{"schemaVersion":"wpf-profile-export-v1","exportedAt":"2026-09-18T15:31:44.930Z","profile":{"slug":"epitalon","name":"Epitalon","aliases":["Epithalon","Epitalon tetrapeptide","AEDG peptide"],"category":"Synthetic tetrapeptide bioregulator"},"synthesis":{"mechanism":"Epitalon (also transliterated Epithalon) is the tetrapeptide Ala-Glu-Asp-Gly associated with Russian peptide-bioregulator research. Proposed effects include modulation of gene expression, circadian biology, oxidative stress, and telomerase-related pathways, but mechanisms and clinical relevance remain uncertain.","evidence":"The literature contains preclinical experiments, reviews, and older or geographically concentrated human reports. Independent replication, modern trial registration, standardized preparations, and detailed risk-of-bias reporting are limited; anti-aging or longevity efficacy is not established.","safety":"Reliable contemporary human safety data, pharmacokinetics, product standards, interaction studies, reproductive toxicology, and long-term surveillance are insufficient. Telomerase-related hypotheses require careful benefit-risk evaluation rather than assumptions of rejuvenation.","observationalBoundary":"This profile includes English-language and international indexed literature while marking preclinical, historical, and related peptide-bioregulator studies as such.","openQuestions":"Can independent laboratories reproduce target engagement? 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Our data suggests that epitalon can ext …","authors":"Al-Dulaimi S, Thomas R, Matta S, Roberts T.","publishingOrg":null,"publicationYear":2025,"doi":"10.1007/s10522-025-10315-x","pubmedId":"40908429","jurisdiction":null,"dateAccessed":"2026-09-08T19:33:45.384Z","editorialNotes":"AI-assisted corpus expansion authorized by owner on 2026-09-08. 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More mechanistic investigations are needed to confirm Epitalon's benefits and safety. Developing oph …","authors":"Gatta M, Dovizio M, Milillo C, Ruggieri AG, Sallese M, Antonucci I, Trofimov A, Khavinson V, Trofimova S, Bruno A, Ballerini P.","publishingOrg":null,"publicationYear":2025,"doi":"10.1007/s12015-025-10911-x","pubmedId":"40493162","jurisdiction":null,"dateAccessed":"2026-09-08T19:33:45.384Z","editorialNotes":"AI-assisted corpus expansion authorized by owner on 2026-09-08. 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Epitalon at 0.1mM was added to the culture medium, and the quality of oocytes was evaluated at 6h, 12h, and 24h of culture. ...Our results suggest that …","authors":"Yue X, Liu SL, Guo JN, Meng TG, Zhang XR, Li HX, Song CY, Wang ZB, Schatten H, Sun QY, Guo XP.","publishingOrg":null,"publicationYear":2022,"doi":"10.18632/aging.204007","pubmedId":"35413689","jurisdiction":null,"dateAccessed":"2026-09-08T19:33:45.384Z","editorialNotes":"AI-assisted corpus expansion authorized by owner on 2026-09-08. 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