductive Axis: Roles of Glucocorticoids, Kisspeptin, and Serotonergic Signalling in Animal Models.

Source reference associated with Kisspeptin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1159/000553326
PubMed
42371829
Open original source
2013Insufficient evidence

Metabolic control of puberty: Roles of leptin and kisspeptins

Content-verified record concerning Kisspeptin: "Metabolic control of puberty: Roles of leptin and kisspeptins" Abstract excerpt: This article is part of a Special Issue "Puberty and Adolescence". Reproduction is an energy-demanding function. Accordingly, puberty is metabolically gated, as a means to prevent fertility in conditions of energy insufficiency. In addition, obesity has been shown to impact the timing of puberty and may be among the causes for the earlier trends of pubertal age reported in various countries. The m

Source
peer_reviewed_research
DOI
10.1016/j.yhbeh.2013.01.014
PubMed
23998663
Open original source
2013Insufficient evidence

Neuroanatomical Evidence That Kisspeptin Directly Regulates Isotocin and Vasotocin Neurons

Content-verified record concerning Kisspeptin: "Neuroanatomical Evidence That Kisspeptin Directly Regulates Isotocin and Vasotocin Neurons" Abstract excerpt: Neuropeptide kisspeptin has been suggested to be an essential central regulator of reproduction in response to changes in serum gonadal steroid concentrations. However, in spite of wide kisspeptin receptor distribution in the brain, especially in the preoptic area and hypothalamus, the research focus has mostly been confined to the kisspeptin regulation on GnRH neurons. Here, by using medaka whose

Source
peer_reviewed_research
DOI
10.1371/journal.pone.0062776
PubMed
23638144
Open original source
2007Insufficient evidence

Direct Pituitary Effects of Kisspeptin: Activation of Gonadotrophs and Somatotrophs and Stimulation of Luteinising Hormone and Growth Hormone Secretion

Content-verified record concerning Kisspeptin: "Direct Pituitary Effects of Kisspeptin: Activation of Gonadotrophs and Somatotrophs and Stimulation of Luteinising Hormone and Growth Hormone Secretion" Abstract excerpt: Recent, compelling evidence indicates that kisspeptins, the products of KiSS-1 gene, and their receptor GPR54, represent key elements in the neuroendocrine control of reproduction, and that they act primarily by regulating gonadotrophin-releasing hormone (GnRH) secretion at the hypothalamus. Conversely, and despite earlier reports showing GPR54 expression in the pituitary, the potential physiologi

Source
peer_reviewed_research
DOI
10.1111/j.1365-2826.2007.01558.x
PubMed
17532794
Open original source
2013Insufficient evidence

Dependence of fertility on kisspeptin–Gpr54 signaling at the GnRH neuron

Content-verified record concerning Kisspeptin: "Dependence of fertility on kisspeptin–Gpr54 signaling at the GnRH neuron" Abstract excerpt: Signaling between kisspeptin and its receptor, G-protein-coupled receptor 54 (Gpr54), is now recognized as being essential for normal fertility. However, the key cellular location of kisspeptin-Gpr54 signaling is unknown. Here we create a mouse with a GnRH neuron-specific deletion of Gpr54 to assess the role of gonadotropin-releasing hormone (GnRH) neurons. Mutant mice are infertile, fail to go th

Source
peer_reviewed_research
DOI
10.1038/ncomms3492
PubMed
24051579
Open original source
2014Insufficient evidence

Glucagon Regulates Hepatic Kisspeptin to Impair Insulin Secretion

Content-verified record concerning Kisspeptin: "Glucagon Regulates Hepatic Kisspeptin to Impair Insulin Secretion" Abstract excerpt: Early in the pathogenesis of type 2 diabetes mellitus (T2DM), dysregulated glucagon secretion from pancreatic &#x3b1; cells occurs prior to impaired glucose-stimulated insulin secretion (GSIS) from &#x3b2; cells. However, whether hyperglucagonemia is causally linked to &#x3b2; cell dysfunction remains unclear. Here we show that glucagon stimulates via cAMP-PKA-CREB signaling hepatic production of

Source
peer_reviewed_research
DOI
10.1016/j.cmet.2014.03.005
PubMed
24703698
Open original source
2018Insufficient evidence

Serum Levels of Spexin and Kisspeptin Negatively Correlate With Obesity and Insulin Resistance in Women

Content-verified record concerning Kisspeptin: "Serum Levels of Spexin and Kisspeptin Negatively Correlate With Obesity and Insulin Resistance in Women" Abstract excerpt: Spexin (SPX) and kisspeptin (KISS) are novel peptides relevant in the context of regulation of metabolism, food intake, puberty and reproduction. Here, we studied changes of serum SPX and KISS levels in female non-obese volunteers (BMI&lt;25 kg/m(2)) and obese patients (BMI&gt;35 kg/m(2)). Correlations between SPX or KISS with BMI, McAuley index, QUICKI, HOMA IR, serum levels of insulin, glucagon,

Source
peer_reviewed_research
DOI
10.33549/physiolres.933467
PubMed
29137471
Open original source
2007Insufficient evidence

Hypertrophy and Increased Kisspeptin Gene Expression in the Hypothalamic Infundibular Nucleus of Postmenopausal Women and Ovariectomized Monkeys

Content-verified record concerning Kisspeptin: "Hypertrophy and Increased Kisspeptin Gene Expression in the Hypothalamic Infundibular Nucleus of Postmenopausal Women and Ovariectomized Monkeys" Abstract excerpt: Human menopause is characterized by ovarian failure, gonadotropin hypersecretion, and neuronal hypertrophy in the hypothalamic infundibular (arcuate) nucleus. Recent studies have demonstrated a critical role for kisspeptins in reproductive regulation, but it is not known whether menopause is accompanied by changes in hypothalamic kisspeptin neurons. Our objective was to map the location of neurons

Source
peer_reviewed_research
DOI
10.1210/jc.2007-0553
PubMed
17488799
Open original source
2020Insufficient evidence

Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour

Content-verified record concerning Kisspeptin: "Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour" Abstract excerpt: The bioactive peptides galanin, spexin and kisspeptin have a common ancestral origin&#xa0;and their pathophysiological roles are increasingly the subject of investigation. Evidence suggests that these bioactive peptides play a role in the regulation of metabolism, pancreatic &#x3b2;-cell function, energy homeostasis, mood and behaviour in several species, including zebrafish, rodents and humans. G

Source
systematic_review_or_meta_analysis
DOI
10.1038/s41574-020-00438-1
PubMed
33273729
Open original source
2008Insufficient evidence

Identification of KiSS-1 Product Kisspeptin and Steroid-Sensitive Sexually Dimorphic Kisspeptin Neurons in Medaka (Oryzias latipes)

Content-verified record concerning Kisspeptin: "Identification of KiSS-1 Product Kisspeptin and Steroid-Sensitive Sexually Dimorphic Kisspeptin Neurons in Medaka (Oryzias latipes)" Abstract excerpt: Recently, a novel physiologically active peptide, kisspeptin (metastin), has been reported to facilitate sexual maturation and ovulation by directly stimulating GnRH neurons in several mammalian species. Despite its importance in the neuroendocrine regulation of reproduction, kisspeptin neurons have only been studied in mammals, and there has been no report on the kisspeptin or kisspeptin neuronal

Source
peer_reviewed_research
DOI
10.1210/en.2007-1503
PubMed
18202129
Open original source

Scientific context

Chemistry and represented biological context

Existing reviewed chemistry is preserved as scientific context. Chemistry and mechanism information do not establish clinical efficacy or safety.

Open chemistry and biological context ↓
Chemical identity

Molecular and structural record

Structured record
Molecular formula
C258H401N79O78
Molecular weight (Da)
5857
SMILES
CCC(C)C(C(=O)N1CCCC1C(=O)NC(C)C(=O)N2CCCC2C(=O)NC(CCC(=O)N)C(=O)NCC(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)N3CCCC3C(=O)NC(CC(=O)N)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CC(=O)N)C(=O)NC(CC5=CNC6=CC=CC=C65)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CC7=CC=CC=C7)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC8=CC=CC=C8)C(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(CC9=CN=CN9)NC(=O)C1CCCN1C(=O)C(C)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C1CCCN1C(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)CNC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCC(=O)O)NC(=O)C1CCCN1C(=O)C1CCCN1C(=O)C1CCCN1C(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)CN
InChI
InChI=1S/C258H401N79O78/c1-21-131(16)204(329-220(381)152(70-77-189(264)351)301-213(374)147(53-34-84-281-257(274)275)299-234(395)173(118-341)322-226(387)164(103-140-110-278-123-288-140)315-242(403)181-58-38-87-331(181)247(408)133(18)290-232(393)172(117-340)321-222(383)158(95-125(4)5)293-197(359)114-287-238(399)178-55-36-88-332(178)249(410)155(71-78-190(265)352)306-218(379)150(68-75-187(262)349)300-212(373)146(52-33-83-280-256(272)273)298-233(394)171(116-339)294-198(360)113-286-210(371)170(115-338)319-237(398)175(120-343)320-219(380)154(73-80-200(363)364)304-241(402)183-60-40-90-334(183)252(413)185-62-43-93-337(185)253(414)184-61-42-92-336(184)251(412)177(122-345)325-223(384)159(96-126(6)7)308-236(397)176(121-344)324-246(407)205(135(20)346)326-194(356)108-260)254(415)335-91-41-56-179(335)239(400)291-134(19)248(409)330-86-37-57-180(330)240(401)303-149(67-74-186(261)348)208(369)284-111-195(357)289-132(17)207(368)327-202(129(12)13)245(406)317-160(97-127(8)9)231(392)328-203(130(14)15)244(405)305-151(69-76-188(263)350)216(377)296-145(51-32-82-279-255(270)271)211(372)302-153(72-79-199(361)362)217(378)295-144(50-30-31-81-259)215(376)314-168(107-201(365)366)230(391)318-169(98-128(10)11)250(411)333-89-39-59-182(333)243(404)316-167(106-193(268)355)228(389)310-162(101-138-63-65-141(347)66-64-138)224(385)312-165(104-191(266)353)227(388)311-163(102-139-109-283-143-49-29-28-48-142(139)143)225(386)313-166(105-192(267)354)229(390)323-174(119-342)235(396)309-161(100-137-46-26-23-27-47-137)209(370)285-112-196(358)292-157(94-124(2)3)221(382)297-148(54-35-85-282-258(276)277)214(375)307-156(206(269)367)99-136-44-24-22-25-45-136/h22-29,44-49,63-66,109-110,123-135,144-185,202-205,283,338-347H,21,30-43,50-62,67-108,111-122,259-260H2,1-20H3,(H2,261,348)(H2,262,349)(H2,263,350)(H2,264,351)(H2,265,352)(H2,266,353)(H2,267,354)(H2,268,355)(H2,269,367)(H,278,288)(H,284,369)(H,285,370)(H,286,371)(H,287,399)(H,289,357)(H,290,393)(H,291,400)(H,292,358)(H,293,359)(H,294,360)(H,295,378)(H,296,377)(H,297,382)(H,298,394)(H,299,395)(H,300,373)(H,301,374)(H,302,372)(H,303,401)(H,304,402)(H,305,405)(H,306,379)(H,307,375)(H,308,397)(H,309,396)(H,310,389)(H,311,388)(H,312,385)(H,313,386)(H,314,376)(H,315,403)(H,316,404)(H,317,406)(H,318,391)(H,319,398)(H,320,380)(H,321,383)(H,322,387)(H,323,390)(H,324,407)(H,325,384)(H,326,356)(H,327,368)(H,328,392)(H,329,381)(H,361,362)(H,363,364)(H,365,366)(H4,270,271,279)(H4,272,273,280)(H4,274,275,281)(H4,276,277,282)/t131-,132-,133-,134-,135+,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,202-,203-,204-,205-/m0/s1
InChIKey
KAHDONZOCXSKII-NJVVDGNHSA-N

Chemical identity describes the recorded molecular information. It does not establish biological activity, clinical efficacy, safety, or therapeutic suitability.

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Research chronology

  1. 2001 · study · Temporal status not established

    The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54

    peer_reviewed_research

  2. 2004 · study · Temporal status not established

    A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse

    peer_reviewed_research

  3. 2004 · study · Temporal status not established

    Central and Peripheral Administration of Kisspeptin‐10 Stimulates the Hypothalamic‐Pituitary‐Gonadal Axis

    peer_reviewed_research

  4. 2004 · study · Temporal status not established

    Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat

    peer_reviewed_research

  5. 2004 · study · Temporal status not established

    Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts

    peer_reviewed_research

  6. 2005 · study · Temporal status not established

    Changes in Hypothalamic KiSS-1 System and Restoration of Pubertal Activation of the Reproductive Axis by Kisspeptin in Undernutrition

    peer_reviewed_research

  7. 2005 · study · Temporal status not established

    Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54

    peer_reviewed_research

  8. 2005 · study · Temporal status not established

    Kisspeptin-10-Induced Signaling of GPR54 Negatively Regulates Chemotactic Responses Mediated by CXCR4: a Potential Mechanism for the Metastasis Suppressor Activity of Kisspeptins

    peer_reviewed_research

  9. 2005 · study · Temporal status not established

    Repetitive Activation of Hypothalamic G Protein-Coupled Receptor 54 with Intravenous Pulses of Kisspeptin in the Juvenile Monkey (Macaca mulatta) Elicits a Sustained Train of Gonadotropin-Releasing Hormone Discharges

    peer_reviewed_research

  10. 2005 · study · Temporal status not established

    Minireview: Kisspeptin Neurons as Central Processors in the Regulation of Gonadotropin-Releasing Hormone Secretion

    systematic_review_or_meta_analysis

  11. 2005 · study · Temporal status not established

    Kisspeptin-54 Stimulates the Hypothalamic-Pituitary Gonadal Axis in Human Males

    peer_reviewed_research

  12. 2005 · study · Temporal status not established

    Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty

    peer_reviewed_research

  13. 2006 · study · Temporal status not established

    Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats

    peer_reviewed_research

  14. 2006 · study · Temporal status not established

    Hypothalamic Expression of KiSS-1 System and Gonadotropin-Releasing Effects of Kisspeptin in Different Reproductive States of the Female Rat

    peer_reviewed_research

  15. 2006 · study · Temporal status not established

    Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat

    peer_reviewed_research

  16. 2006 · study · Temporal status not established

    Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats

    peer_reviewed_research

  17. 2006 · study · Temporal status not established

    Postnatal Development of Kisspeptin Neurons in Mouse Hypothalamus; Sexual Dimorphism and Projections to Gonadotropin-Releasing Hormone Neurons

    peer_reviewed_research

  18. 2006 · study · Temporal status not established

    Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha

    peer_reviewed_research

  19. 2006 · study · Temporal status not established

    A role for kisspeptin in islet function

    peer_reviewed_research

  20. 2006 · study · Temporal status not established

    Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling

    peer_reviewed_research

  21. 2006 · study · Temporal status not established

    Kisspeptin Mediates the Photoperiodic Control of Reproduction in Hamsters

    peer_reviewed_research

  22. 2006 · study · Temporal status not established

    GPR54 and kisspeptin in reproduction

    peer_reviewed_research

  23. 2007 · study · Temporal status not established

    Metastin/Kisspeptin and control of estrous cycle in rats

    peer_reviewed_research

  24. 2007 · study · Temporal status not established

    Involvement of Anteroventral Periventricular Metastin/Kisspeptin Neurons in Estrogen Positive Feedback Action on Luteinizing Hormone Release in Female Rats

    peer_reviewed_research

  25. 2007 · study · Temporal status not established

    Kisspeptin Is Present in Ovine Hypophysial Portal Blood But Does Not Increase during the Preovulatory Luteinizing Hormone Surge: Evidence that Gonadotropes Are Not Direct Targets of Kisspeptin in Vivo

    peer_reviewed_research

  26. 2007 · study · Temporal status not established

    The Kisspeptin Receptor GPR54 Is Required for Sexual Differentiation of the Brain and Behavior

    peer_reviewed_research

  27. 2007 · study · Temporal status not established

    Emerging ideas about kisspeptin– GPR54 signaling in the neuroendocrine regulation of reproduction

    systematic_review_or_meta_analysis

  28. 2007 · study · Temporal status not established

    New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function

    peer_reviewed_research

  29. 2007 · study · Temporal status not established

    The Role of Kisspeptin–GPR54 Signaling in the Tonic Regulation and Surge Release of Gonadotropin-Releasing Hormone/Luteinizing Hormone

    peer_reviewed_research

  30. 2007 · study · Temporal status not established

    The Role of Kisspeptins and GPR54 in the Neuroendocrine Regulation of Reproduction

    systematic_review_or_meta_analysis

  31. 2007 · study · Temporal status not established

    The Kisspeptin/Gonadotropin-Releasing Hormone Pathway and Molecular Signaling of Puberty in Fish1

    peer_reviewed_research

  32. 2007 · study · Temporal status not established

    Kisspeptin-54 Stimulates Gonadotropin Release Most Potently during the Preovulatory Phase of the Menstrual Cycle in Women

    peer_reviewed_research

  33. 2007 · study · Temporal status not established

    Kisspeptin Acts Directly and Indirectly to Increase Gonadotropin-Releasing Hormone Neuron Activity and Its Effects Are Modulated by Estradiol

    peer_reviewed_research

  34. 2007 · study · Temporal status not established

    Kisspeptin Neurons in the Arcuate Nucleus of the Ewe Express Both Dynorphin A and Neurokinin B

    peer_reviewed_research

  35. 2007 · study · Temporal status not established

    Kisspeptin Synchronizes Preovulatory Surges in Cyclical Ewes and Causes Ovulation in Seasonally Acyclic Ewes

    peer_reviewed_research

  36. 2007 · study · Temporal status not established

    Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system

    peer_reviewed_research

  37. 2007 · study · Temporal status not established

    Kisspeptin signalling in the brain: Steroid regulation in the rodent and ewe

    peer_reviewed_research

  38. 2007 · study · Temporal status not established

    Kisspeptin: A key link to seasonal breeding

    peer_reviewed_research

  39. 2007 · study · Temporal status not established

    Kisspeptins and the placenta: Regulation of trophoblast invasion

    peer_reviewed_research

  40. 2007 · study · Temporal status not established

    Kisspeptin expression in the brain: Catalyst for the initiation of puberty

    peer_reviewed_research

  41. 2007 · study · Temporal status not established

    Neuroendocrine factors in the initiation of puberty: The emergent role of kisspeptin

    peer_reviewed_research

  42. 2007 · study · Temporal status not established

    Direct Pituitary Effects of Kisspeptin: Activation of Gonadotrophs and Somatotrophs and Stimulation of Luteinising Hormone and Growth Hormone Secretion

    peer_reviewed_research

  43. 2007 · study · Temporal status not established

    Hypertrophy and Increased Kisspeptin Gene Expression in the Hypothalamic Infundibular Nucleus of Postmenopausal Women and Ovariectomized Monkeys

    peer_reviewed_research

  44. 2008 · study · Temporal status not established

    Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals

    peer_reviewed_research

  45. 2008 · study · Temporal status not established

    Molecular Identification and Functional Characterization of the Kisspeptin/Kisspeptin Receptor System in Lower Vertebrates1

    peer_reviewed_research

  46. 2008 · study · Temporal status not established

    An Increase in Kisspeptin-54 Release Occurs with the Pubertal Increase in Luteinizing Hormone-Releasing Hormone-1 Release in the Stalk-Median Eminence of Female Rhesus Monkeys in Vivo

    peer_reviewed_research

  47. 2008 · study · Temporal status not established

    Central and peripheral administration of kisspeptin activates gonadotropin but not somatotropin secretion in prepubertal gilts

    peer_reviewed_research

  48. 2008 · study · Temporal status not established

    Kisspeptin Depolarizes Gonadotropin-Releasing Hormone Neurons through Activation of TRPC-Like Cationic Channels

    peer_reviewed_research

  49. 2008 · study · Temporal status not established

    The neuroanatomy of the kisspeptin system in the mammalian brain

    peer_reviewed_research

  50. 2008 · study · Temporal status not established

    The role of kisspeptin in the control of gonadotrophin secretion

    peer_reviewed_research

  51. 2008 · study · Temporal status not established

    GPR54 and Kisspeptins

    peer_reviewed_research

  52. 2008 · study · Temporal status not established

    From KISS1 to kisspeptins: An historical perspective and suggested nomenclature

    peer_reviewed_research

  53. 2008 · study · Temporal status not established

    The kisspeptin (KiSS-1)/GPR54 system in cancer biology

    peer_reviewed_research

  54. 2008 · study · Temporal status not established

    Comparison of the effects of peripherally administered kisspeptins

    peer_reviewed_research

  55. 2008 · study · Temporal status not established

    Kisspeptin–GPR54 Signaling Is Essential for Preovulatory Gonadotropin-Releasing Hormone Neuron Activation and the Luteinizing Hormone Surge

    peer_reviewed_research

  56. 2008 · study · Temporal status not established

    Kisspeptin Excites Gonadotropin-Releasing Hormone Neurons through a Phospholipase C/Calcium-Dependent Pathway Regulating Multiple Ion Channels

    peer_reviewed_research

  57. 2008 · study · Temporal status not established

    Kisspeptin Can Stimulate Gonadotropin-Releasing Hormone (GnRH) Release by a Direct Action at GnRH Nerve Terminals

    peer_reviewed_research

  58. 2008 · study · Temporal status not established

    Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback

    peer_reviewed_research

  59. 2008 · study · Temporal status not established

    Kisspeptin and GPR54: Discovery of a Novel Pathway in Reproduction

    peer_reviewed_research

  60. 2008 · study · Temporal status not established

    Kisspeptins and the control of gonadotropin secretion in male and female rodents

    peer_reviewed_research

  61. 2008 · study · Temporal status not established

    Kisspeptins and GnRH neuronal signalling

    systematic_review_or_meta_analysis

  62. 2008 · study · Temporal status not established

    Identification of KiSS-1 Product Kisspeptin and Steroid-Sensitive Sexually Dimorphic Kisspeptin Neurons in Medaka (Oryzias latipes)

    peer_reviewed_research

  63. 2009 · study · Temporal status not established

    Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse

    peer_reviewed_research

  64. 2009 · study · Temporal status not established

    A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10

    peer_reviewed_research

  65. 2009 · study · Temporal status not established

    Distribution of Kisspeptin Neurones in the Adult Female Mouse Brain

    peer_reviewed_research

  66. 2009 · study · Temporal status not established

    Kisspeptin Signalling in the Hypothalamic Arcuate Nucleus Regulates GnRH Pulse Generator Frequency in the Rat

    peer_reviewed_research

  67. 2009 · study · Temporal status not established

    Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women with Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis

    peer_reviewed_research

  68. 2009 · study · Temporal status not established

    Molecular Evolution of Multiple Forms of Kisspeptins and GPR54 Receptors in Vertebrates

    peer_reviewed_research

  69. 2009 · study · Temporal status not established

    Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines

    peer_reviewed_research

  70. 2009 · study · Temporal status not established

    The Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cell Population of the Arcuate Nucleus: Sex Differences and Effects of Prenatal Testosterone in Sheep

    peer_reviewed_research

  71. 2009 · study · Temporal status not established

    Discovery of Potent Kisspeptin Antagonists Delineate Physiological Mechanisms of Gonadotropin Regulation

    peer_reviewed_research

  72. 2009 · study · Temporal status not established

    Postnatal Development of an Estradiol-Kisspeptin Positive Feedback Mechanism Implicated in Puberty Onset

    peer_reviewed_research

  73. 2009 · study · Temporal status not established

    Critical Roles of Kisspeptins in Female Puberty and Preovulatory Gonadotropin Surges as Revealed by a Novel Antagonist

    peer_reviewed_research

  74. 2009 · study · Temporal status not established

    Oestrogen, Kisspeptin, GPR54 and the Pre‐Ovulatory Luteinising Hormone Surge

    peer_reviewed_research

  75. 2009 · study · Temporal status not established

    Characteristics of stimulation of gonadotropin secretion by kisspeptin-10 in female goats

    peer_reviewed_research

  76. 2009 · study · Temporal status not established

    Kisspeptin Signaling in the Brain

    peer_reviewed_research

  77. 2010 · study · Temporal status not established

    Timing and completion of puberty in female mice depend on estrogen receptor α-signaling in kisspeptin neurons

    peer_reviewed_research

  78. 2010 · study · Temporal status not established

    Identification of Prolactin-Sensitive GABA and Kisspeptin Neurons in Regions of the Rat Hypothalamus Involved in the Control of Fertility

    peer_reviewed_research

  79. 2010 · study · Temporal status not established

    Mapping of Kisspeptin Fibres in the Brain of the Pro‐Oestrous Rat

    peer_reviewed_research

  80. 2010 · study · Temporal status not established

    Developmental Changes in the Expression of Kisspeptin mRNA in Rat Hypothalamus

    peer_reviewed_research

  81. 2010 · study · Temporal status not established

    Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat

    peer_reviewed_research

  82. 2010 · study · Temporal status not established

    Characterisation of Arcuate Nucleus Kisspeptin/Neurokinin B Neuronal Projections and Regulation during Lactation in the Rat

    peer_reviewed_research

  83. 2010 · study · Temporal status not established

    Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat

    peer_reviewed_research

  84. 2010 · study · Temporal status not established

    Kisspeptin Cells in the Ewe Brain Respond to Leptin and Communicate with Neuropeptide Y and Proopiomelanocortin Cells

    peer_reviewed_research

  85. 2010 · study · Temporal status not established

    Kisspeptin Directly Excites Anorexigenic Proopiomelanocortin Neurons but Inhibits Orexigenic Neuropeptide Y Cells by an Indirect Synaptic Mechanism

    peer_reviewed_research

  86. 2010 · study · Temporal status not established

    Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion

    peer_reviewed_research

  87. 2010 · study · Temporal status not established

    Molecular coevolution of kisspeptins and their receptors from fish to mammals

    peer_reviewed_research

  88. 2010 · study · Temporal status not established

    Anatomy of the kisspeptin neural network in mammals

    peer_reviewed_research

  89. 2010 · study · Temporal status not established

    Hypothesis: Kisspeptin Mediates Male Hypogonadism in Obesity and Type 2 Diabetes

    peer_reviewed_research

  90. 2010 · study · Temporal status not established

    The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin‐releasing hormone and neurokinin B neurons

    peer_reviewed_research

  91. 2010 · study · Temporal status not established

    Kisspeptin and fertility

    peer_reviewed_research

  92. 2010 · study · Temporal status not established

    Kisspeptin Regulates Prolactin Release through Hypothalamic Dopaminergic Neurons

    peer_reviewed_research

  93. 2010 · study · Temporal status not established

    Kisspeptin antagonists: Unraveling the role of kisspeptin in reproductive physiology

    peer_reviewed_research

  94. 2010 · study · Temporal status not established

    Kisspeptins: Bridging energy homeostasis and reproduction

    peer_reviewed_research

  95. 2010 · study · Temporal status not established

    The Role of Kisspeptin Signaling in Reproduction

    peer_reviewed_research

  96. 2010 · study · Temporal status not established

    Neurokinin B Stimulates GnRH Release in the Male Monkey (Macaca mulatta) and Is Colocalized with Kisspeptin in the Arcuate Nucleus

    peer_reviewed_research

  97. 2011 · study · Temporal status not established

    Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice

    peer_reviewed_research

  98. 2011 · study · Temporal status not established

    Projections of Arcuate Nucleus and Rostral Periventricular Kisspeptin Neurons in the Adult Female Mouse Brain

    peer_reviewed_research

  99. 2011 · study · Temporal status not established

    Female reproductive maturation in the absence of kisspeptin/GPR54 signaling

    peer_reviewed_research

  100. 2011 · study · Temporal status not established

    Kisspeptin Signaling Is Indispensable for Neurokinin B, but not Glutamate, Stimulation of Gonadotropin Secretion in Mice

    peer_reviewed_research

  101. 2011 · study · Temporal status not established

    Comparative insights of the kisspeptin/kisspeptin receptor system: Lessons from non-mammalian vertebrates

    peer_reviewed_research

  102. 2011 · study · Temporal status not established

    Organization of Two Independent Kisspeptin Systems Derived from Evolutionary-Ancient Kiss Genes in the Brain of Zebrafish

    peer_reviewed_research

  103. 2011 · study · Temporal status not established

    Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility

    systematic_review_or_meta_analysis

  104. 2011 · study · Temporal status not established

    Characterization of the kisspeptin system in human spermatozoa

    peer_reviewed_research

  105. 2011 · study · Temporal status not established

    The Effects of Kisspeptin-10 on Reproductive Hormone Release Show Sexual Dimorphism in Humans

    peer_reviewed_research

  106. 2011 · study · Temporal status not established

    Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men

    peer_reviewed_research

  107. 2011 · study · Temporal status not established

    Kisspeptin Resets the Hypothalamic GnRH Clock in Men

    peer_reviewed_research

  108. 2011 · study · Temporal status not established

    Kisspeptin Is Essential for the Full Preovulatory LH Surge and Stimulates GnRH Release from the Isolated Ovine Median Eminence

    peer_reviewed_research

  109. 2011 · study · Temporal status not established

    Kisspeptins in Reproductive Biology: Consensus Knowledge and Recent Developments1

    peer_reviewed_research

  110. 2011 · study · Temporal status not established

    Early Metabolic Programming of Puberty Onset: Impact of Changes in Postnatal Feeding and Rearing Conditions on the Timing of Puberty and Development of the Hypothalamic Kisspeptin System

    peer_reviewed_research

  111. 2012 · study · Temporal status not established

    Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration

    peer_reviewed_research

  112. 2012 · study · Temporal status not established

    Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature

    peer_reviewed_research

  113. 2012 · study · Temporal status not established

    Kisspeptin Neurons from Mice to Men: Similarities and Differences

    peer_reviewed_research

  114. 2012 · study · Temporal status not established

    Kisspeptin Administration to Women: A Window into Endogenous Kisspeptin Secretion and GnRH Responsiveness across the Menstrual Cycle

    peer_reviewed_research

  115. 2012 · study · Temporal status not established

    Kisspeptin-GPR54 Signaling in Mouse NO-Synthesizing Neurons Participates in the Hypothalamic Control of Ovulation

    peer_reviewed_research

  116. 2012 · study · Temporal status not established

    Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms

    peer_reviewed_research

  117. 2012 · study · Temporal status not established

    RFamide-Related Peptide-3 Receptor Gene Expression in GnRH and Kisspeptin Neurons and GnRH-Dependent Mechanism of Action

    peer_reviewed_research

  118. 2012 · study · Temporal status not established

    Seasonal Variation in the Gonadotropin-Releasing Hormone Response to Kisspeptin in Sheep: Possible Kisspeptin Regulation of the Kisspeptin Receptor

    peer_reviewed_research

  119. 2012 · study · Temporal status not established

    Evidence of a Role for Kisspeptin and Neurokinin B in Puberty of Female Sheep

    peer_reviewed_research

  120. 2012 · study · Temporal status not established

    Arcuate Kisspeptin/Neurokinin B/Dynorphin (KNDy) Neurons Mediate the Estrogen Suppression of Gonadotropin Secretion and Body Weight

    peer_reviewed_research

  121. 2012 · study · Temporal status not established

    Cloning and expression of tachykinins and their association with kisspeptins in the brains of zebrafish

    peer_reviewed_research

  122. 2013 · study · Temporal status not established

    Neurokinin B Activates Arcuate Kisspeptin Neurons Through Multiple Tachykinin Receptors in the Male Mouse

    peer_reviewed_research

  123. 2013 · study · Temporal status not established

    Kisspeptin and GnRH Pulse Generation

    peer_reviewed_research

  124. 2013 · study · Temporal status not established

    Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes

    peer_reviewed_research

  125. 2013 · study · Temporal status not established

    Kisspeptin Neurones do not Directly Signal to RFRP ‐3 Neurones but RFRP ‐3 may Directly Modulate a Subset of Hypothalamic Kisspeptin Cells in Mice

    peer_reviewed_research

  126. 2013 · study · Temporal status not established

    Neuroanatomy of the Kisspeptin Signaling System in Mammals: Comparative and Developmental Aspects

    peer_reviewed_research

  127. 2013 · study · Temporal status not established

    Kisspeptin, Neurokinin B, and Dynorphin Act in the Arcuate Nucleus to Control Activity of the GnRH Pulse Generator in Ewes

    peer_reviewed_research

  128. 2013 · study · Temporal status not established

    Expression of Kisspeptins and Kiss Receptors Suggests a Large Range of Functions for Kisspeptin Systems in the Brain of the European Sea Bass

    peer_reviewed_research

  129. 2013 · study · Temporal status not established

    Sex Steroid Regulation of Kisspeptin Circuits

    peer_reviewed_research

  130. 2013 · study · Temporal status not established

    Interactions Between Kisspeptins and Neurokinin B

    peer_reviewed_research

  131. 2013 · study · Temporal status not established

    Neuroanatomy of the Human Hypothalamic Kisspeptin System

    peer_reviewed_research

  132. 2013 · study · Temporal status not established

    Current and future applications of GnRH, kisspeptin and neurokinin B analogues

    systematic_review_or_meta_analysis

  133. 2013 · study · Temporal status not established

    Kisspeptin and energy balance in reproduction

    peer_reviewed_research

  134. 2013 · study · Temporal status not established

    Kisspeptin and Puberty in Mammals

    peer_reviewed_research

  135. 2013 · study · Temporal status not established

    Metabolic control of puberty: Roles of leptin and kisspeptins

    peer_reviewed_research

  136. 2013 · study · Temporal status not established

    Neuroanatomical Evidence That Kisspeptin Directly Regulates Isotocin and Vasotocin Neurons

    peer_reviewed_research

  137. 2013 · study · Temporal status not established

    Dependence of fertility on kisspeptin–Gpr54 signaling at the GnRH neuron

    peer_reviewed_research

  138. 2014 · study · Temporal status not established

    Positive, But Not Negative Feedback Actions of Estradiol in Adult Female Mice Require Estrogen Receptor α in Kisspeptin Neurons

    peer_reviewed_research

  139. 2014 · study · Temporal status not established

    Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization

    peer_reviewed_research

  140. 2014 · study · Temporal status not established

    Kisspeptin modulates fertilization capacity of mouse spermatozoa

    peer_reviewed_research

  141. 2014 · study · Temporal status not established

    The Integrated Hypothalamic Tachykinin-Kisspeptin System as a Central Coordinator for Reproduction

    peer_reviewed_research

  142. 2014 · study · Temporal status not established

    Prolactin Regulation of Kisspeptin Neurones in the Mouse Brain and its Role in the Lactation‐Induced Suppression of Kisspeptin Expression

    peer_reviewed_research

  143. 2014 · study · Temporal status not established

    MOLECULAR EVOLUTION OF GPCRS: Kisspeptin/kisspeptin receptors

    peer_reviewed_research

  144. 2014 · study · Temporal status not established

    Coevolution of the Spexin/Galanin/Kisspeptin Family: Spexin Activates Galanin Receptor Type II and III

    peer_reviewed_research

  145. 2014 · study · Temporal status not established

    Disrupted Kisspeptin Signaling in GnRH Neurons Leads to Hypogonadotrophic Hypogonadism

    peer_reviewed_research

  146. 2014 · study · Temporal status not established

    Habenular kisspeptin modulates fear in the zebrafish

    peer_reviewed_research

  147. 2014 · study · Temporal status not established

    Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity

    peer_reviewed_research

  148. 2014 · study · Temporal status not established

    The kisspeptin-GnRH pathway in human reproductive health and disease

    peer_reviewed_research

  149. 2014 · study · Temporal status not established

    Increasing LH Pulsatility in Women With Hypothalamic Amenorrhoea Using Intravenous Infusion of Kisspeptin-54

    peer_reviewed_research

  150. 2014 · study · Temporal status not established

    Glucagon Regulates Hepatic Kisspeptin to Impair Insulin Secretion

    peer_reviewed_research

  151. 2015 · study · Temporal status not established

    Selective optogenetic activation of arcuate kisspeptin neurons generates pulsatile luteinizing hormone secretion

    peer_reviewed_research

  152. 2015 · study · Temporal status not established

    There is Kisspeptin – And Then There is Kisspeptin

    systematic_review_or_meta_analysis

  153. 2015 · study · Temporal status not established

    Kisspeptin: Beyond the Brain

    peer_reviewed_research

  154. 2015 · study · Temporal status not established

    Kisspeptin signalling and its roles in humans

    peer_reviewed_research

  155. 2015 · study · Temporal status not established

    Kisspeptin Antagonists Reveal Kisspeptin 1 and Kisspeptin 2 Differential Regulation of Reproduction in the Teleost, Morone saxatilis1

    peer_reviewed_research

  156. 2015 · study · Temporal status not established

    Kisspeptin signaling in the amygdala modulates reproductive hormone secretion

    peer_reviewed_research

  157. 2016 · study · Temporal status not established

    The localization of kisspeptin and kisspeptin receptor in the canine ovary during different stages of the reproductive cycle

    peer_reviewed_research

  158. 2016 · study · Temporal status not established

    Phoenixin Activates Immortalized GnRH and Kisspeptin Neurons Through the Novel Receptor GPR173

    peer_reviewed_research

  159. 2016 · study · Temporal status not established

    High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons

    peer_reviewed_research

  160. 2016 · study · Temporal status not established

    Kisspeptins, Estrogens and Male Fertility

    peer_reviewed_research

  161. 2017 · study · Temporal status not established

    Is there a role for kisspeptin in pathogenesis of polycystic ovary syndrome?

    peer_reviewed_research

  162. 2017 · study · Temporal status not established

    Kisspeptin modulates sexual and emotional brain processing in humans

    peer_reviewed_research

  163. 2018 · study · Temporal status not established

    Female sexual behavior in mice is controlled by kisspeptin neurons

    peer_reviewed_research

  164. 2018 · study · Temporal status not established

    Kisspeptin/Kisspeptin Receptor System in the Ovary

    peer_reviewed_research

  165. 2018 · study · Temporal status not established

    Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation

    peer_reviewed_research

  166. 2018 · study · Temporal status not established

    Kisspeptin and LH pulsatile temporal coupling in PCOS patients

    peer_reviewed_research

  167. 2018 · study · Temporal status not established

    The role of kisspeptin neurons in reproduction and metabolism

    peer_reviewed_research

  168. 2018 · study · Temporal status not established

    Serum Levels of Spexin and Kisspeptin Negatively Correlate With Obesity and Insulin Resistance in Women

    peer_reviewed_research

  169. 2019 · study · Temporal status not established

    Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism

    peer_reviewed_research

  170. 2019 · study · Temporal status not established

    Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery

    peer_reviewed_research

  171. 2020 · study · Temporal status not established

    Metabolic regulation of kisspeptin - the link between energy balance and reproduction.

    peer_reviewed_research

  172. 2020 · study · Temporal status not established

    Kisspeptin and Testicular Function—Is It Necessary?

    peer_reviewed_research

  173. 2020 · study · Temporal status not established

    Kisspeptin and GnRH interactions in the reproductive brain of teleosts

    peer_reviewed_research

  174. 2020 · study · Temporal status not established

    Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour

    systematic_review_or_meta_analysis

  175. 2022 · study · Temporal status not established

    Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.

    peer_reviewed_research

  176. 2022 · study · Temporal status not established

    Gestational exposure to bisphenol analogues and kisspeptin levels in pregnant women and their children: A pregnancy-birth cohort study.

    peer_reviewed_research

  177. 2022 · study · Temporal status not established

    Kisspeptin-10 in cryodiluent improves the post-thaw quality of Nili-Ravi buffalo (Bubalus bubalis) bull spermatozoa.

    peer_reviewed_research

  178. 2022 · study · Temporal status not established

    Morphometric and Myelin Basic Protein Expression Changes in Arcuate Nucleus Kisspeptin Neurons Underlie Activation of Hypothalamic Pituitary Gonadal-axis in Monkeys (<i>Macaca Mulatta</i>) during the Breeding Season.

    peer_reviewed_research

  179. 2022 · study · Temporal status not established

    Effects of intracerebroventricular and intravenous administration of Kisspeptin-54 and Gonadotropin-releasing hormone agonist in rats with ovarian hyperstimulation.

    peer_reviewed_research

  180. 2022 · study · Temporal status not established

    Mechanism of LH release after peripheral administration of kisspeptin in cattle.

    peer_reviewed_research

  181. 2022 · study · Temporal status not established

    Kisspeptin in the Prediction of Pregnancy Complications.

    peer_reviewed_research

  182. 2022 · study · Temporal status not established

    Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides.

    peer_reviewed_research

  183. 2022 · study · Temporal status not established

    Stereology of gonadotropin-releasing hormone and kisspeptin neurons in PACAP gene-deficient female mice.

    peer_reviewed_research

  184. 2022 · study · Temporal status not established

    GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice.

    peer_reviewed_research

  185. 2022 · study · Temporal status not established

    Effects of empagliflozin on the expression of kisspeptin gene and reproductive system function in streptozotocin-induced diabetic male rats.

    peer_reviewed_research

  186. 2022 · study · Temporal status not established

    What is the protective effect of preischemic kisspeptin-10 administration against ischemia/reperfusion injury of striatum on mice?

    peer_reviewed_research

  187. 2022 · study · Temporal status not established

    Sex-specific hypothalamic expression of kisspeptin, gonadotropin releasing hormone, and kisspeptin receptor in progressive demyelination model.

    peer_reviewed_research

  188. 2022 · study · Temporal status not established

    Socs3 ablation in kisspeptin cells partially prevents lipopolysaccharide-induced body weight loss.

    peer_reviewed_research

  189. 2022 · study · Temporal status not established

    Current Perspectives on Kisspeptins Role in Behaviour.

    peer_reviewed_research

  190. 2022 · study · Temporal status not established

    Invited review: Translating kisspeptin and neurokinin B biology into new therapies for reproductive health.

    peer_reviewed_research

  191. 2022 · study · Temporal status not established

    Novel therapeutic avenues for kisspeptin.

    peer_reviewed_research

  192. 2022 · study · Temporal status not established

    The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction.

    peer_reviewed_research

  193. 2022 · study · Temporal status not established

    Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction.

    peer_reviewed_research

  194. 2022 · study · Temporal status not established

    Acute Effects of Kisspeptin Administration on Bone Metabolism in Healthy Men.

    peer_reviewed_research

  195. 2022 · study · Temporal status not established

    Kisspeptins and the neuroendocrine control of reproduction: Recent progress and new frontiers in kisspeptin research

    peer_reviewed_research

  196. 2022 · study · Temporal status not established

    Stress, kisspeptin, and functional hypothalamic amenorrhea.

    peer_reviewed_research

  197. 2023 · study · Temporal status not established

    Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.

    peer_reviewed_research

  198. 2023 · study · Temporal status not established

    Kisspeptin: a potential therapeutic target in patients with unexplained infertility?

    peer_reviewed_research

  199. 2023 · study · Temporal status not established

    Kisspeptin neuron projections to oxytocin neurons are not necessary for parturition in the mouse.

    peer_reviewed_research

  200. 2023 · study · Temporal status not established

    Kisspeptin and lactational anestrus: Current understanding and future prospects.

    peer_reviewed_research

  201. 2023 · study · Temporal status not established

    Kisspeptin induces Kiss-1 and GnRH gene expression in mHypoA-55 hypothalamic cell models: Involvement of the ERK and PKA signaling pathways.

    peer_reviewed_research

  202. 2023 · study · Temporal status not established

    Kisspeptin decreases the adverse effects of human ovarian vitrification by regulating ROS-related apoptotic occurrences.

    peer_reviewed_research

  203. 2023 · study · Temporal status not established

    Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity.

    peer_reviewed_research

  204. 2023 · study · Temporal status not established

    Kisspeptin regulates the proliferation and apoptosis of ovary granulosa cells in polycystic ovary syndrome by modulating the PI3K/AKT/ERK signalling pathway.

    peer_reviewed_research

  205. 2023 · study · Temporal status not established

    Kisspeptin Suppresses Inflammasome-NLRP3 Activation and Pyroptosis Caused by Hypothyroidism at the Maternal-Fetal Interface of Rats.

    peer_reviewed_research

  206. 2023 · study · Temporal status not established

    Hindbrain Adenosine 5-Triphosphate (ATP)-Purinergic Signaling Triggers LH Surge and Ovulation via Activation of AVPV Kisspeptin Neurons in Rats.

    peer_reviewed_research

  207. 2023 · study · Temporal status not established

    Treadmill exercise has healing effects on obesity-induced sexual behavior disorder through kisspeptin and kiss1R expression in male rats.

    peer_reviewed_research

  208. 2023 · study · Temporal status not established

    [Effects of electroacupuncture on the secretion function of ovarian cells and kisspeptin/kiss1r system in rats with polycystic ovarian syndrome].

    peer_reviewed_research

  209. 2023 · study · Temporal status not established

    Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse model.

    peer_reviewed_research

  210. 2023 · study · Temporal status not established

    Fasting Modulates GABAergic Synaptic Transmission to Arcuate Kisspeptin Neurons in Female Mice.

    peer_reviewed_research

  211. 2023 · study · Temporal status not established

    Physiological and pathological roles of locally expressed kisspeptin and KISS1R in the endometrium.

    peer_reviewed_research

  212. 2023 · study · Temporal status not established

    The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin.

    peer_reviewed_research

  213. 2023 · study · Temporal status not established

    The impact of inflammatory stress on hypothalamic kisspeptin neurons: Mechanisms underlying inflammation-associated infertility in humans and domestic animals.

    peer_reviewed_research

  214. 2023 · study · Temporal status not established

    Serum kisspeptin, neurokinin B and inhibin B levels can be used as alternative parameters to distinguish idiopathic CPP from premature thelarche in the early stages of puberty.

    peer_reviewed_research

  215. 2023 · study · Temporal status not established

    Role of kisspeptin in decidualization and unexplained recurrent spontaneous abortion via the ERK1/2 signalling pathway.

    peer_reviewed_research

  216. 2023 · study · Temporal status not established

    Role of kisspeptin in polycystic ovarian syndrome: A metabolomics study.

    peer_reviewed_research

  217. 2023 · study · Temporal status not established

    CRISPR-Cas9 knockdown of ESR1 in preoptic GABA-kisspeptin neurons suppresses the preovulatory surge and estrous cycles in female mice.

    peer_reviewed_research

  218. 2023 · study · Temporal status not established

    Effects of Kisspeptin on the reproductive function in the Dabry's sturgeon (Acipenser dabrynus).

    peer_reviewed_research

  219. 2023 · study · Temporal status not established

    The role of kisspeptin in the pathogenesis of a polycystic ovary syndrome.

    peer_reviewed_research

  220. 2023 · study · Temporal status not established

    Hypothalamic Kisspeptin Neurons as a Target for Whole-Cell Patch-Clamp Recordings.

    peer_reviewed_research

  221. 2023 · study · Temporal status not established

    Effects of <i>KISS1</i> structural polymorphism on the risk of polycystic ovary syndrome and reproductive hormones in Iraqi women who take metformin.

    peer_reviewed_research

  222. 2023 · study · Temporal status not established

    Mechanism of Arcuate Kisspeptin Neuron Synchronization in Acute Brain Slices From Female Mice.

    peer_reviewed_research

  223. 2023 · study · Temporal status not established

    Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovary syndrome.

    peer_reviewed_research

  224. 2023 · study · Temporal status not established

    Effects of electroacupuncture on the kisspeptin-gonadotropin-releasing hormone (GnRH) /luteinizing hormone (LH) neural circuit abnormalities and androgen receptor expression of kisspeptin/neurokinin B/dynorphin neurons in PCOS rats.

    peer_reviewed_research

  225. 2023 · study · Temporal status not established

    The interplay between kisspeptin and endocannabinoid systems modulates male hypothalamic and gonadic control of reproduction <i>in vivo</i>.

    peer_reviewed_research

  226. 2023 · study · Temporal status not established

    Optogenetics studies of kisspeptin neurons.

    peer_reviewed_research

  227. 2023 · study · Temporal status not established

    Deletion of Androgen Receptors From Kisspeptin Neurons Prevents PCOS Features in a Letrozole Mouse Model.

    peer_reviewed_research

  228. 2023 · study · Temporal status not established

    Deletion of GABAB receptors from <i>Kiss1</i> cells affects glucose homeostasis without altering reproduction in male mice.

    peer_reviewed_research

  229. 2023 · study · Temporal status not established

    Conditional Oprk1-dependent Kiss1 deletion in kisspeptin neurons caused estrogen-dependent LH pulse disruption and LH surge attenuation in female rats.

    peer_reviewed_research

  230. 2023 · study · Temporal status not established

    Correlation between kisspeptin and biochemical markers in obese and non-obese women with polycystic ovary syndrome.

    peer_reviewed_research

  231. 2023 · study · Temporal status not established

    Editorial: The versatile kisspeptin: advances in cancer, metabolism, and reproduction.

    peer_reviewed_research

  232. 2023 · study · Temporal status not established

    Oral sodium oxybate does not alter plasma kisspeptin levels in healthy male volunteers.

    peer_reviewed_research

  233. 2023 · study · Temporal status not established

    The effects of kisspeptin on food intake in women with overweight or obesity.

    peer_reviewed_research

  234. 2023 · study · Temporal status not established

    A fresh look at kisspeptin neuron synchronization.

    peer_reviewed_research

  235. 2023 · study · Temporal status not established

    Is There an Association Between Circulating Kisspeptin Levels and Ovarian Reserve in Women of Reproductive Age?

    peer_reviewed_research

  236. 2023 · study · Temporal status not established

    Kisspeptin as a predictor of miscarriage: a systematic review.

    systematic_review_or_meta_analysis

  237. 2024 · study · Temporal status not established

    Kisspeptin expression levels in patients with placenta previa: A randomized trial.

    peer_reviewed_research

  238. 2024 · study · Temporal status not established

    Kisspeptin signalling and its correlation with placental ultrastructure and clinical outcomes in pregnant South African women with obesity and gestational diabetes.

    peer_reviewed_research

  239. 2024 · study · Temporal status not established

    [Notch1/Akt/Foxo1 Pathway Regulated by Kisspeptin Is Involved in Endometrial Decidualization in Patients With Recurrent Spontaneous Abortion].

    peer_reviewed_research

  240. 2024 · study · Temporal status not established

    Kisspeptin and DLK1 levels for monitoring treatment of girls with central precocious puberty.

    peer_reviewed_research

  241. 2024 · study · Temporal status not established

    A prospective study to evaluate whether serum kisspeptin is a marker predictive of the first-trimester miscarriage of women who conceive in IVF.

    peer_reviewed_research

  242. 2024 · study · Temporal status not established

    Associations between maternal urinary kisspeptin in late pregnancy and decreased fetal growth: a pregnancy-birth cohort study.

    peer_reviewed_research

  243. 2024 · study · Temporal status not established

    Urinary phthalate/DINCH metabolites associations with kisspeptin and reproductive hormones in teenagers: A cross-sectional study from the HBM4EU aligned studies.

    peer_reviewed_research

  244. 2024 · study · Temporal status not established

    Kisspeptin expression during menstruation in PCOS patients undergoing ovulation induction and the correlation with early pregnancy.

    peer_reviewed_research

  245. 2024 · study · Temporal status not established

    The evolutionary conserved miR-137/325 tandem mediates obesity-induced hypogonadism and metabolic comorbidities by repressing hypothalamic kisspeptin.

    peer_reviewed_research

  246. 2024 · study · Temporal status not established

    Elevated temperature impairs gonadal development by suppressing the expression of the genes for kisspeptin, GnRH1 and GTH subunits in Nile tilapia Oreochromis niloticus.

    peer_reviewed_research

  247. 2024 · study · Temporal status not established

    Kisspeptin administration may promote precopulatory behavior in male rats independently or supplementally to testosterone and contribute to proceptive behavior in female partners, reducing mating failure.

    peer_reviewed_research

  248. 2024 · study · Temporal status not established

    Kisspeptin prevents pregnancy loss by modulating the immune microenvironment at the maternal-fetal interface in recurrent spontaneous abortion.

    peer_reviewed_research

  249. 2024 · study · Temporal status not established

    Kisspeptin/KISS1R Signaling Modulates Human Airway Smooth Muscle Cell Migration.

    peer_reviewed_research

  250. 2024 · study · Temporal status not established

    Kisspeptin signaling in astrocytes modulates the reproductive axis.

    peer_reviewed_research

  251. 2024 · study · Temporal status not established

    Kisspeptin Regulates Cell Invasion and Migration in Endometrial Cancer.

    peer_reviewed_research

  252. 2024 · study · Temporal status not established

    Kisspeptin Alleviates Human Hepatic Fibrogenesis by Inhibiting TGFβ Signaling in Hepatic Stellate Cells.

    peer_reviewed_research

  253. 2024 · study · Temporal status not established

    Kisspeptin and Endometriosis-Is There a Link?

    peer_reviewed_research

  254. 2024 · study · Temporal status not established

    Kisspeptin is elevated in the brain after intracerebral haemorrhagic stroke.

    peer_reviewed_research

  255. 2024 · study · Temporal status not established

    Kisspeptin in functional hypothalamic amenorrhea: Pathophysiology and therapeutic potential.

    peer_reviewed_research

  256. 2024 · study · Temporal status not established

    Kisspeptin upregulates β-cell serotonin production during pregnancy.

    peer_reviewed_research

  257. 2024 · study · Temporal status not established

    Jiawei Buzhong Yiqi Decoction attenuates polycystic ovary syndrome through regulating kisspeptin-GPR54-AKT-SHBG system.

    peer_reviewed_research

  258. 2024 · study · Temporal status not established

    Chronic estradiol exposure suppresses luteinizing hormone surge without affecting kisspeptin neurons and estrogen receptor alpha in anteroventral periventricular nucleus†.

    peer_reviewed_research

  259. 2024 · study · Temporal status not established

    Structural basis for the ligand recognition and G protein subtype selectivity of kisspeptin receptor.

    peer_reviewed_research

  260. 2024 · study · Temporal status not established

    The effect of coadministration of vitamin D and tramadol on serum kisspeptin, testosterone, oxidative stress levels and testicular histology in Wistar rats: a preliminary report.

    peer_reviewed_research

  261. 2024 · study · Temporal status not established

    Investigating the detection of the novel doping‐relevant peptide kisspeptin‐10 in urine using liquid chromatography high‐resolution mass spectrometry.

    peer_reviewed_research

  262. 2024 · study · Temporal status not established

    Phenytoin causes behavioral abnormalities and suppresses kisspeptin expression, reducing reproductive performance in Japanese medaka.

    peer_reviewed_research

  263. 2024 · study · Temporal status not established

    Decoding the effect of photoperiodic cues in transducing kisspeptin-melatonin circuit during the pubertal onset in common carp.

    peer_reviewed_research

  264. 2024 · study · Temporal status not established

    Adipose Kiss1 controls aerobic exercise-related adaptive responses in adipose tissue energy homeostasis.

    peer_reviewed_research

  265. 2024 · study · Temporal status not established

    AVPV <i>Kiss1</i> neuron-specific knockdown of purinergic P2X2 receptor suppresses LH surge and ovulation in <i>Kiss1-Cre</i> rats.

    peer_reviewed_research

  266. 2024 · study · Temporal status not established

    Deletion of Nuclear Progesterone Receptors From Kisspeptin Cells Does Not Impair Negative Feedback in Female Mice.

    peer_reviewed_research

  267. 2024 · study · Temporal status not established

    Predictive efficiency of phoenixin, spexin and kisspeptin neuropeptides concentration levels in diagnosis of bipolar disorder in paediatric population.

    peer_reviewed_research

  268. 2024 · study · Temporal status not established

    Effects of kisspeptin on the maturation of human ovarian primordial follicles <i>in vitro</i>.

    peer_reviewed_research

  269. 2024 · study · Temporal status not established

    Reduced voluntary wheel running behaviour in Kiss1r knockout mice.

    peer_reviewed_research

  270. 2024 · study · Temporal status not established

    Alteration in kisspeptin and reproductive hormones during different superovulation protocols in dromedary camel.

    peer_reviewed_research

  271. 2024 · study · Temporal status not established

    Development of KISS1 knockout pigs is characterized by hypogonadotropic hypogonadism, normal growth, and reduced skatole†.

    peer_reviewed_research

  272. 2024 · study · Temporal status not established

    Participation of kisspeptin, progesterone, and GnRH receptors on lordosis behavior induced by kisspeptin.

    peer_reviewed_research

  273. 2024 · study · Temporal status not established

    Does the miR-105-1-Kisspeptin Axis Promote Ovarian Cell Functions?

    peer_reviewed_research

  274. 2024 · study · Temporal status not established

    Interactions between kisspeptin and bone: Cellular mechanisms, clinical evidence, and future potential.

    peer_reviewed_research

  275. 2024 · study · Temporal status not established

    Nitric oxide mediated kisspeptin regulation of steroidogenesis and gametogenesis in the catfish, Clarias batrachus.

    peer_reviewed_research

  276. 2024 · study · Temporal status not established

    The role of placental kisspeptin in trophoblast invasion and migration: an assessment in <i>Kiss1r</i> knockout mice, BeWo cell lines and human term placenta.

    peer_reviewed_research

  277. 2024 · study · Temporal status not established

    Intracerebroventricular injection of kisspeptin in male rats activates hypothalamo-pituitary-gonadal axis, but not hypothalamo-pituitary-adrenal axis.

    peer_reviewed_research

  278. 2024 · study · Temporal status not established

    Targeted inhibition of kisspeptin neurons reverses hyperandrogenemia and abnormal hyperactive LH secretion in a preclinical mouse model of polycystic ovary syndrome.

    peer_reviewed_research

  279. 2024 · study · Temporal status not established

    Selective depletion of kisspeptin neurons in the hypothalamic arcuate nucleus in early juvenile life reduces pubertal LH secretion and delays puberty onset in mice.

    peer_reviewed_research

  280. 2024 · study · Temporal status not established

    Obesity Alters POMC and Kisspeptin Neuron Cross Talk Leading to Reduced Luteinizing Hormone in Male Mice.

    peer_reviewed_research

  281. 2024 · study · Temporal status not established

    The antidepressant-like effects of kisspeptin-10 are reversed by kisspeptin antagonist peptide 234 in male rats.

    peer_reviewed_research

  282. 2024 · study · Temporal status not established

    Investigation of effect peripheral kisspeptin treatment on hypothalamo-pituitary-gonadal axis and hypothalamo-pituitary-adrenal axis in male rats.

    peer_reviewed_research

  283. 2024 · study · Temporal status not established

    Comprehensive Analysis of Kisspeptin Signaling: Effects on Cellular Dynamics in Cervical Cancer.

    peer_reviewed_research

  284. 2024 · study · Temporal status not established

    Intraperitoneal administration of kisspeptin-10 modulates follicle maturation, gonadal steroids, calcium and metabolites in Sterlet sturgeon, Acipenser ruthenus.

    peer_reviewed_research

  285. 2024 · study · Temporal status not established

    Chronic Nasal Administration of Kisspeptin-54 Regulates Mood-Related Disorders Via Amygdaloid GABA in Hemi-Parkinsonian Rats

    peer_reviewed_research

  286. 2024 · study · Temporal status not established

    Spatial local expressions of kisspeptin in the uterus and uterine tubes and its relationship to the reproductive potential in goats.

    peer_reviewed_research

  287. 2024 · study · Temporal status not established

    Chronic inflammation decreases arcuate kisspeptin expression in male sheep.

    peer_reviewed_research

  288. 2024 · study · Temporal status not established

    Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor.

    peer_reviewed_research

  289. 2024 · study · Temporal status not established

    Role of serum kisspeptin as a biomarker to detect miscarriage: a systematic review and meta-analysis.

    systematic_review_or_meta_analysis

  290. 2024 · study · Temporal status not established

    Lunar Age-Dependent Oscillations in Expression of the Genes for Kisspeptin, GnIH, and Their Receptors in the Grass Puffer during the Spawning Season.

    peer_reviewed_research

  291. 2024 · study · Temporal status not established

    Characterizing the relationship between gonadotropin releasing hormone (GnRH), kisspeptin, and RFamide related peptide 3 (RFRP-3) neurons in the equine hypothalamus across the estrous cycle and in the anovulatory seasons.

    peer_reviewed_research

  292. 2024 · study · Temporal status not established

    Kisspeptin and mammalian reproduction.

    peer_reviewed_research

  293. 2024 · study · Temporal status not established

    Dynamics in cortisol levels in Danio rerio fish under the influence of a synthetic analog of kisspeptin 1.

    peer_reviewed_research

  294. 2024 · study · Temporal status not established

    Kisspeptin and neurokinin B neuroendocrine pathways in the control of human ovulation.

    systematic_review_or_meta_analysis

  295. 2024 · study · Temporal status not established

    Kisspeptin stimulates sheep ovarian follicular development <i>in vitro</i> through homologous receptors.

    peer_reviewed_research

  296. 2025 · study · Temporal status not established

    Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study.

    peer_reviewed_research

  297. 2025 · study · Temporal status not established

    The association between 1st trimester serum kisspeptin level and antenatal complications.

    peer_reviewed_research

  298. 2025 · study · Temporal status not established

    Recurrent spontaneous ovarian hyperstimulation in a young nonpregnant Chinese woman with Rathke cleft cyst and a KISS1R variant: A rare case report and literature review.

    peer_reviewed_research

  299. 2025 · study · Temporal status not established

    AMH and Kisspeptin Receptor Expression in Rare Hydropic Leiomyoma: A Case Study.

    peer_reviewed_research

  300. 2025 · study · Temporal status not established

    Central administration of p234, kisspeptin antagonist, but not kisspeptin-10, reduces the power of epileptiform activity and slow EEG waves in male rats.

    peer_reviewed_research

  301. 2025 · study · Temporal status not established

    Early Development of Hypothalamic Neurons Expressing Proopiomelanocortin Peptides, Neuropeptide Y, and Kisspeptin in Fetal Rhesus Macaques.

    peer_reviewed_research

  302. 2025 · study · Temporal status not established

    Postnatal undernutrition increases estradiol plasma levels and sexual receptivity and disrupts the kisspeptin-GnRH pathway in adult female rats.

    peer_reviewed_research

  303. 2025 · study · Temporal status not established

    Kisspeptin 10 Inhibited the Proliferation, Migration, and Stemness of Esophageal Cancer Cells via Regulating the SIX1/Wnt/β-Catetin Signaling.

    peer_reviewed_research

  304. 2025 · study · Temporal status not established

    Kisspeptin as a marker for male infertility: a comparative study of serum and seminal plasma kisspeptin between fertile and infertile men.

    peer_reviewed_research

  305. 2025 · study · Temporal status not established

    Kisspeptin control of hypothalamus-pituitary-ovarian functions.

    peer_reviewed_research

  306. 2025 · study · Temporal status not established

    Kisspeptin system-physiology and clinical perspectives.

    peer_reviewed_research

  307. 2025 · study · Temporal status not established

    Kisspeptin-54 ameliorates chondrocyte senescence in osteoarthritis via SIRT3-mediated telomere protection and p53 acetylation inhibition.

    peer_reviewed_research

  308. 2025 · study · Temporal status not established

    Kisspeptin-13 induces hyperalgesia and modulates the expression of opioid and glutamate receptors in mice.

    peer_reviewed_research

  309. 2025 · study · Temporal status not established

    Kisspeptin participates in the positive reward state induced by paced mating and modulates sexual receptivity and paced mating behavior in female rats.

    peer_reviewed_research

  310. 2025 · study · Temporal status not established

    Kisspeptin Suppresses the Growth of Primary Pterygial Cells via Inhibiting Chemokine (C-X-C Motif) Ligands in Microenvironment.

    peer_reviewed_research

  311. 2025 · study · Temporal status not established

    Kisspeptin-54 Restores Blood-Brain Barrier Integrity via GATA-4 in Ischemic Stroke.

    peer_reviewed_research

  312. 2025 · study · Temporal status not established

    Kisspeptin fiber and receptor distribution analysis suggests its potential role in central sensorial processing and behavioral state control.

    peer_reviewed_research

  313. 2025 · study · Temporal status not established

    Kisspeptin-dependent puberty onset triggered by increased Kiss1 and Pdyn expression in arcuate Tac3 neurons under reduced estrogen negative feedback and sufficient energy balance in female rats.

    peer_reviewed_research

  314. 2025 · study · Temporal status not established

    Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models.

    peer_reviewed_research

  315. 2025 · study · Temporal status not established

    Kisspeptin isoforms: versatile players in reproduction and beyond.

    peer_reviewed_research

  316. 2025 · study · Temporal status not established

    Kisspeptin Retards Tumor Growth of Lewis Lung Carcinoma Cells Through p38 MAPK-mediated Senescence.

    peer_reviewed_research

  317. 2025 · study · Temporal status not established

    Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice.

    peer_reviewed_research

  318. 2025 · study · Temporal status not established

    Kisspeptin Administration and mRNA Expression in Adult Syrian Hamsters.

    peer_reviewed_research

  319. 2025 · study · Temporal status not established

    Kisspeptin Mitigates Hepatic De Novo Lipogenesis in Metabolic Dysfunction-Associated Steatotic Liver Disease.

    peer_reviewed_research

  320. 2025 · study · Temporal status not established

    Sodium benzoate exposure disrupts HPG-axis in male rats: insights into oxidative stress, hormonal dysregulation, histopathology and kisspeptin/RFRP-3 expression.

    peer_reviewed_research

  321. 2025 · study · Temporal status not established

    Brain-derived neurotrophic factor (BDNF), an autocrine/paracrine regulator of basic ovarian functions and antagonist of kisspeptin.

    peer_reviewed_research

  322. 2025 · study · Temporal status not established

    Quercetin-loaded PEGylated liposomes alleviate testicular dysfunction in alloxan-induced diabetic rats: The role of Kisspeptin/Neurokinin B/Dynorphin pathway.

    peer_reviewed_research

  323. 2025 · study · Temporal status not established

    Involvement of nuclear receptor corepressor 2 (NCOR2) in estrogen-induced repression of arcuate Kiss1 expression in female rats.

    peer_reviewed_research

  324. 2025 · study · Temporal status not established

    The effect of COVID-19 on placental functioning in South African pregnancies: investigation of kisspeptin expression and vascular and inflammatory alterations.

    peer_reviewed_research

  325. 2025 · study · Temporal status not established

    Kisspeptin-10 Protects Against TNF-α-Induced Chondrocyte Senescence via the SIRT1/p53/p21 Signaling.

    peer_reviewed_research

  326. 2025 · study · Temporal status not established

    Kisspeptin-10 Improves Gestational Diabetes Mellitus Symptoms in Rats by Suppressing Insulin Resistance in Placental Trophoblast Cells by Activating the Cyclic AMP/Protein Kinase A Pathway.

    peer_reviewed_research

  327. 2025 · study · Temporal status not established

    Kisspeptin-10 Prevents the Development of Cerebral Aneurysms by Reducing the Expression of Egr-1.

    peer_reviewed_research

  328. 2025 · study · Temporal status not established

    Maternal high-fat diet programs reproductive function of female offspring rat through IL-6-mediated regulation of Kiss1 gene methylation.

    peer_reviewed_research

  329. 2025 · study · Temporal status not established

    Design and implication of a breast cancer-targeted drug delivery system utilizing the Kisspeptin/GPR54 system.

    peer_reviewed_research

  330. 2025 · study · Temporal status not established

    The Neuroendocrine Regulation of Reproductive Behavior and Emotional Control by Kisspeptin.

    peer_reviewed_research

  331. 2025 · study · Temporal status not established

    Perinatal exposure to bisphenol A or S alters differently sexual behavior and kisspeptin system in mice.

    peer_reviewed_research

  332. 2025 · study · Temporal status not established

    Comprehensive chemoanatomical mapping, and the gonadal regulation, of seven kisspeptin neuronal populations in the mouse brain.

    peer_reviewed_research

  333. 2025 · study · Temporal status not established

    SRA deficiency induces follicular dysplasia by disrupting the hypothalamic Kisspeptin-GPR54 system in mice†.

    peer_reviewed_research

  334. 2025 · study · Temporal status not established

    Developmental expression patterns of gonadal hormone receptors in arcuate kisspeptin and GABA neurons of the postnatal female mouse.

    peer_reviewed_research

  335. 2025 · study · Temporal status not established

    Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice.

    peer_reviewed_research

  336. 2025 · study · Temporal status not established

    Lipopolysaccharide-induced inflammation modulates testicular kisspeptin system in mice.

    peer_reviewed_research

  337. 2025 · study · Temporal status not established

    The kisspeptin analog C6 reverses reproductive dysfunction in a mouse model of hyperprolactinemia.

    peer_reviewed_research

  338. 2025 · study · Temporal status not established

    Effect of active immunization with recombinant GnRH6-kisspeptin fusion protein on reproductive function in male rats.

    peer_reviewed_research

  339. 2025 · study · Temporal status not established

    Central kisspeptin injection enhances food consumption in broiler chickens: role of opioidergic and dopaminergic receptors.

    peer_reviewed_research

  340. 2025 · study · Temporal status not established

    Profile of opioid peptide receptors in GnRH and kisspeptin neurons of female mice and rats.

    peer_reviewed_research

  341. 2025 · study · Temporal status not established

    Exogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer.

    peer_reviewed_research

  342. 2025 · study · Temporal status not established

    Effect of Kisspeptin Fortification in Freezing Media on Post-Thaw Quality and Fertility of Buffalo Bull Semen.

    peer_reviewed_research

  343. 2025 · study · Temporal status not established

    Effect of kisspeptin, neurokinin, and dynorphin neurons on regulation of reproduction.

    peer_reviewed_research

  344. 2025 · study · Temporal status not established

    Effect of galanin-like peptide on hypothalamic kisspeptin expression in female Zucker fatty rats.

    peer_reviewed_research

  345. 2025 · study · Temporal status not established

    Effects of Kisspeptin on rabbit ovulation: a comprehensive study of ovulatory, endocrine and histological response.

    peer_reviewed_research

  346. 2025 · study · Temporal status not established

    Hypothalamic kisspeptin alleviates myasthenia gravis by regulating Th1/Th17/Treg balance through Inhibition of NF-κB signaling pathway.

    peer_reviewed_research

  347. 2025 · study · Temporal status not established

    Manipulating seasonality by using PMSG and Kisspeptin hormones and the impact of the MTNR1A gene on reproduction efficiency in ewes.

    peer_reviewed_research

  348. 2025 · study · Temporal status not established

    Association of Kisspeptin and KISS&lt;sub&gt;1&lt;/sub&gt; Gene Polymorphism (rs35431622) with Circulating Sex Hormones and Male Infertility.

    peer_reviewed_research

  349. 2025 · study · Temporal status not established

    Brainstem noradrenergic modulation of the kisspeptin neuron GnRH pulse generator in mice.

    peer_reviewed_research

  350. 2025 · study · Temporal status not established

    Recombinant GnRH6-kisspeptin-CRM197 vaccine inhibits reproductive function in male rats and dogs.

    peer_reviewed_research

  351. 2025 · study · Temporal status not established

    Potential role of kisspeptin in the estradiol-induced modulation of inhibin subunit gene expression: Insights from in vivo rat models and hypothalamic cell models.

    peer_reviewed_research

  352. 2025 · study · Temporal status not established

    Synthesis and characterisation of DOTA-kisspeptin-10 as a potential gallium-68/lutetium-177 pan-tumour radiopharmaceutical.

    peer_reviewed_research

  353. 2025 · study · Temporal status not established

    Exploring GABA and Kisspeptin Roles in Reproductive and Metabolic Regulation: Insights from Kiss1-GABAB1KO Female Mice.

    peer_reviewed_research

  354. 2025 · study · Temporal status not established

    Evidence for human kisspeptin receptor homo-oligomerisation and its functional relevance.

    peer_reviewed_research

  355. 2025 · study · Temporal status not established

    Distribution of the kisspeptin system and its relation with gonadotropin-releasing hormone in the hypothalamus.

    peer_reviewed_research

  356. 2025 · study · Temporal status not established

    Multiple effects of kisspeptin on neuroendocrine, reproduction, and metabolism in polycystic ovary syndrome.

    peer_reviewed_research

  357. 2025 · study · Temporal status not established

    Adult Neurogenesis Is Regulated by the Endocannabinoid and Kisspeptin Systems.

    peer_reviewed_research

  358. 2025 · study · Temporal status not established

    Regulatory Involvement of Kisspeptin in Energy Balance and Reproduction.

    peer_reviewed_research

  359. 2025 · study · Temporal status not established

    A novel mechanism of kisspeptin regulating ovarian granulosa cell function via down-regulating let-7b to activate ERK/PI3K-Akt pathway in Tan sheep.

    peer_reviewed_research

  360. 2025 · study · Temporal status not established

    The role of neonatal kisspeptin in long-term social behavior in mammals.

    peer_reviewed_research

  361. 2025 · study · Temporal status not established

    Nociceptin-Opioid-Related Nociceptin Receptor 1 Signaling Partly Mediates Glucoprivic Suppression of Luteinizing Hormone Pulses in Female Rats: Arcuate &lt;italic&gt;Kiss1&lt;/italic&gt; Neurons as a Possible Target for Nociceptin.

    peer_reviewed_research

  362. 2025 · study · Temporal status not established

    Estrogen-Regulated Lateral Septal Kisspeptin Neurons Abundantly Project to GnRH Neurons and the Hypothalamic Supramammillary Nucleus.

    peer_reviewed_research

  363. 2025 · study · Temporal status not established

    Existence of Coexpressive Role of Kisspeptin and Insulin-2 in the Regulation of Luteinizing Hormone in Chronic Stress-Induced Polycystic Ovarian Syndrome-Like Phenotype in Rattus norvegicus.

    peer_reviewed_research

  364. 2025 · study · Temporal status not established

    Critical role of arcuate nucleus kisspeptin and Kiss1R in regulation of the ovine luteinizing hormone surge.

    peer_reviewed_research

  365. 2025 · study · Temporal status not established

    Administration of Exogenous Kisspeptin Induces Breeding Competence in Post-pubertal Female Common Carp (Cyprinus carpio).

    peer_reviewed_research

  366. 2025 · study · Temporal status not established

    Hypothyroidism Alters Uterine Kisspeptin System and Activity Modulators in Cyclic Rats.

    peer_reviewed_research

  367. 2025 · study · Temporal status not established

    Kisspeptin and neurokinin B: roles in reproductive health.

    peer_reviewed_research

  368. 2025 · study · Temporal status not established

    Serum kisspeptin is higher in hypertensive than non-hypertensive female subjects and positively correlated with systolic blood pressure.

    peer_reviewed_research

  369. 2025 · study · Temporal status not established

    Activity of arcuate kisspeptin/neurokinin B neurons and the melanocortin system during pubertal development in female sheep†.

    peer_reviewed_research

  370. 2025 · study · Temporal status not established

    The Investigation of Kisspeptin, Spexin and Galanin in Euthyroid Women with Hashimoto's Thyroiditis.

    peer_reviewed_research

  371. 2025 · study · Temporal status not established

    Dysregulated serum levels of kisspeptin, NKB, GABA in women with polycystic ovary syndrome and their association with hormonal profiles.

    peer_reviewed_research

  372. 2025 · study · Temporal status not established

    Anatomic distribution of kisspeptin neurons in the adult sheep amygdala: Associations with sex, estrogen receptor alpha, androgen receptor, and sexual partner preference.

    peer_reviewed_research

  373. 2025 · study · Temporal status not established

    Direct effect of kisspeptin on steroidogenesis, proliferation and apoptosis in Tan sheep ovarian granulosa cells.

    peer_reviewed_research

  374. 2025 · study · Temporal status not established

    Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans.

    peer_reviewed_research

  375. 2025 · study · Temporal status not established

    Serum Kisspeptin levels in patients undergoing maintenance hemodialysis: a case-control study protocol.

    peer_reviewed_research

  376. 2025 · study · Temporal status not established

    The Kisspeptin analogue C6 induces more synchronized ovulation than eCG in the transition period to breeding season in Corriedale ewes.

    peer_reviewed_research

  377. 2025 · study · Temporal status not established

    Can kisspeptin be a new treatment for sexual dysfunction?

    systematic_review_or_meta_analysis

  378. 2025 · study · Temporal status not established

    Sex-dependent increases in oxytocin levels in response to intravenous kisspeptin in humans.

    peer_reviewed_research

  379. 2025 · study · Temporal status not established

    Kisspeptin levels in infertile and miscarried women: a cross-sectional study on the relationship with methylenetetrahydrofolate reductase gene polymorphisms and biochemical parameters.

    peer_reviewed_research

  380. 2025 · study · Temporal status not established

    Kisspeptin and its Current Clinical Status-A Systematic Review.

    systematic_review_or_meta_analysis

  381. 2025 · study · Temporal status not established

    Kisspeptin Receptor Agonists and Antagonists: Strategies for Discovery and Implications for Human Health and Disease.

    peer_reviewed_research

  382. 2025 · study · Temporal status not established

    Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans.

    peer_reviewed_research

  383. 2026 · study · Temporal status not established

    Novel KISS1 Gene Mutation Leading to Male Hypogonadotropic Hypogonadism.

    peer_reviewed_research

  384. 2026 · study · Temporal status not established

    Dynamic changes of Kisspeptin during controlled ovarian hyperstimulation (COH) in polycystic ovary syndrome patients and its correlation with COH outcomes.

    peer_reviewed_research

  385. 2026 · study · Temporal status not established

    Serological biomarker models composed of luteinizing hormone, kisspeptin, vitamin D and estradiol, and their clinical test value in girls.

    peer_reviewed_research

  386. 2026 · study · Temporal status not established

    First clinical use of the kisspeptin analog TAK-683 in the treatment of a follicular cyst in a goat: case report.

    peer_reviewed_research

  387. 2026 · study · Temporal status not established

    Kisspeptin as a Precision Biomarker in Personalized Pharmacy: Implications for Individualized Monitoring of Early Pregnancy Viability.

    peer_reviewed_research

  388. 2026 · study · Temporal status not established

    Therapeutic potential of nasal kisspeptin-54 for reducing α-synuclein accumulation and restoring hippocampal synaptic plasticity in a 6-hydroxydopamine-induced rat model of Parkinson's disease.

    peer_reviewed_research

  389. 2026 · study · Temporal status not established

    Sodium benzoate induces reproductive toxicity via hormonal disruption, ovarian damage and altering kisspeptin/RFRP-3 expression.

    peer_reviewed_research

  390. 2026 · study · Temporal status not established

    [Effect of acupuncture on ovarian function in rats with premature ovarian insufficiency based on kisspeptin/GPR54 pathway].

    peer_reviewed_research

  391. 2026 · study · Temporal status not established

    Kisspeptin System: A Modulator of Neuroinflammation and Behaviour in Temporal Lobe Epileptic Rats.

    peer_reviewed_research

  392. 2026 · study · Temporal status not established

    Kisspeptin-2 stimulates testicular function in adult pejerrey (Odontesthes bonariensis): Does it act directly on the testes?

    peer_reviewed_research

  393. 2026 · study · Temporal status not established

    Kisspeptin-10 attenuates pulmonary arterial hypertension via restoration of mitochondrial function in pulmonary artery smooth muscle cells.

    peer_reviewed_research

  394. 2026 · study · Temporal status not established

    Kisspeptin-54 attenuates acute lung injury in septic mice through AMPK-mediated suppression of NLRP3 inflammasome.

    peer_reviewed_research

  395. 2026 · study · Temporal status not established

    Kisspeptin-54 confers renal protection in diabetic nephropathy by ameliorating endothelial permeability through ZEB1 inhibition.

    peer_reviewed_research

  396. 2026 · study · Temporal status not established

    Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders.

    peer_reviewed_research

  397. 2026 · study · Temporal status not established

    Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats.

    peer_reviewed_research

  398. 2026 · study · Temporal status not established

    Kisspeptin and early pregnancy: Insights from animal models into hormonal regulation and miscarriage.

    peer_reviewed_research

  399. 2026 · study · Temporal status not established

    Kisspeptin exacerbates androgen-induced follicular dysplasia by promoting Drp1 phosphorylation imbalance and mitochondrial excessive fission in granulosa cells of polycystic ovary syndrome.

    peer_reviewed_research

  400. 2026 · study · Temporal status not established

    Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females.

    peer_reviewed_research

  401. 2026 · study · Temporal status not established

    Kisspeptin improves local ovarian insulin resistance in PCOS by modulating the PI3K/AKT/GLUT4 signaling pathway.

    peer_reviewed_research

  402. 2026 · study · Temporal status not established

    Kisspeptin Signaling Suppresses HRas&lt;sup&gt;G12V&lt;/sup&gt;-induced Tumor Growth and Metastasis by Inhibiting SP1-dependent N-cadherin Expression in NIH3T3 Cells.

    peer_reviewed_research

  403. 2026 · study · Temporal status not established

    Progestogen priming is not essential to trigger ovulation in seasonal anoestrus ewes injected twice with a synthetic kisspeptin analogue.

    peer_reviewed_research

  404. 2026 · study · Temporal status not established

    Kisspeptin Neurons as Integrative Hub: Cross-Talk of HPO-HPT-HPA Axes in Perimenopausal Reproductive Health.

    peer_reviewed_research

  405. 2026 · study · Temporal status not established

    The p75 neurotrophin receptor is expressed in brain regions mastering reproduction but not in kisspeptin or GnRH neurons.

    peer_reviewed_research

  406. 2026 · study · Temporal status not established

    Dlk1-deficient mice achieve puberty despite low body weight and low levels of leptin and kisspeptin.

    peer_reviewed_research

  407. 2026 · study · Temporal status not established

    High-Fat Diet Promotes Glycolysis in Hepatocellular Carcinoma by Suppressing Hepatic Kisspeptin Signaling in Mice.

    peer_reviewed_research

  408. 2026 · study · Temporal status not established

    Integrated transcriptomics and miRNA-mRNA network analysis reveals Kisspeptin-10 mediated regulation of EMT and apoptosis in glioblastoma.

    peer_reviewed_research

  409. 2026 · study · Temporal status not established

    Evolution of neurohormone function revealed by actions of kisspeptin-type peptides in an echinoderm.

    peer_reviewed_research

  410. 2026 · study · Temporal status not established

    Photoperiodic modulation of puberty through melatonin-kisspeptin-GnRH signalling in female Wistar rats.

    peer_reviewed_research

  411. 2026 · study · Temporal status not established

    The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.

    peer_reviewed_research

  412. 2026 · study · Temporal status not established

    The KISS1/KISS1R Axis in Human Placentation: Molecular Mechanisms and Implications for Foetal Growth Restriction and Pre-Eclampsia.

    peer_reviewed_research

  413. 2026 · study · Temporal status not established

    Endocrine-metabolic effects of kisspeptin in mammals.

    peer_reviewed_research

  414. 2026 · study · Temporal status not established

    Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice.

    peer_reviewed_research

  415. 2026 · study · Temporal status not established

    KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone-independent manner.

    peer_reviewed_research

  416. 2026 · study · Temporal status not established

    Deciphering protein-DNA interactions of &lt;i&gt;KISS1&lt;/i&gt; with transcription factors through molecular docking, molecular dynamics simulations, and gene expression analysis.

    peer_reviewed_research

  417. 2026 · study · Temporal status not established

    Molecular and functional characterization of the kisspeptin receptor Kissr3 in the large yellow croaker (Larimichthys crocea).

    peer_reviewed_research

  418. 2026 · study · Temporal status not established

    Maternal Kisspeptin-10 Treatment Partially Rescues Fetal and Postnatal Cardiac Programming Disrupted by Maternal Hypothyroidism.

    peer_reviewed_research

  419. 2026 · study · Temporal status not established

    Preoptic kisspeptin-nNOS-GnRH (KiNG) neuronal network regulates LH rhythmicity through activation-inhibition in mice.

    peer_reviewed_research

  420. 2026 · study · Temporal status not established

    The role of Kiss1 neurons in regulating metabolism and energy balance.

    peer_reviewed_research

  421. 2026 · study · Temporal status not established

    Gonadotropin secretion and ovarian response of KISS1 knockout gilts treated with hormone analogs activating the hypothalamic-pituitary-gonadal axis†.

    peer_reviewed_research

  422. 2026 · study · Temporal status not established

    Progesterone-KISS1 axis impairs amniotic epithelial cell function and promotes premature rupture of membranes.

    peer_reviewed_research

  423. 2026 · study · Temporal status not established

    Expressions of Kisspeptin System and Ki-67 in the Reproductive Tissues of Cyclic Bitches.

    peer_reviewed_research

  424. 2026 · study · Temporal status not established

    Atrazine alters kisspeptin signaling and downstream neuroendocrine regulation following embryonic exposure in zebrafish.

    peer_reviewed_research

  425. 2026 · study · Temporal status not established

    Evaluation of Betatrophin, Chemerin, and Kisspeptin Levels in Acromegaly Patients.

    peer_reviewed_research

  426. 2026 · study · Temporal status not established

    Targeting the NR5A1-KISS1R-EMT axis with a small-molecule inhibitor suppresses lung adenocarcinoma progression and metastasis.

    peer_reviewed_research

  427. 2026 · study · Temporal status not established

    Vesicular GABA transport expression in kisspeptin cells may contribute to the preovulatory gonadotropin surge.

    peer_reviewed_research

  428. 2026 · study · Temporal status not established

    Associations between kisspeptin hormone level and its genetic polymorphisms with polycystic ovary syndrome.

    peer_reviewed_research

  429. 2026 · study · Temporal status not established

    Prolonged oscillating preoptic area kisspeptin neuron activity underlies the preovulatory luteinizing hormone surge in mice.

    peer_reviewed_research

  430. 2026 · study · Temporal status not established

    The role of hypothalamic kisspeptin neurons in coordinating reproduction and metabolism.

    peer_reviewed_research

  431. 2026 · study · Temporal status not established

    GABA receptor modulation of arcuate kisspeptin neuron bursting and synchronization activity in female mice.

    peer_reviewed_research

  432. 2026 · study · Temporal status not established

    Robust serotonin activation of the kisspeptin GnRH pulse generator in male and female mice.

    peer_reviewed_research

  433. 2026 · study · Temporal status not established

    Phase-dependent changes in serum kisspeptin and irisin levels across the menstrual cycle in healthy women.

    peer_reviewed_research

  434. 2026 · study · Temporal status not established

    Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography-High-Resolution Mass Spectrometry for Doping Control Purposes.

    peer_reviewed_research

  435. 2026 · study · Temporal status not established

    Kisspeptin-10 regulates glycosaminoglycan and decorin content in human cardiac fibroblast cultures.

    peer_reviewed_research

  436. 2026 · study · Temporal status not established

    Daily Rhythmic Changes in Kisspeptin Gene Expression and Testosterone Hormone in Male Syrian Hamsters (&lt;i&gt;Mesocricetus auratus&lt;/i&gt;).

    peer_reviewed_research

  437. 2026 · study · Temporal status not established

    Exploring the Role of Kisspeptin in Polycystic Ovary Syndrome and Its Associated Pregnancy Complications.

    systematic_review_or_meta_analysis

  438. 2026 · study · Temporal status not established

    Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men.

    peer_reviewed_research

  439. 2026 · study · Temporal status not established

    The Expression of Kisspeptin Receptor, Catsper 3 and Acrosome Integrity in Oligozoospermic and Normozoospermic Individuals.

    peer_reviewed_research

  440. 2026 · study · Temporal status not established

    Intravenous kisspeptin 112-121 bolus does not acutely impact circulating vasopressin in humans.

    peer_reviewed_research

  441. 2026 · study · Temporal status not established

    Effect of kisspeptin with or without cabergoline on the estrus cycle and reproductive hormones in female dogs.

    peer_reviewed_research

  442. 2026 · study · Temporal status not established

    Serum kisspeptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis.

    systematic_review_or_meta_analysis

  443. 2026 · study · Temporal status not established

    Neurotransmitter and neuromodulator imbalance in kisspeptin/GnRH regulation in rodent models of polycystic ovary syndrome and its implications for mental health disorders: A systematic review.

    systematic_review_or_meta_analysis

  444. 2026 · regulatory · Temporal status not established

    Regulatory review: not_approved

    European Union — EMA

  445. 2026 · regulatory · Temporal status not established

    Regulatory review: not_approved

    United States — FDA

  446. 2027 · study · Temporal status not established

    Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche.

    peer_reviewed_research

  447. Date unavailable · study · Temporal status not established

    Effects of chrysin on Kisspeptin, neurokinin B, and dynorphin neurons and &lt;i&gt;gonadotropin-releasing hormone&lt;/i&gt; gene expression in stress-induced rats: An experimental study.

    other

  448. Date unavailable · study · Temporal status not established

    Relationship between kisspeptin-10, neurokinin B and dynorphin A in the course of normal and delayed puberty in ewes.

    other

  449. Date unavailable · study · Temporal status not established

    IGF-1 supplementation improves &lt;i&gt;in vitro&lt;/i&gt; maturation quality of &lt;i&gt;Capra hircus&lt;/i&gt; oocytes via PDE3A activation, gap junction remodeling, apoptosis suppression, and kisspeptin signaling.

    other

  450. Date unavailable · study · Temporal status not established

    Serum kisspeptin levels in pregnant and non-pregnant diestrus bitches: a pilot study.

    other

  451. Date unavailable · study · Temporal status not established

    Correction: IGF-1 supplementation improves &lt;i&gt;in vitro&lt;/i&gt; maturation quality of &lt;i&gt;Capra hircus&lt;/i&gt; oocytes via PDE3A activation, gap junction remodeling, apoptosis suppression, and kisspeptin signaling.

    other

  452. Date unavailable · study · Temporal status not established

    Kisspeptin.

    other

  453. Date unavailable · study · Temporal status not established

    Dynamic modulation of LH secretion by continuous kisspeptin infusion in healthy men.

    other

  454. Date unavailable · study · Temporal status not established

    Naringenin protects against renal ischemia-reperfusion injury following unilateral nephrectomy via modulation of oxidative stress and kisspeptin expression.

    other

  455. Date unavailable · study · Temporal status not established

    Stress as a Neuroendocrine Modulator of the Reproductive Axis: Roles of Glucocorticoids, Kisspeptin, and Serotonergic Signalling in Animal Models.

    other

The represented chronology reflects records currently included in the governed dataset and does not claim to represent the entire scientific literature.

What still needs investigation

Claim traceability

No institutional claim record is currently represented for this peptide.

Evidence is missing or not represented as studied; this is not a conclusion that the intervention does not work.

Connections

Follow the scientific relationships

Connections appear only when they are represented by the project’s underlying records.

Open 3 represented connections ↓

institution

peer_reviewed_research

represented evidence source

institution

systematic_review_or_meta_analysis

represented evidence source

institution

other

represented evidence source

Traceability

Follow the record back to its source

The experience makes incomplete links visible instead of presenting a false impression of perfect provenance.

Source publication state

A governed source may be verified and approved for publication while its claim-to-evidence link is still incomplete.

Reviewer provenance state

“Human scientist reviewed: no” means that specific source-path attribution is not recorded. It does not silently negate the separate publication-review state.

Domain conclusion → Evidence

Connected

Evidence → Source

Connected

Source → Original record

Connected

Traceability documents how the project connects statements to records. It does not establish that a source is scientifically valid or that a claim is clinically true.

Reconciled for 6 domain conclusions and 0 featured studies.

Detailed study-to-domain mappings and original-source paths appear in the Kisspeptin evidence-governance section.

Inspect the ranked source records

Observational archive

What contributors reported

Observational archive data is intentionally separated from published scientific evidence.

Observational boundary

Insufficient eligible observations are available for display under the current filters.

Insufficient eligible observations are currently represented to display aggregated findings for this peptide.

Regulatory context

Published jurisdictional records

Regulatory status is jurisdiction-specific and time-dependent. It is presented as context, not as a recommendation for use or a substitute for scientific evidence evaluation.

United States — FDA

Regulator: FDA

not_approved

As of: 9/23/2026 · Temporal status not established

FDA Drugs@FDA database

Research + media

Media connected to this scientific record

Only media explicitly linked through the project’s relationship system appears here.

No scientifically connected media is currently represented for this peptide.

Sources + provenance

Read the scientific record with its boundaries intact

The public record organizes reviewed evidence; it does not establish scientific truth by itself.
Association, mechanism, observation and regulatory status must not be represented as proof of clinical efficacy or safety.
Observational reports describe contributor experiences and cannot establish causation, effectiveness, safety or clinical benefit.
Contradictory and qualifying evidence must remain visible rather than being silently discarded.
Absence of represented evidence is not evidence that research does not exist.
Research gaps identify unresolved questions; they are not negative conclusions.
Regulatory status is distinct from scientific evidence quality.
Media relationships provide context and explanation; they do not increase the strength of scientific evidence.
A section with no represented records is an incomplete project record, not a scientific conclusion.
Researcher and institutional relationships are shown only when supported by represented records and must not be interpreted as rankings or endorsements.

Generated: 11/8/2026, 5:29:00 PM

global evidence atlas

Kisspeptin research, ranked and separated by purpose

This is a deduplicated literature screening registry—not a claim that every mention directly proves efficacy or safety. Machine proposals remain visibly separate from governed human appraisal.

700Discoverable source universe
500Ranked screening records
6Research domains
0Accountably approved conclusions

500 matching records · ranked 2026-09-18

Page 1 of 20

Count reconciliation: 700 discoverable source records match the peptide identity query; 500 are retained in this bounded, ranked screening view; 0 belong to the separate governed layer labeled “Accountably approved conclusions.” Domain totals overlap because one publication may inform several questions.

governance and regulatory context

Kisspeptin: what this atlas does and does not establish

Last checked
2026-09-18
Accountable publication approval
Not yet approved by a named accountable reviewer. Machine screening only.

No new outcome conclusion is inferred from discovery metadata. Named accountable approval is required for governed scientific conclusions.

Known limitations of this pass

  • no current regulatory record located in governed sources

No machine-proposed evidence-strength grades exist yet for this compound; all screening records are unassigned pending further review.

Kisspeptin evidence · ranking key

How evidence is ranked

A tier describes the evidentiary role and design strength of a source. It is not a popularity score, proof that every conclusion is correct, or a substitute for claim-level review.

A

Practice-defining evidence

Large, well-conducted randomized trials; prespecified major outcomes; rigorous systematic reviews or meta-analyses; and major regulatory assessments.

B

Strong supporting evidence

Smaller randomized trials, strong prospective cohorts, prespecified secondary analyses, and high-quality comparative-effectiveness studies.

C

Contextual evidence

Retrospective cohorts, claims-database studies, pharmacovigilance analyses, mechanistic human research, and well-documented case series.

D

Signal-generating evidence

Case reports, conference abstracts, preclinical research, hypothesis-generating analyses, and expert commentary.

Tier and confidence answer different questions

Tier classifies source design and evidentiary role. Confidence reflects risk of bias, sample size, comparator quality, outcome relevance, follow-up, missing data, directness, replication, reporting quality, and whether conclusions stay within the measured results.

Funding and conflicts are disclosed and considered, but sponsorship never automatically changes a tier. Corrections, retractions, and expressions of concern override the original rating.

Suggested citation

  • APA

    World Peptide Foundation. (n.d.). Kisspeptin — Peptide Scientific Intelligence. World Peptide Foundation. (Updated September 26, 2026.) https://www.worldpeptidefoundation.org/directory/kisspeptin

  • AMA / Vancouver

    World Peptide Foundation. Kisspeptin — Peptide Scientific Intelligence. World Peptide Foundation website. Updated September 26, 2026. https://www.worldpeptidefoundation.org/directory/kisspeptin