{"schemaVersion":"wpf-profile-export-v1","exportedAt":"2026-09-18T15:31:04.311Z","profile":{"slug":"tesamorelin","name":"Tesamorelin","aliases":["Egrifta","Egrifta SV","TH9507"],"category":"Growth hormone-releasing hormone analog"},"synthesis":{"mechanism":"Tesamorelin is a stabilized N-terminally modified analog of the 44-amino-acid human growth hormone–releasing hormone. It activates pituitary GHRH receptors, increasing endogenous growth-hormone release and downstream IGF-1 signaling. In the labeled population this pathway reduces visceral adipose tissue; it is not a general weight-loss mechanism.","evidence":"Evidence is strongest for reducing excess abdominal fat in adults with HIV-associated lipodystrophy: FDA approval is supported by randomized phase 3 trials. Smaller randomized studies report hepatic-fat reductions in selected people with HIV, while cognition and anti-aging uses remain investigational.","safety":"Current US labeling addresses active malignancy, disruption of the hypothalamic-pituitary axis, pregnancy, hypersensitivity, elevated IGF-1, fluid retention, glucose intolerance or diabetes, and injection-site reactions. Safety depends on the labeled product, indication, patient factors, and monitoring.","observationalBoundary":"Governed corpus spanning FDA labeling, pivotal and extension trials, liver-fat studies, and a controlled cognition study. Approved and investigational findings are separated.","openQuestions":"Long-term outcomes beyond body-composition surrogates; durability after discontinuation; cardiometabolic outcomes; broader applicability; and whether liver or cognitive signals translate into durable clinical benefit."},"completion":{"version":"wpf-profile-v1.0","complete":false,"checks":[{"key":"overview","passed":true,"actual":348,"required":100,"severity":"blocking"},{"key":"evidence_summary","passed":true,"actual":302,"required":100,"severity":"blocking"},{"key":"safety_summary","passed":true,"actual":304,"required":100,"severity":"blocking"},{"key":"archive_boundary","passed":true,"actual":174,"required":75,"severity":"blocking"},{"key":"open_questions","passed":true,"actual":217,"required":75,"severity":"blocking"},{"key":"verified_sources","passed":true,"actual":25,"required":25,"severity":"blocking"},{"key":"reviewed_sources","passed":true,"actual":25,"required":1,"severity":"blocking"},{"key":"chemistry","passed":true,"actual":true,"required":true,"severity":"blocking"},{"key":"regulatory_context","passed":false,"actual":1,"required":2,"severity":"blocking"},{"key":"claims","passed":true,"actual":25,"required":1,"severity":"blocking"},{"key":"claim_traceability","passed":true,"actual":0,"required":0,"severity":"blocking"},{"key":"regulatory_freshness","passed":true,"actual":0,"required":0,"severity":"warning"}],"failures":["regulatory_context"]},"chemistry":{"id":"eca5eb38-8bb7-4fa7-804c-96045c6c405a","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","molecularFormula":"C221H366N72O67S","molecularWeight":5135.9,"aminoAcidSequence":null,"smiles":null,"inchi":null,"inchikey":null,"structureImageUrl":null,"createdAt":"2026-09-08T22:50:27.254Z","updatedAt":"2026-09-08T22:50:27.254Z"},"evidence":[{"id":"da42a663d05ed6438e209dff00bd2868","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Body composition, hepatic fat, metabolic, and safety outcomes of Tesamorelin, a GHRH analogue, in HIV-associated lipodystrophy: A meta-analysis of randomized controlled trials.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/41545261/","evidenceTier":"observational","summary":"HIV-associated lipodystrophy leads to visceral fat accumulation, metabolic complications, body image concerns, medication non-adherence, and increased cardiovascular risks. We thought to assess the effects of Tesamorelin, a synthetic growth hormone-releasing hormone analogue, that has been proposed as a targeted therapy. We systematically searched PubMed, Embase, Scopus, Web of Science, and CENTRAL through July 2025 for randomized controlled trials (RCTs) evaluating Tesamorelin versus placebo in adults with HIV. Random-effects meta-analysis was applied. Outcomes included changes in body composition, hepatic and metabolic parameters, hormonal markers, and adverse events. Risk of bias was...","authors":"Ahmed Samy Badran, Abdulrhman Helal, Karim Samir Shata, Hazem Ayesh","publishingOrg":null,"publicationYear":2026,"doi":"10.1016/j.orcp.2026.01.002","pubmedId":"41545261","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"systematic_review_or_meta_analysis","claimSupported":"This source contributes meta_analysis evidence concerning Body composition, hepatic fat, metabolic, and safety outcomes of Tesamorelin, a GHRH analogue, in HIV-associated lipodystrophy: A meta-analysis of randomized controlled trials.","supportNature":"contextualizes","qualification":"Secondary synthesis; certainty depends on included studies, heterogeneity, publication bias, and review methods.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.orcp.2026.01.002","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"meta_analysis","extractionPayload":{"limitations":["Secondary synthesis; certainty depends on included studies, heterogeneity, publication bias, and review methods."],"studyDesign":"Systematic review and meta-analysis","sourceStrength":{"grade":"A","score":83,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Meta-Analysis","Journal Article","Systematic Review"]},"provenancePayload":{"doi":"10.1016/j.orcp.2026.01.002","pmid":"41545261","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"7cfc30a2673b282c10c15ef5f49f89c7","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Efficacy and Safety of Tesamorelin in People Living With HIV (PLWH) With Lipodystrophy: A Systematic Review and Meta-Analysis.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/42538058/","evidenceTier":"observational","summary":"BackgroundHIV-associated lipodystrophy, a complication of combined antiretroviral therapy (CART), causes significant physical and psychological distress in people living with HIV (PLWH), compromising treatment adherence. Tesamorelin, a growth hormone-releasing hormone (GHRH) analogue, has emerged as a therapeutic option.ObjectiveTo systematically evaluate the efficacy and safety of tesamorelin in HIV-infected individuals with lipodystrophy receiving CART, incorporating GRADE assessment.MethodsWe searched PubMed, https://ClinicalTrials.gov, and Scopus from inception to February 9, 2026, for randomized controlled trials evaluating tesamorelin in HIV-associated lipodystrophy. Mean...","authors":"Aqsa Mohammed Ditta, Ruqaiya Muhammad Naeem, Muhammad Mohsin Sami, Muhammad Abdul Rafey, Hunain Ali, Muhammad Waqar Amjad, Fahad Jahangir, Kehan Ali Rizvi","publishingOrg":null,"publicationYear":2026,"doi":"10.1177/23259582261475549","pubmedId":"42538058","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"systematic_review_or_meta_analysis","claimSupported":"This source contributes meta_analysis evidence concerning Efficacy and Safety of Tesamorelin in People Living With HIV (PLWH) With Lipodystrophy: A Systematic Review and Meta-Analysis.","supportNature":"contextualizes","qualification":"Secondary synthesis; certainty depends on included studies, heterogeneity, publication bias, and review methods.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1177/23259582261475549","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"meta_analysis","extractionPayload":{"limitations":["Secondary synthesis; certainty depends on included studies, heterogeneity, publication bias, and review methods."],"studyDesign":"Systematic review and meta-analysis","sourceStrength":{"grade":"A","score":83,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Journal Article","Systematic Review","Meta-Analysis"]},"provenancePayload":{"doi":"10.1177/23259582261475549","pmid":"42538058","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"f864ddb73480b8f5a607aec618183737","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"EGRIFTA (tesamorelin acetate) prescribing information, revised March 2025","sourceUrl":"https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/022505s020lbl.pdf","evidenceTier":"fda_approved","summary":"Current US labeling limits the indication to reduction of excess abdominal fat in adults with HIV and lipodystrophy; it is not indicated for weight-loss management.","authors":null,"publishingOrg":null,"publicationYear":2025,"doi":null,"pubmedId":null,"jurisdiction":"United States","dateAccessed":"2026-09-08T18:31:47.338Z","editorialNotes":"AI-assisted synthesis; owner-authorized governed publication 2026-09-08.","sourceType":"official_product_labeling","claimSupported":"FDA approval is narrow and labeling governs contraindications, warnings, adverse reactions, and monitoring.","supportNature":"contextualizes","qualification":"Jurisdiction- and revision-specific; not comparative-effectiveness evidence.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-reference-corpus-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"url:https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/022505s020lbl.pdf","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:31:47.338Z","retrievalProvider":"US government source","retrievalPayloadRef":"wpf:tesamorelin:reference-corpus:2026-09-08","evidenceLane":"regulatory","extractionPayload":{"finding":"FDA approval is narrow and labeling governs contraindications, warnings, adverse reactions, and monitoring.","population":"Adults with HIV and lipodystrophy","sampleSize":null,"limitations":["Jurisdiction- and revision-specific; not comparative-effectiveness evidence."],"studyDesign":"Official US prescribing information","sourceStrength":{"note":"Automated baseline based on evidence tier; full-text risk-of-bias review may revise it","grade":"A+","score":95,"version":"WPF-ESR-1.0","provisional":true}},"provenancePayload":{"doi":null,"pmid":null,"reviewBatch":"tesamorelin-reference-corpus-2026-09-08"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:31:47.338Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"97da563802bc798d556939708236a85d","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Effects of Tesamorelin on Neurocognitive Impairment in Persons With HIV and Abdominal Obesity.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/39813152/","evidenceTier":"phase_1_2","summary":"In people with HIV who are virally suppressed with antiretroviral therapy, abdominal obesity (AO) is linked to neurocognitive impairment (NCI), potentially due to visceral adiposity, inflammation, and reduced insulin-like growth factor 1 (IGF-1). Tesamorelin, a growth hormone-releasing hormone, reduces AO and increases IGF-1, suggesting that it might mitigate NCI in people with HIV and viral suppression. This 6-month phase 2 randomized open-label clinical trial compared tesamorelin vs standard of care (SOC) for NCI in people with HIV who were virally suppressed and abdominally obese (elevated waist circumference [WC]). Exclusions included conditions other than HIV causing NCI, active...","authors":"Ronald J Ellis, Florin Vaida, Keren Hu, Michael Dube, Brook Henry, Felicia Chow, Robert K Heaton, Daniel Lee","publishingOrg":null,"publicationYear":2025,"doi":"10.1093/infdis/jiaf012","pubmedId":"39813152","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"This source contributes human_interventional evidence concerning Effects of Tesamorelin on Neurocognitive Impairment in Persons With HIV and Abdominal Obesity.","supportNature":"contextualizes","qualification":"Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1093/infdis/jiaf012","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"limitations":["Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration."],"studyDesign":"Randomized or controlled human clinical trial","sourceStrength":{"grade":"A","score":86,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Clinical Trial, Phase II","Journal Article","Multicenter Study","Randomized Controlled Trial"]},"provenancePayload":{"doi":"10.1093/infdis/jiaf012","pmid":"39813152","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"8ef7abb51f1c3dfc38d6e6a2162b05df","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Efficacy and safety of tesamorelin in people with HIV on integrase inhibitors.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/38905488/","evidenceTier":"phase_1_2","summary":"Tesamorelin is the only FDA-approved therapy to treat abdominal fat accumulation in people with HIV (PWH). Phase III clinical trials were conducted prior to the introduction of integrase inhibitors (INSTIs), which are now a mainstay of HIV antiretroviral therapy. We leveraged a randomized double-blind trial of 61 PWH and metabolic dysfunction-associated steatotic liver disease to evaluate the efficacy and safety of tesamorelin 2 mg once daily vs. identical placebo among participants on INSTI-based regimens at baseline. In the parent clinical trial, visceral fat cross-sectional area, hepatic fat fraction, and trunk-to-appendicular fat ratio were quantified using magnetic resonance...","authors":"Samuel C Russo, Mollie W Ockene, Allison K Arpante, Julia E Johnson, Hang Lee, Mabel Toribio, Takara L Stanley, Colleen M Hadigan","publishingOrg":null,"publicationYear":2024,"doi":"10.1097/QAD.0000000000003965","pubmedId":"38905488","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"This source contributes human_interventional evidence concerning Efficacy and safety of tesamorelin in people with HIV on integrase inhibitors.","supportNature":"contextualizes","qualification":"Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1097/qad.0000000000003965","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"limitations":["Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration."],"studyDesign":"Randomized or controlled human clinical trial","sourceStrength":{"grade":"A","score":86,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Journal Article","Randomized Controlled Trial","Research Support, Non-U.S. Gov't","Research Support, N.I.H., Extramural"]},"provenancePayload":{"doi":"10.1097/QAD.0000000000003965","pmid":"38905488","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"85e4f539659adfa313482d3a09c35085","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Effects of tesamorelin on hepatic transcriptomic signatures in HIV-associated NAFLD.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/32701508/","evidenceTier":"phase_1_2","summary":"Nonalcoholic fatty liver disease (NAFLD) is a common comorbidity among people living with HIV that has a more aggressive course than NAFLD among the general population. In a recent randomized placebo-controlled trial, we demonstrated that the growth hormone-releasing hormone analog tesamorelin reduced liver fat and prevented fibrosis progression in HIV-associated NAFLD over 1 year. As such, tesamorelin is the first strategy that has shown to be effective against NAFLD among the population with HIV. The current study leveraged paired liver biopsy specimens from this trial to identify hepatic gene pathways that are differentially modulated by tesamorelin versus placebo. Using gene set...","authors":"Lindsay T Fourman, James M Billingsley, George Agyapong, Shannan J Ho Sui, Meghan N Feldpausch, Julia Purdy, Isabel Zheng, Chelsea S Pan","publishingOrg":null,"publicationYear":2020,"doi":"10.1172/jci.insight.140134","pubmedId":"32701508","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"This source contributes human_interventional evidence concerning Effects of tesamorelin on hepatic transcriptomic signatures in HIV-associated NAFLD.","supportNature":"contextualizes","qualification":"Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1172/jci.insight.140134","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"limitations":["Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration."],"studyDesign":"Randomized or controlled human clinical trial","sourceStrength":{"grade":"A","score":86,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Journal Article","Randomized Controlled Trial","Research Support, N.I.H., Extramural","Research Support, N.I.H., Intramural","Research Support, Non-U.S. Gov't"]},"provenancePayload":{"doi":"10.1172/jci.insight.140134","pmid":"32701508","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"d0a237e878dbd4d633190d2884e259f2","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31611038/","evidenceTier":"phase_1_2","summary":"A multicentre randomized trial found reduced hepatic fat and less fibrosis progression over 12 months in people with HIV and NAFLD.","authors":null,"publishingOrg":null,"publicationYear":2019,"doi":"10.1016/S2352-3018(19)30338-8","pubmedId":"31611038","jurisdiction":null,"dateAccessed":"2026-09-08T18:31:47.338Z","editorialNotes":"AI-assisted synthesis; owner-authorized governed publication 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"Hepatic fat decreased in this selected population.","supportNature":"supports","qualification":"Modest sample, surrogate outcomes, investigational indication, replication needed.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-reference-corpus-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/s2352-3018(19)30338-8","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:31:47.338Z","retrievalProvider":"PubMed/Crossref verification","retrievalPayloadRef":"wpf:tesamorelin:reference-corpus:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"finding":"Hepatic fat decreased in this selected population.","population":"People with HIV and NAFLD","sampleSize":"61 randomized","limitations":["Modest sample, surrogate outcomes, investigational indication, replication needed."],"studyDesign":"Randomized double-blind multicentre trial","sourceStrength":{"note":"Automated baseline based on evidence tier; full-text risk-of-bias review may revise it","grade":"B+","score":82,"version":"WPF-ESR-1.0","provisional":true}},"provenancePayload":{"doi":"10.1016/S2352-3018(19)30338-8","pmid":"31611038","reviewBatch":"tesamorelin-reference-corpus-2026-09-08"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:31:47.338Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"9775312ff3487c849a1afe1135d3b5a4","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31237318/","evidenceTier":"phase_1_2","summary":"Tesamorelin, a growth hormone-releasing hormone analogue, decreases visceral adipose tissue in people living with HIV, however, the effects on skeletal muscle fat and area are unknown. The goals of this exploratory secondary analysis were to determine the effects of tesamorelin on muscle quality (density) and quantity (area). Secondary, exploratory analysis of two previously completed randomized (2:1), clinical trials. U.S. and Canadian sites. People living with HIV and with abdominal obesity. Tesamorelin participants were restricted to responders (visceral adipose tissue decrease ≥8%). Tesamorelin or placebo. Computed tomography scans (at L4-L5) were used to quantify total and lean...","authors":"S Adrian, A Scherzinger, A Sanyal, J E Lake, J Falutz, M P Dubé, T Stanley, S Grinspoon","publishingOrg":null,"publicationYear":2019,"doi":"10.14283/jfa.2018.45","pubmedId":"31237318","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"This source contributes human_interventional evidence concerning The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV.","supportNature":"contextualizes","qualification":"Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.14283/jfa.2018.45","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"limitations":["Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration."],"studyDesign":"Randomized or controlled human clinical trial","sourceStrength":{"grade":"A","score":86,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Journal Article","Randomized Controlled Trial"]},"provenancePayload":{"doi":"10.14283/jfa.2018.45","pmid":"31237318","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"631691e11107bcc7ae45dbd10992f51e","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Safety and metabolic effects of tesamorelin, a growth hormone-releasing factor analogue, in patients with type 2 diabetes: A randomized, placebo-controlled trial.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/28617838/","evidenceTier":"phase_1_2","summary":"Use of growth hormone is associated with side effects, including insulin resistance. The objective of this study was to determine whether tesamorelin, a stabilized growth hormone-releasing hormone analogue, would alter insulin sensitivity or control of diabetes. A 12-week randomized, placebo-controlled study of 53 patients with type 2 diabetes. Three treatment groups: placebo, 1 and 2 mg tesamorelin. Fasting glucose, glucose and insulin from oral glucose tolerance test, glycosylated hemoglobin (HbA1c), home blood glucose, insulin-like growth factor-1, and lipids. Relative insulin response following oral ingestion of glucose. No significant differences were observed between groups in...","authors":"David R Clemmons, Sam Miller, Jean-Claude Mamputu","publishingOrg":null,"publicationYear":2017,"doi":"10.1371/journal.pone.0179538","pubmedId":"28617838","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"This source contributes human_interventional evidence concerning Safety and metabolic effects of tesamorelin, a growth hormone-releasing factor analogue, in patients with type 2 diabetes: A randomized, placebo-controlled trial.","supportNature":"contextualizes","qualification":"Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1371/journal.pone.0179538","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"limitations":["Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration."],"studyDesign":"Randomized or controlled human clinical trial","sourceStrength":{"grade":"A","score":86,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Journal Article","Multicenter Study","Randomized Controlled Trial"]},"provenancePayload":{"doi":"10.1371/journal.pone.0179538","pmid":"28617838","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"b209856c429f4e4c025ec39ae61bf4f9","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Population pharmacokinetic analysis of tesamorelin in HIV-infected patients and healthy subjects.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25358450/","evidenceTier":"phase_1_2","summary":"Tesamorelin is a synthetic analogue of growth hormone-releasing factor (GRF), which increases basal and pulsatile growth hormone (GH) secretion and subsequently increases insulin-like growth factor (IGF)-1. Limited information is available about the pharmacokinetics of this compound. Consequently, the aim of this study was to characterize the population pharmacokinetics of tesamorelin in HIV-infected patients and healthy subjects. A total of 38 HIV-infected patients and healthy subjects receiving subcutaneous tesamorelin doses of 1 or 2 mg administered daily during 14 consecutive days were included in the analysis. An open one-compartment model with first- and zero-order absorption and...","authors":"Mario González-Sales, Olivier Barrière, Pierre Olivier Tremblay, Fahima Nekka, Jean-Claude Mamputu, Sylvie Boudreault, Mario Tanguay","publishingOrg":null,"publicationYear":2015,"doi":"10.1007/s40262-014-0202-x","pubmedId":"25358450","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"This source contributes human_interventional evidence concerning Population pharmacokinetic analysis of tesamorelin in HIV-infected patients and healthy subjects.","supportNature":"contextualizes","qualification":"Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s40262-014-0202-x","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"limitations":["Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration."],"studyDesign":"Randomized or controlled human clinical trial","sourceStrength":{"grade":"A","score":86,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Clinical Trial, Phase I","Journal Article","Randomized Controlled Trial","Research Support, Non-U.S. Gov't"]},"provenancePayload":{"doi":"10.1007/s40262-014-0202-x","pmid":"25358450","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"e05f7bb4471463192334032faa352542","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Population pharmacokinetic and pharmacodynamic analysis of tesamorelin in HIV-infected patients and healthy subjects.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25895899/","evidenceTier":"phase_1_2","summary":"The objective of this analysis was to characterize the time course of selected pharmacodynamic (PD) markers of tesamorelin: growth hormone (GH) and insulin-like growth factor (IGF-1) concentrations in HIV-infected patients and healthy volunteers. A total of 41 subjects in Phase I trials receiving subcutaneous daily doses of 1 or 2 mg of tesamorelin during 14 consecutive days were included in this analysis. A previous pharmacokinetic (PK) model of tesamorelin was used as the input function for the PD model of GH. Tesamorelin was hypothesized to stimulate the secretion of GH in an \"episodic\" manner, i.e., for a finite duration of time. The resulting PK/PD model of GH was used to describe...","authors":"Mario González-Sales, Olivier Barrière, Pierre Olivier Tremblay, Fahima Nekka, Jean-Claude Mamputu, Sylvie Boudreault, Mario Tanguay","publishingOrg":null,"publicationYear":2015,"doi":"10.1007/s10928-015-9416-2","pubmedId":"25895899","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"This source contributes human_interventional evidence concerning Population pharmacokinetic and pharmacodynamic analysis of tesamorelin in HIV-infected patients and healthy subjects.","supportNature":"contextualizes","qualification":"Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1007/s10928-015-9416-2","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"limitations":["Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration."],"studyDesign":"Randomized or controlled human clinical trial","sourceStrength":{"grade":"A","score":86,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Clinical Trial, Phase I","Journal Article","Research Support, Non-U.S. Gov't"]},"provenancePayload":{"doi":"10.1007/s10928-015-9416-2","pmid":"25895899","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"20d6e923c8ba0e2e976ca2ff7526963f","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Predictors of Treatment Response to Tesamorelin, a Growth Hormone-Releasing Factor Analog, in HIV-Infected Patients with Excess Abdominal Fat.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/26457580/","evidenceTier":"phase_1_2","summary":"Tesamorelin, a synthetic analog of human growth hormone-releasing factor, decreases visceral adipose tissue (VAT) in human immunodeficiency virus (HIV)-infected patients with lipodystrophy. 1) To evaluate the utility of patient characteristics and validated disease-risk scores, namely indicator variables for the metabolic syndrome defined by the International Diabetes Federation (MetS-IDF) or the National Cholesterol Education Program (MetS-NCEP) and the Framingham Risk Score (FRS), as predictors of VAT reduction during tesamorelin therapy at 3 and 6 months, and 2) To explore the characteristics of patients who reached a threshold of VAT <140 cm2, a level associated with lower risk of...","authors":"Alexandra Mangili, Julian Falutz, Jean-Claude Mamputu, Miganush Stepanians, Brooke Hayward","publishingOrg":null,"publicationYear":2015,"doi":"10.1371/journal.pone.0140358","pubmedId":"26457580","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"This source contributes human_interventional evidence concerning Predictors of Treatment Response to Tesamorelin, a Growth Hormone-Releasing Factor Analog, in HIV-Infected Patients with Excess Abdominal Fat.","supportNature":"contextualizes","qualification":"Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1371/journal.pone.0140358","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"limitations":["Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration."],"studyDesign":"Randomized or controlled human clinical trial","sourceStrength":{"grade":"A","score":86,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Journal Article","Randomized Controlled Trial","Research Support, Non-U.S. Gov't"]},"provenancePayload":{"doi":"10.1371/journal.pone.0140358","pmid":"26457580","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"4f85dd95c2b0299fb3281d3b34667090","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/25038357/","evidenceTier":"phase_1_2","summary":"A small randomized trial found reductions in visceral adipose tissue and hepatic lipid over six months; early fasting glucose increased but six-month glucose differences were not significant.","authors":null,"publishingOrg":null,"publicationYear":2014,"doi":"10.1001/jama.2014.8334","pubmedId":"25038357","jurisdiction":null,"dateAccessed":"2026-09-08T18:31:47.338Z","editorialNotes":"AI-assisted synthesis; owner-authorized governed publication 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"Visceral and liver fat decreased relative to placebo over six months.","supportNature":"mixed","qualification":"Small sample, short duration, surrogate endpoints, and specific HIV population.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-reference-corpus-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1001/jama.2014.8334","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:31:47.338Z","retrievalProvider":"PubMed/Crossref verification","retrievalPayloadRef":"wpf:tesamorelin:reference-corpus:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"finding":"Visceral and liver fat decreased relative to placebo over six months.","population":"HIV-infected adults with abdominal fat accumulation","sampleSize":"50 randomized; 48 treated","limitations":["Small sample, short duration, surrogate endpoints, and specific HIV population."],"studyDesign":"Randomized double-blind placebo-controlled trial","sourceStrength":{"note":"Automated baseline based on evidence tier; full-text risk-of-bias review may revise it","grade":"B+","score":82,"version":"WPF-ESR-1.0","provisional":true}},"provenancePayload":{"doi":"10.1001/jama.2014.8334","pmid":"25038357","reviewBatch":"tesamorelin-reference-corpus-2026-09-08"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:31:47.338Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"efc6ca28be7c106c2529f780fb8174cd","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"The effects of tesamorelin on phosphocreatine recovery in obese subjects with reduced GH.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/24178787/","evidenceTier":"phase_1_2","summary":"Few studies have assessed the relationship between GH and mitochondrial function. The objective of this study was to determine the effects of improving IGF-I using a GHRH analog, tesamorelin, on mitochondrial function assessed by phosphocreatine (PCr) recovery using (31)P magnetic resonance spectroscopy in obese adults with reduced GH. A total of 39 obese men and women with reduced GH secretion as determined by GHRH-arginine stimulation tests underwent magnetic resonance spectroscopy as part of a 12-month, double-blind, randomized, placebo-controlled trial comparing tesamorelin vs placebo. PCr recovery after submaximal exercise was assessed at baseline and at 12 months. At baseline,...","authors":"Hideo Makimura, Caitlin A Murphy, Meghan N Feldpausch, Steven K Grinspoon","publishingOrg":null,"publicationYear":2014,"doi":"10.1210/jc.2013-3436","pubmedId":"24178787","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"This source contributes human_interventional evidence concerning The effects of tesamorelin on phosphocreatine recovery in obese subjects with reduced GH.","supportNature":"contextualizes","qualification":"Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1210/jc.2013-3436","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"limitations":["Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration."],"studyDesign":"Randomized or controlled human clinical trial","sourceStrength":{"grade":"A","score":86,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Journal Article","Randomized Controlled Trial","Research Support, N.I.H., Extramural","Research Support, Non-U.S. Gov't"]},"provenancePayload":{"doi":"10.1210/jc.2013-3436","pmid":"24178787","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"798c04f6a474ee57a04d87bc2f8a8952","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/22869065/","evidenceTier":"phase_1_2","summary":"A 20-week randomized trial reported favorable composite cognition and executive-function signals, increased IGF-1, and more adverse events than placebo.","authors":null,"publishingOrg":null,"publicationYear":2012,"doi":"10.1001/archneurol.2012.1970","pubmedId":"22869065","jurisdiction":null,"dateAccessed":"2026-09-08T18:31:47.338Z","editorialNotes":"AI-assisted synthesis; owner-authorized governed publication 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"Exploratory cognitive signals were observed over 20 weeks.","supportNature":"mixed","qualification":"Short duration, composite outcomes, attrition, and no long-term disease-modifying evidence.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-reference-corpus-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1001/archneurol.2012.1970","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:31:47.338Z","retrievalProvider":"PubMed/Crossref verification","retrievalPayloadRef":"wpf:tesamorelin:reference-corpus:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"finding":"Exploratory cognitive signals were observed over 20 weeks.","population":"Adults aged 55–87, including mild cognitive impairment","sampleSize":"152 randomized; 137 completed","limitations":["Short duration, composite outcomes, attrition, and no long-term disease-modifying evidence."],"studyDesign":"Randomized double-blind placebo-controlled trial","sourceStrength":{"note":"Automated baseline based on evidence tier; full-text risk-of-bias review may revise it","grade":"B+","score":82,"version":"WPF-ESR-1.0","provisional":true}},"provenancePayload":{"doi":"10.1001/archneurol.2012.1970","pmid":"22869065","reviewBatch":"tesamorelin-reference-corpus-2026-09-08"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:31:47.338Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"5b865ba9c87443cab3cf931ab8cbddbb","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Reduction in visceral adiposity is associated with an improved metabolic profile in HIV-infected patients receiving tesamorelin.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/22495074/","evidenceTier":"phase_3","summary":"Tesamorelin, a growth hormone-releasing hormone analogue, decreases visceral adipose tissue (VAT) by 15%-20% over 6-12 months in individuals with human immunodeficiency virus (HIV)-associated abdominal adiposity, but it is unknown whether VAT reduction is directly associated with endocrine and metabolic changes. In 2 phase III, randomized, double-blind studies, men and women with HIV-associated abdominal fat accumulation were randomly assigned (ratio, 2:1) to receive tesamorelin or placebo for 26 weeks. At week 26, patients initially receiving tesamorelin were randomly assigned to continue receiving tesamorelin or to receive placebo for an additional 26 weeks. In per-protocol analysis of...","authors":"Takara L Stanley, Julian Falutz, Christian Marsolais, Josée Morin, Graziella Soulban, Jean-Claude Mamputu, Hani Assaad, Ralph Turner","publishingOrg":null,"publicationYear":2012,"doi":"10.1093/cid/cis251","pubmedId":"22495074","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"This source contributes human_interventional evidence concerning Reduction in visceral adiposity is associated with an improved metabolic profile in HIV-infected patients receiving tesamorelin.","supportNature":"contextualizes","qualification":"Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1093/cid/cis251","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"limitations":["Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration."],"studyDesign":"Randomized or controlled human clinical trial","sourceStrength":{"grade":"A","score":91,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Clinical Trial, Phase III","Journal Article","Randomized Controlled Trial","Research Support, N.I.H., Extramural","Research Support, Non-U.S. Gov't"]},"provenancePayload":{"doi":"10.1093/cid/cis251","pmid":"22495074","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"ae65f06647aff793347592f6f6341537","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Tesamorelin: a growth hormone-releasing factor analogue for HIV-associated lipodystrophy.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/22298602/","evidenceTier":"insufficient","summary":"To evaluate the efficacy and safety of tesamorelin, a growth hormone releasing factor analogue approved by the Food and Drug Administration in November 2010 for the treatment of lipodystrophy associated with HIV infection. Literature was obtained through MEDLINE (1948-November 2011) and International Pharmaceutical Abstracts (1970-October 2011) using the search terms tesamorelin, TH9507, growth hormone releasing factor, and HIV-associated lipodystrophy syndrome. Additional publications were obtained through review of references within primary literature publications as well as pertinent Web sites. All articles published in English identified from the data sources were evaluated and all...","authors":"Linda M Spooner, Jacqueline L Olin","publishingOrg":null,"publicationYear":2012,"doi":"10.1345/aph.1Q629","pubmedId":"22298602","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"systematic_review_or_meta_analysis","claimSupported":"This source contributes systematic_review evidence concerning Tesamorelin: a growth hormone-releasing factor analogue for HIV-associated lipodystrophy.","supportNature":"contextualizes","qualification":"Secondary synthesis; certainty depends on included studies, heterogeneity, publication bias, and review methods.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1345/aph.1q629","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"systematic_review","extractionPayload":{"limitations":["Secondary synthesis; certainty depends on included studies, heterogeneity, publication bias, and review methods."],"studyDesign":"Narrative or scoped review","sourceStrength":{"grade":"B","score":68,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Journal Article","Review"]},"provenancePayload":{"doi":"10.1345/aph.1Q629","pmid":"22298602","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"36a96cceb20abe815cd2175b097c06e4","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Effects of tesamorelin on inflammatory markers in HIV patients with excess abdominal fat: relationship with visceral adipose reduction.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/21516030/","evidenceTier":"phase_3","summary":"To report the effects of tesamorelin, a growth hormone-releasing hormone analogue, on inflammatory and fibrinolytic markers and to relate these effects to changes in visceral adipose tissue (VAT). Four hundred and ten HIV-infected patients with abdominal adiposity were randomized to 2 mg tesamorelin (n = 273) or placebo (n = 137) subcutaneously daily for 26 weeks. Circulating plasminogen activator inhibitor-1 (PAI-1) antigen, tissue plasminogen activator (tPA) antigen, C-reactive protein (CRP), and adiponectin were assessed. At baseline, VAT was significantly associated with PAI-1 antigen (ρ = 0.36, P < 0.001), tPA antigen (ρ = 0.29, P < 0.001), CRP (ρ = 0.18, P < 0.001), and adiponectin...","authors":"Takara L Stanley, Julian Falutz, Jean-Claude Mamputu, Graziella Soulban, Diane Potvin, Steven K Grinspoon","publishingOrg":null,"publicationYear":2011,"doi":"10.1097/QAD.0b013e328347f3f1","pubmedId":"21516030","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"This source contributes human_interventional evidence concerning Effects of tesamorelin on inflammatory markers in HIV patients with excess abdominal fat: relationship with visceral adipose reduction.","supportNature":"contextualizes","qualification":"Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1097/qad.0b013e328347f3f1","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"limitations":["Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration."],"studyDesign":"Randomized or controlled human clinical trial","sourceStrength":{"grade":"A","score":91,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Clinical Trial, Phase III","Journal Article","Randomized Controlled Trial","Research Support, N.I.H., Extramural","Research Support, Non-U.S. Gov't"]},"provenancePayload":{"doi":"10.1097/QAD.0b013e328347f3f1","pmid":"21516030","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"fd0a86a1a7e5d7344537484055a60b05","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Spotlight on tesamorelin in HIV-associated lipodystrophy.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/22050344/","evidenceTier":"insufficient","summary":"Tesamorelin (Egrifta™) is a synthetic analog of human growth hormone-releasing hormone (also known as growth hormone-releasing factor) that stimulates the synthesis and release of endogenous growth hormone. It is the first and, so far, only treatment indicated for the reduction of excess abdominal fat in patients with HIV-associated lipodystrophy. This article reviews the pharmacological properties, clinical efficacy and tolerability of tesamorelin in patients with HIV-associated central fat accumulation. Subcutaneous tesamorelin was effective in reducing visceral adipose tissue (VAT), but did not affect subcutaneous adipose tissue to a clinically significant extent in two 26-week, well...","authors":"Sohita Dhillon","publishingOrg":null,"publicationYear":2011,"doi":"10.2165/11208290-000000000-00000","pubmedId":"22050344","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"systematic_review_or_meta_analysis","claimSupported":"This source contributes systematic_review evidence concerning Spotlight on tesamorelin in HIV-associated lipodystrophy.","supportNature":"contextualizes","qualification":"Secondary synthesis; certainty depends on included studies, heterogeneity, publication bias, and review methods.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2165/11208290-000000000-00000","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"systematic_review","extractionPayload":{"limitations":["Secondary synthesis; certainty depends on included studies, heterogeneity, publication bias, and review methods."],"studyDesign":"Narrative or scoped review","sourceStrength":{"grade":"B","score":68,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Journal Article","Review"]},"provenancePayload":{"doi":"10.2165/11208290-000000000-00000","pmid":"22050344","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"1c0bdc3af91dfbdd0e0e29da3074bc43","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Tesamorelin: a review of its use in the management of HIV-associated lipodystrophy.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/21668043/","evidenceTier":"insufficient","summary":"Tesamorelin (Egrifta™) is a synthetic analogue of human growth hormone-releasing hormone (also known as growth hormone-releasing factor) that stimulates the synthesis and release of endogenous growth hormone. It is the first and, so far, only treatment indicated for the reduction of excess abdominal fat in patients with HIV-associated lipodystrophy. This article reviews the pharmacological properties, clinical efficacy and tolerability of tesamorelin in patients with HIV-associated central fat accumulation. Subcutaneous tesamorelin was effective in reducing visceral adipose tissue (VAT), but did not affect subcutaneous adipose tissue to a clinically significant extent in two 26-week,...","authors":"Sohita Dhillon","publishingOrg":null,"publicationYear":2011,"doi":"10.2165/11202240-000000000-00000","pubmedId":"21668043","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"systematic_review_or_meta_analysis","claimSupported":"This source contributes systematic_review evidence concerning Tesamorelin: a review of its use in the management of HIV-associated lipodystrophy.","supportNature":"contextualizes","qualification":"Secondary synthesis; certainty depends on included studies, heterogeneity, publication bias, and review methods.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.2165/11202240-000000000-00000","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"systematic_review","extractionPayload":{"limitations":["Secondary synthesis; 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owner-authorized governed publication 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"Visceral fat decreased during treatment; continuation was needed to maintain the effect.","supportNature":"mixed","qualification":"Narrow population, sponsor involvement, and extension design.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-reference-corpus-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"pmid:20101189","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:31:47.338Z","retrievalProvider":"PubMed/Crossref verification","retrievalPayloadRef":"wpf:tesamorelin:reference-corpus:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"finding":"Visceral fat decreased during treatment; continuation was needed to maintain the effect.","population":"Adults with HIV and central fat accumulation","sampleSize":"404 randomized","limitations":["Narrow population, sponsor involvement, and extension design."],"studyDesign":"Randomized placebo-controlled trial with safety extension","sourceStrength":{"note":"Automated baseline based on evidence tier; 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Tesamorelin, a synthetic GFR, has been developed as a potential treatment for a variety of conditions that may be associated with a relative deficiency of GH including HIV-related lipodystrophy. This article reviews the development of tesamorelin and its purported role in HIV-related lipodystrophy and other potential indications. Relevant articles and abstracts were obtained from...","authors":"Ying Wang, Brian Tomlinson","publishingOrg":null,"publicationYear":2009,"doi":"10.1517/13543780802707658","pubmedId":"19243281","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"systematic_review_or_meta_analysis","claimSupported":"This source contributes systematic_review evidence concerning Tesamorelin, a human growth hormone releasing factor analogue.","supportNature":"contextualizes","qualification":"Secondary synthesis; certainty depends on included studies, heterogeneity, publication bias, and review methods.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1517/13543780802707658","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"systematic_review","extractionPayload":{"limitations":["Secondary synthesis; certainty depends on included studies, heterogeneity, publication bias, and review methods."],"studyDesign":"Narrative or scoped review","sourceStrength":{"grade":"B","score":68,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Journal Article","Review"]},"provenancePayload":{"doi":"10.1517/13543780802707658","pmid":"19243281","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"7e9381928b6032f155be746e25be8769","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/18690162/","evidenceTier":"phase_1_2","summary":"Treatment of HIV patients with daily tesamorelin, a growth hormone-releasing factor analogue, for 26 weeks resulted in a significant decrease in visceral adipose tissue (VAT) and improvement in lipids. The objective of the 26-week extension phase was to evaluate long-term safety and effects of tesamorelin. HIV patients with central fat accumulation in the context of antiretroviral therapy were randomized to tesamorelin 2 mg (n = 273) or placebo (n = 137) s.c. daily for 26 weeks. At week 26, patients originally on tesamorelin were rerandomized to 2 mg tesamorelin (T-T group, n = 154) or placebo (T-P group, n = 50), whereas patients originally on placebo were switched to tesamorelin (P-T...","authors":"Julian Falutz, Soraya Allas, Jean-Claude Mamputu, Diane Potvin, Donald Kotler, Michael Somero, Daniel Berger, Stephen Brown","publishingOrg":null,"publicationYear":2008,"doi":"10.1097/QAD.0b013e32830a5058","pubmedId":"18690162","jurisdiction":null,"dateAccessed":"2026-09-08T18:53:38.906Z","editorialNotes":"AI-assisted PubMed corpus expansion; owner authorized 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"This source contributes human_interventional evidence concerning Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation.","supportNature":"contextualizes","qualification":"Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-five-corpus-expansion-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1097/qad.0b013e32830a5058","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:53:38.906Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":"wpf:tesamorelin:expansion:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"limitations":["Applicability is limited to the enrolled population, formulation, comparator, endpoints, and follow-up duration."],"studyDesign":"Randomized or controlled human clinical trial","sourceStrength":{"grade":"A","score":86,"version":"WPF-ESR-1.0","dimensions":{"authority":18,"reporting":10,"directness":15,"replication":"review-sensitive","designAndBias":"publication-type-derived","populationRelevance":"lane-derived"},"provisional":true},"publicationTypes":["Journal Article","Randomized Controlled Trial","Research Support, Non-U.S. Gov't"]},"provenancePayload":{"doi":"10.1097/QAD.0b013e32830a5058","pmid":"18690162","retrievedFrom":"NCBI PubMed"},"validationGates":{"sourceVerified":true,"ownerAuthorized":true,"identityResolved":true,"neutralLanguageVerified":true},"engineState":"promoted_internal","engineRunId":null,"createdAt":"2026-09-08T18:53:38.906Z","updatedAt":"2026-09-08T18:53:38.906Z"},{"id":"b8c89be2c3eb4291e239645880557a65","peptideId":"e0362116-0ace-4898-bf44-bc5eca4e263a","title":"Metabolic Effects of a Growth Hormone–Releasing Factor in Patients with HIV","sourceUrl":"https://doi.org/10.1056/NEJMoa072375","evidenceTier":"phase_3","summary":"A randomized phase 3 trial found that 26 weeks of tesamorelin reduced visceral adipose tissue and improved selected lipid measures in adults with HIV-associated abdominal fat accumulation.","authors":null,"publishingOrg":null,"publicationYear":2007,"doi":"10.1056/NEJMoa072375","pubmedId":"18003959","jurisdiction":null,"dateAccessed":"2026-09-08T18:31:47.338Z","editorialNotes":"AI-assisted synthesis; owner-authorized governed publication 2026-09-08.","sourceType":"peer_reviewed_research","claimSupported":"Tesamorelin reduced visceral adipose tissue over 26 weeks in the studied population.","supportNature":"supports","qualification":"Industry-sponsored, 26 weeks, and not generalizable to routine obesity.","verificationStatus":"verified","publicationStatus":"published","addedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","machineActor":"wpf-reference-corpus-2026-09-08","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1056/nejmoa072375","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-08T18:31:47.338Z","retrievalProvider":"PubMed/Crossref verification","retrievalPayloadRef":"wpf:tesamorelin:reference-corpus:2026-09-08","evidenceLane":"human_interventional","extractionPayload":{"finding":"Tesamorelin reduced visceral adipose tissue over 26 weeks in the studied population.","population":"Adults with HIV and excess abdominal fat","sampleSize":"412 randomized","limitations":["Industry-sponsored, 26 weeks, and not generalizable to routine obesity."],"studyDesign":"Randomized double-blind placebo-controlled phase 3 trial","sourceStrength":{"note":"Automated baseline based on evidence tier; 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Phase III clinical trials for the treatment of HIV-associated lipodystrophy and phase II clinical trials for sleep disorder, chronic obstructive pulmonary disorder, hip fracture and immune system dysfunction are underway. 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