{"schemaVersion":"wpf-profile-export-v1","exportedAt":"2026-09-18T15:17:28.969Z","profile":{"slug":"bpc-157","name":"BPC-157","aliases":["Body Protection Compound 157","PL 14736","Bepecin"],"category":"Synthetic research peptide"},"synthesis":{"mechanism":"BPC-157 is a synthetic 15-amino-acid peptide derived from a sequence associated with gastric proteins. Experimental studies report effects on angiogenesis, nitric-oxide signaling, inflammatory pathways, and tissue repair, but the proposed mechanisms are not established as therapeutic mechanisms in humans.","evidence":"The represented literature is dominated by animal, cell, and narrative-review evidence. A very small amount of uncontrolled human experience has been published, but there is no robust replicated randomized clinical evidence establishing efficacy for musculoskeletal, gastrointestinal, neurologic, or other promoted uses.","safety":"Human pharmacokinetics, dose-response relationships, interaction risks, immunogenicity, carcinogenicity, reproductive toxicity, and long-term safety remain inadequately characterized. Preclinical healing signals do not establish that unsupervised human use is safe.","observationalBoundary":"This profile separates direct BPC-157 studies from reviews, related-pathway context, regulatory records, and anti-doping information. Most positive findings originate from preclinical research.","openQuestions":"Which findings reproduce independently? What are human pharmacokinetics, target engagement, clinically meaningful efficacy, optimal endpoints, and short- and long-term safety in adequately powered controlled trials?"},"completion":{"version":"wpf-profile-v1.0","complete":true,"checks":[{"key":"overview","passed":true,"actual":306,"required":100,"severity":"blocking"},{"key":"evidence_summary","passed":true,"actual":320,"required":100,"severity":"blocking"},{"key":"safety_summary","passed":true,"actual":265,"required":100,"severity":"blocking"},{"key":"archive_boundary","passed":true,"actual":193,"required":75,"severity":"blocking"},{"key":"open_questions","passed":true,"actual":215,"required":75,"severity":"blocking"},{"key":"verified_sources","passed":true,"actual":25,"required":25,"severity":"blocking"},{"key":"reviewed_sources","passed":true,"actual":25,"required":1,"severity":"blocking"},{"key":"chemistry","passed":true,"actual":true,"required":true,"severity":"blocking"},{"key":"regulatory_context","passed":true,"actual":2,"required":2,"severity":"blocking"},{"key":"claims","passed":true,"actual":25,"required":1,"severity":"blocking"},{"key":"claim_traceability","passed":true,"actual":0,"required":0,"severity":"blocking"},{"key":"regulatory_freshness","passed":true,"actual":0,"required":0,"severity":"warning"}],"failures":[]},"chemistry":{"id":"8c62ebfd9ed3996101e1fc653a972007","peptideId":"739cc89b-933c-49c0-a1b7-3a1fbcf5558e","molecularFormula":"C62H98N16O22","molecularWeight":1419.56,"aminoAcidSequence":"GEPPPGKPADDAGLV","smiles":null,"inchi":null,"inchikey":null,"structureImageUrl":null,"createdAt":"2026-09-08T19:33:45.384Z","updatedAt":"2026-09-08T19:33:45.384Z"},"evidence":[{"id":"bc5331774bba888364a4fccf45d34520","peptideId":"739cc89b-933c-49c0-a1b7-3a1fbcf5558e","title":"Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.","sourceUrl":"https://pubmed.ncbi.nlm.nih.gov/41476424/","evidenceTier":"laboratory","summary":"METHODS: A comprehensive literature search was conducted using PubMed to identify biochemical and clinical studies on the most popular types of injectable peptide therapy. Key peptides evaluated included BPC-157, TB-4, TB-500, CJC-1295 + ipamorelin, tesamorelin, and …","authors":"Mayfield CK, Bolia IK, Feingold CL, Lin EH, Liu JN, Rick Hatch GF, Gamradt SC, Weber AE.","publishingOrg":null,"publicationYear":2026,"doi":"10.1177/03635465251357593","pubmedId":"41476424","jurisdiction":null,"dateAccessed":"2026-09-08T19:33:45.384Z","editorialNotes":"AI-assisted corpus expansion authorized by owner on 2026-09-08. 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We also p …","authors":"Józwiak M, Bauer M, Kamysz W, Kleczkowska P.","publishingOrg":null,"publicationYear":2025,"doi":"10.3390/ph18020185","pubmedId":"40005999","jurisdiction":null,"dateAccessed":"2026-09-08T19:33:45.384Z","editorialNotes":"AI-assisted corpus expansion authorized by owner on 2026-09-08. 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