# Kisspeptin: From Hershey to Fertility

World Peptide Foundation — Peptides in 2

## Original research

1. Lee JH, Miele ME, Hicks DJ, et al. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. J Natl Cancer Inst. 1996;88:1731–1737. https://pubmed.ncbi.nlm.nih.gov/8944003/
2. Seminara SB, Messager S, Chatzidaki EE, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349:1614–1627. https://pubmed.ncbi.nlm.nih.gov/14573733/
3. Jayasena CN, Abbara A, et al. Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. J Clin Invest. 2014;124:3667–3677. https://www.jci.org/articles/view/75730
4. Thurston L, Hunjan T, Ertl N, et al. Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial. JAMA Netw Open. 2022;5:e2236131. https://pubmed.ncbi.nlm.nih.gov/36287566/
5. Mills EG, Ertl N, Wall MB, et al. Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial. JAMA Netw Open. 2023;6:e2254313. https://pubmed.ncbi.nlm.nih.gov/36735255/

## Production and editorial notes

- Narration: approved 1,913-character script, one Tom generation; 39 Runway credits. No paid Runway images, video generation or regeneration.
- Visuals: newly generated editorial artwork and original WPF explanatory graphics. Laboratory scenes and people are illustrative; they are not photographs of trial participants or named researchers. Brain and receptor artwork is conceptual rather than diagnostic imaging or a solved molecular structure. Peptide diagrams illustrate length, not molecular conformation.
- Kisspeptin's biological role and early clinical findings are distinguished from established long-term treatment effectiveness. No dosing instructions are included.
- Existing WPF series title artwork is the sole reused visual, as required for series consistency. The map uses geographic coordinate data; its episode-specific design is new.
- Human listening/pronunciation review remains with the owner. Automated alignment is not a listening review.