# MOTS-c: USC discovery, metabolic signaling and research findings

- Lee et al. · First scientific report · Cell Metabolism · 2015
  https://pubmed.ncbi.nlm.nih.gov/25738459/

- USC Leonard Davis School · Discovery announcement · March 2, 2015
  https://gero.usc.edu/2015/03/02/newly-discovered-hormone-mimics-the-effects-of-exercise/

- CohBar · Discovery account and first CB4211 dosing · July 12, 2018
  https://www.globenewswire.com/news-release/2018/07/12/1536594/0/en/cohbar-initiates-clinical-study-with-first-in-human-dosing-of-cb4211-a-novel-mitochondria-based-therapeutic-for-the-treatment-of-nash.html

- ClinicalTrials.gov · CB4211 · NCT03998514
  https://clinicaltrials.gov/study/NCT03998514

- Kim, Son, Benayoun & Lee · Nuclear translocation · Cell Metabolism · 2018
  https://gero.usc.edu/labs/benayounlab/files/2018/07/Kim-2018_MOTSC_nucleus.pdf

- Reynolds et al. · Metabolic and physical-performance findings · Nature Communications · 2021
  https://gero.usc.edu/labs/benayounlab/files/2021/01/Reynolds-2021-Nat_comms_MOTSc_exercise.pdf

- ClinicalTrials.gov · Planned MOTS-MET trial · NCT07505745
  https://clinicaltrials.gov/study/NCT07505745

- FDA · MOTS-c staff briefing · 2026
  https://www.fda.gov/media/193347/download

- FDA · July 23–24, 2026 Pharmacy Compounding Advisory Committee meeting
  https://www.fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026