{"schemaVersion":"wpf-profile-export-v1","exportedAt":"2026-09-18T15:18:27.474Z","profile":{"slug":"ghrp-6","name":"GHRP-6","aliases":[],"category":"Growth hormone secretagogue peptide"},"synthesis":{"mechanism":"Synthetic growth-hormone secretagogue and ghrelin-receptor agonist studied in endocrine and metabolic research.","evidence":"Source identities are PubMed-resolved and provisionally graded by study design. Full-text findings, bias, applicability, contradictions, and regulatory interpretation remain pending.","safety":"Human evidence is limited; hormonal, appetite, glucose, product-quality, and sport-status contexts matter.","observationalBoundary":"A minimum 25-source PubMed corpus and chemistry record are staged for accountable review. This profile remains suppressed until authorized scientific and publication approval.","openQuestions":"Which findings survive full-text risk-of-bias review? 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Machine-staged source candidate; findings and limitations require accountable review before publication.","authors":"Jorge Berlanga-Acosta; Danay Cibrian; Juan Valiente-Mustelier; José Suárez-Alba; Ariana García-Ojalvo; Viviana Falcón-Cama; Baohong Jiang; Linlin Wang; Gerardo Guillén-Nieto","publishingOrg":"Frontiers in pharmacology","publicationYear":2024,"doi":"10.1155/S1110724302000335","pubmedId":"38873418","jurisdiction":null,"dateAccessed":"2026-09-09T11:43:01.757Z","editorialNotes":"Machine-staged candidate; no human approval asserted.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"codex-governed-profile-batch-10-2026-09-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1155/s1110724302000335","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-09T11:43:01.757Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":null,"evidenceLane":"mechanistic","extractionPayload":{"sourceStrength":{"grade":"C","version":"WPF-ESR-1.0","provisional":true},"publicationTypes":"Journal Article"},"provenancePayload":{"doi":"10.1155/S1110724302000335","pmid":"38873418","provider":"NCBI PubMed"},"validationGates":{"pmidResolved":true,"humanReviewed":false,"identityResolved":true,"publicationApproved":false},"engineState":"candidate","engineRunId":null,"createdAt":"2026-09-09T11:43:01.757Z","updatedAt":"2026-09-09T19:33:05.147Z"},{"id":"b208edbc-bf5e-5138-bcde-08c54cf3a33e","peptideId":"6657d302-0ceb-42c8-9ba6-bc6b358b8e0c","title":"Growth hormone secretagogue peptide-6 enhances oreochromicins transcription and antimicrobial activity in tilapia (Oreochromis sp.).","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/34592474/","evidenceTier":"observational","summary":"PubMed-indexed journal article examining growth hormone secretagogue peptide-6 enhances oreochromicins transcription and antimicrobial activity in tilapia (oreochromis sp.). Machine-staged source candidate; findings and limitations require accountable review before publication.","authors":"Liz Hernández; Hanlet Camacho; Adriana Nuñez-Robainas; Daniel O Palenzuela; Antonio Morales; Liliana Basabe; Fidel Herrera; Osmany Rodrigo; Adrian Rodriguez-Gabilondo; Janet Velázquez; Soraya Piloto; Mario P Estrada","publishingOrg":"Fish & shellfish immunology","publicationYear":2021,"doi":"10.1016/j.fsi.2021.08.011","pubmedId":"34592474","jurisdiction":null,"dateAccessed":"2026-09-09T11:43:01.757Z","editorialNotes":"Machine-staged candidate; no human approval asserted.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"codex-governed-profile-batch-10-2026-09-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.fsi.2021.08.011","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-09T11:43:01.757Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":null,"evidenceLane":"mechanistic","extractionPayload":{"sourceStrength":{"grade":"C","version":"WPF-ESR-1.0","provisional":true},"publicationTypes":"Journal Article"},"provenancePayload":{"doi":"10.1016/j.fsi.2021.08.011","pmid":"34592474","provider":"NCBI PubMed"},"validationGates":{"pmidResolved":true,"humanReviewed":false,"identityResolved":true,"publicationApproved":false},"engineState":"candidate","engineRunId":null,"createdAt":"2026-09-09T11:43:01.757Z","updatedAt":"2026-09-09T19:33:05.147Z"},{"id":"ce9a323a-f16b-57ce-a122-4aaf78fbc140","peptideId":"6657d302-0ceb-42c8-9ba6-bc6b358b8e0c","title":"Growth hormone-releasing peptide 6 prevents cutaneous hypertrophic scarring: early mechanistic data from a proteome study.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/29464859/","evidenceTier":"observational","summary":"PubMed-indexed journal article examining growth hormone-releasing peptide 6 prevents cutaneous hypertrophic scarring: early mechanistic data from a proteome study. Machine-staged source candidate; findings and limitations require accountable review before publication.","authors":"Maday Fernández-Mayola; Lázaro Betancourt; Alicia Molina-Kautzman; Sucel Palomares; Yssel Mendoza-Marí; Dayana Ugarte-Moreno; Ana Aguilera-Barreto; Yilian Bermúdez-Álvarez; Vladimir Besada; Luis J González; Ariana García-Ojalvo; Ana J Mir-Benítez","publishingOrg":"International wound journal","publicationYear":2018,"doi":"10.1155/2016/4361702","pubmedId":"29464859","jurisdiction":null,"dateAccessed":"2026-09-09T11:43:01.757Z","editorialNotes":"Machine-staged candidate; no human approval asserted.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"codex-governed-profile-batch-10-2026-09-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1155/2016/4361702","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-09T11:43:01.757Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":null,"evidenceLane":"mechanistic","extractionPayload":{"sourceStrength":{"grade":"C","version":"WPF-ESR-1.0","provisional":true},"publicationTypes":"Journal Article"},"provenancePayload":{"doi":"10.1155/2016/4361702","pmid":"29464859","provider":"NCBI PubMed"},"validationGates":{"pmidResolved":true,"humanReviewed":false,"identityResolved":true,"publicationApproved":false},"engineState":"candidate","engineRunId":null,"createdAt":"2026-09-09T11:43:01.757Z","updatedAt":"2026-09-09T19:33:05.147Z"},{"id":"8f4796eb-604f-5d8f-983b-48cf412ce4c8","peptideId":"6657d302-0ceb-42c8-9ba6-bc6b358b8e0c","title":"Growth hormone releasing peptide-6 enhanced antibody titers against subunit antigens in mice (BALB/c), tilapia (Oreochromis niloticus) and African catfish (Clarias gariepinus).","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/28893476/","evidenceTier":"animal","summary":"PubMed-indexed journal article; research support, non-u.s. gov't examining growth hormone releasing peptide-6 enhanced antibody titers against subunit antigens in mice (balb/c), tilapia (oreochromis niloticus) and african catfish (clarias gariepinus). Machine-staged source candidate; findings and limitations require accountable review before publication.","authors":"Rebeca Martínez; Liz Hernández; Lázaro Gil; Yamila Carpio; Antonio Morales; Fidel Herrera; Alina Rodríguez-Mallón; Yeny Leal; Aracelys Blanco; Mario Pablo Estrada","publishingOrg":"Vaccine","publicationYear":2017,"doi":"10.1016/j.vaccine.2017.07.060","pubmedId":"28893476","jurisdiction":null,"dateAccessed":"2026-09-09T11:43:01.757Z","editorialNotes":"Machine-staged candidate; no human approval asserted.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"codex-governed-profile-batch-10-2026-09-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1016/j.vaccine.2017.07.060","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-09T11:43:01.757Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":null,"evidenceLane":"animal_in_vivo","extractionPayload":{"sourceStrength":{"grade":"C","version":"WPF-ESR-1.0","provisional":true},"publicationTypes":"Journal Article; Research Support, Non-U.S. Gov't"},"provenancePayload":{"doi":"10.1016/j.vaccine.2017.07.060","pmid":"28893476","provider":"NCBI PubMed"},"validationGates":{"pmidResolved":true,"humanReviewed":false,"identityResolved":true,"publicationApproved":false},"engineState":"candidate","engineRunId":null,"createdAt":"2026-09-09T11:43:01.757Z","updatedAt":"2026-09-09T19:33:05.147Z"},{"id":"d2fff6a2-3ae4-56b2-a573-2d5f45db8ac7","peptideId":"6657d302-0ceb-42c8-9ba6-bc6b358b8e0c","title":"Growth Hormone-Releasing Peptide 6 Enhances the Healing Process and Improves the Esthetic Outcome of the Wounds.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/27200188/","evidenceTier":"observational","summary":"PubMed-indexed journal article examining growth hormone-releasing peptide 6 enhances the healing process and improves the esthetic outcome of the wounds. 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Machine-staged source candidate; findings and limitations require accountable review before publication.","authors":"N Subirós; H Pérez-Saad; L Aldana; C L Gibson; W S Borgnakke; D Garcia-Del-Barco","publishingOrg":"Neurological research","publicationYear":2016,"doi":"10.1080/01616412.2016.1235249","pubmedId":"27665924","jurisdiction":null,"dateAccessed":"2026-09-09T11:43:01.757Z","editorialNotes":"Machine-staged candidate; no human approval asserted.","sourceType":"peer_reviewed_research","claimSupported":null,"supportNature":null,"qualification":null,"verificationStatus":"verified","publicationStatus":"published","addedById":null,"machineActor":"codex-governed-profile-batch-10-2026-09-09","reviewedById":"0bf5b853-ea8b-4aa3-bffe-2af0fdd75150","canonicalSourceIdentity":"doi:10.1080/01616412.2016.1235249","sourceIdentityId":null,"sourceStatus":"active","sourceContentHash":null,"sourceVersion":1,"retrievedAt":"2026-09-09T11:43:01.757Z","retrievalProvider":"NCBI PubMed","retrievalPayloadRef":null,"evidenceLane":"mechanistic","extractionPayload":{"sourceStrength":{"grade":"C","version":"WPF-ESR-1.0","provisional":true},"publicationTypes":"Journal Article"},"provenancePayload":{"doi":"10.1080/01616412.2016.1235249","pmid":"27665924","provider":"NCBI PubMed"},"validationGates":{"pmidResolved":true,"humanReviewed":false,"identityResolved":true,"publicationApproved":false},"engineState":"candidate","engineRunId":null,"createdAt":"2026-09-09T11:43:01.757Z","updatedAt":"2026-09-09T19:33:05.147Z"},{"id":"20d372c1-e2bc-538b-9474-2f9236227dc4","peptideId":"6657d302-0ceb-42c8-9ba6-bc6b358b8e0c","title":"[Time course study of growth hormone releasing peptide-6-induced c-fos expression in neurons of feeding-related nuclei of hypothalamus].","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/26915318/","evidenceTier":"observational","summary":"PubMed-indexed journal article examining [time course study of growth hormone releasing peptide-6-induced c-fos expression in neurons of feeding-related nuclei of hypothalamus]. 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