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Machine-staged source candidate; findings and limitations require accountable review before publication.","authors":"P F Searle; B L Davison; G W Stuart; T M Wilkie; G Norstedt; R D Palmiter","publishingOrg":"Molecular and cellular biology","publicationYear":1984,"doi":"10.1128/mcb.4.7.1221-1230.1984","pubmedId":"6095054","jurisdiction":null,"dateAccessed":"2026-09-09T11:42:17.741Z","editorialNotes":"Machine-staged candidate; no human approval asserted.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"codex-governed-profile-batch-10-2026-09-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1128/mcb.4.7.1221-1230.1984","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-09T11:42:17.741Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":null,"evidenceLane":"animal_in_vivo","extractionPayload":{"sourceStrength":{"grade":"C","version":"WPF-ESR-1.0","provisional":true},"publicationTypes":"Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S."},"provenancePayload":{"doi":"10.1128/mcb.4.7.1221-1230.1984","pmid":"6095054","provider":"NCBI PubMed"},"validationGates":{"pmidResolved":true,"humanReviewed":false,"identityResolved":true,"publicationApproved":false},"engineState":"candidate","engineRunId":null,"createdAt":"2026-09-09T11:42:17.741Z","updatedAt":"2026-09-09T19:33:05.147Z"}],"regulatory":[{"id":"39366d723412bb5c6a4b2dec43c6a3b4","peptideId":"6733b24e-19ab-401a-a174-7e1b9bcfb96b","jurisdiction":"European Union","status":"not_approved","approvedIndication":null,"rationale":"No marketing authorization identified in the cited official portal; absence is machine-staged and requires accountable recheck.","sourceTitle":"EMA medicines portal","sourceUrl":"https://www.ema.europa.eu/en/medicines","dateChecked":"2026-09-09T11:45:21.643Z","reviewDueAt":"2027-03-08T11:45:21.643Z","enteredById":null,"reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","publicationStatus":"published","factualObservationId":null,"createdAt":"2026-09-09T11:45:21.643Z","updatedAt":"2026-09-09T19:33:05.147Z"},{"id":"364221d199267267c0981fb5281779b3","peptideId":"6733b24e-19ab-401a-a174-7e1b9bcfb96b","jurisdiction":"United States","status":"not_approved","approvedIndication":null,"rationale":"No FDA marketing approval identified. 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