{"schemaVersion":"wpf-profile-export-v1","exportedAt":"2026-09-18T15:17:28.814Z","profile":{"slug":"hexarelin","name":"Hexarelin","aliases":[],"category":"Growth hormone secretagogue peptide"},"synthesis":{"mechanism":"Synthetic hexapeptide growth-hormone secretagogue acting principally through the ghrelin receptor.","evidence":"Source identities are PubMed-resolved and provisionally graded by study design. Full-text findings, bias, applicability, contradictions, and regulatory interpretation remain pending.","safety":"Proposed uses lack mature confirmatory evidence; endocrine, cardiometabolic, product-quality, and duration limits matter.","observationalBoundary":"A minimum 25-source PubMed corpus and chemistry record are staged for accountable review. This profile remains suppressed until authorized scientific and publication approval.","openQuestions":"Which findings survive full-text risk-of-bias review? 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Machine-staged source candidate; findings and limitations require accountable review before publication.","authors":"Xiu-Li Cheng; Fan Ding; De-Ping Wang; Lan Zhou; Ji-Min Cao","publishingOrg":"Peptides","publicationYear":2019,"doi":"10.1016/j.peptides.2019.170122","pubmedId":"31386895","jurisdiction":null,"dateAccessed":"2026-09-09T11:43:16.162Z","editorialNotes":"Machine-staged candidate; no human approval asserted.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"codex-governed-profile-batch-10-2026-09-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.peptides.2019.170122","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-09T11:43:16.162Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":null,"evidenceLane":"animal_in_vivo","extractionPayload":{"sourceStrength":{"grade":"C","version":"WPF-ESR-1.0","provisional":true},"publicationTypes":"Journal Article; Research Support, Non-U.S. Gov't"},"provenancePayload":{"doi":"10.1016/j.peptides.2019.170122","pmid":"31386895","provider":"NCBI PubMed"},"validationGates":{"pmidResolved":true,"humanReviewed":false,"identityResolved":true,"publicationApproved":false},"engineState":"candidate","engineRunId":null,"createdAt":"2026-09-09T11:43:16.162Z","updatedAt":"2026-09-09T19:33:05.147Z"},{"id":"34f9d091-6b74-5554-93d0-b67cbd6ba232","peptideId":"ed9dddf3-19b5-4e98-8cad-048198e6d961","title":"Hexarelin protects cardiac H9C2 cells from angiotensin II-induced hypertrophy via the regulation of autophagy.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31526442/","evidenceTier":"laboratory","summary":"PubMed-indexed journal article; research support, non-u.s. gov't examining hexarelin protects cardiac h9c2 cells from angiotensin ii-induced hypertrophy via the regulation of autophagy. Machine-staged source candidate; findings and limitations require accountable review before publication.","authors":"E Agbo; M-X Li; Y-Q Wang; R-O Saahene; J Massaro; G-Z Tian","publishingOrg":"Die Pharmazie","publicationYear":2019,"doi":"10.1691/ph.2019.9324","pubmedId":"31526442","jurisdiction":null,"dateAccessed":"2026-09-09T11:43:16.162Z","editorialNotes":"Machine-staged candidate; no human approval asserted.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"codex-governed-profile-batch-10-2026-09-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1691/ph.2019.9324","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-09T11:43:16.162Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":null,"evidenceLane":"in_vitro","extractionPayload":{"sourceStrength":{"grade":"C","version":"WPF-ESR-1.0","provisional":true},"publicationTypes":"Journal Article; Research Support, Non-U.S. Gov't"},"provenancePayload":{"doi":"10.1691/ph.2019.9324","pmid":"31526442","provider":"NCBI PubMed"},"validationGates":{"pmidResolved":true,"humanReviewed":false,"identityResolved":true,"publicationApproved":false},"engineState":"candidate","engineRunId":null,"createdAt":"2026-09-09T11:43:16.162Z","updatedAt":"2026-09-09T19:33:05.147Z"},{"id":"69a1acb4-0e27-5c7a-bfd1-6a8766572195","peptideId":"ed9dddf3-19b5-4e98-8cad-048198e6d961","title":"Modulation of PTEN by hexarelin attenuates coronary artery ligation-induced heart failure in rats.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/31091855/","evidenceTier":"animal","summary":"PubMed-indexed journal article examining modulation of pten by hexarelin attenuates coronary artery ligation-induced heart failure in rats. 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