1
00:00:01,000 --> 00:00:04,660
Mazdutide closes this group with a different milestone,

2
00:00:05,620 --> 00:00:10,560
a dual GLP-1 and glucagon receptor medicine that

3
00:00:10,560 --> 00:00:12,320
reached approval in China.

4
00:00:13,300 --> 00:00:17,220
It originated in Lilly's research, Innovent licensed development

5
00:00:17,220 --> 00:00:20,360
and commercial rights in China in 2019,

6
00:00:21,220 --> 00:00:24,940
connecting American discovery with Chinese clinical development.

7
00:00:25,760 --> 00:00:30,160
Linong Ji and colleagues tested it in GLORY-1.

8
00:00:30,780 --> 00:00:35,540
610 adults in China, randomized to Mazdutide or

9
00:00:35,540 --> 00:00:38,020
placebo for 48 weeks.

10
00:00:38,720 --> 00:00:42,180
Average weight fell 11% in the 4 mg group

11
00:00:42,180 --> 00:00:47,540
and 14.01% in the 6 milligram group.

12
00:00:48,020 --> 00:00:52,000
Placebo participants gained 0.3%.

13
00:00:52,000 --> 00:00:55,420
This analysis includes people who stopped treatment or

14
00:00:55,420 --> 00:00:57,100
started other weight therapies.

15
00:00:57,790 --> 00:01:01,670
Gastrointestinal symptoms were the most common adverse events.

16
00:01:02,730 --> 00:01:06,750
Population averages cannot predict every individual response.

17
00:01:07,710 --> 00:01:10,890
China approved Mazdutide for weight management and type

18
00:01:10,890 --> 00:01:13,430
2 diabetes in 2025.

19
00:01:14,140 --> 00:01:15,760
These are separate indications.

20
00:01:16,460 --> 00:01:20,060
The obesity trial does not establish diabetes outcomes

21
00:01:20,060 --> 00:01:23,460
and approval in one country does not authorize

22
00:01:23,460 --> 00:01:24,700
use everywhere.

23
00:01:25,800 --> 00:01:28,500
As this group ends, connect each claim to

24
00:01:28,500 --> 00:01:30,380
its population, measurement,

25
00:01:31,160 --> 00:01:33,260
safety record and local approval.

26
00:01:34,140 --> 00:01:37,660
The evidence continues beyond any single film.

27
00:01:37,660 --> 00:01:40,080
Peptides in 2.

28
00:01:40,080 --> 00:01:41,960
World Peptide Foundation.

29
00:01:42,860 --> 00:01:43,960
Every experience matters.