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CJC-1295 began with a biotechnology challenge: how
do you make a brief hormone

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signal last for days?

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At ConjuChem in Montreal, Canada, Lucie Jetté,
Roger Léger and colleagues engineered a

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longer-acting version of growth hormone-releasing
hormone.

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Their 2005 paper described the molecule's
development, giving it more than twenty years

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of published research history.

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The key technology is called the drug affinity
complex, or DAC.

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It allows the peptide to attach to albumin, a
protein already circulating in the bloodstream.

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This molecular hitchhiking helps the signal remain
in circulation much longer.

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CJC-1295 stimulates receptors on the pituitary
gland, encouraging the

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body to release growth hormone.

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Growth hormone then supports production of insulin-
like growth factor one, an important

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signal involved in tissue growth and metabolism.

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In two placebo-controlled trials published in 2006,
Sam Teichman and colleagues

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studied healthy adults.

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After a single injection, average growth hormone
levels rose for at least six days,

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while insulin-like growth factor one remained
elevated for nine to eleven days.

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Those findings demonstrated sustained hormone
stimulation.

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They did not establish improvements in strength,
recovery, fat loss or longevity.

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Another important distinction: products called
CJC-1295 without

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DAC are not the same long-acting molecule.

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Findings from the albumin-binding version cannot
simply be transferred to them.

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CJC-1295 remains an investigational peptide,
without an FDA-approved use.

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Reported safety concerns include increased heart
rate and reactions involving blood-vessel widening.

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Its research story is one of molecular engineering:
extending the lifetime of a

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biological message, and studying what that longer
signal can achieve.

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World Peptide Foundation.

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Peptides in 2.

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Every experience matters.